New hope for breast cancer patients with brain tumors: drug combo trial underway

NCT ID NCT05386108

Recruiting now Disease control Sponsor: Stemline Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about 73 adults and is currently recruiting at multiple sites worldwide.

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Conditions

The condition(s) this trial relates to.

brain cancer brain disorder brain neoplasm breast disorder breast neoplasm central nervous system cancer central nervous system disorder central nervous system neoplasm hormone receptor-positive breast cancer neoplasm Neoplasms by Site

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN DISEASES BRAIN NEOPLASMS BREAST DISEASES BREAST NEOPLASMS CENTRAL NERVOUS SYSTEM DISEASES CENTRAL NERVOUS SYSTEM NEOPLASMS NEOPLASMS NEOPLASMS BY SITE

Contacts and locations

Locations

A. O. Ospedali Riuniti Parpardo, Piemonte, Messina
RECRUITING

Messina, Italy
AOU Città della Salute e della Scienza di Torino, Ospedale Molinette
RECRUITING

Torino, Italy
AOU Ospedali Riuniti Umberto I-G.M.Lancisi -G.Salesi
RECRUITING

Ancona, Italy
Acibadem Altunizade Hospital
RECRUITING

Istanbul, Turkey (Türkiye)
Adana Sehir Hastanesi
RECRUITING

Adana, Turkey (Türkiye)
Ankara Bilkent Sehir Hastanesi Tibbi Onkoloji Klinigi
RECRUITING

Ankara, Turkey (Türkiye)
Ankara University Medical Faculty
RECRUITING

Ankara, Turkey (Türkiye)
Antwerp University Hospital
RECRUITING

Edegem, 2650, Belgium
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliera Santa Maria di Terni
RECRUITING

Terni, Italy
Azienda Ospedaliera Universitaria Federico II
RECRUITING

Naples, Italy
Azienda Ospedaliero-Universitaria di Modena, Policlinico di Modena
RECRUITING

Modena, Italy
California Research Institute
RECRUITING

Los Angeles, California, 90027, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States
Centre Francois Baclesse - Oncologie Medicale - Cancerolo
RECRUITING

Caen, France
Centre Hospitalier Universitaire de Poitiers
RECRUITING

Poitiers, 86000, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, France
Centre Léon Bérard - Département Oncologie Médicale
RECRUITING

Lyon, France
Centre de Cancerologie du Grand Montpellier
RECRUITING

Montpellier, 37070, France
Clara Campal Comprehensive Cancer Center (CIOCC)
RECRUITING

Madrid, Madrid, 28050, Spain
Clinica Universidad de Navarra
RECRUITING

Madrid, Spain
Clinica Universidad de Navarra
RECRUITING

Pamplona, Spain
Complexo Hospitalario Universitario De Santiago
RECRUITING

Santiago de Compostela, 15706, Spain
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi
RECRUITING

Ankara, Turkey (Türkiye)
EUROMEDICA General Clinic of Thessaloniki
COMPLETED

Thessaloniki, 54645, Greece
Ege University Medical Faculty
RECRUITING

Bornova, Turkey (Türkiye)
Ewha Womans University MokDong Hospital
RECRUITING

Seoul, 07985, South Korea
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, Italy
Fundación Instituto Valenciano De Oncología
RECRUITING

Valencia, Spain
Gangnam Severance Hospital
RECRUITING

Seoul, 06273, South Korea
Gulhane Egitim ve Arastirma Hastanesi Tibbi Onkoloji Klinigi
RECRUITING

Ankara, Turkey (Türkiye)
Guy's and St Thomas' NHS Foundation Trust
RECRUITING

London, United Kingdom
Hacettepe University Medical Faculty
RECRUITING

Ankara, Turkey (Türkiye)
Helios Klinikum Wuppertal
RECRUITING

Wuppertal, Germany
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Hospital Clinic De Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clínico San Carlos
RECRUITING

Madrid, Spain
Hospital Universitari Vall D Hebron
RECRUITING

Barcelona, Spain
Hospital Universitario Quirónsalud Madrid
RECRUITING

Madrid, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Valencia, Spain
Hôpital Morvan - CHRU de Brest - cancérologie et d'hématologie
RECRUITING

Brest, France
Hôpital de la Pitiê Salpêtriêre
RECRUITING

Paris, 75103, France
IEO - Istituto Europeo di Oncologia, IRCCS
RECRUITING

Milan, Italy
IRCCS Policlinico San Matteo, Università degli studi di Pavia, Pavia Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, Italy
Institut Claudius Regaud
RECRUITING

Toulouse, 31100, France
Institut de Cancerologie de l'Ouest site Paul Papin
RECRUITING

Angers, France
Interbalkan European Medical Center
RECRUITING

Thessaloniki, 57001, Greece
Istituto Nazionale dei Tumori - Fondazione Pascale, IRCCS
RECRUITING

Naples, Italy
Istituto Oncologico Veneto IOV - IRCCS
RECRUITING

Padova, Italy
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST IRCCS
RECRUITING

Meldola, Italy
Istituto di Candiolo, IRCCS
RECRUITING

Candiolo, Italy
Klinikum Bayreuth GmbH
RECRUITING

Bayreuth, 95445, Germany
Klinikum Worms gGmbH
RECRUITING

Worms, 67550, Germany
Medipol Mega Hospital - Medical Oncology
RECRUITING

Istanbul, Turkey (Türkiye)
Medizinische Hochschule Hannover
RECRUITING

Hanover, Germany
Memorial Ankara Hastanesi Tibbi Onkoloji
RECRUITING

Ankara, Turkey (Türkiye)
Metropolitan Hospital [Oncology]
RECRUITING

Piraeus, 12462, Greece
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States
National and Capodistrian University of Athens - University General Hospital Attikon
RECRUITING

Athens, 12462, Greece
Oregon Health & Science University
COMPLETED

Portland, Oregon, 97239, United States
Ospedale San Gerardo, ASST di Monza, IRCCS
RECRUITING

Monza, Italy
Prof. Dr. Suleyman Yalcin Sehir Hastanesi
RECRUITING

Istanbul, Turkey (Türkiye)
Providence Medical Foundation
RECRUITING

Fullerton, California, 92835, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seoul, South Korea
Seoul National University Hospital
RECRUITING

Seoul, South Korea
The Christie NHS Foundation Trust - Medical Oncology
RECRUITING

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
WITHDRAWN

Liverpool, United Kingdom
UT Health San Antonio University of Texas
COMPLETED

San Antonio, Texas, 78229, United States
Uniklinik Koeln - Klinik und Poliklinik fuer Frauenheilkunde
COMPLETED

Cologne, Germany
Universitaetsklinikum Duesseldorf
RECRUITING

Düsseldorf, Germany
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
RECRUITING

Leuven, Belgium
Universitatsklinikum Carl Gustav Carus
RECRUITING

Dresden, Germany
Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc
RECRUITING

Woluwe-Saint-Lambert, Belgium
University Clinical Hospital Virgen de la Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain
University College London Hospitals NHS Foundation Trust - University College Hospital (UCH) - Macmillan Cancer Centre
RECRUITING

London, United Kingdom
University Hospital 12 de Octubre
RECRUITING

Madrid, Madrid, 28041, Spain
University Hospital Ramón y Cajal
RECRUITING

Madrid, Madrid, 28034, Spain
University Hospital Reina Sofía
RECRUITING

Córdoba, Andalusia, 14004, Spain
University Hospitals of Leicester NHS Trust -Glenfield Hospital
WITHDRAWN

Leicester, United Kingdom
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Universitätsklinikum Erlangen
RECRUITING

Erlangen, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Germany
Virginia Cancer Institute
RECRUITING

Norfolk, Virginia, 00115, United States

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