HEART FAILURE WITH PRESERVED EJECTION FRACTION

This study is testing whether special pacemaker settings can help people with a specific type of heart failure feel better and be more active. Researchers will implant pacemakers in about 105 participants and then randomly assign them to receive either the experimental pacing the…

This study is testing whether temporarily stopping beta-blocker medication for 4 weeks improves how patients with a specific type of heart failure feel and function. Researchers will enroll 30 patients who are currently stable on these medications to measure changes in their exer…

This trial is testing a small, implanted heart device called an Optimizer. It delivers CCM therapy, which uses electrical pulses to help the heart pump more effectively. The study aims to see if this device can help people with certain types of heart failure walk farther, feel be…

This study is testing if a medical procedure can help people with two common heart problems: heart failure with a strong heart pump and permanent atrial fibrillation (an irregular heartbeat). Researchers want to see if a procedure that regulates the heartbeat, combined with a pac…

This study is testing a special support program for people with a common type of heart failure who are leaving the hospital. The program provides education, a self-care kit, and follow-up phone calls to help patients manage their condition at home. The main goal is to see if this…

This study is testing if a pacemaker can help people with a specific type of heart failure where the heart pumps normally but is stiff and doesn't speed up properly during activity. Thirty patients will have a pacemaker implanted and then be randomly assigned to have it turned on…

This study is testing if a 12-week low-calorie diet can improve symptoms and physical function in adults with a common type of heart failure linked to obesity and type 2 diabetes. About 63 participants will be randomly assigned to either start the diet immediately or receive stan…

This study is testing whether a home-based cardiac rehabilitation program delivered through a custom mobile app can help people with heart failure. The program aims to improve physical activity, quality of life, and reduce hospital visits by guiding exercise and healthy behaviors…

This study is testing whether a new drug, TX000045, can safely reduce high blood pressure in the lungs of people with a specific type of heart failure. About 180 participants will receive either the drug or a placebo via injection every two weeks for 24 weeks. Researchers will me…

This large, late-stage study is testing whether a new injectable drug, maridebart cafraglutide, can help people who have a specific type of heart failure and are also obese. The main goal is to see if the drug, added to standard care, can reduce the risk of dying from heart probl…

This study is testing a small device called a Coronary Sinus Reducer in people with a specific type of heart failure where the heart pumps normally but still causes symptoms like shortness of fatigue. The goal is to see if the implant improves blood flow to the heart muscle. Rese…

This study is testing if a single dose of intravenous iron can improve exercise capacity in people with a specific type of heart failure who also have low iron. About 66 participants will be randomly assigned to receive either the iron treatment or a placebo. The main goal is to …

This study is testing whether a special type of MRI scan done during exercise can help doctors better diagnose, understand, and predict risks for a common form of heart failure. Researchers will compare the scan results in 400 people: those with heart failure, those with shortnes…

This study is testing if a simple, at-home heat therapy can help people with a specific type of heart failure feel better and be more active. Researchers will have 90 participants use special water-heated trousers on their legs daily to see if it improves their ability to exercis…

This study is testing a new type of PET scan to see if it can detect and measure scarring in the heart muscle of people with a specific kind of heart failure (HFpEF). Researchers will compare scans from 35 people with HFpEF to scans from people with another heart condition and he…

This study is creating a live registry using the health records of 40,000 heart failure patients within the Yale New Haven Health System. Its purpose is to monitor patients in real-time to identify gaps in recommended treatments and understand patterns in hospital readmissions. T…

This study aims to understand why postmenopausal women have a higher risk of developing a specific type of heart failure where the heart muscle is stiff. Researchers will analyze heart tissue samples from 500 women undergoing heart surgery to study how the loss of estrogen affect…