Personalized chemo and transplants aim to beat infant leukemia

NCT ID NCT06516679

Recruiting now ⭐️ CURE ⭐️ Sponsor: Yonsei University Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adjusting chemotherapy and using stem cell transplants based on each infant's genetic profile can improve survival. Infants under one year old with newly diagnosed leukemia receive a risk-stratified treatment plan. The study aims to see if this personalized approach leads to better outcomes and fewer long-term side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a combination of chemotherapy drugs (prednisolone, dexamethasone, vincristine, daunorubicin, L-asparaginase, cytarabine, etoposide, cyclophosphamide, methotrexate, 6-mercaptopurine) and hematopoietic stem cell transplantation
What this could lead to: If successful, this approach could lead to a more personalized treatment plan that improves survival for infants with leukemia while reducing unnecessary side effects.
What could go wrong: This is a relatively small, early-phase trial, so results may not apply to all infants. Chemotherapy and stem cell transplants carry serious risks, including infection and long-term health problems.

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Conditions

The condition(s) this trial relates to.

acute leukemia of ambiguous lineage acute lymphoblastic leukemia lymphoid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA, LYMPHOID

Contacts and locations

Locations

Asan Medical Center
RECRUITING

Seoul, South Korea
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, South Korea
Chungnam National University Hospital
NOT_YET_RECRUITING

Daejeon, South Korea
Jeju National University Hospital
RECRUITING

Jeju City, South Korea
Kyungpook National University Chilgok-Hospital
NOT_YET_RECRUITING

Daegu, South Korea
Pusan National University Yangsan Hospital
RECRUITING

Pusan, South Korea
Samsung Medical Cente
RECRUITING

Seoul, South Korea
Seoul National University Hospital
RECRUITING

Seoul, South Korea
Seoul saint Mary's Hospital
RECRUITING

Seoul, South Korea
Severance Hospital
RECRUITING

Seoul, South Korea

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