Cure My Disease

Don't miss your cure!

 Log in / Sign up

Iron showdown: IV vs. pills for heart failure fatigue

NCT ID NCT07053475

Terminated Disease control Sponsor: Syed Hamza Mufarrih Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This trial tests whether intravenous (IV) iron or oral iron pills work better for adults with congestive heart failure who also have low iron levels. Participants are randomly assigned to receive either a one-time IV infusion of ferric carboxymaltose (with a possible repeat dose) or twice-daily ferrous sulfate capsules for 24 weeks. The study measures walking distance, symptoms, quality of life, and safety to help doctors choose the best iron treatment for this group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ferric carboxymaltose (IV iron) and ferrous sulfate (oral iron)
What this could lead to
If IV iron proves superior, it could become the standard way to treat iron deficiency in heart failure, improving patients' ability to walk and quality of life.
What could go wrong
This is a small, single-center trial, so results may not apply broadly. IV iron carries rare risks like allergic reactions, and oral iron may cause stomach upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HEART FAILURE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure Iron Deficiencies iron deficiency anemia systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF) HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF) IRON DEFICIENCY IRON DEFICIENCY ANEMIA (IDA)

Contacts and locations

Locations

  • The Medical Center

    Bowling Green, Kentucky, 42101, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.