New device zaps kidney nerves to tame high blood pressure

NCT ID NCT02649426

First seen Apr 23, 2026 · Last updated May 16, 2026 · Updated 4 times

Summary

This study tests a device that uses energy to calm overactive nerves in the kidneys, which can help lower blood pressure. It included 282 adults with high blood pressure, some on medication and some not. Participants were randomly assigned to get the real procedure or a sham (fake) procedure to see if the device safely reduces blood pressure.

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Contacts and locations

Locations

  • CHRU Lille - Institut Coeur Poumon

    Lille, 59000, France

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90211, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinique Pasteur

    Toulouse, 31300, France

  • Cliniques Universitaires St Luc

    Brussels, 1200, Belgium

  • Columbia University / NewYork Presbyterian Hospital

    New York, New York, 10032, United States

  • Conquest Hospital - Hastings

    Hastings, TN37 7RD, United Kingdom

  • Deborah Heart and Lung Center

    Browns Mills, New Jersey, 08015, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308, United States

  • Erasmus Medical Center

    Rotterdam, 3015 CE, Netherlands

  • Franciscan Health Indianapolis

    Indianapolis, Indiana, 46237, United States

  • Hôpital Européen Georges-Pompidou

    Paris, 75015, France

  • Hôpital Saint-André - CHU Bordeaux

    Bordeaux, 33000, France

  • Hôpital de la Croix Rousse

    Lyon, 69004, France

  • Imperial College London, Hammersmith Hospital

    London, England, SW7 2AZ, United Kingdom

  • Institute of Cardiology

    Warsaw, 04-628, Poland

  • Katholisches Klinikum Mainz

    Mainz, 55131, Germany

  • Leipzig Heart Center

    Leipzig, 04289, Germany

  • Maastricht University Hospital

    Maastricht, 6229 HX, Netherlands

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical University of Gdansk

    Gdansk, 80-952, Poland

  • Medical University of South Carolina

    Charleston, South Carolina, 29403, United States

  • Minneapolis Heart Institute

    Minneapolis, Minnesota, 55407, United States

  • New York University School of Medicine

    New York, New York, 10010, United States

  • Nottingham University Hospitals NHS Trust

    Nottingham, NG5 1PB, United Kingdom

  • Ochsner Heart and Vascular Insitute

    New Orleans, Louisiana, 70121, United States

  • Renown Institute for Heart& Vascular Health

    Reno, Nevada, 89502, United States

  • Royal Bournemouth Hospital

    Bournemouth, England, BH7 7DW, United Kingdom

  • Royal Devon and Exeter Hospital (Wonford)

    Exeter, EX2 5DW, United Kingdom

  • Sana Kliniken Lübeck GmbH

    Lübeck, 23560, Germany

  • Southern Illinois University Medicine

    Springfield, Illinois, 62794, United States

  • St Bartholomew's Hospital

    London, EC1A 7BE, United Kingdom

  • Stamford Hospital

    Stamford, Connecticut, 06904, United States

  • Sutter Health Medical Center

    Sacramento, California, 95816, United States

  • The Brigham and Women's Hospital

    Boston, Massachusetts, 02120, United States

  • The Cardiac and Vascular Institute

    Gainesville, Florida, 32605, United States

  • The Essex Cardiothoracic Centre - Basildon & Thurrock University Hospitals

    Basildon, United Kingdom

  • The Heart Hospital Baylor Plano

    Plano, Texas, 75093, United States

  • University Clinic Dusseldorf

    Düsseldorf, 40225, Germany

  • University Clinic Erlangen

    Erlangen, 91054, Germany

  • University Clinic of Saarland

    Homburg, 66421, Germany

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University Medical Center Utrecht

    Utrecht, 3584 CX, Netherlands

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of North Carolina at Chapel Hill School of Medicine

    Chapel Hill, North Carolina, 27599-7075, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

  • Universitäts-Herzzentrum Freiburg-Bad Krozingen GmbH

    Freiburg im Breisgau, D-91054, Germany

  • Vanderbilt University

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.