Could a second drug boost stroke recovery?
NCT ID NCT05892510
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly assigned to receive either the drug or a placebo within 24 hours of symptoms. The goal is to see if the drug reduces disability and improves independence.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Alfred Hospital
RECRUITINGMelbourne, Australia
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Austin Hospital
RECRUITINGMelbourne, Australia
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Christchurch Hospital
NOT_YET_RECRUITINGChristchurch, New Zealand
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Fiona Stanley Hospital
RECRUITINGPerth, Australia
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Gold Coast Univeristy Hospital
RECRUITINGGold Coast, Queensland, Australia
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Liverpool Hospital
RECRUITINGSydney, Australia
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Monash Medical Centre
RECRUITINGMelbourne, Australia
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Royal Adelaide Hospital
RECRUITINGAdelaide, Australia
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Royal Melbourne Hospital
RECRUITINGMelbourne, Australia
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Royal North Shore Hospital
RECRUITINGSydney, Australia
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Sir Charles Gairdner Hospital
RECRUITINGPerth, Australia
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Townsville University Hospital
RECRUITINGTownsville, Australia
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Herbal capsule may boost brain repair after stroke
- Stroke recovery: which blood pressure target works best?
- Antioxidants may unlock sex differences in brain blood flow
- Could a stomach acid blocker shield stroke patients from bleeding?
- New stroke treatment aims to bust clots directly in the brain