New hope for medium vessel strokes? trial tests direct Clot-Busting drug
NCT ID NCT07185022
First seen Jun 25, 2026 · Last updated Jun 25, 2026
Summary
This study tests whether giving a clot-dissolving drug (tenecteplase) directly into the blocked brain artery can improve recovery in people with a medium-sized vessel stroke. About 282 participants will be randomly assigned to receive either the intra-arterial drug or standard medical care. The main goal is to see if more people achieve a good functional outcome (no or minimal disability) 90 days after treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fu Yang People's Hospital
RECRUITINGFuyang, Anhui, China
Contact Phone: •••-•••-••••
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Lin Quan People's Hospital
RECRUITINGFuyang, Anhui, China
Contact Phone: •••-•••-••••
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Lishui Central Hospital
RECRUITINGLishui, Zhejiang, China
Contact Phone: •••-•••-••••
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LiuZhou Worker's Hospital
RECRUITINGLiuzhou, Guangxi, China
Contact Phone: •••-•••-••••
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Shucheng People's Hospital
RECRUITINGLu'an, Anhui, China
Contact Phone: •••-•••-••••
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The Second (Affiliated) Hospital of Anhui Medical University
RECRUITINGHefei, Anhui, 230031, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tenecteplase (clot-dissolving drug given directly into the brain artery)
What this could lead to
If it works, this could provide a new treatment option for strokes caused by medium-sized artery blockages, where current therapies have not shown clear benefit.
What could go wrong
This is an early-stage trial with only 282 participants. Previous similar trials found no benefit, and there is a risk of bleeding in the brain from the procedure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.