VASCULAR DISEASES

This study is testing the safety of a new inhaled drug, mosliciguat, when added to an existing inhaled medication (treprostinil) for people with pulmonary hypertension caused by scarred lungs (interstitial lung disease). It will enroll about 20 participants who are already using …

This study is testing a new medical device called the Supernova stent retriever for treating acute ischemic strokes caused by large blood clots. The device is designed to physically remove clots from blocked brain arteries to restore blood flow. Researchers will enroll 100 stroke…

This study is testing if a simple, non-invasive treatment can help people recover better after a life-threatening brain bleed caused by a burst aneurysm. The treatment involves repeatedly inflating and deflating a blood pressure cuff on the arm or leg, which may trigger the body'…

This international study is testing whether using just one blood-thinning medication is as safe and effective as using two after a specific type of heart artery procedure. It focuses on patients aged 75 and older or those at high risk for bleeding. The goal is to find the best ba…

This study compares two different guidance methods for accessing blocked leg arteries during minimally invasive procedures. Researchers want to see which approach—using road mapping or ultrasound—is more successful and causes fewer complications. The study includes 32 adults with…

This study is testing the safety and early effectiveness of a new medical procedure that targets nerves in both the kidney and liver to help lower blood pressure. It is for adults with uncontrolled high blood pressure, including those with other heart or kidney risks. The goal is…

This study is collecting real-world information about an FDA-approved device that treats high blood pressure in people who can't control it with lifestyle changes and medications. The device uses a catheter to deliver ultrasound energy to calm overactive nerves around the kidneys…

This study aims to see if a medical procedure called renal denervation, when added to standard blood pressure medications, provides better long-term blood pressure control for Medicare patients. Researchers will compare health records from about 1,000 patients who received the pr…

This study is testing if a temporary spinal cord stimulator can help people with type 2 diabetes who have painful nerve damage in their legs. Researchers want to see if the device not only reduces pain but also improves blood circulation and artery health in the lower limbs. The …

This study is testing a new medical device called the EVSS, which is a small scaffold or stent, to open blocked arteries in the leg. It aims to see if the device is safe and can improve blood flow for people with leg pain or cramping caused by peripheral artery disease. The study…

This study is observing whether an ultrasound treatment called the Recor Paradise System helps control high blood pressure long-term in older adults whose blood pressure remains high despite medication. Researchers will follow 1,000 Medicare-eligible patients to see how well the …

This study is testing if adding a specially trained 'heart health doula' to standard care helps new mothers recover from pregnancy-related high blood pressure. Researchers will compare two groups: one gets standard home blood pressure monitoring, and the other gets that plus week…

This study is testing whether sildenafil (the active ingredient in Viagra) can protect blood vessels in people with advanced heart failure who use a mechanical heart pump (LVAD). The goal is to see if the drug can reduce the rapid aging and damage that happens to blood vessels wh…

This study is testing if a faster version of a kidney nerve-calming procedure works as well as the older, longer method to lower high blood pressure. It will involve about 130 adults whose blood pressure remains high despite treatment. Researchers aim to see if simplifying where …

This study aims to see if using a special heart CT scan to plan a procedure is as good as or better than the current standard method, which uses an ultrasound probe inside the artery. Researchers will compare the two approaches in 700 patients with hardened, clogged heart arterie…

This study tests whether a live video call between paramedics on scene and a hospital neurologist can improve the accuracy of diagnosing a stroke before the patient arrives at the hospital. Faster and more accurate diagnosis in the ambulance could help get patients the right trea…

This study is testing a portable, headset-like device that measures brain waves (EEG) to help ambulance crews quickly identify if a patient is having a severe type of stroke. The goal is to get these patients directly to the right specialized hospital for urgent treatment, avoidi…

This study is testing if taking low-dose aspirin for six months after a pregnancy with preeclampsia helps new mothers' blood vessels recover and lowers their blood pressure. Up to 60 women who recently had preeclampsia will be randomly assigned to take either aspirin or a placebo…

This study is investigating whether eating beef daily as part of a healthy diet helps the body absorb zinc better, which might improve blood vessel function. Researchers are recruiting 20 adults aged 55-70 to compare two healthy diets—one with beef and one with other protein sour…

This study aims to understand why blood vessels malfunction in preeclampsia, a dangerous high-blood-pressure condition during pregnancy. Researchers will collect small tissue samples from 166 women during their planned C-sections, comparing those with and without preeclampsia. By…

This study aims to understand what factors influence patient recovery and survival after major heart and blood vessel surgeries. Researchers will look back at the medical records of 5,000 adults who had these surgeries at UC Davis between 2001 and 2013. The goal is to identify pa…

This study aims to deeply understand stroke by observing thousands of patients over time. It will collect detailed medical information and scan results to see how stroke changes the brain and body. The goal is to gather knowledge that will help scientists design better future tre…

This study aims to understand why some people with atrial fibrillation (AF, an irregular heartbeat) still have a stroke even while taking blood-thinning medication. Researchers will follow 500 stroke patients with AF for about a year, collecting blood samples and heart scan data.…

This study aims to understand how social and lifestyle factors—like education, income, and where you live—affect a person's thinking skills and recovery after a stroke. Researchers will conduct a 45-minute phone interview with 450 adults who have had a stroke, asking about their …

This study aims to understand if a short, 3-month course of high-dose cholesterol medication (statin) can change the fatty buildup (plaque) in heart arteries, as seen on special heart scans. Researchers will follow 140 patients with chest pain but no prior statin use for 24 month…

This early study aims to understand how stimulating nerves near the kidneys affects the body before and after a blood pressure treatment called renal denervation. It will enroll 19 adults with high blood pressure who are already on 1-3 medications. The main goal is to gather safe…

This study aims to better understand how diseases involving blood clots, inflammation, and blood vessels start and progress over many years. Researchers will observe 1,000 participants, including people with these conditions, their healthy relatives, and unrelated healthy volunte…