Can a new injection ease heart and lung strain in obesity?
NCT ID NCT07123779
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This trial is testing an experimental drug called HS235 in obese adults who have both pulmonary hypertension and heart failure with preserved ejection fraction. The study aims to see if the drug is safe, how it moves through the body, and whether it can improve heart and lung function. Participants will receive either HS235 or a placebo as a subcutaneous injection, and researchers will monitor for side effects and measure the drug's effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HS235, an experimental biologic given as a subcutaneous injection
- What this could lead to
- If successful, HS235 could offer a new treatment option for obese people with pulmonary hypertension and heart failure with preserved ejection fraction, potentially improving symptoms and quality of life.
- What could go wrong
- This is an early-phase trial, so the drug may not work as hoped or could cause side effects. Results from a small group may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Investigational Site-101
RECRUITINGGreenville, South Carolina, 29605, United States
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