Hypertensive disorder

This phase 2 study tests whether spironolactone, a drug already used for fluid retention, can improve exercise capacity and blood vessel function in people with pulmonary arterial hypertension (PAH). About 70 adults with PAH will receive either spironolactone or a placebo for 24 …

This trial is testing an experimental drug called HS235 in obese adults who have both pulmonary hypertension and heart failure with preserved ejection fraction. The study aims to see if the drug is safe, how it moves through the body, and whether it can improve heart and lung fun…

This trial is testing an experimental drug called HS235, given as a shot under the skin, in adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and can strain the heart. The study aims to see if adding HS2…

This study looks at whether a gentle laser treatment (SLT) works as well as the standard version for people with glaucoma or high eye pressure. It also tests if getting the gentle laser once a year can delay or prevent the need for daily eye drops. About 790 adults will take part…

This study tests a stem cell transplant using the patient's own blood cells to treat severe scleroderma (systemic sclerosis) that hasn't improved with standard drugs. The goal is to see if this high-dose therapy is safe and can stop the disease from getting worse. The trial enrol…

This study tests a single dose of an experimental drug called ALN-AGT01 in adults with mild to moderate high blood pressure who have already been treated with another drug, zilebesiran. The goal is to see if it safely helps control blood pressure by measuring changes in blood pre…

This phase 3 trial tests an inhaled drug called treprostinil palmitil in 344 adults with pulmonary hypertension caused by interstitial lung disease. Participants take the drug or a placebo once daily for 24 weeks. The main goal is to see if the drug helps them walk farther in six…

This study tests whether empagliflozin, a diabetes medicine, can improve right heart function in 78 adults with pulmonary arterial hypertension (PAH). Participants continue their usual PAH treatments and receive either empagliflozin or a placebo. The main goal is to see if the dr…

This phase 3 study tests the long-term safety of an inhaled drug called treprostinil palmitil for people with pulmonary hypertension caused by interstitial lung disease. About 344 adults who completed an earlier trial will take the drug for up to 2 years. Researchers will track s…

This study looks at whether taking melatonin for 12 weeks can help lower blood pressure in women going through menopause who already have high blood pressure. Researchers will measure nighttime blood pressure and check for changes in stress markers. The goal is to find a simple, …

This trial tests whether nurse-led motivational interviewing—a counseling style that helps people find their own motivation to change—can improve blood pressure control in adults with hypertension. Participants are randomly assigned to usual care, individual counseling, or counse…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study compares different ways to give blood pressure cuffs and training to adults with uncontrolled high blood pressure during routine primary care visits. Participants receive a cuff either in the clinic or by mail, and training either hands-on or through written instructio…

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study is tracking 1,000 patients with high blood pressure who receive the Paradise Ultrasound Renal Denervation treatment. The procedure uses ultrasound energy to calm overactive nerves near the kidneys, which can help lower blood pressure. Researchers are monitoring blood p…

This study looks at whether spinal cord stimulation, a device already used for chronic pain, can also reduce blood pressure in people with hypertension and low back pain. Researchers will measure blood pressure changes and pain levels, and explore how different stimulation patter…

This study tests a drug called mirivadelgat in people with high blood pressure in the lungs caused by lung scarring (PH-ILD). The goal is to see if it improves blood flow in the lungs, exercise ability, and overall well-being. About 126 participants will take the drug or a placeb…

This trial tests an experimental therapy called CTX340, which uses CRISPR gene editing to disable a gene in the liver that regulates blood pressure. It is designed for adults with uncontrolled hypertension despite taking multiple blood pressure medications. The study will first a…

This study tests whether treating mild high blood pressure (stage 1 hypertension) during pregnancy can improve baby birth weight. 74 pregnant people with blood pressure between 130-139/80-89 mmHg will be randomly assigned to either active treatment with blood pressure medication …

This long-term study follows people with pulmonary arterial hypertension (PAH) who previously took part in sotatercept trials. Sotatercept is a targeted therapy that aims to stop PAH from getting worse. Researchers will monitor safety, side effects, and how well patients tolerate…

This study tests an experimental oral drug called ROC-101 in 40 adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (ILD-PH). Participants take the drug alongside their standard care for 24 weeks, with a long-term follow…

This early study tests a new device called HyperQure that uses a keyhole surgery to disable certain nerves around the kidneys. The goal is to help people with resistant hypertension—high blood pressure that stays high despite taking three or more medications. The study will enrol…

This study tests whether doing strength exercises one limb at a time (unilateral) or both limbs together (bilateral) makes a bigger difference in heart rate variability, muscle strength, and daily function for adults with high blood pressure. Adults aged 40-75 with hypertension w…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This phase 3 trial tests whether metformin, a diabetes drug, can safely prolong pregnancy in women with preterm preeclampsia. Currently, the only treatment is early delivery, which risks the baby's health. The study will enroll 294 women across Nordic countries, giving them metfo…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This study looks at whether giving enalapril, a standard blood pressure medicine, to women who had preeclampsia during pregnancy can help control their blood pressure after childbirth. Researchers will enroll 60 postpartum women and randomly assign them to enalapril or usual care…

This study tests an experimental drug called REGN13335 in 99 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive either the drug or a placebo, on top of their usual PAH medica…

This study tests whether a combination of nifedipine and enalapril controls high blood pressure after childbirth better than nifedipine and labetalol. It involves 200 postpartum women with persistent hypertension. The goal is to reduce hospital stays, readmissions, and severe blo…

This Phase 2 trial tests an inhaled drug called LAM-001 (sirolimus) in 85 adults who have pulmonary hypertension (high blood pressure in the lungs) along with interstitial lung disease (lung scarring). The study compares the drug to a placebo to see if it improves blood flow in t…

This early-phase trial tests an experimental antibody called DIAG723 in 93 adults with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. The study will check if the drug is safe and how the body processes it, with…

This phase 3 trial is testing whether a blood pressure treatment plan that focuses on diuretics (water pills) works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. The study will include 720 participants and t…

This study tests whether doing wall squats at home, along with lifestyle advice, is a practical and acceptable way for people with high blood pressure to manage their condition. Seventy adults with hypertension will do supervised wall squat exercises three times a week for 12 wee…

This study tests a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. About 261 adults with hypertension will either get the real procedure or a sham (fake) one. The goal is to see if this approach safely lowers blood pressu…

This early-stage study tests a new way to use a heart-lung machine (ECMO) in 4 people waiting for a lung transplant who also have heart failure from high blood pressure in the lungs. The goal is to see if this approach can keep them alive and stable until they receive a transplan…

This Phase 2 trial tests a new drug called HDY015, which combines two medicines (QCZ484 and inclisiran) into a single injection. The goal is to see if it can safely lower both blood pressure and cholesterol in people who have both conditions. About 120 adults aged 18-75 with hype…

This study compares two ways to intensify treatment for people with pulmonary arterial hypertension (PAH) who are not doing well enough on standard dual therapy. One group adds a third type of medication (a prostacyclin pathway agent), while the other group increases the dose of …

This study looks at the long-term safety and effectiveness of the drug QCZ484 in people with high blood pressure. It is for patients who already completed a previous study with the same drug. Researchers will monitor side effects and track blood pressure changes over time.

This trial tests a new implant that slowly releases the glaucoma drug timolol inside the eye. It is for people with open-angle glaucoma or ocular hypertension who are already having cataract surgery. The study compares three doses of the implant against standard timolol eye drops…

This trial tests whether a community health worker-led education program, called Heart Health and Nutrition for Life (HHNL), can help people with high blood pressure lower their numbers. The program covers healthy eating, physical activity, medication adherence, stress reduction,…

This study tests whether a mobile health program—combining home blood pressure monitoring with virtual coaching—can help midlife women control high blood pressure after having had a hypertensive disorder of pregnancy (like preeclampsia). About 50 women who had such a pregnancy 10…

This study tests whether a simple isometric wall squat exercise can lower blood pressure in adults with both hypertension and obstructive sleep apnea treated with CPAP. Each participant will complete one session of wall squats and one rest-only session, with blood pressure monito…

This trial tests whether a device called remote ischemic conditioning can safely help lower blood pressure in people with essential hypertension. The treatment involves inflating a blood pressure cuff on the upper arm to briefly stop blood flow, then releasing it, in repeated cyc…

This trial tests whether a diet adapted to Puerto Rican culture can lower the risk of heart disease, type 2 diabetes, and obesity. Researchers will compare culturally tailored nutrition advice—emphasizing traditional healthy foods and limiting unhealthy ones—with standard healthy…

This phase 2 trial tests an injected drug called TX000045 in 25 people who have high blood pressure in the lungs due to scarring lung disease. The main goal is to see if the drug lowers lung blood pressure and is safe over 16 weeks. Researchers will also check for side effects an…

This trial tests whether using a handgrip device for isometric exercise can lower blood pressure in people with elevated blood pressure or hypertension who are not on medication. Half the participants will use the Zona Plus handgrip device, while the other half will listen to rel…

This trial tests whether a digital health tool that uses artificial intelligence can help people with high blood pressure lower their numbers. The AI analyzes daily habits and blood pressure readings to give each person personalized lifestyle suggestions. Researchers will compare…

This pilot trial tests whether using placental tissue analysis from a prior complicated pregnancy can guide treatment with the blood thinner enoxaparin to reduce the risk of recurrent adverse outcomes. The study enrolls women who had a previous pregnancy affected by early deliver…

This phase 2 trial tests whether pioglitazone, a drug used for diabetes, can improve how cells use oxygen in people with pulmonary hypertension caused by chronic lung disease. Participants take pioglitazone or a placebo daily for 28 days, then switch after a 2-week break. The stu…

This study looks at whether giving people with high blood pressure and food insecurity free food and kitchen skills training can improve their health. About 200 adults aged 35-75 will either get the program or standard care. Researchers will measure blood pressure and blood sugar…

This early-stage study tests a new drug called HJB647 in Japanese adults with elevated blood pressure or mild-to-moderate hypertension. The main goal is to check safety and how the drug moves through the body. About 74 participants will receive either HJB647 or a placebo, with do…

This study tests an investigational drug called IMC-003 in 120 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants receive multiple injections of the drug or a placebo, alongside their usual treatments. The go…

This study tests whether a structured nutrition counselling program can improve diet, blood sugar, blood pressure, and quality of life in adults who have both type 2 diabetes and hypertension. About 308 participants from 14 hospitals in Ethiopia will either receive six individual…

This study tests whether an AI-powered digital health platform can help people manage their blood pressure better than support from a human case manager. Adults aged 18 to 75 with high blood pressure use the platform to get reminders, health education, and alerts for abnormal rea…

This study tests a program to help new mothers with chronic conditions like high blood pressure, diabetes, or depression transition smoothly from obstetric to primary care after giving birth. The program includes automatically scheduling a primary care visit, sending personalized…

This study tests whether a mobile health program, including self-measured blood pressure monitoring and help scheduling doctor visits, can lower blood pressure better than usual care. It enrolls adults who have very high blood pressure during a safety-net emergency department vis…

This study tests a structured behavioral program called the BMW Toolkit for pregnant women with both gestational diabetes and pregnancy-induced hypertension. The toolkit includes diet, exercise, sleep, and self-care guidance delivered over 7-8 sessions. Researchers will compare b…

This study tests whether a 12-week program of home-delivered DASH-diet groceries and cooking classes can help adults with high blood pressure and obesity lower their blood pressure and lose weight. 150 participants will be randomly assigned to either the food program or usual car…

This study tests whether regular phone calls and text messages with lifestyle advice can help adults in Nepal with uncontrolled high blood pressure lower their numbers. Five hundred participants will receive either the mobile health program or usual care for six months. The goal …

This study tests whether a newer drug, finerenone, works better and is safer than the standard drug spironolactone for people with high blood pressure due to primary aldosteronism—a condition where the adrenal glands make too much of the hormone aldosterone. About 104 adults with…

This study tests whether a simple breathing exercise, called Inspiratory Muscle Strength Training (IMST), can safely lower blood pressure in pregnant women during their third trimester. Participants do 5 to 8 minutes of breathing against light or moderate resistance each day for …

This study is testing a 20-week exercise program that combines endurance and resistance training in postmenopausal women with or without high blood pressure. Researchers want to see which mix of exercises best improves heart health, body composition, and quality of life. Sixty ph…

This early-stage study tests STX-1150, a new medicine that temporarily turns off a gene (PCSK9) in the liver to lower bad cholesterol (LDL-C). It does not change your DNA. Up to 64 adults with high LDL-C will receive one or more doses and be followed for a year. The main goal is …

This study tests whether doing simple handgrip exercises—squeezing a device for two minutes at a time—can lower blood pressure in people with hypertension. Participants will perform these exercises either two or four times a week for six weeks. The goal is to find the smallest ef…

This trial compares two different dual blood pressure medications in people aged 50–70 with high blood pressure and heart disease who have just received a heart stent. Participants are randomly assigned to one of two drug combinations: losartan plus hydrochlorothiazide or amlodip…

This trial studies two experimental drugs, UIC202601 and UIC202602, designed to treat high blood pressure and high cholesterol. It enrolls healthy adults aged 19 to 55 to see how the drugs interact when taken together, focusing on safety and how the body processes them. Participa…

This trial tests whether intermittent dietary restrictions—either low-carb or calorie-restricted diets on two days per week—can reverse early signs of heart and metabolic problems in school-aged children aged 7 to 18. Participants have at least one risk factor like prediabetes, a…

This study tests a drug called tonlamarsen in adults who were recently hospitalized for dangerously high blood pressure. Participants receive either the drug or a placebo as a shot under the skin every 4 weeks. The goal is to see if tonlamarsen can lower blood pressure and reduce…

This early-stage trial is testing a new drug called KK3910 in healthy people and those with high blood pressure. The main goal is to check safety and how the drug moves through the body. It is a small, placebo-controlled study, so it is too soon to know if the drug actually works…

This study will give 800 pregnant women biweekly food kits with fruits, vegetables, and other healthy foods to see if it improves their diet and pregnancy outcomes. Participants will be followed from early pregnancy through birth. The goal is to learn whether providing healthy fo…

This study is testing the safety of an inhaled dry powder form of treprostinil (LIQ861) for people with pulmonary hypertension (high blood pressure in the lungs) due to lung disease. About 80 adults will take the drug using a special inhaler, and researchers will monitor for side…

This study tests a procedure called pulmonary artery denervation (PADN) for people who still have high blood pressure in their lung arteries after a mitral valve repair. The procedure uses a catheter to deliver radiofrequency energy to specific nerve points in the main pulmonary …

This phase 3 trial tests TFC-003, a new eye drop, in 188 adults with primary open-angle glaucoma or ocular hypertension. Participants use the drops twice daily for up to 24 weeks. The main goal is to see if TFC-003 lowers eye pressure better than an active control. The study is c…

This study tests a decision aid—a tool that provides information and goal-setting exercises—to help women who had high blood pressure during pregnancy take steps to protect their heart health after childbirth. The goal is to improve engagement in preventive care like blood pressu…

This study tests whether doing wall squat exercises for 14 minutes, three times a week, can lower blood pressure and slow the buildup of plaque in arteries. Researchers will compare 100 people doing the squats with 100 people doing gentle stretching, all with high blood pressure.…

This trial investigates whether 16 weeks of yoga—including breathing, postures, relaxation, and meditation—can improve blood pressure, heart health, mental well-being, and thinking skills in adults aged 40 and older with high blood pressure. Participants are randomly assigned to …

This phase 3 trial tests whether a preservative-free version of bimatoprost eye drops works as well as the standard Lumigan drops for lowering eye pressure. About 600 adults with primary open-angle glaucoma or ocular hypertension in both eyes will receive either the new formulati…

This study tests a technology-based program to help women aged 18-44 with high blood pressure lower their blood pressure before getting pregnant. Participants will receive support through their primary care clinic and use online tools. The goal is to improve heart health and medi…

This study tests whether different oxygen targets (higher vs. lower) improve outcomes in 39 preterm infants with bronchopulmonary dysplasia and pulmonary hypertension. Each infant will experience both oxygen levels in a crossover design. The goal is to see which level reduces dan…

This study tests an experimental drug called SAL0140 in people whose high blood pressure remains high despite current treatments. About 252 adults aged 18-75 with uncontrolled hypertension will receive either the drug or a placebo for 12 weeks. The goal is to see if SAL0140 safel…

This phase 3 trial is testing whether a once-daily inhaled medication called treprostinil palmitil can help adults with pulmonary arterial hypertension (PAH) walk farther. About 344 participants will receive either the drug or a placebo for 24 weeks. The main goal is to see if th…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This study tests a health coaching program called STAR-MAP to help older adults (age 40+) with high blood pressure take their medication regularly. About 402 participants with uncontrolled blood pressure and low medication adherence will be recruited through a Louisiana health in…

This study compares two treatments for a condition called primary aldosteronism, where a small adrenal gland tumor causes high blood pressure. One treatment is laparoscopic surgery to remove the tumor; the other is radiofrequency ablation (RFA), which uses heat delivered through …

This study tests whether a program called BETTER can help pregnant women have healthier births. The program includes a one-on-one coaching session and regular text messages to help women connect with resources for housing, food, and transportation. Researchers will compare outcom…

This study compares two common blood pressure medications, labetalol and nifedipine, in 110 new mothers with postpartum hypertension. The goal is to see which drug controls blood pressure better and reduces the need for ongoing medication beyond six weeks after delivery. Particip…

This study looks at whether giving older adults with high blood pressure practical advice and air cleaners can reduce their exposure to heat and air pollution. About 100 people aged 65 and older from Barcelona and Nicosia will take part. They will wear sensors to track temperatur…

This study is tracking 3000 people with high blood pressure who have been treated with the Paradise Ultrasound Renal Denervation System, a device that uses ultrasound to calm overactive kidney nerves. The goal is to see how safe and effective the treatment is over many years by m…

This Phase 3 trial tests whether the drug HRS-7535 can lower blood pressure better than a placebo in 648 adults with hypertension who are also overweight or obese. Participants will take the drug or placebo for up to 48 weeks, and researchers will measure changes in blood pressur…

This study tests whether taking low-dose aspirin for six months after childbirth can help blood vessels heal and lower blood pressure in women who had preeclampsia. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple treatment can redu…

This study tests whether a travoprost drug implant (iDose TR) plus a tiny stent (iStent infinite) can lower eye pressure better than the implant alone in people with open-angle glaucoma or high eye pressure. About 150 adults will receive either the combo or a sham procedure and b…

This study tests whether Yufeng Ningxin, a traditional Chinese medicine, can safely lower blood pressure in adults with mild hypertension. About 350 people aged 18-65 with untreated or washed-out high blood pressure will receive either the herbal tablet or a placebo for 8 weeks. …

This study enrolls 864 Black adults with uncontrolled high blood pressure to see if a home monitoring program with pharmacist and community health worker support works better than usual clinic care. Participants will either get a home BP monitor plus remote medication management …

This study is testing a community-based program that uses exercise training and lifestyle changes to help people with high blood pressure, high blood sugar, or high cholesterol. The goal is to improve heart and lung function and overall disease control. The program will enroll 10…

This Phase 3 trial tests a drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese. Participants receive weekly injections of either the drug or a placebo for 48 weeks. The main goal is to see if IBI362 lowers blood pressure more th…

This study tests whether adding Qishen Yiqi Dropping Pills, a Chinese herbal medicine, to standard therapy can improve exercise ability and quality of life in 120 adults with severe pulmonary hypertension. Participants will be randomly assigned to receive either the herbal pills …

This early-phase study aims to see if a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a placebo infusion, and researchers…

This study is testing whether a year-long program of daily blueberries, protein powder, and three weekly exercise sessions can reduce frailty and lower the risk of heart disease in older adults. Researchers will enroll 240 people aged 65 and older in Nova Scotia. The goal is to s…

This study looks at whether royal jelly, a substance made by bees, can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will give 34 participants royal jelly or a placebo for two months and measure changes in blood markers. The goal is to s…

This study tests whether taking propolis and royal jelly supplements for two months can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will measure inflammatory markers in blood samples from 48 participants. The goal is to see if these na…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study is testing whether taking green propolis extract and royal jelly together can reduce inflammation and oxidative stress in people with high blood pressure or chronic kidney disease. Over two months, 153 participants will take capsules of the supplements or a placebo. Re…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests an experimental drug called IKT-001 in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and move. About 486 adults will receive either IKT-001 or a placebo to see if the drug improves b…

This study looks at whether adding a slow breathing technique (coherent breathing) to aerobic exercise improves heart and lung health and quality of life more than exercise alone. Forty adults with stage 1 high blood pressure will take part in a 4-week program. Researchers will m…

This study is testing whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). Researchers will give 60 adults either valsartan or a placebo for 24 weeks to see if it improves how far they can walk in six minutes …

This early-phase study tests whether an oral supplement called L-Citrulline is safe for preterm babies born at or before 30 weeks who have lung problems (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of a natural substance in the blood can reduce…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This study compares two FDA-approved laser treatments for open-angle glaucoma: the standard SLT and a newer, non-contact version called DSLT. Both aim to lower eye pressure and prevent vision loss. About 172 adults with glaucoma or high eye pressure will be randomly assigned to o…

This study tests whether adding a 10-week health coaching program from a community health worker to remote blood pressure monitoring helps women who had high blood pressure during pregnancy. 240 women will be followed for 6 months after delivery. The goal is to see if the combine…

This study looks at whether two types of strength training (dynamic and isometric) can improve heart health, mental well-being, and physical fitness in adults aged 60 and older who have high blood pressure. Sixty participants will be randomly assigned to one of the two exercise p…

This pilot study is testing whether giving progesterone (17 OHPC) to pregnant women diagnosed with preeclampsia before 34 weeks can improve outcomes for both mother and baby. The study will enroll 60 participants at the University of Mississippi Medical Center. Researchers will m…

This study tests a new wearable device that measures blood pressure without a cuff, called CART BP Pro, to help manage high blood pressure in Korean adults whose condition is not well controlled by current medications. About 400 participants will either use the device to guide th…

This study is testing a new educational tool called the Decreased Salt High Potassium (DSHP) Tool, designed to help adults with high blood pressure reduce their salt intake and eat more potassium-rich foods. About 190 participants from two clinics in Singapore will either receive…

This study tests whether a new combination drug works better than taking two separate medicines for people with both high blood pressure and type 2 diabetes. About 228 adults will take either the combo pill or a single-ingredient pill for 12 weeks. Researchers will check changes …

This study looks at whether a special form of folic acid (5-MTHF) can improve blood vessel health in pregnant women with high blood pressure or pre-eclampsia. Researchers will measure key molecules in the blood, placenta, and umbilical cord to see if the supplement helps. The tri…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe …

This pilot study tests a 12-week community-based program to help adults with uncontrolled high blood pressure. A team including a pharmacist, nurse, and community health workers provides medication management, monitoring, and education in local settings. The goal is to see if thi…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by lung scarring. The goal is to see if the combination is safe and tolerable. About 20 adults with this condition will particip…

This study tests whether a natural substance called inorganic nitrate can safely lower blood pressure in pregnant women with chronic hypertension. About 144 women will receive either nitrate or a placebo from the second trimester onward. The goal is to see if nitrate reduces the …

This study looks at whether community health workers can help emergency department patients with high blood pressure connect to local resources that address their social needs, like food or housing. Fifteen adults with uncontrolled hypertension will complete surveys and receive r…

This study tests whether a quick laser treatment called DSLT can help people with glaucoma or high eye pressure use fewer daily eye drops. Sixty adults whose eye pressure is already controlled with 1-3 types of drops will receive the laser in one or both eyes. Researchers will ch…

This study looks at whether adding Pilates breathing or diaphragmatic breathing to moderate cycling can improve blood pressure, chest expansion, lung function, and quality of life in people with hypertension. 45 adults aged 20–55 with stage 1 or 2 high blood pressure will be spli…

This study tests whether adding sleep health coaching to a diet and exercise program can improve heart health, especially blood pressure. About 150 adults with high blood pressure from underserved NYC neighborhoods will take part. The program includes sleep education, a Fitbit tr…

This study compares two fluids—sodium lactate and a concentrated saline solution—in 40 adults with septic shock. The goal is to see which one better supports blood flow and acid balance. Participants will receive either fluid in a double-blind setup, and researchers will measure …

This study tests whether combining pharmacist advice with help from community health workers can improve blood pressure control in African American adults aged 55 and older. Participants will receive support for 24 months to help them take their medications and make healthier lif…

This study tests whether beetroot powder, which is rich in nitrates, can help lower blood pressure in people with resistant hypertension (high blood pressure that doesn't respond well to standard medications). Researchers will monitor blood pressure changes in 50 participants ove…

This study compares a wearable blood pressure monitor (Aktiia G1) to a traditional arm cuff in adults with uncontrolled high blood pressure. Over 6 months, researchers will see which method leads to better blood pressure control. Participants must have a smartphone and attend two…

This study tests whether eating grape powder daily for 3 weeks can improve gut health, reduce inflammation, and improve blood vessel function in 40 overweight adults aged 45-70. Participants will drink grape or placebo powder twice a day and provide blood and stool samples. The g…

This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participa…

This observational study will follow 12,000 Korean adults with stage 1 hypertension who are newly prescribed OLMETEC or OLMETEC Plus. The main goal is to see how well the medication controls blood pressure over 24 hours, especially at night. Participants will have their blood pre…

This study tests a program that combines online education, a medication reminder app, and a home blood pressure monitor to help African American adults aged 50+ better manage their hypertension. Participants use these tools for 6 months while continuing their regular care. The go…

This study tests a home blood pressure monitoring program for 1,200 women in Nigeria who had high blood pressure during pregnancy. The program includes patient education, home BP monitors, follow-up care, and free medication if needed. Researchers want to see if this approach lea…

This Phase 3 trial tests a second-generation implant placed inside the eye that slowly releases travoprost, a drug that lowers eye pressure. The study will enroll 510 adults with open-angle glaucoma or high eye pressure. The goal is to see if the implant is safe and effective at …

This early study tests a new medicine called SC101, given as a single injection around the kidneys, for people with resistant high blood pressure and moderate to severe chronic kidney disease. The main goal is to check safety, with only 3 participants. Researchers will also monit…

This study tests a device called the Alma system for women who have severe bleeding after childbirth that does not stop with standard treatments. About 50 women who experience heavy bleeding after vaginal or C-section delivery will be enrolled. If usual care fails, the Alma syste…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This Yale study tests two ways to help people with high blood pressure: a remote monitoring program alone, or that program plus a community health worker who helps with home monitoring, appointments, and social needs like food or housing. 1,440 participants with elevated blood pr…

This study looks at whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to fresh groceries. About 80 participants from Baltimore will be randomly assigned to receive either standa…

This study tests a cloud-connected blood pressure monitoring program for new mothers with high blood pressure disorders. The goal is to see if remote monitoring helps more women track their blood pressure after giving birth and reduces hospital readmissions. About 540 pregnant an…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study tests whether coaching and support from community health workers, delivered by phone or video, can help people with dangerously high blood pressure avoid serious heart problems. Over 3,600 adults who came to the emergency room with very high blood pressure will be rand…

This study compares two telehealth programs designed to help new mothers get faster care after childbirth, especially those with low income. About 3,500 women will receive either virtual education with reminders or a more interactive telehealth model. The goal is to see which app…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests a program designed to help people with high blood pressure and high cholesterol lower their risk of heart disease. About 1,980 adults from Penn Medicine primary care clinics in West/Southwest Philadelphia and Lancaster will take part. The program uses tools and b…

This study tests whether sildenafil (the drug in Viagra) can help people with severe lung high blood pressure caused by long-term rheumatic heart valve disease. Researchers will give 100 participants either sildenafil or a placebo three times daily for six weeks. The main goal is…

This study tests whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes. The health workers will lead group meetings, provide health education, and coordinate care with local clinics. About 398 adults with both c…

This study tests whether extra guidance from a pharmacist can help people with pulmonary arterial hypertension (PAH) use their inhaled iloprost correctly and consistently. PAH is a rare, serious lung condition that makes it hard to breathe. The trial will enroll 72 adults who alr…

This study tests a new way to program pacemakers to help lower blood pressure in people who have both high blood pressure and a slow heart rate. About 30 adults who already have or need a special pacemaker will try two different setup sessions. Researchers will check if the new s…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, high cholesterol, and overweight. About 1,780 adults will take part in cooking demonstrations and learn how to eat more traditional Hawaiian foods. The goal is to…

This study tests whether a daily pill called engagliflozin (a type of SGLT2 inhibitor) can improve heart function in people who have high blood pressure and early signs of heart failure but do not have diabetes. About 120 adults will receive either the drug or a placebo for 6 mon…

This study tests whether the antibiotic minocycline can lower blood pressure in people whose hypertension does not respond to standard treatments. Researchers will give 120 adults either minocycline or a placebo daily for three months to see if the drug works by changing gut bact…

This study tests a program called PILI 'Āina that combines lifestyle lessons, home gardens, and cooking classes to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity. About 210 overweight or obese Native Hawaiian adults with these conditions will take …

This study is for people with idiopathic intracranial hypertension (IIH) who have been on the drug acetazolamide for over a year without enough relief. It tests whether placing a small stent in a narrowed brain vein can lower the pressure and improve symptoms like headache and vi…

This study tests if dapagliflozin, a diabetes drug, can reduce heart and blood vessel risks in women who had high blood pressure during pregnancy. About 200 participants will take either the drug or a placebo daily for six months after delivery. The goal is to see if the drug imp…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study tests a second-generation travoprost implant placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 610 participants will receive either the implant, timolol eye drops, a sham procedure, or placebo drops. The main goal …

This study tests a redesigned inserter for the travoprost implant, a tiny device placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 30 adults will receive the implant using the updated inserter. The main goal is to see if doct…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests whether a smartphone app called FAITH! can help African-American adults with uncontrolled high blood pressure lower their numbers and improve heart-healthy habits. About 100 participants will use the app or receive standard care, and their blood pressure and self…

This study tests a program where trained peers deliver blood pressure medications directly to patients' homes and use health technology to support adherence. The goal is to see if this approach helps people with uncontrolled high blood pressure take their pills regularly and lowe…

This study tests whether a daily dose of pravastatin, a common heart medication, can safely prolong pregnancy in women diagnosed with severe early-onset preeclampsia or fetal growth restriction. The trial will include 154 pregnant women between 24 and 30 weeks of gestation, rando…

This study tests a procedure called FETO for unborn babies with a severe form of congenital diaphragmatic hernia (CDH), where the diaphragm has a hole and the lungs don't grow well. Doctors place a tiny balloon in the baby's windpipe to block it, which may help the lungs expand a…

This study is for people with resistant hypertension, meaning their blood pressure stays high even with three or more medications. Researchers want to see if a drug that blocks endothelin-1, a substance that tightens blood vessels, can improve blood vessel function and lower bloo…

This study tests whether artificial intelligence (AI) can help doctors in China pick better blood pressure medications for their patients. Over 2,000 adults with high blood pressure will be treated at primary care clinics. Some clinics will use AI software that considers patient …

This study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will track changes in blood pressure and blood sugar over 6 months in 100 adults aged 18-60. The goal is to see if home-based care leads to better control o…

This study tests whether a program led by community health workers can help refugees with high blood pressure take their medication as prescribed and lower their blood pressure. The program includes an education booklet, a pill organizer, and two counseling sessions. Researchers …

This study is testing a mini-program (like a smartphone app) that gives personalized exercise advice to people with high blood pressure, high blood sugar, high cholesterol, and high uric acid. Over six months, 100 participants will use the app to increase their daily steps and ph…

This study tests whether placing a small tube (stent) in a narrowed brain vein works better than standard medication for people with idiopathic intracranial hypertension (high pressure in the brain). About 74 adults with this condition and a narrowed vein will be randomly assigne…

This study tests whether trained community health workers can help people in Nepal prevent and control high blood pressure. Over 3,500 participants with high blood pressure will receive home visits and group counseling from health workers. The goal is to see if this approach lowe…

This study compares two common blood pressure medications, Nifedipine and Labetalol, to see which works better and is safer for women who develop high blood pressure after giving birth. About 500 new mothers will be randomly assigned to one of the two drugs. The goal is to reduce…

This study tests whether combining transcutaneous electrical nerve stimulation (TENS) with isometric exercise can improve blood pressure in people with resistant hypertension. Resistant hypertension means blood pressure stays high despite taking three or more medications. The tri…

This study tests whether giving iron through a vein can help people with pulmonary hypertension (high blood pressure in the lungs) who also have low iron levels. Many patients with this condition have trouble absorbing iron from pills. The trial will compare intravenous iron to a…

This study tests whether powerful weight loss drugs (like semaglutide or tirzepatide) can lower blood pressure enough for young adults (ages 18-40) with obesity and early-stage hypertension to stop taking daily blood pressure pills. Sixty participants will either receive the weig…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests if using focused ultrasound to modify fat around the kidney can safely lower blood pressure in people with hypertension. About 30 adults with mild high blood pressure despite medication will be enrolled. The treatment is compared to a sham procedure to see if it …

This study tests whether gentle shockwaves applied to the kidneys can lower blood pressure in people with chronic kidney disease. Thirty adults with high blood pressure and moderate-to-severe kidney disease will receive either real or fake (sham) treatments over three weeks. The …

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This study is testing whether taking a low-dose aspirin (81 mg) daily for three weeks after giving birth can improve blood vessel function in women who had severe preeclampsia. About 100 women will be randomly assigned to receive either aspirin or a placebo. The main goal is to s…

This study tests whether adding the drug sotatercept to usual treatments can improve exercise ability in adults with pulmonary arterial hypertension (PAH) from unrepaired heart defects, including Eisenmenger syndrome. About 36 adults in Japan will be randomly assigned to receive …

This study looks at whether using a CPAP machine, sometimes with a mild sleep aid, can help lower blood pressure in people with both sleep apnea and high blood pressure. About 200 adults aged 18-70 will use CPAP every night for 3 months. Those with insomnia can also take trazodon…

This study tests a tiny implant placed inside the eye during cataract surgery that slowly releases travoprost, a drug that lowers eye pressure. About 132 adults with glaucoma or high eye pressure will receive either the implant plus surgery or surgery alone. The goal is to see if…

This study compares a 5-minute daily breathing exercise (IMST) to brisk walking for lowering blood pressure in postmenopausal women aged 50 and older with above-normal blood pressure. Researchers will measure changes in blood pressure and blood vessel function after 3 months of t…

This study tests whether a pharmacist-led care pathway can improve blood sugar control in 600 adults with type 2 diabetes who are not meeting their A1C targets. Participants will receive step-by-step guidance from pharmacists using a web-based tool, compared to usual care from th…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with severe pulmonary hypertension caused by chronic obstructive pulmonary disease (COPD). About 200 adults with both conditions will receive either tadalafil or a placebo daily for 16…

This Phase 3 trial tests a new eye drop called HUC3-637 in 206 adults with primary open-angle glaucoma or ocular hypertension. The goal is to see if it safely lowers eye pressure better than an existing active control. Participants will use the drops daily and have their eye pres…

This study tests whether combining remote blood pressure monitors with support from community health workers helps Latinx patients better manage their high blood pressure. About 300 adults with uncontrolled hypertension will take part. The goal is to see if this approach lowers b…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study is testing a chest-patch that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings over 24 hours to the standard cuff-based method in 600 adults with or without high blood pressure. The goal is to see if the patch i…

This study explored whether a special type of MRI using inhaled xenon gas could detect changes in the small blood vessels of the lungs in people with pulmonary hypertension. The goal was to see if this imaging method could track disease progression or response to treatment. Howev…

This observational study is testing whether a combination of non-invasive measurements—including blood pressure monitoring, ultrasound, blood and urine tests, and a light-based technique called photoplethysmography—can detect early damage to blood vessels and organs in adults at …

This study tests whether an artificial intelligence (AI) tool that analyzes a simple ECG can help doctors find undiagnosed pulmonary hypertension (high blood pressure in the lungs) in people with interstitial lung disease. About 900 adults with severe lung scarring will be random…

This study is testing whether a digital stethoscope, combined with artificial intelligence, can detect two serious conditions: high blood pressure in the lungs (pulmonary hypertension) and a weak heart pump (low ejection fraction). About 3,850 adults will have their heart sounds …

This study is testing whether a digital stethoscope and a simple heart monitor (ECG) can detect pulmonary hypertension, a serious condition where blood pressure in the lungs is too high. About 1,500 adults who are already scheduled for heart tests will have their heart sounds and…

This study is testing whether a special digital stethoscope, combined with artificial intelligence, can detect pulmonary hypertension (high blood pressure in the lungs) by listening to heart sounds and recording a single-lead ECG. Researchers will enroll over 2,400 adults who are…

This study tests a wearable ring that measures blood pressure, comparing it to the standard 24-hour monitor in 100 people with heart failure and reduced pumping ability. The goal is to see if the ring is accurate and easy to use. If successful, it could make blood pressure tracki…

This study tests whether the Withings BPM Pro 2, an automatic blood pressure cuff, gives accurate readings for pregnant women, including those with high blood pressure or pre-eclampsia. About 45 participants will have their blood pressure measured with both the device and a stand…

This study is testing a new blood test called the MaiRa Preeclampsia Test to see if it can accurately predict preeclampsia early in pregnancy. Preeclampsia is a serious condition that can harm both mother and baby. The test looks at genetic material in the mother's blood to ident…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study tests a new smart contact lens that measures eye pressure continuously for 24 hours, compared to standard spot checks. It involves 12 adults with glaucoma or high eye pressure. The goal is to see if the lens provides accurate readings day and night, which could lead to…

This study tests a new steroid-based blood test to see if it can more accurately diagnose primary aldosteronism—a common, treatable cause of high blood pressure—in people who are already taking blood pressure medications. Current tests often require patients to temporarily stop o…

This study looks at whether a brain wave monitor (BIS) and two blood tests (sFIT/PIGF ratio and adrenomedullin) can more accurately grade the severity of preeclampsia and eclampsia in pregnant women. Researchers will enroll 48 participants to see if these tools can predict risk b…

This study is testing a wrist-worn device that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings to standard blood pressure measurements in 355 adults over four weeks. The goal is to see if this optical method is accurate e…

This study looks for early signs of pulmonary hypertension (high blood pressure in the lungs) in people with chronic lung diseases like COPD or pulmonary fibrosis. Researchers will analyze collagen fragments in blood and lung tissue to create a 'fingerprint' that could lead to si…

This study explores whether a smartphone can reliably screen for high blood pressure by analyzing video recorded at your fingertip. About 100 adults will record their blood pressure using both a smartphone and a standard arm cuff, three times each morning and evening for a week. …

This study tests whether a non-invasive device called electrical impedance tomography (EIT) can accurately diagnose pulmonary hypertension, a serious lung condition. Currently, diagnosis requires an invasive procedure called right heart catheterization. Researchers will compare E…

This study compares two new investigational devices for measuring eye pressure against the current standard methods in 200 adults with glaucoma or suspected glaucoma. The goal is to find a more objective, reproducible, and portable way to measure eye pressure. Participants will h…

This study tests a wrist-worn device called ViTrack that measures blood pressure continuously without needles. Researchers will compare its readings to standard invasive monitoring in 40 adults having noncardiac surgery. The goal is to see if the device can accurately track blood…

This early-phase study tests whether a special PET scan tracer, 18F-fluoroglutamine, can detect pulmonary arterial hypertension (PAH) earlier and more accurately. PAH is a serious disease of the lung's blood vessels that often goes undiagnosed for years. The study will scan 71 ad…

This study is testing whether a quick, non-invasive test of blood vessel function can help predict and diagnose preeclampsia and other high blood pressure disorders in pregnancy. Researchers will follow 400 first-time pregnant women, measuring vessel health early in pregnancy and…

This study is testing whether three substances in the blood can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 120 pregnant women between 20 and 36 weeks. The goal is to find a…

This study is testing whether a simple ultrasound of the optic nerve can quickly detect brain swelling and inflammation in ICU patients with conditions like meningitis, encephalitis, or stroke. Researchers will measure the optic nerve sheath diameter in 200 adults and compare it …

This study tests whether taking progesterone early in pregnancy can prevent preeclampsia, a condition that causes high blood pressure and organ damage. Over 600 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. Researchers will track who d…

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This trial tests whether a single polypill combining three medications—finerenone, empagliflozin, and losartan—can help prevent heart failure and maintain exercise capacity in people with type 2 diabetes who are at high risk. Participants will take either the polypill or the same…

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This trial tests whether taking a low-dose aspirin pill every day for six weeks after delivery can prevent dangerous blood clots in the legs or lungs as effectively as the standard daily heparin injections. The study enrolls people who have given birth and have one or more risk f…

This study looks at whether combining the MIND diet (a mix of Mediterranean and DASH diets) with aerobic exercise can help prevent memory and thinking problems in Black adults aged 35-75 who have high blood pressure. Participants will be randomly assigned to either receive food d…

This trial tests whether starting intensive blood pressure medication soon after childbirth can prevent chronic hypertension in women who had preeclampsia. Participants are randomly assigned to receive nifedipine ER when their blood pressure reaches different thresholds during th…

This trial looks at whether pregnant women at high risk for preeclampsia can safely stop taking daily aspirin at 24-28 weeks instead of continuing until 36 weeks. Around 300 women will be randomly assigned to either stop or continue aspirin. The goal is to see if stopping early l…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study compares two different doses of vitamin D3 supplements in pregnant women who have low vitamin D levels. The goal is to see if a higher dose (50,000 IU every two weeks) is better than a lower dose (5,000 IU weekly) at preventing preeclampsia, a serious pregnancy complic…

This study tests whether giving HIV prevention pills (PrEP) to people right in the emergency room helps them start and stay on prevention. Researchers will enroll 250 HIV-negative adults at risk for HIV in Dallas. Participants get a 30-day pill supply and a clinic appointment to …

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests whether taking a daily low-dose aspirin (150 mg) starting early in pregnancy can prevent preterm preeclampsia in first-time mothers who became pregnant through assisted reproductive technology (ART) like IVF. About 1,164 women will be randomly assigned to receive…

This study looks at whether natural salicylates found in foods like fruits and vegetables can help prevent preeclampsia, a dangerous pregnancy condition. Researchers will track the diets of 500 pregnant women and measure salicylate levels in their blood and urine. The goal is to …

This study is testing whether a simple screening test in early pregnancy (around 11-14 weeks) can predict and help prevent preeclampsia, a dangerous condition involving high blood pressure. The trial will involve 14,500 pregnant women and aims to reduce severe complications like …

This study tests a program to help Black women in Baltimore start taking PrEP, a medication that prevents HIV. The program addresses challenges like intimate partner violence and racism that can make it hard to get PrEP. About 300 Black women who are HIV-negative and at risk will…

This study aims to see if a new screening program during the first trimester can better identify pregnant women at risk for preeclampsia—a condition causing high blood pressure that can harm both mother and baby. Up to 80,000 women in Denmark will take part. Those found to be hig…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study tests whether starting a higher dose of aspirin very early in pregnancy (before 7 weeks) can lower the risk of preeclampsia and pregnancy loss in women with risk factors. About 1,150 pregnant women will take either 162 mg of aspirin daily or a placebo followed by stand…

This study compares two methods of releasing a tourniquet (a tight band that stops blood flow) during arm surgery in patients with high blood pressure. The goal is to see which method causes less of a sudden drop in blood pressure. The trial will include 68 adults whose blood pre…

This study tests whether a 16-week home exercise program can improve daily function in 30 adults with pulmonary hypertension linked to interstitial lung disease. Participants will receive daily texts or emails with aerobic and strength exercises. Researchers will measure changes …

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This study is testing a smartphone app called MedlyPeds that lets children with heart disease send their weight, blood pressure, and heart rate to their doctors from home. The app also asks about symptoms and sends personalized tips. The goal is to see if the app is easy to use a…

This study is testing a mobile health app called Moms@Home to help pregnant women with high blood pressure monitor their readings at home. About 100 women with gestational or chronic hypertension will use the app and share their home blood pressure data. The goal is to see if the…

This study looks at whether drinking beetroot juice every day for 12 weeks can help postmenopausal women get more heart and blood vessel benefits from exercise. The researchers will compare two groups of women doing the same exercise program—one group gets real beetroot juice, th…

This study tests whether a simple handgrip exercise can safely lower blood pressure and improve thinking skills in pregnant women with and without chronic hypertension. Thirty pregnant women will either perform short handgrip squeezes or rest quietly, and researchers will measure…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This study tests whether a 12-week home-based exercise program, started soon after diagnosis, improves walking distance and quality of life in people with pulmonary hypertension. Forty participants will either exercise early or wait six months. The goal is to see if exercise plus…

This study tests whether diaphragmatic breathing exercises can reduce heart rate, blood pressure, and dizziness in pregnant women with Postural Orthostatic Tachycardia Syndrome (POTS). 44 pregnant women will be split into two groups: one doing breathing exercises, the other recei…

This study tests whether doing very short wall-squats (just a few minutes) at four different times each day can lower blood pressure in people with hypertension or pre-hypertension. Researchers will compare this approach to doing all the squats at once. The goal is to find a simp…

This study tests whether supervised exercise sessions done at home through video calls can improve breathing, fatigue, and quality of life in people with elevated pulmonary artery pressure. Twelve adults with stable symptoms will be randomly assigned to either telerehabilitation …

This study tests whether a 16-week home exercise program, guided by a smartwatch, can help children aged 8-18 with pulmonary hypertension become more active and improve their muscle strength and quality of life. Participants will wear activity trackers and follow a personalized e…

This pilot study tests whether semaglutide (Ozempic), a drug used for diabetes and obesity, is safe and tolerable for weight loss in people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take weekly injections for 12 weeks. Res…

This study looks at whether a laser treatment called DSLT can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. Researchers will measure eye pressure at three times during one day before the laser and again six months after. The goal is …

This study tests whether an 8-week program of supervised physical and cognitive exercises can improve walking, thinking, strength, and quality of life in 374 adults with Long COVID and conditions like high blood pressure or diabetes. Participants are randomly assigned to either t…

This study tests an 8-week group mindfulness program designed for African American adults who have both high blood pressure and depression. Researchers want to see if the program improves mood and blood pressure, and if it works well in a community setting. Participants will lear…

This study tests whether a medication given as a nose spray (dexmedetomidine) can keep blood pressure stable in elderly patients with high blood pressure who are having cataract surgery. About 126 people aged 65 and older will take part. The goal is to see if the spray reduces da…

This study tests whether a mobile health program can help adolescents with pulmonary arterial hypertension increase their daily step counts. About 50 teens aged 10-21 will use a Fitbit and receive coaching to boost activity over 12 weeks. The goal is to improve exercise and quali…

This study looks at whether Street Racket, a simple racket sport, can be added to standard pulmonary rehabilitation for people with chronic lung disease. Twelve participants will play Street Racket every two weeks during their rehab program. Researchers will measure how acceptabl…

This study is testing whether a beetroot extract supplement can lower blood pressure and improve muscle oxygen levels in older women (ages 60-70) with high blood pressure during a single aerobic exercise session. Twenty participants will take either the beetroot supplement or a p…

This study is testing whether an 8-week telephone-based mindfulness program (MIND-BP) can help Black women with high blood pressure lower their blood pressure and reduce stress. The study will compare the mindfulness program to a general support group (BOOST). 300 Black women fro…

This study tests whether a smartphone game that responds to your activity can help Native American adults with high blood pressure become more active. Half of the 220 participants will get the game plus a fitness tracker, while the other half gets only the tracker. Researchers wi…

This study tests whether applying gentle heat to the abdomen overnight can safely lower high blood pressure that occurs when lying down in people with autonomic failure. About 20 adults with conditions like Parkinson's or Multiple System Atrophy who have this nighttime hypertensi…

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This natural history study follows 270 adults with pulmonary arterial hypertension (PAH) and healthy volunteers to track how the disease changes over time. Researchers will use blood tests, heart and lung imaging, and a six-minute walk test to find new markers of disease severity…

This study follows up to 3,500 people with sickle cell disease to learn more about how the condition progresses and what complications arise. Participants receive their usual medical care outside the hospital and visit the clinic for check-ups and research tests. No experimental …

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study is testing a smart device called CONNECTDROP® that clips onto eye drop bottles to track how often glaucoma patients use their medication. About 200 adults with open-angle glaucoma will use the device and a smartphone app for one year. The goal is to see if the technolo…

This study explores whether a simple, radiation-free scan of the nailbeds—called nailfold capillaroscopy—can help diagnose and monitor pulmonary hypertension (PH), a condition of high blood pressure in the lungs. Researchers will compare nailbed blood vessel measurements with inv…

This study investigates why arteries stiffen and harden faster in children and young people with chronic kidney disease (CKD) and high blood pressure. Researchers will use non-invasive tests to compare arterial stiffness between those with CKD and matched controls, including heal…

This study looks at how partial sleep deprivation affects blood pressure in healthy young adults whose parents have high blood pressure compared to those whose parents have normal blood pressure. Participants will spend 10 days in a sleep lab, with some nights allowing only 5 hou…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study explores whether a measure called perfusion index (PI), taken from a pulse oximeter on the ear, finger, or toe, can reliably predict changes in blood pressure in people with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI and healthy…

This study will compare two types of heart-lung machines used during coronary bypass surgery to see how they affect blood flow to the brain. Researchers will measure brain pressure using an eye ultrasound and brain oxygen levels with a forehead sensor in 70 patients. The goal is …

This study looks at whether stopping certain blood pressure medications (ACE inhibitors or ARBs) before colorectal cancer surgery can reduce the risk of heart injury. Researchers will monitor 156 adults for signs of heart damage after surgery. The goal is to find the safest way t…

This study investigates whether certain progesterone receptors in the placenta are linked to preeclampsia, a serious pregnancy condition marked by high blood pressure. Researchers will compare placental tissue from women with preeclampsia to that from healthy pregnant women, meas…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study explores whether work-related frustration and stress are linked to higher-risk blood pressure patterns, such as masked or white-coat hypertension. Researchers will monitor the blood pressure of working adults aged 40 to 65 over 24 hours and compare it with their percei…

Women who had preeclampsia are at higher risk for both depression and heart disease later in life. This study investigates whether antidepressant medication can improve blood vessel function in these women. Researchers will measure skin blood vessel responses in 40 women, compari…

This study looks at what happens to blood pressure when healthy adults sleep only 4 hours a night. Researchers will compare normal-weight and obese participants to see if lack of sleep affects their blood pressure differently. The goal is to better understand the link between sle…

This study investigates whether microscopic particles shed from blood vessels, called endothelial extracellular vesicles, can serve as early warning signs of blood vessel damage in children with newly diagnosed, untreated high blood pressure. Researchers will compare these partic…

This study looks at whether tiny particles shed from blood vessels, called endothelial extracellular vesicles, can serve as early warning signs for hypertensive disorders of pregnancy, such as preeclampsia. Researchers will compare levels of these particles in pregnant women with…

This study compares levels of tiny particles shed from blood vessels in people with newly diagnosed, untreated high blood pressure versus those with normal blood pressure. Researchers want to see if these particles can serve as early, non-invasive markers of blood-vessel injury. …

This study will analyze health records from 15,000 adults with high blood pressure in Brazil's public primary care system. Researchers want to see how often patients with uncontrolled blood pressure get their treatment adjusted. The goal is to understand patterns of care and iden…

This study looks at data from over 6,000 Brazilian patients with heart failure, kidney disease, diabetes, or high blood pressure to understand how common high potassium levels (hyperkalemia) are and how doctors manage it. By analyzing medical records, researchers hope to identify…

This study looks at how tiny particles released by the placenta, called extracellular vesicles, affect pregnancy complications like pre-eclampsia and gestational diabetes. Researchers will collect samples from 360 pregnant and non-pregnant women to understand these particles bett…

This study follows 200 pregnant women in Ghana from their third trimester through six months after birth. It measures blood pressure and artery stiffness to see if a structured education program on heart health, nutrition, and stress management can reduce long-term cardiovascular…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study follows people with chronic thromboembolic disease (CTD) or chronic thromboembolic pulmonary hypertension (CTEPH) — conditions where blood clots scar the lungs' blood vessels. Researchers track survival, exercise ability, oxygen use, and quality of life over time using…

This study checks how well a non-invasive blood pressure cuff matches the readings from an arterial line, the current gold standard. Adults aged 18 and older who already have an arterial line as part of their care may join. The goal is to see if the cuff-based device can provide …

This study measures how common heart disease, diabetes, obesity, and infections like dengue and COVID-19 are among adults in La Reunion. Researchers will also look at possible risk factors, including gut bacteria, genetics, and social conditions. Participants provide blood, DNA, …

This study looks at whether stretching the veins in your legs causes a rise in blood pressure when you stand up, a condition called orthostatic hypertension. Researchers will use a tilt table and inflatable trousers to gently stretch leg veins in 30 healthy adults and people with…

This study tests a new monitoring tool called the Cerebral Adaptive Index (CAI) that may help doctors set personalized blood pressure targets during heart surgery. The tool tracks brain blood flow in real time. Researchers will observe 120 adults aged 45 and older who are at high…

This study is testing a new non-invasive blood pressure device that uses a cuff and special algorithm to measure blood pressure. Researchers will compare its readings to those from an arterial line, which is the most accurate method but requires a needle in an artery. The study i…

This study aims to understand how tiny particles called exosomes, released from the placenta, may cause preeclampsia—a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these pa…

This study looks at why some cancer patients develop neurological problems after receiving immunotherapy drugs called checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to find immune cells that may mistakenly attack the nervous system. T…

This study looks at why people with pulmonary arterial hypertension (PAH) lose muscle mass and how that affects their daily life and activity. Researchers will measure body composition, heart fat, diet, and physical function in 150 adults with PAH. No new treatment is being teste…

This study tests a new non-invasive blood pressure (NIBP) device in newborns and children up to 18 years old. The device uses a cuff on the arm or thigh to measure blood pressure without needles. Researchers compare these readings to standard invasive measurements to see how accu…

This study compares two eye drop treatments—latanoprost alone versus a combination of netarsudil and latanoprost (Rocklatan)—to see if the combination improves blood flow in the veins around the eye. Researchers will use special imaging techniques to measure blood flow in adults …

This study looks at whether home blood pressure readings can correctly identify different types of high blood pressure (like masked or white coat hypertension) in children aged 6 to 18. Researchers will compare home measurements to 24-hour ambulatory monitors in 52 kids referred …

This study looks at whether detailed heart scans (echocardiograms and MRIs) can improve how doctors predict short-term risks in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension). Researchers will follow 50 adults for 6 months to see if addin…

This observational study will follow 5000 people with pulmonary hypertension to understand a severe complication called pulmonary hypertension crisis. Researchers will collect medical data and samples to build a risk prediction tool. The goal is to identify who is at risk and imp…

This study follows 50 adults who have had pulmonary endarterectomy surgery for chronic blood clots in the lungs. Researchers will measure walking ability, muscle strength, lung function, and frailty before and after surgery. The goal is to understand how recovery progresses and w…

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the back of the eye. Researchers will follow about 1,050 people with retinal diseases like diabetic retinopathy and healthy volunteers to see how these images can help detect early …

This observational study is looking at whether people with primary aldosteronism (a cause of high blood pressure) have hormone levels that vary in cycles or differ between day and night. Researchers will collect urine samples over 24 hours from 100 participants to see if this met…

This study checks if a French version of the MEPS/MEPI elbow score works well for children aged 4 to 17. It includes kids with and without elbow injuries to see if the score accurately measures elbow pain and function. The goal is to make sure doctors can use this tool reliably i…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study uses special cameras to take detailed pictures of the eye's drainage system in people with glaucoma or high eye pressure. Half of the 50 participants will use Rhopressa eye drops daily for two weeks, while the other half will use artificial tears. The goal is to see if…

This study compares three new wearable blood pressure monitors (ABPMPro, Aktiia, and Spacelabs) to see how well they measure blood pressure and physical activity. One hundred adults with normal or high blood pressure will wear the devices for 48 hours. The goal is to find out if …

This study aims to better understand pre-eclampsia and intrauterine growth restriction (IUGR), serious pregnancy complications affecting about 9% of pregnancies. Researchers will collect placenta, blood, and urine samples from 500 pregnant women—both with and without these condit…

This study is testing whether a mobile phone app can help pregnant women at high risk for preeclampsia in Karachi, Pakistan, monitor their blood pressure and symptoms at home. Fifty women will use the app to send daily readings to their healthcare team, who can then respond if ne…

This study looks at whether women with high blood pressure who skip their medication have more sexual problems than those who take it regularly. Researchers will compare sexual function in 348 women using questionnaires and blood tests. The goal is to understand if not taking med…

This study looks at the best way to treat a fluid pocket (pseudomeningocele) that can form under the scalp after brain surgery. It compares doing nothing active (just watching and caring for the wound) with doing a procedure like draining the fluid or another surgery. The goal is…

This study examines why fat accumulates in the right ventricle of people with pulmonary arterial hypertension (PAH) and how it affects heart function and exercise ability. Researchers will use MRI and blood tests in 75 adults with PAH to track changes over time. The goal is to be…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section, so better …

This study follows 60 kidney transplant recipients in Denmark to find out how often blood vessel problems cause poor kidney function or hard-to-treat high blood pressure. Participants will get special imaging tests, and if a narrowed artery is found, they may receive balloon trea…

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study looks at the connection between high blood pressure and obstructive sleep apnea (OSA) using heart rate variability (HRV), a simple heart monitoring method. Researchers will track 100 adults with high blood pressure who are at risk for OSA, using heart monitors and slee…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and often experience high blood pressure during physical activity. Researchers will test whether regular cycling exercise, a drug called Kuvan, or supplements like histidine and beta-alanine …

This study looks at whether giving older adults (65+) with diabetes or high blood pressure access to their visit notes and audio recordings of their appointments helps them feel better and manage their health. About 1,022 participants will be randomly assigned to receive either w…

This study looks at how taking 81mg of aspirin twice a day affects blood platelets in pregnant women who are at high risk for preeclampsia. Researchers will collect blood samples about 4 weeks after starting aspirin to measure platelet function. The goal is to understand the best…

This study uses a quick, painless eye scan (OCT) to see if blood vessels in the eye look different in people with high blood pressure or chronic kidney disease compared to healthy people. Researchers want to learn if these differences improve with treatment. About 150 adults aged…

This study is looking at 150 Division I athletes from historically Black colleges and universities (HBCUs) to see how not getting enough calories—called low energy availability—might harm their hearts. Researchers will measure things like artery stiffness, blood sugar, and choles…

This study aims to see if a short, interval fitness test (the IFT 30-15) can reliably measure heart and lung fitness in both healthy people and those with high blood pressure or obesity. Researchers will compare results from this test with a standard treadmill test and a six-minu…

This study looks at how changing the pressure on a ventilator affects the lungs and heart of very premature babies (born before 34 weeks). Researchers will try different pressure levels and use ultrasound and imaging to see which setting works best for breathing and blood flow. T…

This study is testing whether a bedside imaging technique called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of patients with chronic blood clots. Thirty-six people scheduled for surgery to remove these clots will be monitored with EIT befor…

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart strain to help develop better treatments in the future. About 60 adults aged 40 and older with COPD will…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers will use heart imaging and other tests to identify different patterns of heart dysfunction. The goal is to better understand these patterns so that future …

This study looks at whether a structured goal-setting program can help people with chronic conditions like high blood pressure, diabetes, or high cholesterol adopt healthier behaviors. Researchers will compare 600 participants who receive the program to those who get usual care. …

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study tests whether nicotinamide riboside, a form of vitamin B3, can improve how cells produce energy in people with combined pulmonary hypertension (CPH). CPH is a serious lung and heart condition with no approved treatments. Ten participants will receive both the supplemen…

This study looks at whether giving low-income adults aged 40 and older free meal kits and nutrition education can improve their food security, diet quality, mental health, and heart health. About 120 participants will be split into two groups: one gets meal kits plus nutrition cl…

This study is collecting blood samples from 100 pregnant women with and without preeclampsia to measure key proteins involved in the condition. The goal is to better understand the angiogenic imbalance that causes symptoms and to develop a device that filters out harmful proteins…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is tracking 70 adults on long-term dialysis to find out how often they develop high blood pressure in the lungs (pulmonary hypertension) and what causes it. Participants get heart ultrasounds and, if needed, more tests to confirm the condition. Researchers will follow …

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study aims to find genes that make some people with congenital heart defects develop a serious lung condition called pulmonary arterial hypertension (PAH). Researchers will analyze DNA from blood samples of 21 patients with heart defects who also have PAH. The goal is to ide…

This study from the University of Oxford looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel disease later in life. Researchers will follow 200 women who gave birth 10 to 25 years ago, using heart scans, exercise tests…

This study looks at whether adding a heart ultrasound (echocardiogram) to regular check-ups helps doctors better manage high blood pressure in young adults aged 18 to 40. Researchers will collect data from 750 participants during their routine clinic visits and follow them for up…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study is for 12 adults with severe brain injuries or tumors in the back part of the brain. Doctors will place two small pressure sensors to measure pressure in both the front and back of the brain. The goal is to learn what normal and dangerous pressure levels are in the bac…

This study tracks 25 adults with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull causes headaches and vision problems. Researchers will measure body mass index (BMI) every three months and see how it relates to the success of treatment…

This study looks at whether giving mothers in Brazil an extra $40 per month (compared to just $2) can protect their children's brain development and mental health. About 450 children aged 7-10 from low-income families will be followed for 2 years. Researchers will measure stress,…

This study looks at whether digital devices like smartwatches and blood pressure cuffs can help detect high blood pressure and related pregnancy problems in refugee women. About 75 pregnant refugee women will use these tools at home and complete surveys. The goal is to see if thi…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study looks at how a specific biological pathway (BMPR2-activin) affects pulmonary hypertension in people with left heart disease. Researchers will follow 150 heart failure patients for one year, using blood tests, imaging, and heart tissue analysis. The goal is to better un…

This study is testing a unified first trimester screening approach to predict serious pregnancy complications like preeclampsia, fetal growth restriction, and birth defects. Researchers will enroll 2,000 pregnant women in the Czech Republic to see if combining standard tests can …

This study looks at how different arm positions change blood pressure readings in pregnant women. About 300 pregnant women will have their blood pressure taken with their arm in three positions: supported at heart level, on the lap, and hanging at the side. The goal is to find ou…

This study aims to find early signs of heart failure in women who had preeclampsia, a pregnancy complication involving high blood pressure. Researchers will use exercise stress tests and heart imaging to compare 250 women with a history of preeclampsia to 250 women with normal pr…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will measure stiffness caused by blood pressure itself and by changes in the artery wall, and explore genetic factors. The goal is to…

This study looks at whether a special heart pressure wave test can better track recovery in adults with chronic blood clots in the lungs (CTEPH) who are getting a procedure to open blocked arteries (balloon pulmonary angioplasty). Researchers will measure walking distance, heart …

This study is creating a registry of over 10,000 people with high blood pressure. Researchers will collect data on their health, treatments, and outcomes to find patterns and improve care. The goal is to help doctors provide more personalized and effective treatment based on real…

This study is following 250 pregnant women diagnosed with preeclampsia, a serious condition involving high blood pressure and organ problems. Researchers will collect health data and samples from mothers and babies during pregnancy, at birth, and a few months after. The goal is t…

This study observes 50 adults having surgery to understand why their blood pressure drops. Researchers will use machine learning to find patterns in how different patients respond to treatment. The goal is to create personalized recommendations for managing low blood pressure dur…

This study is an observational registry that will follow about 120 adults with pulmonary hypertension who are being treated with the drug sotatercept at the Mayo Clinic. Researchers will track changes in quality of life, exercise ability, heart function, and side effects like ble…

This observational study will enroll 8,000 adults undergoing routine health checkups. Researchers will measure hormone levels and collect health data to understand how environment, genes, and proteins interact in conditions like high blood pressure and diabetes. The goal is to cr…

This study will screen blood pressure in over 22,000 children aged 5-18 across South Africa. The goal is to create the country's first reference charts for normal blood pressure, since current charts are based on US and European data. This will help doctors correctly diagnose and…

This study watches 220 adults aged 75 and older who have high blood pressure. Researchers want to see if brief drops in daytime blood pressure (below 90 mmHg) raise the risk of falls, hospital stays, heart problems, or death. Participants wear a 24-hour blood pressure monitor and…

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint'…

This study is creating a large database of children with pulmonary hypertension (high blood pressure in the lungs) to better understand how the disease progresses and how treatments work in real life. Researchers will follow 450 children and adolescents over time, collecting info…

This study is checking whether people newly diagnosed with high blood pressure who also have high homocysteine levels are more likely to have early signs of heart stiffness. Researchers will measure homocysteine in blood and use ultrasound to look at heart function in 500 adults.…

This study is building a large database of 1,200 people with malignant hypertension, a severe form of high blood pressure that can damage organs quickly. Researchers will track patients for five years to learn how the disease behaves today and how doctors treat it. The goal is to…

This study is building a large collection of blood samples and health information from 5,000 adults with congenital heart disease and related conditions. Researchers will use this data to better understand how these diseases work and what affects patient health. No treatments or …

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study looks at how the body controls blood pressure and heart rate in healthy young adults and older adults with high blood pressure. Participants will do tests like standing up and cycling while their heart and blood vessels are monitored. The goal is to better understand t…

This early-stage study tests a new tablet called F230 in 136 healthy adults to see if it is safe and how the body processes it. The drug is designed to treat pulmonary hypertension, a serious lung condition. Researchers will also check if food changes how the drug works. This stu…

This study looks at how often the diaphragm — the main muscle used for breathing — becomes weak after a C-section in women with severe preeclampsia. Researchers will use ultrasound to measure diaphragm movement before and 24 hours after surgery in 52 women. The goal is to find ou…

This study is collecting blood, amniotic fluid, and placenta samples from 100 pregnant women, including those with pregnancy-induced hypertension and those who have had a miscarriage. Researchers will test these samples to look for differences in immune cells and other markers. T…

This study is looking at people with pulmonary arterial hypertension (PAH), those with a genetic risk but no disease, and healthy individuals. Researchers aim to find molecular and physical markers that explain why some people get PAH and others stay healthy. The goal is to impro…

This study tests whether a simple fetal ECG monitor worn at home can effectively track the health of babies in high-risk pregnancies. Fifty pregnant women who need weekly fetal testing will use the device for 30-minute sessions, three times a week, starting at 32 weeks. The goal …

This study compares noninvasive heart ultrasound (echocardiogram) with the standard invasive right heart catheterization in 3000 people referred for catheterization. The goal is to see if ultrasound can accurately measure heart function and blood flow during exercise. Participant…

This study is looking at whether the level of bicarbonate in the blood can help predict if a patient will die or need intensive care within 48 hours of arriving at the emergency department. Researchers will track 6,500 adults who have a blood test done as part of their regular ca…

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study partners with community organizations to improve participation in health research among Black, Latino, and Native American communities in Colorado. Researchers will track changes in diet, transportation access, and social support over time. The goal is to build lasting…

This study looks at how blocking certain nerve signals for two weeks changes the way the body produces sugar in people who have both obesity and high blood pressure. Twelve participants will receive a placebo, a blood pressure drug, or a nerve-blocking drug in a random order. The…

This observational study compares airway measurements using ultrasound among three groups: nonpregnant women, pregnant women with normal blood pressure, and pregnant women with preeclampsia. Researchers will measure distances from the skin to key airway structures and assess lary…

This pilot study aims to see if a special MRI sequence can detect lymphatic damage in people with brain vein narrowing or clots. About 100 adults will get an extra MRI scan during their regular care. No new treatment is tested; the goal is to learn if this MRI method can spot lym…

This study looks at small molecules (metabolites) in the blood and urine of people with pulmonary hypertension caused by lung fibrosis. Researchers want to see how these metabolites change with treatment and whether they can tell who will respond well. The goal is to better under…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study looks at why pregnant women living at high altitudes have higher rates of preeclampsia and poor fetal growth. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare how their …

This study looks at why women who had preeclampsia during pregnancy have higher heart disease risk later in life. Researchers will test a drug called eplerenone on small skin blood vessels in 40 women (some with prior preeclampsia, some without) to see if it improves vessel funct…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some have a 'non-dipping' pattern where blood pressure stays high at night. The goal is to uncover mec…

This study is building a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to explore how genetic variations relate to heart disease, high blood pressure, diabetes, and obesity. Participants provide samples and data, but no experime…

This study looks at eye problems in people with craniosynostosis, a condition where skull bones close too early. Researchers will check for issues like crossed eyes, lazy eye, and pressure inside the head. The goal is to better understand these eye problems to help improve care.

This study looks at whether three common blood pressure medications (beta-blockers, ACE inhibitors, and calcium channel blockers) affect balance and fall risk in adults newly diagnosed with high blood pressure. About 186 participants will be randomly assigned to one of the three …

This study looks at whether trained community health workers can effectively screen and manage chronic diseases like high blood pressure and diabetes in rural Lesotho. About 17,500 adults will take part, with health workers using simple tools and eHealth apps to monitor and refer…

This study looks at whether not using inhaled nitric oxide (iNO) in newborns with congenital diaphragmatic hernia (CDH) leads to better outcomes, like fewer needing life support or dying. About 600 babies from multiple hospitals will be included. The goal is to see if stopping th…

This study looks at how different salty condiments, like soy sauce or fish sauce, affect blood pressure and blood vessel health shortly after eating. Researchers want to create a system to rank these condiments based on heart risks. The study involves 32 adults aged 50 to 75 with…

This study looks at how often people with cystic fibrosis and diabetes develop complications like eye, kidney, and nerve problems. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks in a diverse group of 200 adolescents and ad…

This study involves 100 people with suspected pulmonary hypertension who are already scheduled for a right heart catheterization. During the procedure, doctors will take two extra blood samples from a specific position in the lung artery to analyze oxygen and other gas levels. Th…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to understand how these images change after treatments like blood transfusions or oxygen therapy. The study involves 125 adul…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This early-phase study tests a new MRI method that uses a special injection called hyperpolarized pyruvate to see how the heart uses energy. Researchers will scan the hearts of up to 112 people with high blood pressure, heart thickening, or heart failure. The goal is to see if th…

This study looks at how the diaphragm, the main muscle used for breathing, works in people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. About 800 adults will take breat…

This study follows 1,260 women 3 to 6 years after their first pregnancy to see how pregnancy complications like preeclampsia affect heart health. Researchers will check blood pressure, heart function, and artery health, and also look at lifestyle and environment. The goal is to c…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study collects tissue samples from women with and without preeclampsia during C-sections to examine blood vessel function. Researchers focus on a protein called AT2R, which may play a role in the condition. The goal is to better understand how preeclampsia affects blood vess…

This study looks back at medical records of 1,000 people with COPD who also had a special heart test called right heart catheterization. Researchers want to understand a specific lung-heart problem called pulmonary hypertension. By analyzing this data, they hope to better identif…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study is creating a large database of information from 900 people who have pulmonary hypertension (high blood pressure in the lungs) or are at risk for it. Researchers will collect medical history, test results, and follow-up data over time. The goal is to improve understand…

This study aims to understand why the right side of the heart fails in people with heart failure and high blood pressure in the lungs. Researchers will look at heart tissue samples from 50 adults to find the best ways to diagnose and treat this condition. Participants must be bet…