Yonsei University

This phase 2 trial tests a combination of a DNA vaccine (GX-188E), an immune booster (GX-I7), and an immunotherapy drug (nivolumab) in 21 adults with HPV-related head and neck cancer that has returned or spread. The goal is to see if the combo can shrink tumors and improve surviv…

This study compares two cholesterol-lowering strategies in adults aged 75 and older who have heart or blood vessel disease. One group aims for a very low LDL cholesterol target (below 55 mg/dL) using high-intensity statins, while the other receives standard moderate-intensity sta…

This phase 2 trial tests the drug T-DXd (Enhertu) in 27 adults with advanced HER2-mutant lung cancer that has spread to the brain but is not causing symptoms. The main goal is to see how long the drug can keep brain tumors from growing. T-DXd is already approved for certain lung …

This study tests whether combining an HPV DNA vaccine with immunotherapy drugs can shrink advanced head and neck cancers caused by HPV types 16 or 18 before surgery. About 56 adults with resectable tumors will receive one of three treatment combinations. The main goal is to see i…

This phase 2 trial tests a combination of lazertinib (a targeted pill) plus two chemotherapy drugs (pemetrexed and carboplatin) in 87 adults with a specific type of advanced lung cancer (EGFR mutation-positive non-small cell lung cancer) that has stopped responding to lazertinib …

This study compares two high-dose statin/ezetimibe combinations (rosuvastatin/ezetimibe vs. atorvastatin/ezetimibe) in 200 adults who have received a drug-eluting stent for coronary artery disease. The goal is to see which combo better maintains LDL cholesterol below 55 mg/dL ove…

This study is testing a special drug-coated stent called Cre8 in 300 people with long blockages (at least 30 mm) in their heart arteries. The stent releases a medicine to help keep the artery open. Researchers are watching to see if it is safe and effective, looking for problems …

This study looks at whether using wearable devices and a mobile app can help people who have had a stroke improve their walking and daily activity during a 6-week home exercise program. About 120 adults who can walk but have some difficulty will be split into two groups: one usin…

This study is a registry that will track 3,600 patients who need coronary angiography or intervention (like stenting) using the distal radial artery in the wrist. Researchers want to see how often the procedure is successful and how often complications occur. It does not test a n…

This study looks at whether a specific type of heart stent (zotarolimus-eluting) can be expanded more than usual to treat tricky blockages. Researchers will use a special camera (OCT) to check the stent's size and safety in 30 adults with coronary artery disease. The goal is to s…

This study gives the immunotherapy drug durvalumab to people with operable non-small cell lung cancer before their surgery. The main goal is to see how the drug changes the tumor and immune system, not to cure the disease. About 25 adults with stage IIA to IIIB lung cancer will t…

This study looks at whether a common diabetes medicine (SGLT2 inhibitor) can help prevent future heart problems in people with type 2 diabetes who have had a heart attack. Researchers will compare health records of 200,000 adults in Korea who took either an SGLT2 inhibitor or ano…