Can Omega-3s cool inflammation in stiff hearts?

NCT ID NCT07634640

Recruiting now Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study is testing whether omega-3 fatty acids can reduce inflammation in the heart muscle of people with heart failure with preserved ejection fraction (HFpEF). Researchers will use special MRI scans before and after an iron-based infusion to detect changes in inflammation. The study involves 70 participants and is focused on understanding the biology, not yet on improving symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ferumoxytol infusion
What this could lead to: If successful, this could point toward a new way to treat heart inflammation in HFpEF patients.
What could go wrong: This is a very early, small study (70 people) that only looks for signs of inflammation, not whether symptoms improve. The results may not lead to a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)

Contacts and locations

Locations

University of Florida
RECRUITING

Gainesville, Florida, 32608, United States

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