Heart failure

This trial is testing an experimental drug called HS235 in obese adults who have both pulmonary hypertension and heart failure with preserved ejection fraction. The study aims to see if the drug is safe, how it moves through the body, and whether it can improve heart and lung fun…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with standard treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the BrioVAD or an existing pump to see if the n…

This study tests whether opening blood vessels (vasodilation) or removing fluid (diuretics) is better for treating sudden fluid buildup in the lungs from heart failure. About 1,100 adults with severe shortness of breath and low oxygen levels will receive one of three treatments i…

This trial investigates whether adding either metolazone or acetazolamide to standard loop diuretics helps adults hospitalized with acute heart failure and fluid overload. Participants are randomly assigned to one of three treatment arms, and the study tracks days alive and out o…

This study tests whether providing home-delivered low-sodium meals and short-term dietary counseling helps older veterans with heart failure recover better after a hospital stay. About 1,400 veterans aged 60 and older will be randomly assigned to receive either the meals plus cou…

This study tests a device that creates a small opening between the heart's upper chambers to relieve pressure in people with chronic heart failure. Unlike other shunts, this one leaves no permanent implant behind. The trial will compare the device to a sham procedure in 700 patie…

This study tests a new device that creates a small passage in the heart to relieve pressure, without leaving a permanent implant. It is for 350 people with heart failure and reduced pumping ability. The goal is to see if it reduces deaths, need for a heart pump or transplant, and…

This study tests the drug acalabrutinib in people with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. Researchers want to see if acalabrutinib causes fewer heart-related side effects compared to other standard treatments. About 60 adults will t…

This trial is testing whether a higher dose of adenosine, a drug used during cardiac MRI to stress the heart, improves blood flow imaging compared to the standard dose. The study includes 180 adults with suspected or known coronary artery disease or heart failure. By comparing th…

This trial tests whether slowly lowering the speed of a Left Ventricular Assist Device (LVAD) — a mechanical pump that helps a failing heart — can encourage the heart muscle to work harder and recover. The study enrolls people with end-stage heart failure who are waiting for a he…

This early trial tests a device that keeps donor hearts cool and oxygenated during transport, instead of the usual ice cooler. The goal is to see if this method is safe and works for heart transplants from both brain-dead and circulatory-death donors. Twenty adult patients awaiti…

This study is testing a pacemaker lead placed in a specific area of the heart called the left bundle branch area. The goal is to see if this placement is safe and helps the heart beat more naturally in people with slow heart rates. About 140 participants will get the lead and be …

This study tests a small device called C-MIC that is implanted without open-heart surgery to help people with heart failure. It includes 22 adults with weak heart pumping (ejection fraction between 25% and 50%) despite standard medications. The device delivers microcurrents to th…

This trial tests whether a gentle electrical stimulation applied to the ear—a technique called low-level transcutaneous vagus nerve stimulation—can help older adults with systolic heart failure. The study will compare daily one-hour sessions of real stimulation versus a sham (ina…

This phase 3 trial studies whether patients with acute decompensated heart failure who are already taking an SGLT2 inhibitor like empagliflozin should continue it during hospitalization. About 536 participants will either keep taking empagliflozin or switch to a placebo while in …

This study tests a small sensor implanted in a large vein near the heart to help doctors monitor fluid buildup in people with heart failure. The sensor sends daily readings so treatment can be adjusted early. The trial will compare standard care plus sensor guidance to standard c…

This study tests whether the drug vericiguat can help children with heart failure caused by a weak left heart chamber. About 342 children aged 1 month to 18 years will receive either vericiguat or a placebo for 16 weeks. The main goal is to see if the drug lowers a key heart stre…

This study tests a compact heart-lung machine called Cardiohelp in 50 children with severe heart failure. The device supports the heart for up to 30 days while kids recover or await a transplant. The trial also compares two blood thinners to see which causes fewer bleeding or clo…

This study tests whether starting the drug finerenone early during a hospital stay for acute heart failure can improve outcomes. About 550 adults with heart failure and preserved ejection fraction will receive either finerenone or a placebo. Researchers will track deaths, worseni…

This trial tests whether a 3-month program of virtual visits and remote monitoring can improve recovery in adults recently hospitalized for heart failure. Participants receive either virtual heart failure care or routine care, and researchers track medication optimization, health…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This clinical trial is testing an experimental drug called CRD-4730 in people with heart failure with reduced ejection fraction (HFrEF), a condition where the heart's main pumping chamber is weak. The drug works by blocking a protein called CaMKII, which is thought to contribute …

This study tests whether adding vicadrostat to the standard medicine empagliflozin helps people with heart failure who have a preserved ejection fraction (heart pumps normally but is stiff). About 6000 adults with symptoms will take either vicadrostat plus empagliflozin or a plac…

This Phase 3 study tests whether adding vicadrostat to the standard drug empagliflozin helps adults with chronic heart failure and a weak heart pump (ejection fraction below 40%). About 4200 participants will take either vicadrostat or a placebo, plus empagliflozin, once daily fo…

This study tests a small implanted device that sends gentle electrical signals to strengthen heart contractions in people with heart failure whose hearts still pump fairly well (ejection fraction 40-70%). Researchers will compare the device to a sham (inactive) implant in 1,500 p…

This study tests whether sending doctors a reminder about IV iron guidelines helps heart failure patients with iron deficiency get the recommended treatment. About 3,000 hospitalized adults with heart failure and low iron will be included. Doctors in the intervention group receiv…

This study tests if delivering oxygen directly into the gut through a thin tube can help people with ischemic-hypoxic bowel disease, a condition where the bowel doesn't get enough oxygen. About 90 adults with symptoms like belly pain, bloating, and trouble pooping will receive ei…

This study tests a new medicine called CDR132L in 200 people with a type of heart failure where the heart is stiff and thickened. The goal is to see if it can improve heart structure and function. Participants will receive either the study drug or a placebo by chance, and the stu…

This study compares a newer pacing method (Left Bundle Branch Area Pacing) with the standard cardiac resynchronization therapy for people with heart failure. About 850 adults with moderate to severe heart failure will take part. The goal is to see if the newer method reduces deat…

This study tests a device called Aortix, a small pump placed in the main artery, to help remove excess fluid in people hospitalized with acute heart failure who are not responding well to diuretic medications. About 320 participants will be randomly assigned to receive either the…

This study tests whether a pacemaker programmed to each person's needs can improve symptoms and outcomes for people with a common type of heart failure (HFpEF). About 700 adults with heart failure but normal pumping strength will receive either personalized pacing or minimal/no p…

This study tests a new heart pump (CorWave LVAS) in 20 people with advanced heart failure. The pump helps the heart pump blood when it is too weak. The goal is to see if the device is safe and works well, with a focus on survival and avoiding serious problems like bleeding, infec…

This trial is testing whether sacubitril/valsartan, a newer heart failure medication, can improve heart function and reduce harmful heart remodeling better than the older drug ramipril. The study enrolls adults with ischemic heart failure (caused by reduced blood flow to the hear…

This early-stage study tests a new way to use a heart-lung machine (ECMO) in 4 people waiting for a lung transplant who also have heart failure from high blood pressure in the lungs. The goal is to see if this approach can keep them alive and stable until they receive a transplan…

This study compares a newer pacing method (HIS or left bundle branch pacing) to the standard biventricular pacing in 1100 heart failure patients across Nordic countries. The goal is to see if the new approach reduces death or unplanned heart failure hospitalizations. Participants…

This study tests a telemedicine program for people aged 65-80 with both atrial fibrillation and heart failure living in rural China. Village clinics are randomly assigned to offer either standard care or a program that includes a digital health system, a smartwatch for monitoring…

This study tests whether dapagliflozin, a drug already approved for diabetes and heart failure, can improve exercise ability and heart function in people who have had the Fontan procedure. About 30 participants aged 12 and older will take the drug daily for 3 months. The goal is …

This trial investigates whether implanting the kidney in a separate, delayed surgery after the heart transplant—rather than both at once—can improve outcomes for patients needing a combined heart and kidney transplant. The kidney is kept healthy using a machine that pumps cold, o…

This study compares a low-carbohydrate ketogenic diet to a low-fat mixed diet in people with heart failure with preserved ejection fraction who also have diabetes, prediabetes, metabolic syndrome, or obesity. The goal is to see whether the ketogenic diet can improve exercise tole…

This phase 3 trial investigates whether starting a combination of finerenone and empagliflozin early during a hospital stay for heart failure can improve outcomes compared to usual care. About 1,500 adults hospitalized with heart failure will be enrolled. The study measures effec…

This study tests whether lumacaftor, a drug used for cystic fibrosis, can improve blood flow to the brain and thinking abilities in people with stable heart failure and reduced pumping function. About 60 participants will receive either lumacaftor or a placebo for one month. The …

This study tests whether giving a diuretic (furosemide) to reduce fluid buildup can better protect the kidneys from contrast dye damage compared to standard IV fluids. It involves 190 adults hospitalized with acute heart failure and moderate kidney problems who need a CT scan. Re…

This study tests a new medicine called NNC0487-0111 in about 5,600 people who have both heart failure and obesity. Participants receive either the drug or a placebo as a weekly injection. The goal is to see if the drug reduces the risk of heart failure worsening, hospitalization,…

This trial tests a temporary heart pump called the CorVad system in people with severe right heart failure that does not improve with standard medications. The pump is placed through a blood vessel to help the right ventricle pump blood, giving the heart a chance to recover or br…

This study tests whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard rate for patients with advanced kidney disease hospitalized due to severe fluid overload. Participants are randomly assigned to receive either a…

This early-stage trial tested a new cell therapy called CAR-DC in 8 people with end-stage dilated cardiomyopathy, a condition that weakens the heart. The therapy targets a protein called FAP to calm the immune system and improve heart function. The main goal was to check safety, …

This study tests whether an electronic alert in a patient's medical record can prompt doctors to prescribe guideline-recommended heart failure medications that are not yet being used. The trial includes 5,000 adults with heart failure and a reduced ejection fraction (≤40%) seen a…

This study tests two simple tools to improve medication use in people with heart failure with reduced ejection fraction (HFrEF). One tool is a short animated video and checklist sent to patients before a clinic visit to encourage them to discuss their medications. The other is an…

This study will test the safety and performance of a new generation of implantable heart devices called CorSky ICDs and CRT-Ds. These devices help control dangerous heart rhythms in people with heart failure or tachyarrhythmia. About 151 participants will be implanted with the de…

This phase 3 trial tests whether finerenone, a non-steroidal mineralocorticoid receptor antagonist, can reduce cardiovascular death and heart failure events in patients with heart failure and reduced ejection fraction who cannot tolerate or are not eligible for standard steroidal…

This trial investigates whether empagliflozin, a drug originally used for diabetes, can help children with heart failure. About 60 children aged 1 month to 18 years with confirmed heart failure will receive either standard care plus empagliflozin or standard care alone for 90 day…

This study tests a special pacemaker setting called SyncAV, used with left bundle branch area pacing, in people with heart failure and a heart block. The goal is to see if this setting can improve the heart's electrical timing and pumping strength. About 50 adults who already nee…

This study compares two implantable heart devices—Cardiac Contractility Modulation (CCM) and Cardiac Resynchronization Therapy (CRT)—in people with Chagas heart disease and advanced heart failure. The goal is to see which device better improves quality of life and heart function.…

This early-stage trial is testing an experimental drug called HJB647 in 12 adults with stable chronic heart failure and reduced pumping ability. The study aims to check the drug's safety and how the body processes it at two different doses. Participants will receive both the drug…

This phase 3 trial tests whether Qishen Yiqi Dripping Pills, a traditional Chinese herbal medicine, can improve exercise ability and quality of life in people with chronic heart failure caused by coronary heart disease. The study enrolls adults aged 18 to 80 with reduced heart pu…

This study tests whether using portable air cleaners at home after a heart failure hospital stay can improve heart health. About 400 adults will receive either a real air cleaner or a fake one. Researchers will measure changes in a heart stress marker and track hospital readmissi…

This trial tests whether a structured physical rehabilitation and exercise program can help older adults (age 60+) who have been hospitalized for heart failure with preserved ejection fraction (HFpEF). Participants will receive a progressive, multi-domain rehab intervention after…

This study tests whether the drug finerenone can reduce hospitalizations and deaths in people with a certain type of heart failure (with preserved or mildly reduced pumping ability). About 5,200 adults who are currently or recently hospitalized for heart failure will receive eith…

This early study tests whether a second infusion of a patient's own modified immune cells (CAR-DC) is safe and can improve heart function in 5 adults with end-stage dilated cardiomyopathy. Participants had already received one dose but saw their heart function worsen again. The g…

This study looks at whether a hybrid care pathway that includes home telemonitoring helps people with heart failure spend more days at home and out of the hospital. Participants measure their weight, blood pressure, heart rate, and symptoms daily, sending the data to a medical ce…

This study looks at whether changing from standard heart failure medications to a newer drug (sacubitril-valsartan) can improve the health and daily life of people with heart failure in rural Tanzania. About 298 adults with heart failure will be switched to the new drug and follo…

This study tests whether a pacemaker plus a heart ablation procedure is better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. Participants will either get a pacemaker implant and ablation, or continue with optim…

This early-stage trial tests a one-time gene therapy called RP-A701 in 8 adults with dilated cardiomyopathy caused by a faulty BAG3 gene. The therapy uses a harmless virus to deliver a working copy of the gene, aiming to improve heart function. The main goal is to check safety, b…

This study tests whether a small wireless sensor placed in the pulmonary artery can help doctors better manage medications for people with heart failure and a leaky mitral valve. The sensor constantly measures pressure inside the heart, giving doctors real-time data to adjust tre…

This study tests a device called Barostim that is implanted in the body to stimulate blood pressure sensors, which may help the heart work better. It involves 58 adults with heart failure who are already on the best available medications. The goal is to see if the device improves…

This trial investigates whether people with heart failure and a traditional right ventricular pacemaker feel better and have stronger hearts after switching to a more natural pacing method, such as His bundle or biventricular pacing. Participants will have their pacemaker upgrade…

This study compares a standard leg exercise program alone versus the same program combined with neuromuscular electrical stimulation (NMES) in heart failure patients who have a temporary heart pump (intra-aortic balloon pump) in their leg. The goal is to see if adding NMES helps …

This study compares a remote monitoring system called HeartLogic to standard in-person follow-up for people with heart failure who have a special defibrillator. About 578 adults will be randomly assigned to either get alerts from the device that prompt early check-ins or to conti…

This study compares weight loss using semaglutide (a drug) versus a calorie-restricted diet in 100 people with obesity and heart failure with reduced ejection fraction. The goal is to see which approach better improves peak oxygen uptake, a measure of exercise capacity, after 52 …

This study looks at whether people with acute heart failure can be safely followed up at home using digital tools instead of going to the hospital. About 450 patients will be randomly assigned to either in-person hospital visits or remote digital check-ups. The goal is to see if …

This study looks at whether the diabetes drug dapagliflozin can improve how well the right side of the heart works after off-pump coronary bypass surgery. Researchers will measure heart function in 72 patients with weak hearts before and after 6 months of taking the drug. The goa…

This study tests whether empagliflozin, a diabetes drug, can prevent death, new dialysis, or lasting kidney damage in people with cardiorenal syndrome type 1—a condition where heart failure suddenly worsens kidney function. About 200 hospitalized adults will receive either empagl…

This study is testing whether an implantable defibrillator (ICD) helps people with a certain type of heart failure (non-ischemic cardiomyopathy) live longer. About 2,500 participants will be randomly assigned to receive an ICD or not, and their survival will be tracked for up to …

This study is tracking the safety and effectiveness of a small device called the Occlutech Atrial Flow Regulator in 150 people with chronic heart failure. The device is implanted to create a small opening between the upper chambers of the heart, which may help reduce pressure and…

This study tests a new device called the Icoms FlowMaker, designed to help the heart pump more blood in people with severe heart failure. Ten patients who are too sick for standard treatments will receive the implant. The main goal is to see if the device is safe and works well f…

This study is testing whether potassium nitrate, alone or combined with two supplements (propionyl-L-carnitine and nicotinamide riboside), can improve exercise endurance in people with a type of heart failure called HFpEF. About 53 participants will take these agents and undergo …

This study looks at whether people with heart failure caused by a treatable problem, like a blocked artery or a faulty heart valve, can safely wait to start certain heart failure medications after the problem is fixed. About 80 adults whose heart function improved after surgery o…

This study tests a 12-week home-based cardiac rehabilitation program delivered through a smartphone app for 332 adults with heart failure who cannot attend in-person rehab. Participants are split into two groups: one uses the app program, the other receives standard attention. Th…

This study tests an experimental pill (PF-07328948) for adults with heart failure. About 620 participants will receive either the drug or a placebo to see if it improves walking distance and heart-related symptoms over 36 weeks. The goal is to manage the condition and reduce the …

This study tests whether a carefully controlled high-fat diet can improve heart function in people with a specific type of heart failure (non-ischemic dilated cardiomyopathy). Researchers believe that switching the heart's fuel source back to fats may help it pump more effectivel…

This study tests whether adding Qishen Yiqi Dropping Pills, a Chinese herbal medicine, to standard therapy can improve exercise ability and quality of life in 120 adults with severe pulmonary hypertension. Participants will be randomly assigned to receive either the herbal pills …

This study tests a new pacing method called left bundle branch area pacing for people with heart failure whose heart pumps less blood than normal (ejection fraction 50% or lower). It is for patients who cannot get standard pacing or need a backup option. The goal is to see if thi…

This study tests whether a high-protein DASH diet, resistance exercise, or both can help people with heart failure and reduced ejection fraction maintain or increase muscle mass. About 100 adults over age 30 with stable heart failure will take part. The goal is to see if these li…

This study tests a new device called the SATURN system, which is implanted through a tube in a blood vessel to replace a leaky mitral heart valve. It is for people aged 65 and older with severe symptoms who are not good candidates for open-heart surgery. The goal is to see if the…

This study tests whether telemedicine follow-up helps doctors adjust heart failure medications more effectively than standard in-person visits. Eighty adults with newly diagnosed heart failure with reduced ejection fraction will be randomly assigned to either remote monitoring or…

This study compares a newer pacing method called conduction system pacing (CSP) with the standard biventricular pacing (BiVP) in heart failure patients who already have a right ventricular pacemaker and need an upgrade. Researchers want to see if CSP is as good as BiVP at improvi…

This study tests a new heart pacing method (LOT-CRT) against the standard one (BiVP) in 86 heart failure patients with a specific type of heart block. The goal is to see if the new method better preserves heart pumping function. Participants will be followed for at least 6 months…

This study tests whether enavogliflozin, a drug originally for diabetes, can prevent atrial fibrillation (AF) from returning after a catheter ablation procedure in people with AF and heart failure. About 390 adults will receive either the drug or a placebo daily for a year. The m…

This Phase 3 trial tests whether injecting lab-grown heart muscle cells (HiCM-188) into the heart during bypass surgery can help people with severe heart failure (NYHA class III-IV). Eighty participants will receive either the stem cells plus bypass or bypass alone. The main goal…

This study tests a small implantable sensor that monitors pressure in the lung artery for patients with severe tricuspid regurgitation and heart failure. The sensor is placed before a minimally invasive valve repair, and pressure readings are tracked for a year. The goal is to se…

This study tests whether a mechanical heart pump (LVAD) works better than standard medications for people with end-stage heart failure who are not yet bedridden. About 92 participants will either receive the pump or continue their current drug therapy. The goal is to see which ap…

This study tests a small device implanted in the heart that measures pressure and creates a small opening to help blood flow. It is for people with chronic heart failure whose heart pumps weakly (ejection fraction 40% or less) and who still have symptoms despite standard treatmen…

This study looks at whether people hospitalized for acute heart failure can safely drink as much as they want instead of limiting fluids. About 420 participants will be randomly assigned to either a strict 1.5 liters per day limit or a thirst-driven liberal intake. Researchers wi…

This study tests whether replacing unhealthy gut bacteria with healthy donor bacteria (via capsules) is safe and doable for people with chronic heart failure. About 40 adults with stable heart failure will take the capsules and be monitored for side effects and adherence. The goa…

This study is testing whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). Researchers will give 60 adults either valsartan or a placebo for 24 weeks to see if it improves how far they can walk in six minutes …

This study tests a program called FamLit, where nurses use simple language to coach heart failure patients and their care partners on working together to overcome barriers to taking medications as prescribed. The goal is to improve medication adherence, reduce hospitalizations, a…

This study tests a program called I-TRANSFER-HF for people with heart failure who need home care after leaving the hospital. The program combines early nurse visits at home with quick follow-up doctor appointments to prevent patients from returning to the hospital within 30 days.…

This study compares a low-sodium (2 g/day) diet to a regular diet (3-4 g/day) in 500 adults hospitalized for heart failure. The goal is to see if a low-sodium diet actually reduces hospital stay length and 30-day readmission rates. Participants follow the assigned diet only while…

This study tests whether a three-drug combination (SGLT2 inhibitor, ARNI, and MRA) can improve heart structure, function, and symptoms in 50 people with advanced HFpEF, a type of heart failure where the heart is stiff but pumps normally. Participants will receive either the tripl…

This study tests whether a digital remote-management platform can help doctors better adjust heart failure medications after patients leave the hospital. About 252 adults with heart failure and reduced pumping function will use the platform to report symptoms and vital signs, wit…

This study tests whether taking a daily selenium supplement (200 micrograms) can reduce hospitalizations and heart-related deaths in people with heart failure. Selenium is a nutrient important for heart health, and low levels are common in Northern Europe. The trial will include …

This study tests whether a procedure to open narrowed kidney arteries (renal artery stenting) helps high-risk patients with resistant high blood pressure, declining kidney function, or heart failure. About 80 participants will either receive the real procedure or a sham procedure…

This study tests whether colchicine, a common anti-inflammatory drug, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive either colchicine or a placebo to see if it prevents worsening heart failur…

This study looks at whether having a specially trained community paramedic visit people with heart failure at home can reduce hospital stays and emergency visits compared to standard care. About 75 adults with worsening heart failure will take part. The goal is to see if this app…

This study tests whether a virtual ward—using a tablet, scale, and blood pressure monitor at home—can reduce hospital readmissions for heart failure patients. 346 adults who were recently hospitalized for heart failure will either receive the virtual ward or standard care. Resear…

This study tests whether finerenone, a drug already used for kidney disease, can help protect transplanted kidneys. About 100 adults who received a kidney transplant 1 to 10 years ago will take either finerenone or a placebo daily for 12 months. Researchers will check how well th…

This study tests whether using urine sodium levels to adjust diuretic doses helps people with acute heart failure recover faster and live longer. About 556 adults hospitalized with acute heart failure will receive either standard care or a tailored diuretic plan. The goal is to s…

This study looks at whether people whose heart failure has improved can safely cut back on some of their daily medications. Participants will either continue all four standard drugs or gradually reduce to just two under close monitoring. The goal is to see if heart function stays…

This study tests whether a daily tablet called sotagliflozin can improve quality of life for people with both type 1 diabetes and heart failure. Researchers will give 320 participants either the drug or a placebo for 4 months, then compare symptoms like breathlessness and tiredne…

This study compares two types of heart pacing—conduction system pacing and standard biventricular resynchronization—in 320 adults with heart failure and wide QRS. The goal is to see which method better reduces the risk of death, heart transplant, or hospitalization for heart fail…

This study is testing whether a small wireless sensor placed in the lung artery can help doctors manage heart failure better. The sensor measures pressure in the lung artery and sends readings to a doctor, who can then adjust medications early to prevent flare-ups. The study will…

This study tests whether measuring sodium in urine can help doctors adjust diuretic doses more accurately for people with chronic heart failure. About 300 participants will be assigned to either a urine-guided approach or standard care. The goal is to reduce congestion and hospit…

This study looks at heart failure patients whose heart function has improved to normal levels. It tests whether gradually stopping one of their heart medications (RAS blocker or beta blocker) is safe, compared to staying on all medications. The goal is to see if patients can main…

This study is testing whether people aged 70 and older with heart failure and a weak heart pump live just as long with only medication as they do with an implanted defibrillator (ICD). The trial will randomly assign 730 participants to receive either an ICD plus medication or med…

This study tests a new approach using a wearable device called ReDS to monitor fluid levels in adults hospitalized for heart failure. The goal is to see if this method reduces the risk of death, readmission, or urgent visits within a month after discharge. About 1,014 participant…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This trial tests whether doing a coronary angiogram (a special X-ray of the heart arteries) within 2 hours of diagnosis is better than waiting until the patient's heart failure symptoms improve. The study includes 780 adults with a type of heart attack called NSTEMI who also have…

This pilot study tests whether an implanted heart pressure monitor (CardioMEMS) can help prevent complications in 40 patients who survived cardiogenic shock. Participants will have the device implanted and receive regular pressure checks and medication adjustments. The goal is to…

This study tests whether a one-year program led by heart failure nurses, using online training and a mobile app, can reduce repeat hospital stays and improve quality of life for people with heart failure. About 200 adults who were recently hospitalized for worsening heart failure…

This study tests a procedure that uses a catheter to treat a nerve in the body, aiming to improve symptoms in people with a type of heart failure called HFpEF. About 150 participants will be enrolled to see if the procedure is safe and effective. The goal is to help patients feel…

This early-stage trial tests whether heart cells grown from a patient's own stem cells are safe to inject into people with severe congenital heart disease. About 50 participants will receive the cells or be in a control group. The main goal is to check for serious side effects wi…

This study looks at whether combining two common diabetes drugs (GLP-1 agonists and SGLT2 inhibitors) can improve heart function and artery health in people with type 2 diabetes who are at high risk for heart problems. About 240 adults will be split into four groups, each receivi…

This study tests whether a home-based cardiac rehabilitation program using wearable devices and remote monitoring can improve exercise capacity in adults with chronic heart failure. Researchers will compare the home program to standard in-hospital rehab. The goal is to see if the…

This study looks at whether a procedure to repair a leaky tricuspid heart valve can improve kidney function, reduce swelling, and boost physical activity in older adults. Researchers will follow 100 participants for changes in kidney health, walking ability, and daily function. T…

This study tests whether a potassium-lowering drug called sodium zirconium cyclosilicate (Lokelma) can help elderly patients with heart failure and chronic kidney disease safely take higher doses of RAASi medications, which are often limited by high potassium levels. The trial wi…

This study tests whether a daily pill called engagliflozin (a type of SGLT2 inhibitor) can improve heart function in people who have high blood pressure and early signs of heart failure but do not have diabetes. About 120 adults will receive either the drug or a placebo for 6 mon…

This study tests whether adding the drug vericiguat to standard heart failure treatment can reduce hospital stays and deaths in people with severe, decompensated heart failure. About 130 participants will be randomly assigned to get vericiguat or a placebo, and researchers will t…

This study looks at 128 people with advanced heart failure who have a HeartMate3 heart pump. All take warfarin to prevent clots, and half will also stop taking aspirin. The goal is to see if skipping aspirin lowers the risk of serious bleeding without raising the chance of danger…

This pilot study tests whether the drug eplerenone is safe and feasible for people with both heart failure (reduced pumping ability) and severe chronic kidney disease. Previous studies excluded such patients due to risks like high potassium. The trial will enroll 40 participants …

This study tests whether heart failure patients who fully recover after treatment for a fast heart rhythm (like atrial fibrillation) can safely stop their heart failure medications. 348 participants will be randomly assigned to either gradually stop their drugs or continue them a…

This study aims to find out which type of specialist pacemaker works best for people with heart failure and a delay in how the heart's lower chambers beat together. Sixty participants will be randomly assigned to one of three pacing methods and followed for six months. Researcher…

This study looks at whether a special type of pacemaker, called cardiac resynchronization therapy (CRT), can help people with heart failure who develop a heart block after having their aortic valve replaced. The trial will include 360 adults who have a new, persistent heart block…

This study tests whether social prescribing—connecting patients to community resources for issues like housing, income, or loneliness—can help women with heart failure better adhere to their medications and improve their quality of life. Researchers will enroll 200 women across f…

This early-stage trial tests a patch made from stem cells that is implanted onto the heart to help it pump better. It is for people with severe heart failure who cannot have a heart transplant. The study will check if the patch is safe and if it improves heart function and sympto…

This study tests a temporary heart pump called the Supira System in 45 people with heart failure and severe coronary artery disease who need high-risk angioplasty. The pump is inserted through a leg artery to help the heart pump blood during and after the procedure. Researchers w…

This study tests whether using a simple bedside ultrasound to measure fluid levels can help doctors give the right amount of medication to heart failure patients. The goal is to reduce hospital readmissions within 30 days and prevent kidney damage. About 588 adults hospitalized w…

This study tests whether a structured telemedicine program before heart surgery can reduce complications in people with heart failure. The program includes education, medication adjustments, remote monitoring, and supervised exercise. Researchers will compare outcomes like death,…

This study tests whether empagliflozin, a drug already used for diabetes, can help people hospitalized with acute heart failure. About 444 adults will receive either the drug or a placebo to see if it reduces deaths, hospital readmissions, and other serious events within 90 days.…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study tests a multidisciplinary clinic that provides heart failure patients with educational videos, a self-management kit, and follow-up phone calls after hospital discharge. The goal is to reduce 30-day readmission rates and improve patient satisfaction. The trial enrolls …

This study looks at whether the drug vericiguat can help repair the hearts of adults with stable heart failure with reduced ejection fraction (HFrEF). Researchers will compare people taking vericiguat plus standard care to those on standard care alone, measuring changes in heart …

This study compares a new type of heart pacing (His-bundle pacing) to standard pacing in 120 adults with heart failure and right bundle-branch block. The goal is to see if the new method better improves the heart's pumping ability over 6 months. Participants will receive one of t…

This phase 2 trial tests whether spironolactone, a potassium-sparing diuretic, can slow the deterioration of the right ventricle and reduce arrhythmias in people with arrhythmogenic right ventricular dysplasia (ARVD). About 120 participants will receive either spironolactone or a…

This study tests whether a patient's own bone marrow cells, processed and delivered to the heart via a catheter, can improve outcomes for people with chronic ischemic heart failure. About 250 participants with moderate-to-severe heart failure will either receive the cell treatmen…

This study tests if using two devices together can help people with advanced heart failure. Participants get a CardioMems sensor to monitor heart pressure and later a BaroStim device to regulate blood pressure. The goal is to improve symptoms, walking ability, and reduce hospital…

This early study tests a device called ContraBand™, which is implanted in the lung arteries to reduce pressure on the heart. The goal is to see if it's safe and can improve exercise ability and symptoms in people with left-sided heart failure. About 55 adults with moderate to sev…

This pilot study is testing a new procedure called electroporation ablation (using the FARAPULSE system) to treat atrial fibrillation in 200 people who also have heart failure with preserved ejection fraction. Half will get the procedure, half will get standard medical care. The …

This study is testing a wearable system called Sensinel CPM to see if it can help people with chronic heart failure avoid hospital visits and reduce healthcare costs. About 1200 participants with moderate to severe heart failure will use the device, and their results will be comp…

This study tests a new liquid (Custodiol-N) used to preserve donor hearts before transplant in children. 15 children receiving their first heart transplant will be randomly assigned to get a heart stored in either the new or standard solution. The main goal is to check if the new…

This study compares a new pacing method (left bundle branch pacing) with a standard pacemaker-defibrillator in 30 people who have hypertrophic cardiomyopathy and a specific heart block after myectomy surgery. The goal is to see if the new method better prevents heart failure wors…

This study tests whether using portable air filters at home can improve the health of people with heart failure. Researchers will measure how far participants can walk in six minutes, along with blood pressure and heart-related blood markers. The study involves 255 adults in Indi…

This study is testing the Aeson total artificial heart, a device that replaces both heart ventricles, in 95 people with severe heart failure. The goal is to confirm that the device works safely and effectively as a bridge to heart transplant. Researchers will measure survival rat…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This pilot trial tests whether a patient's own stem cells can help the heart muscle recover in people with advanced chronic heart failure who already have a mechanical heart pump (LVAD). Ten patients will receive their own CD34+ stem cells injected into a heart artery. Researcher…

This study is testing two different procedures—AF catheter ablation and AV node ablation—in 70 people who have heart failure, atrial fibrillation, and a CRT device that isn't pacing enough. The goal is to see which procedure better improves heart function and quality of life afte…

This early-phase trial tests whether sildenafil (the drug in Viagra) can reduce blood vessel damage in people with advanced heart failure who have a mechanical heart pump (LVAD). LVADs help patients live longer, but they often cause blood vessel aging that leads to strokes or ble…

This study tracks 500 people who received a heart transplant from a donor with hepatitis C. Researchers want to see if using these organs is safe and works well. They will measure cure rates for hepatitis C, organ rejection, and survival after one year.

This study looks at whether hearts from HIV-positive deceased donors are as safe and effective for HIV-positive recipients as hearts from HIV-negative donors. Fifty HIV-positive patients with advanced heart failure will receive a heart transplant, with the donor's HIV status dete…

This study tests whether people with heart failure whose heart function has returned to normal can safely stop taking beta-blockers. About 1,300 participants will either gradually stop their beta-blockers or continue them as usual. The goal is to see if stopping the drug leads to…

This study tests a small, wearable patch that measures heart function from outside the body in people with heart failure (NYHA class II or higher). The goal is to see if remote monitoring can help doctors adjust medications in time to prevent hospitalizations. The patch is low-co…

This study tests a telemedicine-based care model for heart failure patients who are frequently readmitted to hospital and cannot join standard rehab. Researchers will provide on-demand video and chat support from cardiologists to general practitioners and community health workers…

This study looks at 140 heart failure patients to see if taking a medicine called ARNI before coming to the hospital leads to better short-term health. Researchers will compare those who were already on ARNI with those who were not, tracking heart and kidney events during the hos…

This study tests if a newer pacing method, left bundle branch area pacing, is better than standard right ventricular pacing for people who need a pacemaker. Researchers will compare outcomes like death, heart failure, and heart damage in 450 participants over two years. The goal …

This study tests a new device that uses a sensor placed on the chest to measure kidney function in 15 adults with heart failure. Participants receive an injection of a fluorescent dye (Relmapirazin) and a standard contrast agent (iohexol), then the sensor tracks how quickly the d…

This study is testing a new artificial intelligence (AI) tool that analyzes electrocardiograms (ECGs) to find a condition called left ventricular systolic dysfunction (LVSD), a type of heart failure where the heart's main pumping chamber is weak. Researchers will enroll 15,000 ad…

This trial tests whether a machine-learning algorithm can detect atrial fibrillation (AF) early by analyzing pulse wave signals from a wearable sensor. The study involves 200 adults with heart failure, comparing the algorithm's readings against standard ECG results. If it works, …

This study investigates whether a portable, AI-assisted ultrasound device can accurately measure heart function in patients aged 75 and older hospitalized with heart failure. Geriatricians, after a one-day training, use the AI tool to assess the heart's pumping ability, and resul…

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This trial investigates whether adding a simple blood test (NT-proBNP) and a quick heart ultrasound (POCUS) to standard care helps doctors diagnose heart failure more accurately in people aged 50 and older. Participants are randomly assigned to receive standard care alone or with…

This study looks at whether blood clots in the lungs (pulmonary embolism) are often missed in people hospitalized with acute heart failure. About 740 patients across multiple hospitals will take part. In half the hospitals, doctors will follow their usual approach; in the other h…

This trial evaluates a new device called CardioStory that uses fiber-optic sensors to measure heart filling pressure in about two minutes—without needles or catheters. Researchers are enrolling 850 adults who come to the emergency department with recent shortness of breath. The g…

This study tests whether a device called FibroScan, which measures liver stiffness, can quickly diagnose acute heart failure in people who come to the emergency room with shortness of breath. Researchers will enroll 100 adults and compare the FibroScan results with standard tests…

This study is testing whether a digital stethoscope, combined with artificial intelligence, can detect two serious conditions: high blood pressure in the lungs (pulmonary hypertension) and a weak heart pump (low ejection fraction). About 3,850 adults will have their heart sounds …

This study tests a wearable ring that measures blood pressure, comparing it to the standard 24-hour monitor in 100 people with heart failure and reduced pumping ability. The goal is to see if the ring is accurate and easy to use. If successful, it could make blood pressure tracki…

This study tests whether an AI program can help emergency doctors find undiagnosed heart failure, COPD, and cancer by analyzing chest X-rays. Researchers will compare diagnosis rates when doctors have access to the AI's findings versus when they don't. The trial involves 17,000 a…

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study is testing whether artificial intelligence can spot early signs of worsening heart failure by analyzing changes in a patient's voice, cough, and breathing sounds. Researchers will enroll 250 adults with chronic heart failure to record sounds and compare them with stand…

This pilot study explores whether data from the HeartMate 3 heart pump can be used to monitor heart function without invasive tests or frequent imaging. Researchers will compare high-resolution pump data with standard echocardiograms and ECGs in 60 patients with end-stage heart f…

This study aims to see if a special MRI done during exercise can help doctors better diagnose and predict outcomes in people with a type of heart failure called HFpEF. Researchers will enroll 400 adults, including those with HFpEF, those with shortness of breath from other causes…

This study is testing a new smartphone-connected 12-lead ECG device to see if it can accurately diagnose heart attacks (STEMI and NSTEMI) in people with chest pain. Researchers will compare the smartphone ECG readings to standard hospital ECGs in 1000 adults. The goal is to valid…

This study will enroll 5,000 adults across five hospitals in Taiwan to see if an artificial intelligence program can accurately detect low heart pumping function and structural heart disease using a single-lead ECG recorded from devices like an Apple Watch. Participants will have…

This study is testing a new wearable ultrasound sensor that sticks to the skin like a patch. The goal is to see if it can help doctors find and monitor deep vein thrombosis (blood clots) and heart conditions early, without needing bulky machines. About 300 adults with heart failu…

This study looks at whether advanced heart scans (echocardiogram and MRI) can help diagnose a type of heart failure called HFpEF, where the heart is stiff but pumps normally. Standard tests often miss it, leaving many without proper treatment. Researchers will study 40 adults wit…

This study is testing a special vest called HALD that records heart and lung sounds. Researchers want to see if the recordings are as accurate as what a doctor hears with a stethoscope. About 200 adults with or without heart or lung conditions will wear the vest during a clinic v…

This study tests a new PET imaging method that uses a special tracer called XTR003 along with FDG to see which parts of the heart are still alive in people with heart failure from blocked arteries. About 40 to 60 participants will be randomly assigned to receive either the new fa…

This study trains non-expert staff in GP practices to perform quick heart ultrasounds on people 65 and older. The goal is to find hidden heart valve disease or heart failure early, especially in diverse communities. Researchers hope this approach can reduce emergency hospital vis…

This study tests whether ultrasound contrast agents (microbubbles) can estimate pressure inside the heart, potentially replacing invasive catheters. Ten adults with suspected heart disease will receive a standard ultrasound with contrast while also having a catheter for compariso…

This early-phase study tests whether a special PET scan tracer, 18F-fluoroglutamine, can detect pulmonary arterial hypertension (PAH) earlier and more accurately. PAH is a serious disease of the lung's blood vessels that often goes undiagnosed for years. The study will scan 71 ad…

This trial tests whether a single polypill combining three medications—finerenone, empagliflozin, and losartan—can help prevent heart failure and maintain exercise capacity in people with type 2 diabetes who are at high risk. Participants will take either the polypill or the same…

Heart failure often goes undiagnosed because its early symptoms—like fatigue and shortness of breath—are mistaken for normal aging. This study tests whether a three-part strategy can change that: raising awareness among patients and doctors, using a blood test (NT-proBNP) to spot…

This study tests whether a telemedicine program, led by village doctors and supported by wearable devices and remote specialists, can prevent heart failure in older adults (65-80) with atrial fibrillation living in rural China. About 1,268 participants will be assigned to either …

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This study tests a new way to screen for heart failure risk in people with type 2 diabetes. Doctors use a blood test (NT-proBNP) and a risk score to identify high-risk patients, then offer early prevention treatments. About 300 patients are taking part. The goal is to see if this…

This study tests a 10-session program called ViCCY for caregivers of heart failure patients who also have mild to moderate memory problems. About 256 caregivers and 60 patients will take part. The goal is to see if the program improves caregivers' mental health and reduces stress…

This trial tests a device called the Pedal Pump, which moves the feet for 10 minutes to help reduce lower leg swelling (edema) in hospitalized patients. The study includes 60 adults with edema due to conditions like heart failure, kidney disease, or chronic venous insufficiency. …

This study tests whether a special breathing exercise program, called inspiratory muscle training, can improve how well the breathing muscles work during exercise in people with heart failure. Researchers will measure blood flow to breathing and leg muscles, and how long particip…

This study tests whether adding inspiratory muscle training (using a device called PowerBreathe) to standard cardiac rehabilitation can improve how well the heart and muscles work during exercise in people with heart failure. Researchers will measure blood flow and oxygen use in …

This study tests whether combining breathing exercises with mild electrical muscle stimulation can help people hospitalized with worsening heart failure. 135 patients will be split into three groups: one gets both treatments plus standard care, one gets breathing exercises only, …

This study tests different arm exercise routines in 36 adults with heart failure who have an implanted heart device (ICD or CRT). The goal is to see which type of arm workout best improves arm function and overall fitness. Participants will do either high-intensity interval or mo…

This study tests whether combining breathing exercises with cognitive tasks (like memory games) can improve thinking and daily function in adults with heart failure. 54 participants will be randomly assigned to dual-task breathing training, standard breathing training, or a contr…

This study tests whether a supervised cardiac rehabilitation program is feasible and beneficial for people with cardiac amyloidosis, a condition where abnormal protein builds up in the heart. Participants attend three one-hour exercise sessions per week for 12 weeks. The study me…

This study tests a new care model called TIER-HF-PC, which matches heart failure patients to one of three levels of palliative support based on their needs. Researchers want to see if this approach improves quality of life for both patients and their caregivers compared to usual …

This study looks at the best way to give the water-removing medicine furosemide to people hospitalized with acute heart failure and too much fluid in the body. About 436 adults will be randomly assigned to receive the medicine either as a slow continuous infusion or as several in…

This study tests a wearable suit called AquaPass that removes excess fluid through sweat in people with chronic heart failure and fluid overload. Participants wear the suit for up to 5 hours in a hospital or clinic, alongside their usual medications. The goal is to see if the sui…

This study is testing a smartphone app called MedlyPeds that lets children with heart disease send their weight, blood pressure, and heart rate to their doctors from home. The app also asks about symptoms and sends personalized tips. The goal is to see if the app is easy to use a…

This study tests whether a 12-week resistance training program can improve physical function, quality of life, and heart-related biomarkers in people with heart failure who are on the waiting list for a heart transplant. Participants will be randomly assigned to either the exerci…

This study tests whether a mobile-based telemedicine program—using phone calls and text messages for health education, medication reminders, and lifestyle advice—can improve quality of life in adults with chronic heart failure. About 70 patients in Ethiopia will be split into two…

This study looks at whether a special type of exercise called eccentric training (where muscles lengthen under tension) can help people with heart failure and reduced pumping ability. Researchers will compare eccentric bike and strength training to standard cardio and strength ex…

This study tests a 6-week online support programme called HELP for carers of people with heart failure. Around 180 carers and 180 patients will take part across three UK sites. The programme includes weekly online group sessions led by heart failure nurses, plus an educational bo…

This study tests whether special breathing exercises can improve breathing muscle strength in people hospitalized for heart failure. About 30 adults will either do breathing exercises with resistance or without. The goal is to see if this safe, simple training helps them feel bet…

This study is testing a new group exercise program combined with remote activity monitoring for older adults with heart failure with preserved ejection fraction (HFpEF). The goal is to see if this approach can improve exercise habits, physical function, and quality of life. About…

This study looks at whether doing simple breathing exercises every day before a heart transplant can help patients breathe, cough, and swallow better after surgery. About 90 adults waiting for a heart transplant will take part. They will do daily breathing exercises and have thei…

This study is testing a new online resource called Choice-ICD for people who have or are getting an implantable cardioverter defibrillator (ICD). The app includes videos, quizzes, and a forum to help patients and their families understand the device and live better with it. About…

This study looks at whether a special sequence of gentle exercises called Baduanjin can improve heart and lung function and quality of life in people who have both acute coronary syndrome and heart failure. About 65 participants will either do these exercises plus standard care o…

This study tests whether blocking signals from the splanchnic nerve can reduce congestion and improve exercise ability in people with heart failure. About 54 adults with heart failure and reduced pumping function will receive either a nerve-blocking procedure or a sham procedure.…

This study tests whether a daily capsule of potassium nitrate (KNO3) can improve leg muscle power and overall exercise capacity in people with heart failure. 75 adults with reduced heart function will take either KNO3 or a placebo for 6 weeks. Researchers will measure changes in …

This study looks at whether placing stents in blocked heart arteries can improve quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 participants will be randomly assigned to receive either…

This study tests whether adjusting a pacemaker's lower heart rate to an individual's optimal level can improve symptoms and quality of life in people with heart failure and bradycardia. Researchers will compare this personalized approach to the standard fixed rate of 60 beats per…

This study looks at whether removing fluid from around the lungs (a procedure called thoracentesis) can reduce shortness of breath in people hospitalized for heart failure. About 216 adults will either get standard heart failure medicines alone or medicines plus the fluid removal…

This study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 participants will take these medications and be tested on how well t…

This study tests a 12-week phone program that uses positive psychology and motivational interviewing to help 280 heart failure patients stick to their diet, exercise, and medications. Participants get weekly phone sessions and text messages. The goal is to see if this approach im…

This study looks at whether giving a special ketone drink through a feeding tube is safe and practical for people with severe heart failure. The goal is to see if it can help the heart use energy better. The study involves 12 participants with very weak hearts who are in the hosp…

This study tests whether empagliflozin (a diabetes drug) and potassium nitrate (a supplement) can improve exercise endurance in people with heart failure with preserved ejection fraction (HFpEF). About 53 participants will take one of three combinations of these drugs for a perio…

This study tests whether using lung ultrasound to guide fluid removal in adults hospitalized for acute heart failure leads to better outcomes than standard physical exams. Researchers will compare how long patients stay alive and out of the hospital over 40 days, as well as sympt…

This study tests whether a 12-week chair yoga program is practical and helpful for 20 heart failure patients aged 55 and older living in rural Alabama. Researchers will work with patients and community members to design the program and measure changes in thinking skills and quali…

This study tests whether high-flow oxygen therapy can improve heart function in people with chronic heart failure who have recently had heart surgery. Researchers will compare it to non-invasive ventilation (a breathing machine) in 30 adults. The goal is to see if the oxygen ther…

This study tests an 8-week hybrid exercise program for people with HIV who are at risk for heart failure. Participants attend one supervised session at a center and do two unsupervised home workouts each week, plus receive education and coaching. The goal is to see if this approa…

This study tests whether a special exercise bike that connects to video games can help children aged 10-18 who have had a heart transplant get more fit. Ten kids will use the MedBIKE at home for 12 weeks, doing short bursts of intense exercise. The main goal is to see if the prog…

This study tests a nurse-led home care program for people with advanced heart failure and their family caregivers in rural Appalachia. The program uses faith-based nurses and local volunteers to improve quality of life and reduce symptoms. About 208 patients and their caregivers …

This international study tests whether a smartphone game called Heart Farming can help inactive heart failure patients sit less and move more. 750 participants will either get standard activity advice or the game, which rewards walking with virtual farm products. The goal is to s…

This study tests whether a low dose of colchicine, an anti-inflammatory drug, can improve exercise capacity in people with heart failure and chronic inflammation. Sixty participants will be randomly assigned to receive either colchicine or a placebo for three months. Researchers …

This pilot study tests the Reprieve System, a bedside device that automatically adjusts the delivery of a diuretic (furosemide) and saline based on the patient's real-time urine output. The goal is to safely and quickly remove excess fluid from 50 hospitalized adults with acute d…

This study tests whether electrically pacing the diaphragm through a vein near the heart can improve heart function in people with heart failure. Ten adults who are already scheduled for a heart device (CRT) will have an extra pacing lead placed temporarily. Researchers will chec…

This study tests three different drugs—empagliflozin, acetazolamide, and metolazone—added to standard water pills (loop diuretics) in 66 adults hospitalized for acute decompensated heart failure. The goal is to see which drug works best at increasing urine output over three days.…

This study is testing whether using mobile health apps and receiving tailored text messages can help people with chronic heart failure take better care of themselves and avoid hospital stays. Researchers will enroll 360 adults with Stage C heart failure and randomly assign them t…

This study tests whether a sensor-controlled digital game can motivate adults with heart failure to regularly check their weight and stay active. About 200 participants will either get the game plus sensors or just the sensors alone. The goal is to see if the game helps people st…

This study tests whether a 14-week elastic band exercise program can improve muscle mass, strength, and physical function in heart failure patients aged 50 and older who also have sarcopenia (age-related muscle loss). Researchers will measure changes in muscle, symptoms, and qual…

This study looks at whether shorter or longer sessions of high-intensity interval training (HIIT) work better for people with chronic heart failure. Researchers will measure changes in walking ability, heart function, and quality of life in 45 participants. The goal is to find a …

This study looks at whether a pacemaker can improve exercise ability and quality of life in people with heart failure with preserved ejection fraction (HFpEF) who also have a small heart chamber and a low heart rate during activity. About 30 participants will get a pacemaker and …

This study looks at whether two proteins released by a struggling heart can be detected in the blood during acute heart failure. Researchers will measure these proteins in about 500 adults—some with stable or worsening heart failure and some healthy—to see if higher levels relate…

This study looks at whether two proteins released when heart muscle is damaged can be detected in the blood during a heart attack. Researchers want to see if higher levels of these proteins are linked to a greater chance of developing heart failure afterward. The study includes a…

This study looks at whether liver function and blood clotting tests can help doctors better understand and monitor cardiac transthyretin amyloidosis (ATTR-CA), a condition where abnormal protein builds up in the heart. Researchers will compare these tests in people with ATTR-CA a…

This study collects heart tissue and blood samples from people with advanced heart failure who are receiving a mechanical heart pump (LVAD) or a heart transplant. The samples are compared with healthy donor heart tissue to learn more about the biology of heart disease. The goal i…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is looking for tiny molecules in the blood called microRNAs that can help doctors tell if a heart transplant patient's immune system is too active (causing rejection) or too weak (causing infection). Researchers will follow 250 adult heart transplant recipients for one…

This study uses advanced MRI to measure the fat around the heart in people with a type of heart failure called HFpEF. Researchers want to see if the fat's composition, not just its amount, is linked to disease severity. They will also test if a diabetes drug called semaglutide ch…

This study is looking at tiny molecules called microRNAs in the blood of children who have had a heart transplant. The goal is to find patterns that can predict which children are at risk for infection or rejection of the new heart. By understanding these patterns, doctors hope t…

This study tests a special toilet device that automatically measures urine and stool output in hospital patients. About 54 adults receiving stem cell transplants will use the device during their stay. The goal is to see if the device is as accurate as nurses manually measuring ou…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study aims to understand why some people with heart failure respond well to standard guideline-directed medical therapy while others do not. By analyzing genetic data and biomarkers from a large biobank of 5,000 patients, researchers hope to identify predictors of treatment …

This study is looking at whether advanced heart imaging, especially cardiac MRI, can help identify the cause of cardiomyopathy and predict risks like death or heart failure in a diverse group of patients. The research focuses on adults in the Bronx, including many from Hispanic a…

This study looks at whether measuring the heart's 'reserve'—its ability to pump harder under stress—can predict how patients with advanced heart failure will do. Five patients with weak hearts (ejection fraction 40% or less) will be randomly assigned to receive the drug milrinone…

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers want to see if a genetic marker called TRPC6 can predict who will develop heart problems. By analyzing blood samples, they hope to find early warning signs and ways to p…

This study is looking at whether detailed heart imaging can help predict heart problems in people with liver cirrhosis who undergo a procedure called TIPSS, which creates a shunt to relieve pressure in the liver. Participants will have heart MRIs and echocardiograms before, short…

This study compares two ultrasound techniques—2D and 3D speckle-tracking echocardiography—to see which measures heart muscle contraction more accurately in people with heart failure and reduced pumping function. Researchers will enroll 419 patients from seven cardiac rehabilitati…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…

This observational study will follow 600 adults hospitalized with acute heart failure or cardiogenic shock. Researchers will collect information from routine care, plus extra blood and urine samples, to see if they can better identify different types of shock and predict who is a…

This study explores barriers to heart failure self-care and care transitions for adults facing social challenges. Researchers will interview patients, caregivers, and community health workers to identify what gets in the way of good care. The goal is to use these insights to desi…

This study looks at data from over 6,000 Brazilian patients with heart failure, kidney disease, diabetes, or high blood pressure to understand how common high potassium levels (hyperkalemia) are and how doctors manage it. By analyzing medical records, researchers hope to identify…

This observational study will test whether an artificial intelligence algorithm can accurately detect heart sounds using data from a wearable ECG patch in 50 people with heart failure. Participants will wear the patch and have their heart sounds recorded with a digital stethoscop…

This study investigates whether adding inspiratory muscle training—breathing exercises that strengthen the diaphragm—to standard cardiac rehabilitation can improve blood flow and blood pressure responses during exercise in people with heart failure. The trial includes both heart …

This study tests a clinical decision support tool that helps doctors decide when to refer heart failure patients to palliative care. The tool uses a risk model to predict one-year survival and provides guidance at the point of care. Researchers will enroll 2,260 participants, inc…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study looks at 350 adults hospitalized for acute heart failure. Researchers want to see if combining a lung ultrasound score with a blood lactate test at discharge can better predict who will be readmitted or die within 30 days. The goal is to improve risk assessment beyond …

This study looks at why some people with severe heart failure (called HFrEF) see their heart function improve after standard medical therapy, while others do not. Researchers will collect blood samples and imaging data from 1,740 patients in China and follow them for 12 months. T…

This study investigates whether clonal hematopoiesis of indeterminate potential (CHIP)—a condition where blood cells carry certain mutations—plays a role in heart failure. Researchers will examine 300 adults with acute or chronic heart failure to see how common CHIP is and how it…

This study tests whether ultrasound scans can detect leftover fluid in the lungs and veins of people hospitalized for heart failure. About 580 adults will get scans at several points during their stay, but doctors won't see the results. Researchers will then track who is readmitt…

This study tests new MRI techniques to examine the heart's small blood vessels and scarring in people with a type of heart failure called HFpEF. Researchers will compare scans from healthy volunteers and patients to see if these methods can reveal hidden heart problems. The goal …

This observational study will track 300 adults with advanced heart failure to see how well they follow a four-medication treatment plan. Researchers will also measure quality of life using standard questionnaires. The goal is to understand real-world adherence and identify areas …

This study will see if an Apple Watch can help predict when heart failure gets worse. Researchers will compare data from the watch with standard tests in 360 adults with heart failure. The goal is to find a simpler way to monitor patients and catch problems early.

This study is testing whether a special type of imaging called FAPI can better predict how much heart function will improve after bypass surgery or stenting in people with ischemic heart failure. Researchers will follow 122 patients for 12 months, measuring changes in heart pumpi…

This registry tracks 2,000 adults with congenital heart disease who are on the waiting list for a heart or heart-lung transplant. The goal is to understand why some patients get worse or die while waiting, while others improve enough to be removed from the list. By collecting dat…

This early-stage study tests a new drug called CDR132L in 32 healthy adults. Researchers want to see how much of the drug gets into the blood when given as a shot under the skin compared to an IV drip. The goal is to find the best way to give this medicine to people with heart fa…

This study looks at whether a person's genetic makeup can predict how well they respond to the heart failure drug metoprolol. Researchers will give the drug to 100 people with heart failure and track their heart function and drug levels. The goal is to see if a genetic score can …

This study will observe 1000 people who receive BIOTRONIK pacemakers for conditions like slow heartbeat or heart failure. The goal is to see how well the devices work in everyday medical practice, focusing on safety and performance over time. Researchers will track device-related…

This early-stage study tests the safety and how the body processes a new drug called HRS-7156 in 66 healthy adults aged 18 to 55. The goal is to check for side effects and measure drug levels in the blood, not to treat heart failure. Participants must be healthy and not take any …

This study is testing a non-invasive device that uses sensors placed on the chest to monitor heart failure patients during their hospital stay and for 90 days after discharge. The goal is to see if the device's measurements can help predict which patients are at higher risk of be…

This study is testing a skin patch called MyHeartSentinel that records heart electrical and mechanical signals in people with heart failure. Researchers want to see if the patch can detect early signs of a worsening episode (decompensation) while patients are in the hospital and …

This study tests a new PET scan technique to better track heart damage in people with a condition called ATTR-CM, a progressive heart muscle disease. Researchers will scan 140 participants to see if the imaging can show how well treatments are working. The goal is to improve moni…

This study looks at 110 patients aged 80 and older who are in the hospital for acute heart failure. Researchers will use ultrasound and blood tests to measure muscle loss (sarcopenia) and see how it affects their recovery over six months. The goal is to find better ways to predic…

This study tests whether pacing the heart to mimic the speed of a workout can improve heart function in people with heart failure. Fifty-two adults with a weak heart and an implanted defibrillator will receive either active pacing or a sham (fake) pacing for 6 weeks. Researchers …

This study aims to uncover the genetic causes of cardiomyopathy in children by analyzing DNA from affected individuals and their families. Researchers hope to identify mutations that lead to different types of cardiomyopathy, which could improve genetic counseling and deepen unde…

This study looks at whether people with heart failure can reduce their intake of ultra-processed foods (like packaged snacks, sugary drinks, and fast food) and whether doing so improves their health. Participants will track their meals using a smartphone app and receive coaching …

This study tests whether a new referral program helps more Veterans with heart conditions get into cardiac rehabilitation. Researchers will compare referral and attendance rates before and after the program starts at three VA hospitals, involving 816 participants over 12 months. …

This study looks at whether breast cancer patients on HER2-targeted therapy can safely have fewer heart tests. Currently, patients get heart scans every three months, but most don't change treatment. Researchers will test a personalized schedule based on heart risk, comparing it …

This study collects data from wearable devices like Fitbit and Apple Watch to learn about daily habits and health in people with or at risk of heart failure. Researchers will combine this data with medical records to find patterns that might predict health problems. The goal is t…

This study looks at whether a program called ADAPT, where nurses and social workers call people with heart failure weekly to help manage symptoms and improve well-being, can work outside of a research setting. The program aims to reduce hospital visits and improve quality of life…

This study aims to measure how well infants' hearts can make new muscle cells, especially in those with a heart condition called Tetralogy of Fallot. Researchers will use a special imaging technique on heart tissue that is normally removed and thrown away during surgery. The goal…

This registry will collect health information from 8,000 patients with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track what treatments patients receive and how they fare, including survival rates in the hosp…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This early-phase study is testing whether omega-3 fatty acids can reduce inflammation in the heart muscle of people with heart failure with preserved ejection fraction (HFpEF). Researchers will use special MRI scans before and after an iron-based infusion to detect changes in inf…

This study is testing whether a detailed analysis of an electrocardiogram (ECG) can give doctors more information about patients hospitalized with acute heart failure. Researchers will look at how the ECG results relate to lab tests and patient outcomes over one year. The goal is…

This study looks at 200 people with heart failure who are getting a left ventricular assist device (LVAD), a type of heart pump. Researchers will use a special 3D ultrasound during surgery to take detailed pictures of the right side of the heart. The goal is to better understand …

This study examines why fat accumulates in the right ventricle of people with pulmonary arterial hypertension (PAH) and how it affects heart function and exercise ability. Researchers will use MRI and blood tests in 75 adults with PAH to track changes over time. The goal is to be…

This study looks at 500 adult survivors of childhood cancer to see if a newer type of heart ultrasound, called speckle tracking, can find heart problems earlier than the usual method. Researchers want to know if this technique can detect heart damage sooner, which could help with…

This study will follow 2,500 elderly people (ages 65-80) in rural China who have atrial fibrillation, a common heart rhythm problem. Researchers will screen them for heart failure using blood tests and heart ultrasounds, then check on them every three months to see how their cond…

This early-stage study tests the safety of a new oral drug called HRS-5765, which may one day treat heart failure. About 74 healthy adults aged 18-65 will receive single or multiple doses to see how the drug moves through the body and if it causes side effects. No direct treatmen…

This study follows 60 kidney transplant recipients in Denmark to find out how often blood vessel problems cause poor kidney function or hard-to-treat high blood pressure. Participants will get special imaging tests, and if a narrowed artery is found, they may receive balloon trea…

This observational study looks at whether removing excess fluid from the body (diuresis) can reduce sleep apnea severity in adults hospitalized with heart failure. Fifty participants will wear a sleep monitor before and after fluid removal, and researchers will track changes in n…

This study aims to understand why some heart failure patients do not respond well to diuretics (water pills). Researchers will give 75 heart failure patients different doses of a diuretic called bumetanide and measure how their kidneys handle sodium. The goal is to identify biolo…

This study looks at why some people with heart failure don't get rid of excess fluid with standard water pills (diuretics). Researchers will test adding two other types of diuretics—bendroflumethiazide and amiloride—to see if they improve the body's response. Fifty adults with he…

This study uses three wearable devices—a continuous glucose monitor, a heart monitor, and an activity tracker—to see if high blood sugar is linked to heart problems in people with Duchenne muscular dystrophy. Researchers will compare 80 participants with and without DMD. The goal…

This study looks at why some people with heart failure don't respond well to diuretics (water pills). Researchers will give 50 participants either ammonium chloride or a placebo, along with standard diuretics, to see how it affects kidney function. The goal is to understand the b…

This study looks at whether CD34+ stem cells, which help maintain tiny blood vessels in the heart, are linked to how well the heart recovers in people with Takotsubo syndrome (also known as broken heart syndrome). Researchers will measure heart function in 40 participants at the …

This study is collecting high-quality ECG data from 1000 people with heart failure to build a library that could help develop a tool to track disease progression. Participants will also share their experiences with standard heart failure care and procedures. The goal is to improv…

This study is observing 400 adults with advanced heart failure who have received a continuous-flow ventricular assist device (VAD), a mechanical pump that helps the heart circulate blood. Researchers will track survival rates in the hospital and at one and five years after implan…

This study follows 1,000 adults with chronic heart failure to learn what factors influence their health outcomes, such as heart-related death or unplanned hospital visits. Researchers will collect data on genetics, gut bacteria, environment, and other markers. The goal is to bett…

This study is testing whether wearable devices and home monitors can safely track the health of children with heart failure. One hundred kids aged 8 to 18 from four Canadian hospitals will use a chest band, blood pressure cuff, pulse oximeter, and scale for 12 weeks. The goal is …

This study looks at how social factors like race, income, insurance, and community distress affect whether heart failure is caught early and treated properly. Researchers will follow 1,000 adults at risk for heart failure, using blood tests and heart ultrasounds to make diagnoses…

This study looks at how the changing seasons impact physical activity in people with heart failure who have a cardiac implantable electronic device. Researchers will measure activity levels using a wrist-worn accelerometer and questionnaires over a full year. The goal is to under…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study looks at whether breathing a low-density helium-oxygen gas mixture can reduce breathlessness and improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF) and obesity. Researchers will measure how much oxygen the body uses during b…

This study tests whether an AI tool called EchoGo can help doctors spot early signs of heart failure in people with type 2 diabetes who have no symptoms. Researchers will send alerts to doctors about patients at risk, and see if this leads to more prescriptions of heart-protectin…

This study tests whether MRI can accurately measure fluid buildup in the lungs of people hospitalized for acute heart failure. Researchers will track 300 patients from admission to discharge to see how lung water changes with treatment and whether these measurements can predict w…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

Researchers at the University of Calgary are testing a new, non-invasive way to assess heart function using a handgrip exercise. The study involves 100 adults, half with heart failure and half without. Participants squeeze a device with maximum force for two minutes while sensors…

This study looks at whether a special heart failure care network can help people who were recently in the hospital for worsening heart failure. About 1000 adults with moderate to severe heart failure will take part at five heart centers in Germany. Half will get extra support fro…

This study is testing whether using a blood test called NTproBNP can help doctors decide the best time to discharge patients hospitalized with worsening heart failure. 750 participants will be randomly assigned to either a biomarker-guided discharge plan or usual care. The goal i…

This study uses advanced MRI scans with a special manganese dye to look at how the heart handles calcium and energy in people with heart failure with preserved ejection fraction (HFpEF). Researchers will compare 40 people with HFpEF (half with type 2 diabetes) and 20 healthy volu…

This study is recruiting 130 people with heart failure with preserved ejection fraction (HFpEF), both obese and non-obese. Researchers will use CT and MRI scans, blood tests, and other checks to see if having more fat around the heart leads to worse heart function. The goal is to…

This study tests whether regular heart failure symptom questionnaires delivered by a chatbot can detect worsening health early. 120 people with heart failure will answer questions every two weeks for a year. The goal is to see if this approach is practical and if changes in score…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to create a digital decision-making aid for older adults with heart failure who are considering getting an implantable cardioverter-defibrillator (ICD). The tool will help patients weigh the benefits of preventing sudden cardiac death against the downsides of the …

This study follows 100 people newly diagnosed with esophageal cancer in Hungary. Researchers will track heart function, nutrition, physical ability, and mental health before and after surgery. The goal is to find which factors are linked to better survival and quality of life, so…

This study looks at two ways to teach medical residents how to use a special ultrasound technique (VExUS) to check for fluid overload in patients with acute heart failure. About 23 residents will be trained either in-person or remotely, and their ultrasound skills will be compare…

This study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy volunteers, then have the veterans do 8 weeks of knee exercises to see if i…

This study looks at how severe obesity can lead to a type of heart failure called HFpEF, where the heart becomes stiff and has trouble filling with blood. Researchers will study 250 people with obesity using heart ultrasounds and blood tests to find early signs of heart problems.…

This study follows 500 people with a type of heart failure called HFpEF (heart failure with preserved ejection fraction) for at least 3 years. Researchers want to find out which medical signs or test results can predict serious problems like hospitalization or death. No new treat…

This study looks at how a specific biological pathway (BMPR2-activin) affects pulmonary hypertension in people with left heart disease. Researchers will follow 150 heart failure patients for one year, using blood tests, imaging, and heart tissue analysis. The goal is to better un…

This study aims to find early signs of heart failure in women who had preeclampsia, a pregnancy complication involving high blood pressure. Researchers will use exercise stress tests and heart imaging to compare 250 women with a history of preeclampsia to 250 women with normal pr…

This study looks at why some heart failure patients choose to join programs that help coordinate their care after leaving the hospital, like the PRADO-IC program or telemedicine monitoring. Researchers will follow 700 patients in France to see what factors—such as social, cultura…

This study aims to create a tool that uses stress heart MRI and routine medical data to predict which patients with dilated cardiomyopathy (a weakened, enlarged heart) are at highest risk for serious problems like heart failure or sudden cardiac death. Researchers will follow 2,0…

This study looks at 26 people with severe heart failure who are in cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure specific markers in the blood related to inflammation and blood vessel health. The goal is to bette…

This study looks at how small blood vessels work in people who have had a heart transplant. Researchers will use a non-invasive laser device to measure skin blood flow. The goal is to learn more about heart health after transplant, not to test a new treatment. About 31 participan…

This study is looking at 1,000 people with and without heart failure to better understand the different types of the condition. Researchers will use heart images and blood tests to find patterns that could lead to more personalized treatments. The goal is to improve care for peop…

This study is collecting information from 20,000 people with chronic heart failure in Russia to understand how they are diagnosed, treated, and monitored. Researchers will look at patient ages, treatments, and hospital visits. The goal is to find gaps in care and improve future t…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study looks at heart tissue from 180 people with a type of heart failure called HFpEF. Researchers take tiny samples of heart muscle during a routine procedure to find changes in the tissue. The goal is to learn what causes this condition so better treatments can be develope…

This study follows 400 adults diagnosed with pulmonary embolism (a blood clot in the lungs) at a Swedish hospital. Researchers will repeatedly check heart tests and blood markers during the first 48 hours to see if early changes can better predict who will worsen. The goal is to …

This study looks at how a common diabetes drug (SGLT2 inhibitor) changes the way the heart and muscles use energy from ketones. Researchers want to see if these changes can improve exercise ability and daily function in 30 adults with type 2 diabetes and heart failure. Participan…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study looks at whether people with stable heart failure whose heart function has improved can safely stop taking a type of medication called a mineralocorticoid antagonist (MRA). Researchers will monitor 90 participants over 24 weeks to see if stopping the drug leads to a de…

This study is for adults with advanced heart failure who are getting a mechanical heart pump (LVAD). Researchers want to see if a substance in the blood called GDF-15 can help predict early complications or death after surgery. The goal is to better identify high-risk patients be…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome by analyzing immune cells from a blood sample. Researchers will compare calcium and inflammation signals in these cells between patients with and without heart probl…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This pilot study is testing whether a 12-week monitored exercise program can improve heart health in veterans with a type of heart failure called HFpEF. Only 4 participants are being enrolled to see if the facility can support a larger study and if exercise shows any benefit with…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study looks at why postmenopausal women have a higher risk of diastolic heart failure. Researchers will examine heart tissue from 500 patients undergoing cardiac surgery to study how estrogen loss affects heart energy and blood vessel health. The goal is to better understand…

This study is building a large collection of blood samples and health information from 5,000 adults with congenital heart disease and related conditions. Researchers will use this data to better understand how these diseases work and what affects patient health. No treatments or …

This study follows 160 heart failure patients who are scheduled for coronary artery bypass surgery. Researchers want to see if measuring a substance called GDF-15 in the blood before surgery can help predict who will have serious heart problems in the next year. The study does no…

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study is re-examining 1,400 adults in Stockholm to find early signs and risk factors for heart, lung, and liver diseases. Participants will get advanced scans, blood tests, and questionnaires. The goal is to better understand how these diseases develop and how to predict the…

This study is testing whether a special wearable device, combined with artificial intelligence, can help people with chronic heart failure avoid hospital visits. About 205 adults will wear the device for six months while their health data is monitored remotely. The goal is to see…

This study looks at 360 adults hospitalized with acute heart failure who also have possible respiratory virus symptoms. Researchers will test for viruses like flu, RSV, and coronavirus using a nose swab. The goal is to see how often these viruses are present and whether they affe…

This study tests a noninvasive light sensor placed on the thumb to measure oxygen levels in children with heart failure. Researchers want to see if these measurements can show how severe the heart failure is. The study will enroll 130 children and young adults under 25 who are st…

This study aims to develop a way to predict when congestive heart failure suddenly worsens, using data from a non-invasive wearable device. About 60 adults who already have a heart monitor implant will wear the device for up to a year. Researchers will look for patterns in the we…

This study follows 2,000 people with chronic heart failure to see how their physical activity levels relate to hospitalizations and survival. Participants wear a pedometer or smartwatch and answer activity questionnaires every six months. No new treatment is given—the goal is sim…

This study is looking for early warning signs in the blood that could predict chronic heart failure in people with type 2 diabetes. Researchers will follow 500 participants over time, using heart scans and blood tests to see if certain biomarkers can spot trouble before symptoms …

This study uses magnetic resonance spectroscopy, a special MRI technique, to measure the heart's energy levels without needles or biopsies. Researchers will compare healthy volunteers, people with heart failure, and those with other heart conditions to see if low energy metabolis…

This study is looking at people with pulmonary arterial hypertension (PAH), those with a genetic risk but no disease, and healthy individuals. Researchers aim to find molecular and physical markers that explain why some people get PAH and others stay healthy. The goal is to impro…

This study looks at why people with a type of heart failure (HFpEF) have trouble exercising. Researchers will measure energy use in the heart and leg muscles using special scans. They aim to link these energy problems to how well patients can walk and exercise. The study does not…

This study creates a live registry of up to 40,000 heart failure patients across the Yale New Haven Health System. Researchers will track hospitalizations and use of recommended therapies like beta blockers and ACE inhibitors. The goal is to monitor and improve heart failure care…

This study tests a special MRI that can show how heart cells process energy in people with ischemic heart disease. About 15 adults with chronic heart failure will get this scan along with standard tests. The goal is to see if this new method can tell healthy from damaged heart ti…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study looks at whether a structured education program helps heart failure patients understand their condition and practice self-care. About 1000 adults hospitalized for heart failure will take part. They attend a one-hour interactive session led by doctors and nurses, then c…

This study observes 500 adults in intensive care with acute respiratory distress syndrome (ARDS) who are on mechanical ventilation. Researchers will use heart ultrasounds and medication data to track how often right heart failure occurs and how it changes over time. The goal is t…

This pilot study at Mayo Clinic will use cardiac MRI scans to examine how the heart's main pumping chamber changes in people with severe mitral regurgitation before and after valve repair surgery. The goal is to see if this approach can help identify patients at risk of developin…

This study enrolls 60 heart failure patients who already have an implanted sensor to measure lung artery pressure. Participants record their voice daily for 3 months using a smartphone app. After the study, researchers will use artificial intelligence to see if voice changes can …

This study looks at whether pharmacist-led medication checkups and easy-to-understand education can help people with heart failure get the right medicines. It involves 40 patients in Denver who have limited access to care. The goal is to see if this approach is practical and impr…

This study looks at whether early heart ultrasound results can predict which patients hospitalized with heart failure will need to return to the hospital or have a higher risk of death. Researchers will measure heart structure and function before starting IV diuretics in 76 adult…

This study tests whether heart failure patients can safely drink as much fluid as they want instead of restricting it. Researchers will compare lung congestion, blood markers, quality of life, and hospital readmissions in 326 participants over time. The goal is to see if liberal …

This study looks back at medical records of 100 children with a genetic condition called RASopathy that causes severe heart thickening and heart failure. Researchers want to collect detailed information on how the disease progressed in the past. This will help design future studi…

This study looks at why diabetes can damage the heart even without clogged arteries. Researchers will examine heart tissue and use advanced imaging in 500 adults with heart failure, with or without type 2 diabetes. The goal is to find early warning signs and new treatment targets…

This study looks at how a specific type of heart failure (left ventricular diastolic dysfunction) affects short-term results after heart surgery, especially in women. Researchers will track 1,000 patients undergoing cardiac surgery, comparing men and women to find differences in …

This study will use cardiac MRI to track changes in heart structure and function in 40 patients who have had endovascular repair for aortic disease. Researchers will compare heart measurements taken before surgery and again at 6 and 12 months afterward. The goal is to understand …

This study looks at whether a special breathing technique (negative pressure ventilation) can improve heart function in people who have a left ventricular assist device (LVAD), a mechanical heart pump. Researchers will compare this method to standard breathing support in 30 patie…

This international registry is tracking 400 adults with congenital heart disease who are taking SGLT2 inhibitors, a type of diabetes medication that also benefits the heart. Researchers want to see how these drugs are being prescribed, how well they are tolerated, and whether the…

This study from Stanford University is looking at what happens inside the body when people with heart failure exercise. Researchers will measure thousands of proteins in the blood before and after a single workout, and again after a 12-week cardiac rehab program. By comparing the…

This study looks at how extreme head-down positioning (Trendelenburg) and gas inflation during robotic surgery affect the heart's ability to pump blood. Researchers will monitor 80 patients—some with normal heart function and some with heart failure—using a special probe and brai…

This study is for 100 people with heart failure. Researchers will use advanced blood tests and a home monitoring system to learn more about the disease and find better ways to manage treatment. The goal is to reduce hospital stays and improve outcomes.

This study looks at how often heart failure with preserved ejection fraction (HFpEF) occurs in people with COPD and how it affects their health over time. Researchers will follow 200 adults aged 50–70 in Russia who are hospitalized with COPD. They will use heart and lung tests to…

This study looks at how SGLT2 inhibitors, a type of diabetes medicine, change energy levels in the heart and muscles. Researchers will measure key energy molecules in 71 adults with type 2 diabetes and heart failure. The goal is to understand how these drugs work, not to test a n…

This study follows 300 adults with end-stage heart failure who receive a left ventricular assist device (LVAD) as part of their routine care. Researchers will track survival, complications, and hospital readmissions over 3-5 years, and analyze heart tissue and blood samples to fi…

This study observes 300 adults in South Korea with chronic heart failure who are prescribed finerenone as part of their usual care. Researchers will track side effects and treatment satisfaction over one year. The goal is to see how safe and effective finerenone is in everyday me…

This early-phase study tests a new MRI method that uses a special injection called hyperpolarized pyruvate to see how the heart uses energy. Researchers will scan the hearts of up to 112 people with high blood pressure, heart thickening, or heart failure. The goal is to see if th…

This study follows 270 heart transplant recipients to track how their heart and body metabolism change over time. Researchers will use imaging, blood tests, and biopsies to monitor heart function, rejection, kidney health, infections, and cancer risk. The goal is to better unders…

This study looks at whether acute stress can cause sudden worsening of congestive heart failure. Researchers will monitor 112 heart failure patients who have an implanted device that measures pressure in the lung artery. They will compare pressure readings during stressful and ca…

This study uses artificial intelligence to analyze electrocardiograms (ECGs) and identify people at high risk for developing left ventricular dysfunction, a type of heart muscle weakness. Researchers will then see if giving standard heart medications—like ACE inhibitors, beta-blo…

This study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…

This study looks at fat tissue surrounding the heart arteries in 60 patients who had a heart transplant. Researchers want to see if the size of fat cells close to the artery differs from those farther away, and if that relates to artery disease. The goal is to better understand h…

This early-phase study is testing whether a drink containing ketones can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink for seven days while researchers measure heart efficiency wi…

This study looks at whether doing a hard exercise test before a blood draw can make the AlloSure test better at spotting heart transplant rejection. Researchers will test 27 heart transplant recipients, both with stable transplants and those showing signs of rejection. The goal i…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study looks at whether simple, non-invasive skin tests can detect early signs of heart disease by measuring how well small blood vessels work. Researchers will study 900 people aged 60-75, comparing skin blood flow measurements with detailed heart scans. The goal is to find …

This study is testing whether sending a portable ECG monitor to people with elevated NT-proBNP (a heart stress marker) can catch hidden atrial fibrillation and reduce strokes. 4,000 adults aged 40+ without known AF will be randomly assigned to either 7 days of home monitoring or …

This study aims to understand why the right side of the heart fails in people with heart failure and high blood pressure in the lungs. Researchers will look at heart tissue samples from 50 adults to find the best ways to diagnose and treat this condition. Participants must be bet…

This study looks at how different types of platelets change in patients on ECMO, a machine that helps the heart and lungs. Researchers will track 75 adults in intensive care to see if shifts in platelet populations relate to bleeding or clotting problems. The goal is to better un…

This study looks at how heart rate affects metabolism in people with heart failure and diabetes. Researchers will take small samples of fat, muscle, and blood during pacemaker surgery to understand the link. The goal is to find new ways to treat heart failure by targeting metabol…

This study looks at data from the HeartMate 3 heart pump to see if it can help predict problems like bleeding, infection, or frailty in people with advanced heart failure. Researchers will track 150 adults getting the pump and compare pump alarms and readings to their health over…