Can a new pill ease the burden of heart failure with preserved pumping?

NCT ID NCT07761117

Not yet recruiting Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether an experimental drug called elecoglipron can reduce serious heart failure events, such as hospitalizations or urgent visits, in adults with heart failure with preserved or mildly reduced ejection fraction. Participants will receive either elecoglipron or a placebo, alongside their usual heart failure medications, including dapagliflozin. The study aims to see if the drug lowers the risk of cardiovascular death or heart failure events and improves patient-reported outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Elecoglipron (an experimental oral drug taken as a tablet)
What this could lead to: If successful, elecoglipron could become a new treatment to lower the risk of heart failure events and improve quality of life for people with HFpEF or HFmrEF.
What could go wrong: This is a large phase 3 trial, but the drug is still experimental. It may not prove better than placebo, and side effects or lack of benefit could limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH MILDLY REDUCED EJECTION FRACTION (HFMREF) HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)

Contacts and locations

Locations

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Fairhope, Alabama, 36532, United States
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Beverly Hills, California, 90211, United States
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Huntington Beach, California, 92647, United States
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Huntington Park, California, 90255, United States
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Loma Linda, California, 92350, United States
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Lomita, California, 90717, United States
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Northridge, California, 91324, United States
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Tarzana, California, 91356, United States
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New Haven, Connecticut, 06519, United States
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Hialeah, Florida, 33012, United States
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Jacksonville, Florida, 32209, United States
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Lakeland, Florida, 33813, United States
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Miami, Florida, 33125, United States
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Miami, Florida, 33144, United States
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Atlanta, Georgia, 30303, United States
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Columbus, Georgia, 31904, United States
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Tucker, Georgia, 30084, United States
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Champaign, Illinois, 61822, United States
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Park Ridge, Illinois, 60068, United States
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Schaumburg, Illinois, 60173, United States
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Indianapolis, Indiana, 46254, United States
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Waterloo, Iowa, 50701, United States
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Bossier City, Louisiana, 71111, United States
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Covington, Louisiana, 70433, United States
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Lafayette, Louisiana, 70503, United States
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New Orleans, Louisiana, 70121, United States
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Shreveport, Louisiana, 71105, United States
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Baltimore, Maryland, 21229, United States
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Lanham, Maryland, 20706, United States
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Oxon Hill, Maryland, 20745, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02118, United States
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New Bedford, Massachusetts, 02740, United States
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Worcester, Massachusetts, 01655, United States
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Flint, Michigan, 48503, United States
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Southfield, Michigan, 48076, United States
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Kansas City, Missouri, 64111, United States
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St Louis, Missouri, 63136, United States
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Millville, New Jersey, 08332, United States
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Trenton, New Jersey, 08690, United States
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Buffalo, New York, 14215, United States
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New York, New York, 10001, United States
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The Bronx, New York, 10451, United States
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The Bronx, New York, 10455, United States
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Chapel Hill, North Carolina, 27599, United States
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Durham, North Carolina, 27710, United States
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Greensboro, North Carolina, 27410, United States
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Statesville, North Carolina, 28625, United States
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Wilmington, North Carolina, 28401, United States
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Fargo, North Dakota, 58104, United States
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Grand Forks, North Dakota, 58201, United States
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Columbus, Ohio, 43228, United States
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Dayton, Ohio, 45435, United States
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Maumee, Ohio, 43537, United States
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Oklahoma City, Oklahoma, 73134, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19107, United States
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Yardley, Pennsylvania, 19067, United States
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DeSoto, Texas, 75115, United States
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El Paso, Texas, 79905, United States
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Houston, Texas, 77025, United States
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Humble, Texas, 77338, United States
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Lancaster, Texas, 75216, United States
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Plano, Texas, 75093, United States
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San Antonio, Texas, 78231, United States
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Victoria, Texas, 77901, United States
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Burlington, Vermont, 05401, United States
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Arlington, Virginia, 22205, United States
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Redmond, Washington, 98052, United States
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Buenos Aires, C1425AGC, Argentina
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CABA, C1061, Argentina
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Córdoba, 5000, Argentina
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Córdoba, X5003DCE, Argentina
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Granadero Baigorria, S2152BOF, Argentina
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Lanus, B1824KAJ, Argentina
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Mar del Plata, B7600GNY, Argentina
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Mendoza, 5500, Argentina
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Rosario, S2000PBJ, Argentina
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San Nicolás, B2900ACL, Argentina
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Santa Fe, S3000FWO, Argentina
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Blacktown, 2148, Australia
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Rockhampton, 4700, Australia
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Bad Ischl, 4820, Austria
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Feldkirch, 6800, Austria
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Graz, 8020, Austria
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Klagenfurt, 9020, Austria
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Linz, 4021, Austria
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Saint Stefan/Stainz, 8511, Austria
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Sankt Pölten, 3100, Austria
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Vienna, 1090, Austria
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Vienna, 1100, Austria
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Vienna, 1160, Austria
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Vienna, 1210, Austria
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Wels, 4600, Austria
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Aracaju, 49015-380, Brazil
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Belém, 66073-005, Brazil
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Bragança Paulista, 12916-542, Brazil
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Brasília, 70390-700, Brazil
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Campinas, 13060-080, Brazil
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Curitiba, 80230-130, Brazil
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Joinville, 89204-251, Brazil
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Natal, 59020-035, Brazil
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Porto Alegre, 90630-165, Brazil
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Porto Alegre, 91350-280, Brazil
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Ribeirão Preto, 14051-140, Brazil
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Rio Branco, 69915-030, Brazil
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Rio de Janeiro, 22270-060, Brazil
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São Paulo, 04012-180, Brazil
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Barrie, Ontario, L4M 6M2, Canada
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Hamilton, Ontario, L8L 5G4, Canada
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Kingston, Ontario, K7M 7E4, Canada
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London, Ontario, N6A 5W9, Canada
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Newmarket, Ontario, L3Y 2P6, Canada
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North York, Ontario, M6B 3H7, Canada
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Oakville, Ontario, L6K 3W7, Canada
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Stoney Creek, Ontario, L8J 3W2, Canada
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Thunder Bay, Ontario, P7B 5N3, Canada
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Toronto, Ontario, M6G 1M2, Canada
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Toronto, Ontario, M6N 1B5, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Luoyang, 471001, China
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Tianjin, 300050, China
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Wuhan, 430000, China
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Zhangjiakou, 075061, China
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Benešov, 256 01, Czechia
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Boskovice, 680 01, Czechia
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Brno, 60200, Czechia
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Broumov, 55001, Czechia
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Chlumec nad Cidlinou, 503 51, Czechia
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Česká Lípa, 470 77, Czechia
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Český Krumlov, 381 01, Czechia
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Jaroměř, 551 01, Czechia
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Klatovy, 339 01, Czechia
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Louny, 440 01, Czechia
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Prague, 130 00, Czechia
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Prague, 150 00, Czechia
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Prague, 198 00, Czechia
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Teplice, 415 01, Czechia
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Bad Oldesloe, 23843, Germany
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Bamberg, 96049, Germany
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Berlin, 13187, Germany
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Berlin, 13405, Germany
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Berlin, 13509, Germany
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Bielefeld, 33604, Germany
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Bochum, 44789, Germany
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Bremen, 28277, Germany
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Chemnitz, 09116, Germany
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Cologne, 50733, Germany
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Dresden, 1307, Germany
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Elsterwerda, 04910, Germany
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Erlangen, 91504, Germany
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Essen, 45147, Germany
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Freiburg im Breisgau, 79106, Germany
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Gera, 07548, Germany
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Hamburg, 20099, Germany
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Hamburg, 21075, Germany
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Hamburg, 22459, Germany
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Hamburg, 22559, Germany
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Heidelberg, 69120, Germany
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Homburg, 66424, Germany
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Jena, 07747, Germany
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Kaiserslautern, 67655, Germany
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Karlsbad, 76307, Germany
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Kiel, 24105, Germany
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Ludwigshafen, 67063, Germany
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Ludwigshafen am Rhein, 67071, Germany
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Lüneburg, 21339, Germany
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Magdeburg, 39120, Germany
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Mainz, 55122, Germany
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Mainz, 55131, Germany
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Markkleeberg, 04416, Germany
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Mühldorf A. Inn, 84453, Germany
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Neuruppin, 16816, Germany
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Nuremberg, 90402, Germany
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Obertshausen, 63179, Germany
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Paderborn, 33098, Germany
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Papenburg, 26871, Germany
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Stuttgart, 70199, Germany
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Trier, 54292, Germany
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Tübingen, 72076, Germany
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Ulm, 89077, Germany
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Athens, 11521, Greece
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Athens, 11526, Greece
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Athens, 11527, Greece
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Athens, 11528, Greece
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Athens, 15123, Greece
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Dragana, 68100, Greece
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Heraklion, 71409, Greece
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Heraklio, 71110, Greece
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Thessaloniki, 54636, Greece
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Voula, 16673, Greece
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Budapest, 1122, Hungary
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Ancona, 60100, Italy
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Bergamo, 24127, Italy
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Brescia, 25123, Italy
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Milan, 20132, Italy
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Pavia, 27100, Italy
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Perugia, 06132, Italy
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Riccione, 47838, Italy
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Salerno, 84131, Italy
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Sesto San Giovanni, 20099, Italy
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Vizzolo Predabissi, 20070, Italy
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Aomori, 030-8553, Japan
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Fukui-shi, 910-8526, Japan
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Higashiibaraki-gun, 311-3193, Japan
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Kanazawa, 920-8650, Japan
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Kasugai-shi, 486-8510, Japan
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Kyoto, 604-8845, Japan
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Kyoto, 605-0981, Japan
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Matsusaka-shi, 515-8557, Japan
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Minatoku, 108-0073, Japan
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Mito, 311-4198, Japan
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Nagoya, 466-8560, Japan
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Osaka, 558-8558, Japan
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Ōmihachiman, 523-0082, Japan
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Sapporo, 003-0026, Japan
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Sendai, 981-3133, Japan
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Takatsuki-shi, 569-8686, Japan
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Tokushima, 770-8503, Japan
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Toshima-ku, 171-0014, Japan
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Urasoe-Shi, 901-2102, Japan
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Uruma, 904-2293, Japan
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Wakayama, 640-8158, Japan
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Alor Star, 05460, Malaysia
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Cheras, 56000, Malaysia
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Kuala Lumpur, 50400, Malaysia
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Kuala Lumpur, 50586, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Terengganu, 20400, Malaysia
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Kuantan, 25100, Malaysia
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Kuching, 93586, Malaysia
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Miri, 98000, Malaysia
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Sungai Buloh, 47000, Malaysia
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Alkmaar, 1815 JD, Netherlands
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Almere Stad, 1315 RA, Netherlands
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Amstelveen, 1186 AM, Netherlands
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Doetinchem, 7009 BL, Netherlands
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Leeuwarden, 8934 AD, Netherlands
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Rotterdam, 3015, Netherlands
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Sneek, 8601 ZR, Netherlands
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The Hague, 2545 AA, Netherlands
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Tilburg, 5042 AD, Netherlands
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Zutphens, 7207 AE, Netherlands
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Zwolle, 8025 AB, Netherlands
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Bialystok, 15-375, Poland
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Bialystok, 15-481, Poland
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Częstochowa, 42-217, Poland
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Gdynia, 81-157, Poland
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Gdynia, 81-338, Poland
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Katowice, 40-600, Poland
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Katowice, 40-635, Poland
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Krakow, 30-082, Poland
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Krakow, 31-271, Poland
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Poznan, 61-848, Poland
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Przemyśl, 37-700, Poland
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Radzionków, 41-922, Poland
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Skórzewo, 60-185, Poland
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Szczecin, 71-526, Poland
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Torun, 87-100, Poland
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Warsaw, 02-758, Poland
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Warsaw, 04-628, Poland
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Wroclaw, 50-981, Poland
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Baia Mare, 430124, Romania
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Brasov, 500102, Romania
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Bucharest, 031441, Romania
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Bucharest, 050098, Romania
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Bucharest, 050659, Romania
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Craiova, 200505, Romania
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Satu Mare, 440055, Romania
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Timișoara, 300002, Romania
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Timișoara, 300024, Romania
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Timișoara, 300362, Romania
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Bratislava, 82107, Slovakia
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Bratislava, 83101, Slovakia
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Brezno, 977 01, Slovakia
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Košice, 04001, Slovakia
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Košice, 04022, Slovakia
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Lučenec, 984 01, Slovakia
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Lučenec, 98401, Slovakia
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Nitra, 949 11, Slovakia
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Prešov, 08001, Slovakia
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Svidník, 08901, Slovakia
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Šahy, 93601, Slovakia
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Barcelona, 08003, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Jaén, 23007, Spain
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Madrid, 28034, Spain
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Madrid, 28041, Spain
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Murcia, 30120, Spain
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Salamanca, 37007, Spain
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Sanlúcar de Barrameda (Cádiz), 11540, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Valencia, 46014, Spain
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Valencia, 46026, Spain
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Villamartín, 11650, Spain
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Gothenburg, 416 85, Sweden
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Jönköping, 553 05, Sweden
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Karlstad, 651 85, Sweden
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Lund, 222 21, Sweden
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Mölndal, 431 80, Sweden
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Örebro, 701 85, Sweden
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Stockholm, 112 81, Sweden
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Stockholm, 113 61, Sweden
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Stockholm, 118 83, Sweden
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Stockholm, 171 64, Sweden
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Uppsala, 751 85, Sweden
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Kaohsiung City, 80756, Taiwan
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New Taipei City, 231, Taiwan
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New Taipei City, Taiwan
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Taichung, 40201, Taiwan
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Taichung, 40705, Taiwan
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Taichung, 433004, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 10449, Taiwan
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Taipei, 110, Taiwan
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Taipei, 11101, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan, 333, Taiwan
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Yilan, 260, Taiwan
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Bangkok, 10300, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10700, Thailand
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Changwat Sara Buri, 18000, Thailand
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Chiang Mai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Khlong Luang, 12120, Thailand
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Khon Kaen, 40002, Thailand
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Phitsanulok, 65000, Thailand
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Ratchaburi, 70000, Thailand
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Kyiv, 01601, Ukraine
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Kyiv, 02002, Ukraine
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Kyiv, 03037, Ukraine
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Kyiv, 03049, Ukraine
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Kyiv, 03057, Ukraine
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Kyiv, 03151, Ukraine
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Kyiv, 04050, Ukraine
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Kyiv, 04114, Ukraine
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Kyiv, 04210, Ukraine
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Lviv, 79016, Ukraine
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Uzhhorod, 88002, Ukraine
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Uzhhorod, 88014, Ukraine
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Ashton-under-Lyne, OL6 6EW, United Kingdom
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Basildon, SS16 5NL, United Kingdom
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Belfast, BT16 1RH, United Kingdom
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Birmingham, B75 7RR, United Kingdom
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Brighton, BN2 5BE, United Kingdom
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Bristol, BS34 5TF, United Kingdom
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Clydebank, G81 4DY, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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Glasgow, G51 4TF, United Kingdom
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Kings Lynn, PE30 4ET, United Kingdom
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Leeds, LS1 3EX, United Kingdom
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London, EC1M 6BQ, United Kingdom
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Sandbach, CW11 1EQ, United Kingdom
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Southampton, SO303JB, United Kingdom
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Can Tho, 900000, Vietnam
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Hanoi, 100000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam
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Hochiminh City, 700000, Vietnam
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Hochiminh, 700000, Vietnam

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