VASCULAR DISEASES

This study tests two different drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in all three main heart arteries. Participants receive a stent procedure plus modern heart care like cholesterol-lowering drugs. The goal is to see which ste…

This study tests whether lowering blood pressure more aggressively than current guidelines can prevent major heart problems and strokes in people who have already had a stroke or mini-stroke. About 4,368 participants will be randomly assigned to either intensive blood pressure co…

This study tests a device that uses energy to calm overactive nerves in the kidneys, which can help lower blood pressure. It included 282 adults with high blood pressure, some on medication and some not. Participants were randomly assigned to get the real procedure or a sham (fak…

This study tests a new device called the Aventus Thrombectomy System to safely remove blood clots from the lungs in people with a sudden, severe pulmonary embolism. About 130 adults aged 18 to 80 with symptoms lasting less than two weeks will be enrolled. The goal is to see if th…

This study tests a procedure called renal denervation, which uses a device to calm overactive nerves in the kidneys that can raise blood pressure. About 1,900 adults with uncontrolled high blood pressure will be followed for years to see if the treatment safely and durably lowers…

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who have already been in earlier ralinepag studies will take the drug and be monitored f…

This program offers a lab-grown blood vessel (ATEV) to people with serious vascular disease or kidney failure on dialysis who have no other treatment options and cannot join a clinical study. The goal is to provide a potential solution for creating or repairing blood vessels need…

This study tests a device that uses ultrasound to calm overactive kidney nerves, which can help lower blood pressure. About 154 adults with high blood pressure who are already taking two medications will receive either the ultrasound treatment or a fake procedure. The goal is to …

This study tests an inhaled medicine called mosliciguat in 135 people who have high blood pressure in their lungs due to scarring lung disease. The goal is to see if it improves blood flow and walking ability over 16 weeks. Participants are randomly assigned to receive the drug o…

This study aimed to create a 12-month profile of people admitted for vascular surgery at an Irish hospital. The goal was to understand patient needs and find ways to shorten hospital stays. However, the study was withdrawn before any participants were enrolled.

This study was designed to see if a 4-day low-protein, low-calorie diet before elective vein bypass surgery is practical for patients to follow at home. It also aimed to measure changes in the body's stress and healing signals. The study was withdrawn before enrolling any partici…

This study aimed to see if virtual clinic visits (using video calls) work as well as in-person visits for people with vascular diseases. Doctors would classify patients' need for treatment after both types of visits and compare the results. The study was withdrawn before enrollin…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before e…