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New drug aims to repair heart in common form of heart failure

NCT ID NCT06979362

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 4 times

Summary

This study tests a new medicine called CDR132L in 200 people with a type of heart failure where the heart is stiff and thickened. The goal is to see if it can improve heart structure and function. Participants will receive either the study drug or a placebo by chance, and the study lasts about 60 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 84 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 40-84 years (both inclusive) at the time of signing the informed consent * Documented symptomatic chronic heart failure (HF) diagnosed greater than or equal to (≥) 90 days prior to screening with at least weekly need for oral diuretic treatment, and New York Heart Association class II-III at screening * Clinically stable and on optimised doses and unchanged drug classes of guideline-directed HF therapy ≥45 days prior to randomisation * Left ventricular ejection fraction ≥50% as assessed by echocardiography at screening, measured by central laboratory * Left ventricular hypertrophy assessed by echocardiography at screening measured by central laboratory with any of the following: 1. LVMi (greater than) \>88 gram per square meter (g/m\^2) for female participants and \>102 g/m\^2 for male participants, using the truncated ellipsoid method measured by central laboratory 2. LVMi \>95 g/m2 for female participants and \>115 g/m2 for male participants using the linear method (cube formula). 3. Interventricular septum diameter measured in diastole (IVSd) in the parasternal long axis view ≥1.1 cm for female participants and ≥1.2 cm for male participants. * Body mass index 18.5-40 kilogram per square meter (kg/m\^2) (both inclusive) and body weight less than or equal to (≤) 140 kilogram (kg). Body mass index is calculated in the electronic case report form based on height and body weight at the screening visit (visit 1) * NT-proBNP ≥300 picograms per milliliter (pg/mL); NT-proBNP ≥600 pg/mL if atrial fibrillation/flutter is present at time of screening, measured by central laboratory Exclusion Criteria: * Estimated glomerular filtration rate lesser than (\<) 30 milliliter per minute (mL/min)/1.73 square meter (m\^2) at time of screening, measured by central laboratory * Participants with an episode of acute kidney failure or acute kidney injury, at the discretion of the investigator, within 90 days prior to randomisation * Myocardial infarction, unstable angina pectoris or HF hospitalisation within 30 days prior to screening * Participants receiving intravenous HF medications within 45 days prior to randomisation * Participants with CRT, pacemaker or implantable cardioverter-defibrillator * Planned coronary revascularisation, pacemaker/cardioverter-defibrillator/CRT implantation, ablation of cardiac arrythmias and valve repair/replacement at the time of randomisation * Stroke or transient ischemic attack within 12 months prior to randomisation * Participants with potential disruption of the blood-brain barrier (e.g., multiple sclerosis), in the opinion of the investigator * Known history of severe liver disease and/or alanine aminotransferase or aspartate aminotransferase \>2.5 x upper limit of normal at screening, measured by central laboratory * Known genetic (or highly suspected due to family history) cause of increased cardiac mass (including dilated cardiomyopathy, Fabry disease and likely pathogenic or pathogenic variants within hypertrophic cardiomyopathy \[HCM\]). * Participants with suspected or diagnosed cardiac amyloidosis or sarcoidosis.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    104 sites in 9 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ

    RECRUITING

    Lublin, Lublin Voivodeship, 20-049, Poland

  • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu

    RECRUITING

    Wroclaw, Lower Silesian Voivodeship, 50-981, Poland

  • Abington Memorial Hospital

    COMPLETED

    Abington, Pennsylvania, 19001, United States

  • AdventHealth Orlando

    NOT_YET_RECRUITING

    Orlando, Florida, 32803, United States

  • All India Institute of Medical Sciences (AIIMS), Nagpur

    RECRUITING

    Nagpur, Maharashtra, 441108, India

  • All India Institute of Medical Sciences (AIIMS), Nagpur

    NOT_YET_RECRUITING

    Nagpur, Maharashtra, 441108, India

  • Amarillo Medical Specialists

    NOT_YET_RECRUITING

    Amarillo, Texas, 79124, United States

  • American Heart of Poland S.A.

    RECRUITING

    Bielsko-Biala, 43-316, Poland

  • Apollo Hospital Chennai

    RECRUITING

    Chennai, Tamil Nadu, 600006, India

  • Apollo Hospital Chennai

    NOT_YET_RECRUITING

    Chennai, Tamil Nadu, 600006, India

  • Capital Area Research LLC

    RECRUITING

    Camp Hill, Pennsylvania, 17011, United States

  • Cardio Health Clinical Trials

    NOT_YET_RECRUITING

    Hamilton, Ontario, L8W 3K5, Canada

  • Cardio Health Clinical Trials

    RECRUITING

    Mississauga, Ontario, L5M 2S6, Canada

  • Charité - Campus Benjamin Franklin - Klinik für Kardiologie

    NOT_YET_RECRUITING

    Berlin, 12203, Germany

  • Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU)

    RECRUITING

    Berlin, 13353, Germany

  • Chungbuk National University Hospital

    RECRUITING

    Cheongju-si, 28644, South Korea

  • Duke University

    RECRUITING

    Durham, North Carolina, 27710, United States

  • East Texas Cardiology PA

    RECRUITING

    Houston, Texas, 77002, United States

  • G B Pant Institute of Postgraduate Medical Education and Research

    RECRUITING

    New Delhi, National Capital Territory of Delhi, 110022, India

  • Government Siddhartha Medical College & Government General Hospital, Vijayawada

    RECRUITING

    Vijayawada, NTR District, Andhra Pradesh, 520008, India

  • Guardian Research Org LLC

    NOT_YET_RECRUITING

    Winter Park, Florida, 32792, United States

  • Hamilton General Hospital

    COMPLETED

    Hamilton, Ontario, L8L 5G4, Canada

  • Hamilton Hlth Sc. - General Site

    NOT_YET_RECRUITING

    Hamilton, Ontario, L8L 2X2, Canada

  • Harbor-UCLA Medical Center

    RECRUITING

    Torrance, California, 90502, United States

  • Henry Ford Hospital_Detroit

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Hosp. U Gran Canaria Dr. Negrín_Cardiologia

    NOT_YET_RECRUITING

    Las Palmas de Gran Canaria, 35010, Spain

  • Hospital Clinico Universitario de Valencia

    RECRUITING

    Valencia, 46010, Spain

  • Hospital Ramón y Cajal_Cardiología

    NOT_YET_RECRUITING

    Madrid, 28034, Spain

  • Hospital Univ. La Luz_Cardiología

    NOT_YET_RECRUITING

    Madrid, 28003, Spain

  • Hospital Univ. Virgen de la Arrixaca

    RECRUITING

    El Palmar, Murcia, 30120, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, 28046, Spain

  • Hospital Universitario San Cecilio

    RECRUITING

    Granada, Andalusia, 18016, Spain

  • Hospital del Mar

    RECRUITING

    Barcelona, 08003, Spain

  • Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology

    RECRUITING

    Himeji-shi, Hyogo, 670-8560, Japan

  • IPGME&R and SSKM Hospital

    RECRUITING

    Kolkata, West Bengal, 700020, India

  • IUCPQ - Universite Laval

    NOT_YET_RECRUITING

    Québec, G1V 4G5, Canada

  • Icahn Sch of Med-Mt Sinai Hosp

    NOT_YET_RECRUITING

    New York, New York, 10029, United States

  • Inova Heart and Vascular Institute

    RECRUITING

    Falls Church, Virginia, 22042, United States

  • Inpatient Research Clinic LLC

    RECRUITING

    Miami Lakes, Florida, 33014, United States

  • Instytut Centrum Zdrowia Matki Polki

    RECRUITING

    Lodz, 93-338, Poland

  • Kagawa University Hospital_Cardiology

    COMPLETED

    Kita-gun, Kagawa, 761-0793, Japan

  • Keimyung University Dongsan Hospital

    RECRUITING

    Daegu, 42601, South Korea

  • King's College Hospital

    RECRUITING

    London, SE5 9RS, United Kingdom

  • Kobe City Medical Center General Hospital_Cardiology

    RECRUITING

    Kobe-shi, Hyogo, 650-0047, Japan

  • Korea University Anam Hospital

    RECRUITING

    Seoul, 02841, South Korea

  • Korea University Guro Hospital

    COMPLETED

    Seoul, 08308, South Korea

  • Korea University Guro Hospital

    WITHDRAWN

    Seoul, 08308, South Korea

  • Krakowski Szpital Specjalistyczny im. Jana Pawla II

    COMPLETED

    Krakow, 31-202, Poland

  • Kyunghee University Medical Center

    NOT_YET_RECRUITING

    Seoul, 02447, South Korea

  • Medical Research Institute KITANO HOSPITAL_Cardiovascular Medicine

    RECRUITING

    Osaka-shi, Osaka, 530-8480, Japan

  • Medizinische Hochschule Hannover - Kardiologie und Angiologie

    RECRUITING

    Hanover, 30625, Germany

  • Mitoyo General Hospital_Cardiovascular medicine

    NOT_YET_RECRUITING

    Kagawa, 769-1695, Japan

  • NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine

    RECRUITING

    Bunkyo-ku, Tokyo, 113-8603, Japan

  • Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy

    COMPLETED

    Warsaw, 04-628, Poland

  • National Hospital Organization Mito Medical Center_Cardiovascular medicine

    RECRUITING

    Ibaraki, 311-3193, Japan

  • National Hospital Organization Yokohama Medical Center_Cardiology

    RECRUITING

    Yokohama-shi, Kanagawa, 245-8575, Japan

  • Ome medical center_Cardiology

    NOT_YET_RECRUITING

    Ome-shi, Tokyo, 198-0042, Japan

  • Osaka Metropolitan University Hospital_Cardiovascular Medicine

    RECRUITING

    Osaka-Shi, Osaka, 545-8586, Japan

  • Osmania General Hospital

    RECRUITING

    Hyderabad, Telangana, 500012, India

  • Osmania General Hospital

    NOT_YET_RECRUITING

    Hyderabad, Telangana, 500012, India

  • Pima Heart and Vascular

    NOT_YET_RECRUITING

    Tucson, Arizona, 85741, United States

  • Pomorski Uniwersytet Medyczny

    NOT_YET_RECRUITING

    Szczecin, West Pomeranian Voivodeship, 71-252, Poland

  • Premier Clinical Trial Research Network (PCTRN)

    NOT_YET_RECRUITING

    Hamilton, Ontario, L8L 5G4, Canada

  • Providence St. Vincent Heart

    COMPLETED

    Portland, Oregon, 97225, United States

  • Rhythm Heart Institute - A unit of Synergy Lifecare Pvt

    RECRUITING

    Vadodara, Gujarat, 390022, India

  • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie

    NOT_YET_RECRUITING

    Krakow, 30-688, Poland

  • Sana Kliniken Berlin-Brandenburg GmbH - Lichtenberg

    COMPLETED

    Berlin, 10365, Germany

  • Sapporo Medical University Hospital_Cardiovascular, Kidney, Metabolism Endocrinology

    RECRUITING

    Sapporo-shi, Hokkaido, 060-8543, Japan

  • Sengupta Hospital and Research Institute

    RECRUITING

    Nagpur, Maharashtra, 440033, India

  • Sentara Bayside Hospital

    COMPLETED

    Norfolk, Virginia, 23507-1904, United States

  • Seoul National University Bundang Hospital

    COMPLETED

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Shri Mahant Indiresh Hospital

    RECRUITING

    Dehradun, Uttarakhand, 248001, India

  • Sir Ganga Ram Hospital-Cardiology

    RECRUITING

    New Delhi, 110060, India

  • Slaskie Centrum Chorob Serca W Zabrzu

    NOT_YET_RECRUITING

    Zabrze, 41-800, Poland

  • Southampton General Hospital

    RECRUITING

    Southampton, SO16 6YD, United Kingdom

  • St Bartholomew's Hospital - Cardiac Research Office

    NOT_YET_RECRUITING

    London, EC1A 7BE, United Kingdom

  • St Bartholomew's Hospital - Cardiology

    RECRUITING

    London, EC1A 7BE, United Kingdom

  • St Pauls Hospital

    COMPLETED

    Vancouver, British Columbia, V6Z1Y6, Canada

  • St. Michael's Hospital

    NOT_YET_RECRUITING

    Toronto, Ontario, M5B 1W8, Canada

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

    RECRUITING

    Krakow, 31-826, Poland

  • TMC Hlthcr Clin Res Office

    NOT_YET_RECRUITING

    Tucson, Arizona, 85712, United States

  • Texama Medical Center

    NOT_YET_RECRUITING

    Denison, Texas, 75020, United States

  • The James Cook University Hospital - Cardiology

    RECRUITING

    Middlesbrough, TS4 3BW, United Kingdom

  • The Royal Brompton Hospital - Respiratory CRF

    RECRUITING

    London, SW3 6HP, United Kingdom

  • Trialmed - Midlands

    RECRUITING

    Birmingham, B16 8QQ, United Kingdom

  • UCSD NAFLD Research Center

    RECRUITING

    La Jolla, California, 92037, United States

  • Uniklinik Schleswig-Holstein - Med. Klinik III Kardiologie und Internist. Intensivmedizin

    RECRUITING

    Kiel, 24105, Germany

  • Uniklinik TU Dresden - Herzzentrum Dresden GmbH

    RECRUITING

    Dresden, 01307, Germany

  • UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie

    RECRUITING

    Heidelberg, 69120, Germany

  • Univ of Alabama Birmingham

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • Univ of Colorado at Denver

    NOT_YET_RECRUITING

    Aurora, Colorado, 80045, United States

  • Universitaetsklinikum Essen - Klinik für Kardiologie und Angiologie

    NOT_YET_RECRUITING

    Essen, 45147, Germany

  • University of California San Francisco UCSF

    RECRUITING

    San Francisco, California, 94143, United States

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94110, United States

  • University of Minnesota_Minneapolis_1

    COMPLETED

    Minneapolis, Minnesota, 55455, United States

  • University of Ottawa Heart Institute (UOHI)

    RECRUITING

    Ottawa, Ontario, K1Y 4W7, Canada

  • University of Texas Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390-8830, United States

  • Universitätsklinikum Frankfurt aM - Kardiologie

    RECRUITING

    Frankfurt am Main, 60596, Germany

  • Universitätsklinikum Halle - Innere Medizin III

    RECRUITING

    Halle, 06120, Germany

  • Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu

    RECRUITING

    Wroclaw, 50-556, Poland

  • Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie

    RECRUITING

    Lublin, 20-090, Poland

  • Uniwersytecki Szpital Kliniczny w Bialymstoku

    RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-276, Poland

  • UofL Health Care Outpatient

    NOT_YET_RECRUITING

    Louisville, Kentucky, 40202, United States

  • VMMC & Safdarjung Hospital

    RECRUITING

    New Dehli, New Delhi, 110029, India

  • VMMC & Safdarjung Hospital

    NOT_YET_RECRUITING

    New Dehli, New Delhi, 110029, India

  • Valley Clinical Trials

    RECRUITING

    Covina, California, 91723, United States

  • Valley Clinical Trials

    RECRUITING

    Northridge, California, 91325, United States

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

  • William Osler Hel Bra Civic Hs

    NOT_YET_RECRUITING

    Brampton, Ontario, L6R 3J7, Canada

  • Winchester Dist Memorial Hosp

    RECRUITING

    Winchester, Ontario, K0C 2K0, Canada

  • Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu

    RECRUITING

    Przemyśl, 37-700, Poland

  • Women's College Hospital

    NOT_YET_RECRUITING

    Toronto, Ontario, M5S 1B1, Canada

  • Wonju Severance Christian Hospital

    RECRUITING

    Gangwon-do, 26426, South Korea

  • Wycombe General Hospital

    RECRUITING

    High Wycombe, HP11 2TT, United Kingdom

  • Yokohama City University Medical Center_Cardiovascular Center

    RECRUITING

    Kanagawa, 232-0024, Japan

  • Yokohama City University Medical Center_Cardiovascular Center

    NOT_YET_RECRUITING

    Kanagawa, 232-0024, Japan

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