CEREBROVASCULAR DISORDERS

This study tests if the drug Dimephosphon can improve recovery in people who have had an acute ischemic stroke (a stroke caused by a blood clot). The trial involves 184 adults aged 35-80 who will receive either Dimephosphon or a placebo within 24-72 hours of their stroke. The mai…

This study tests whether lowering blood pressure can slow the growth of white matter lesions (small brain changes linked to thinking problems) in older adults. About 820 people aged 60-88 with high blood pressure and mild cognitive concerns will take part. Researchers will compar…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after a serious brain bleed (aneurysmal subarachnoid hemorrhage) and aneurysm clipping surgery. RIC uses a blood pressure cuff on the arm to create short, harmless …

This study tests whether injecting a clot-dissolving medicine directly into the brain's arteries can improve recovery for people having a stroke caused by a medium-sized blood vessel blockage. About 282 adults with this type of stroke will be randomly assigned to receive either t…

This small pilot study tests whether a home-based cognitive strategy program (PRPP-I) can help adults with chronic stroke become more independent in daily activities like dressing, cooking, and bathing. Researchers will enroll 18 participants to see if the program is feasible and…

This study tests whether virtual reality (VR) and mixed reality (MR) games can help people who had a stroke move their arms and hands better. 45 adults aged 20 to 80 with arm weakness will try these high-tech mirror therapy systems or standard therapy. The goal is to see if the g…

This study tests a new type of stroke rehabilitation that combines mirror therapy with other techniques to help people who have had a stroke regain movement in their arm and hand. About 81 adults who had a stroke at least 3 months ago will participate. The goal is to see if this …

This early-stage study tests whether giving inhaled nitric oxide (a gas) to people having emergency clot removal for a stroke is safe. About 36 adults will receive different doses to find the highest safe amount. The goal is to see if this approach can be used in future studies t…

This study collects blood, clots, and tissue from up to 1000 people having stroke-related procedures. Researchers will analyze these samples to find biological markers and understand what happens in the body during a stroke. The goal is to improve future treatments and make them …

This study aims to understand how brain damage from strokes, tumors, or diseases affects thinking skills. Researchers will use brain scans and memory tests in 400 people with brain injuries and healthy volunteers. The goal is to learn which brain areas are responsible for specifi…

This study looks at how middle-aged adults' hearts and blood vessels respond to a short, challenging mental task. Researchers will measure blood pressure, heart rate, and brain scans to see if stress reactions are linked to brain health. The goal is to understand how stress might…

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will be included. The goal is to see if video assistance helps diagnose …

This study looks at why women who had high blood pressure during pregnancy are more likely to develop high blood pressure and heart disease later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to bett…

This study aims to understand how a protein called BD-tau, which is released into the blood when the brain is injured, changes over time in people having a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults with acute ischemic stroke. The goal is …