CENTRAL NERVOUS SYSTEM DISEASES

This study tests two drugs, elacestrant and abemaciclib, in people whose breast cancer has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults with ER-positive, HER2-negative breast cancer will take part. The study is cur…

This study tests whether adding silevertinib (an oral targeted therapy) to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. About 162 adults whose tumors have certain genetic markers (…

This study tests a drug called donanemab in 1,500 people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. Participants receive the drug or a placebo for up to 93 weeks, and researchers track changes in daily function and dementi…

This early-stage trial tests a specially engineered virus, G207, in children and young adults whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is given to help t…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to quickly identify patients with a large vessel occlusion stroke who need to go directly to a hospital equipped for clot removal. About 275 adult…

This study tests whether increasing daily physical activity using a motivational smartphone app can slow cognitive decline in people with a sleep disorder that often leads to Parkinson's disease. Researchers will enroll 130 participants (80 with the sleep disorder and 50 healthy …

This study tests a non-invasive spinal stimulation technique to help people with a recent spinal cord injury (within 30 days) manage blood pressure drops when sitting up. Participants will receive both real and sham stimulation during a sit-up test to see if it can prevent dizzin…

This study tests whether combining virtual reality training with a gentle brain stimulation technique (tDCS) can improve arm and hand movement in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months post-stroke and have moderate arm weakness.…

This study is testing whether a smartphone app can help doctors better understand and treat depression. Researchers will track daily symptoms, medication use, and treatment response in 200 adults with depression. The goal is to improve care by giving doctors real-time insights fr…

This study tests whether virtual reality (VR) and mixed reality (MR) games can help people who had a stroke move their arms and hands better. 45 adults aged 20 to 80 with arm weakness will try these high-tech mirror therapy systems or standard therapy. The goal is to see if the g…

This study tests whether gentle electrical stimulation on the back can help people with chronic spinal cord injury maintain healthy blood pressure when they sit up. Participants will lie on a tilt table while their blood pressure is measured with and without stimulation. The goal…

This study tests a device called ATNC MDD-V1 that uses gentle magnetic pulses and brain exercises to improve thinking and memory in people with mild Alzheimer's. About 180 adults aged 60 to 85 who are already on stable Alzheimer's medication will receive either the real treatment…

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech function in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed in the brain for less than 30 days to deliver mild electrical p…

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will be included. The goal is to see if video assistance helps diagnose …

This study aims to understand how a protein called BD-tau, which is released into the blood when the brain is injured, changes over time in people having a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults with acute ischemic stroke. The goal is …