New pacing technique may lower heart failure risk in pacemaker patients

NCT ID NCT05585411

Recruiting now Disease control Sponsor: Yonsei University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests if a newer pacing method, left bundle branch area pacing, is better than standard right ventricular pacing for people who need a pacemaker. Researchers will compare outcomes like death, heart failure, and heart damage in 450 participants over two years. The goal is to see if the newer method can prevent complications from long-term pacing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Left bundle branch area pacing (a procedure to place a pacemaker lead in a specific heart area)
What this could lead to: If successful, this could show that a newer pacing method reduces the risk of heart failure and death compared to standard pacing.
What could go wrong: This is an early-stage comparison study with 450 participants, so results may not apply to all patients. The procedure itself carries standard risks of pacemaker implantation, such as infection or lead displacement.

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Conditions

The condition(s) this trial relates to.

atrioventricular block Bradycardia heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIOVENTRICULAR BLOCK BRADYARRHYTHMIA LEFT BUNDLE BRANCH AREA PACING

Contacts and locations

Locations

Asan Medical Center
RECRUITING

Seoul, South Korea
Bucheon Sejong Hospital
RECRUITING

Bucheon-si, South Korea
Chungbuk National University Hospital
RECRUITING

Chungju, South Korea
GyeongSang National University Changwon Hospital
RECRUITING

Changwon, South Korea
Kyunghee University hospital
RECRUITING

Seoul, South Korea
Seoul National University Hospital
RECRUITING

Seoul, South Korea
Seoul Saint Mary's Hospital
RECRUITING

Seoul, South Korea
Yonsei University Health System, Severance Hospital
NOT_YET_RECRUITING

Seoul, South Korea

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