Yonsei University

This study compares aspirin and clopidogrel to prevent leaflet thrombosis (blood clots on the valve) in 254 people who had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. After 4 weeks of both drugs, participants take either aspirin or clopidogrel alon…

This study compares two cholesterol-lowering strategies in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate-dose statin plus ezetimibe, the other gets a high-dose statin alone. The goal is to see if the combo is just as g…

This study tests adding the immunotherapy drug durvalumab to standard chemoradiation before surgery in people with stage III non-small cell lung cancer. About 39 participants will receive the combination, then undergo surgery to remove the tumor. Researchers will monitor side eff…

This study tests whether enavogliflozin, a drug originally for diabetes, can prevent atrial fibrillation (AF) from returning after a catheter ablation procedure in people with AF and heart failure. About 390 adults will receive either the drug or a placebo daily for a year. The m…

This phase II trial is testing whether the immunotherapy drug dostarlimab, alone or combined with bevacizumab, can control recurrent gynecological clear cell carcinoma better than standard chemotherapy. About 198 women with this rare cancer type will be randomly assigned to one o…

This phase 2 trial is testing the combination of two chemotherapy drugs, pemetrexed and cisplatin, in 164 adults with advanced or recurrent soft tissue sarcoma. The goal is to see if this treatment can slow tumor growth in people who have already tried standard therapies. Partici…

This study looks at whether a new drug called ZaStaprazan affects how well the blood thinner clopidogrel works in people who have had a heart procedure (stent placement). About 100 adults with chronic coronary syndrome will take either ZaStaprazan or a standard heartburn drug (PP…

This Phase 2 trial tests whether trastuzumab deruxtecan (T-DXd), a targeted antibody-drug conjugate, works better than standard chemotherapy for recurrent ovarian cancer that has stopped responding to PARP inhibitors. About 116 participants whose tumors express the HER2 protein w…

This study tests whether a drug called pegfilgrastim (Neulasta) can prevent a dangerous drop in white blood cells and fever (febrile neutropenia) in women with triple-negative breast cancer. The 40 participants receive the drug after each round of AC chemotherapy, which follows e…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has worsened after first treatment. About 78 adults will be randomly assigned to one of the two gro…

This study looks at stroke patients who had a clot successfully removed from a large brain artery. After the procedure, some patients have low blood pressure. The trial will test whether carefully raising their blood pressure by 20% (but not above 160 mmHg) leads to better recove…

This Phase 2 trial tests the targeted drug lazertinib, alone or with chemotherapy, before surgery in 160 adults with EGFR-mutant non-small cell lung cancer (stages IB to IIIB). The goal is to see if these treatments can shrink tumors enough to improve surgical outcomes. Participa…

This phase 2 trial tests whether the immunotherapy drug nivolumab can improve outcomes for people with locally advanced nasopharyngeal carcinoma who still have signs of cancer after standard chemoradiotherapy. About 57 adults aged 19 and older will receive nivolumab infusions eve…

This study tests whether taking ezetimibe along with a high-dose statin (atorvastatin) works better than the statin alone for people who have had a heart stent placed. About 4,300 participants will be followed for three years to see if the combination reduces deaths, heart attack…

This study compares taking two blood thinners (aspirin plus clopidogrel or prasugrel) for less than 3 months versus at least 6 months after a heart stent procedure in people with advanced chronic kidney disease. Researchers want to see if a shorter course reduces bleeding without…

This study tests if a newer pacing method, left bundle branch area pacing, is better than standard right ventricular pacing for people who need a pacemaker. Researchers will compare outcomes like death, heart failure, and heart damage in 450 participants over two years. The goal …

This study compares two methods for opening blocked arteries in the lower leg in people with chronic limb-threatening ischemia, a severe condition that can lead to amputation. One group gets standard balloon angioplasty guided by X-ray images (angiography). The other group uses a…

This study tests a special type of radiation called carbon ion radiotherapy in 33 frail patients with pancreatic cancer who cannot have surgery or standard chemotherapy. The goal is to see if this treatment can help them live longer and control the tumor with fewer side effects. …

This study tests a precise type of radiation called carbon ion radiotherapy for people with liver cancer that remains or comes back after a prior treatment (TARE). About 48 adults will receive this targeted radiation, with doctors tracking how well it shrinks tumors and whether s…

This study tests whether a mobile app that provides education, medication reminders, and risk factor management can help people with atrial fibrillation stay free of heart rhythm problems after a new type of heart procedure called FARAPULSE pulse field ablation. The study will in…

This study tests whether adding a precise type of radiation (carbon ion radiotherapy) to standard immunotherapy drugs (atezolizumab and bevacizumab) can better control advanced liver cancer. About 52 adults with liver cancer that cannot be surgically removed will receive this com…

This study compares robot-assisted nipple-sparing mastectomy (RNSM) to conventional open surgery in women with early-stage breast cancer (stage 0 to IIIA) who want immediate breast reconstruction. About 790 participants will be randomly assigned to one of the two procedures. The …

This study checks if the HiCardi M350 patient monitor gives accurate blood pressure readings compared to the traditional cuff method. About 100 adults will have their blood pressure measured with both devices. The goal is to see if the new monitor is reliable enough for everyday …

This study tests a new computer-based ultrasound technique called Fluctuational Imaging (FLI) to diagnose hepatic hemangiomas, the most common benign liver tumors. Researchers will enroll 400 adults with liver lesions to see if FLI can reliably tell hemangiomas apart from other g…

This study looks at whether a low or moderate dose of statin works better and causes fewer muscle problems in healthy adults aged 70 and older who have high cholesterol or heart disease risk. About 724 participants will be randomly assigned to one of two statin doses and followed…

This study tests whether a friendly chatbot app can help high-risk drinkers reduce their alcohol intake. About 220 adults who want to drink less will use the app for four weeks, and researchers will check their drinking habits at 4 and 16 weeks. The goal is to see if the app's mo…

This study tests whether a 6-week exercise program can improve fitness and quality of life in people with nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic lung infection. Researchers will enroll 50 adults aged 40-80 and randomly assign them to start exercise rig…

This study is a large registry that will collect information from 10,000 adults who undergo exercise echocardiography (a heart ultrasound during exercise) as part of their regular care. The goal is to better understand how the heart works during exercise in people with various he…

This study is creating a registry of adults with rare cancers in Korea to see how many take part in clinical trials. Researchers will track participation rates over time. No new treatments or drugs are being tested.

This study tests whether an AI-generated avatar video helps radiotherapy patients understand their treatment and feel less anxious, compared to a standard slide-based video. About 136 patients will watch one of the two videos and answer questionnaires. The goal is to see if the A…

This study looks at how a wearable robotic hip device affects the way healthy adults walk. Fifteen volunteers will walk with different levels of assistance from the exoskeleton. Researchers will measure step length, speed, muscle activity, and foot pressure to understand the devi…

This study tests a dynamic coronary roadmap system that helps doctors guide a pressure wire into narrowed heart arteries. 226 patients with ischemic heart disease will be randomly assigned to have the procedure with or without the roadmap. The main goal is to see if the roadmap r…

This study is testing whether special insoles that measure how you walk can predict your recovery after knee replacement surgery. 200 adults with knee osteoarthritis will wear the insoles before surgery and complete questionnaires about their symptoms. Researchers will use comput…

This study watches 25 people with Fabry disease to see how the drug agalsidase alfa changes heart inflammation over one year. Participants get special heart scans (PET-CMR) at the start and after 12 months of treatment. The goal is to learn if the drug reduces inflammation in the…