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Keto vs. Low-Fat: which diet helps heart failure patients move better?

NCT ID NCT06081543

Recruiting now Disease control Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study compares a low-carbohydrate ketogenic diet to a low-fat mixed diet in people with heart failure with preserved ejection fraction who also have diabetes, prediabetes, metabolic syndrome, or obesity. The goal is to see whether the ketogenic diet can improve exercise tolerance, measured by changes in maximal exercise performance (VO2 max). Participants will receive prepared meals for the first six weeks, then continue with coaching and education for the remainder of the study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a ketogenic diet compared with a low-fat mixed diet
What this could lead to
If the ketogenic diet improves exercise capacity, it could offer a dietary strategy to help people with this type of heart failure feel better and be more active.
What could go wrong
This is a small, early-stage dietary trial with no blinding, so results may be influenced by participant expectations. Dietary adherence can be challenging, and the ketogenic diet may cause side effects like fatigue or nutrient imbalances.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH PRESERVED EJECTION FRACTION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The Ross Heart Hospital

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

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