VASCULAR DISEASES

This study tests a new device called the efemoral vascular scaffold system (EVSS) in 100 people with blocked leg arteries (peripheral artery disease). The scaffold is placed inside the artery to hold it open and improve blood flow. The goal is to see if it is safe and works well …

This study compares two imaging methods to guide stent placement in people with calcium buildup in their heart arteries. About 700 adults with signs of reduced blood flow to the heart will be randomly assigned to have their procedure guided by either a coronary CT angiogram or th…

This study tracks 1,000 Medicare patients with hard-to-control high blood pressure to see if a procedure called renal denervation (RDN) plus standard care works better than standard care alone. Researchers will compare blood pressure changes and heart events over two years using …

This study follows 1,000 adults with high blood pressure that remains high despite lifestyle changes and medication. Participants receive a one-time procedure using the Paradise System, which uses ultrasound to calm overactive kidney nerves. The goal is to see if the device safel…

This study tests whether adding a new inhaled drug, mosliciguat, to an existing treatment (treprostinil) is safe for people with high blood pressure in the lungs caused by lung scarring. About 20 adults with this condition will receive the combination and be monitored for side ef…

This study tests whether sildenafil (a drug often used for erectile dysfunction) can reduce blood vessel damage in people with a left ventricular assist device (LVAD), a mechanical heart pump for advanced heart failure. About 50 adults with an LVAD will receive either sildenafil …

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after a serious brain bleed (aneurysmal subarachnoid hemorrhage) and aneurysm clipping surgery. RIC uses a blood pressure cuff on the arm to create short, harmless …

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys that can raise blood pressure. The goal is to see if the quicker approach works as well as the standard method for lowering blood pressure in peop…

This study is for adults aged 65 and older whose high blood pressure is not well controlled with medication. It uses a procedure called ultrasound renal denervation, which quiets overactive kidney nerves that can raise blood pressure. Researchers will track blood pressure changes…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as using two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 partici…

This study tests whether injecting a clot-dissolving medicine directly into the brain's arteries can improve recovery for people having a stroke caused by a medium-sized blood vessel blockage. About 282 adults with this type of stroke will be randomly assigned to receive either t…

This study tests whether a spinal cord stimulator can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. About 25 adults will receive the device and be monitored for changes in pain, circulation, and vessel stiffness. The goal is to…

This study tests a device that uses energy to calm overactive nerves in the kidney and liver, which may help lower blood pressure. It is for adults aged 18 to 80 with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The goal is to…

This study tests whether taking low-dose aspirin for 6 months after childbirth can help women who had preeclampsia recover their blood vessel health and lower their blood pressure. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple tr…

This study tests whether adding a specially trained doula to standard care helps women who had high blood pressure during pregnancy get their blood pressure under control after giving birth. About 454 women will be randomly assigned to either usual blood pressure monitoring at ho…

This study tests a new smartphone-based 12-lead ECG device to see if it can accurately detect heart attacks (STEMI and NSTEMI) compared to standard hospital ECGs. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to validate the device as a…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to quickly identify patients with a large vessel occlusion stroke who need to go directly to a hospital equipped for clot removal. About 275 adult…

This early study tests a device called the A-FLUX Reducer, placed in a heart vein, to improve chest pain in 30 adults with microvascular angina (small vessel heart disease). The goal is to see if it is safe and can reduce symptoms. Participants must have had persistent chest pain…

This study compares two techniques for guiding a needle into a blocked leg artery during angioplasty: road mapping (using X-ray images) versus ultrasound (using sound waves). The goal is to see which method is more successful and causes fewer complications like bruising or artery…

This study looks back at 5,000 adults who had heart or blood vessel surgery at UC Davis Medical Center. Researchers want to find out what factors affect survival and recovery, both in the hospital and up to a year later. The goal is to learn how to improve care and reduce risks f…

This early study aims to understand how stimulating nerves in the kidney affects the body's response before and after a procedure that quiets those nerves (renal denervation). About 19 adults with high blood pressure will take part. The goal is not to treat the condition directly…

This study aims to better understand stroke and mini-strokes (TIAs) by observing up to 4,000 adults who have had or are at risk for these conditions. Researchers will collect data from standard medical tests and some extra research tests, like blood draws and brain scans, to trac…

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart's arteries. About 140 adults with mild heart disease will get either a statin or a placebo, and advanced CT scans will track changes over 3 months. The goal is to understand wh…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and unrelated healthy v…

This study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will be included. The goal is to see if video assistance helps diagnose …

This study looks at why women who had high blood pressure during pregnancy are more likely to develop high blood pressure and heart disease later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to bett…

This study looks at why some people keep their thinking skills after a stroke while others don't. Researchers will interview 450 adults who had a stroke and had a brain scan. They want to see how things like education, race, and income affect memory and attention over time.

This study looks at why blood vessels behave differently in preeclampsia, a serious pregnancy condition. Researchers will collect tissue from 166 women during C-sections to study a protein called AT2R. The goal is to understand how this protein affects blood vessel function, whic…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improve blood vessel function. Researchers will measure zinc levels inside cells and how well blood vessels work. The goal is to understand how…