Yonsei University

This study compares two cholesterol-lowering approaches in about 1,950 adults with chronic kidney disease and heart disease. One group gets a moderate statin plus ezetimibe, the other a high-dose statin alone. The goal is to see if the combination is as good at preventing heart a…

This study tests whether giving a single dose of intravenous iron the day after heart surgery can reduce the chance of long-term anemia. About 180 adults with low iron or anemia before surgery will be randomly assigned to receive either the iron infusion or a placebo. The main go…

This early-phase study tests a new treatment called AB-201 for people with advanced HER2-positive stomach or gastroesophageal junction cancer that has stopped responding to standard therapies. AB-201 uses specially designed immune cells (CAR-NK cells) to target and kill cancer ce…

This study tests two drug combinations for people with a specific type of advanced lung cancer (EGFR-mutant NSCLC). One group gets a new drug combo as their first treatment, and another group gets it after their current treatment stops working. The goal is to see how the drugs af…

This study tests whether adding a drug called bevacizumab (Onbevzi) to standard chemotherapy (gemcitabine and docetaxel) can shrink tumors better than chemotherapy alone in people with advanced soft tissue sarcoma. About 92 adults whose sarcoma has returned after 1-2 prior treatm…

This study tests a new approach for people with end-stage heart failure and a fast, irregular heartbeat (atrial fibrillation). Participants will get a special pacemaker and a small procedure to control the heart's rhythm, plus an implantable defibrillator (ICD). The goal is to se…

This study compares two types of minimally invasive surgery for early-stage stomach cancer: reduced-port robotic surgery and conventional laparoscopic surgery. About 538 adults aged 20 to 80 with early gastric cancer will be randomly assigned to one of the two procedures. The mai…

This study tests the drug everolimus in 67 people with rare blood vessel growths (vascular anomalies) that haven't responded to other treatments. The goal is to see if everolimus can shrink these growths or improve symptoms. Participants take the drug daily for at least 6 months,…

This study tests a new type of radiation called carbon ion radiotherapy given before surgery for soft tissue sarcoma. The goal is to see if it can better control the tumor and cause fewer wound problems after surgery. About 60 adults with sarcoma that can be removed will take par…

This study compares two ablation procedures for people with persistent atrial fibrillation (AFib). The standard method isolates the pulmonary veins, while the experimental method also looks for and burns extra triggers outside those veins. About 406 adults having their first AFib…

This study compares a newer pacing method (left bundle branch area pacing) with the standard approach for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if the newer method improves the heart's pump…

This study tests whether lecanemab, an FDA-approved Alzheimer's drug, can clear amyloid plaques in the brains of people with Parkinson's disease who also have early Alzheimer's changes. About 60 adults aged 50-90 with mild cognitive impairment or early dementia will receive lecan…

This early-phase study tests a new type of radiation (carbon-ion therapy) given in only 6 sessions instead of the usual 12 for men with low- or intermediate-risk prostate cancer. The goal is to see if it is safe and works well. Twenty men will receive the treatment, and some may …

This study looks at people who had a heart attack and received a stent. It compares different combinations of blood thinners and cholesterol drugs to find the safest and most effective way to prevent future heart problems while reducing side effects like bleeding. About 4,400 adu…

This study checks if a new electronic thermometer (XST600) placed on the skin can accurately measure core body temperature compared to a standard device. About 117 adults who need temperature monitoring in the operating room or intensive care unit will take part. The goal is to s…

This study tests whether an artificial intelligence (AI) tool can help emergency doctors better interpret heart CT scans in patients with chest pain. About 530 adults at intermediate risk for heart attack will be randomly assigned to have their scans read with or without AI assis…

This study will test a small, single-lead ECG patch that sticks to the chest and sends heart rhythm data to a central monitoring system. It aims to help doctors spot serious heart rhythm problems like atrial fibrillation or ventricular tachycardia faster in hospitalized patients.…

This study tests whether an artificial intelligence (AI) tool can improve detection of atrial fibrillation (an irregular heartbeat) in adults who have symptoms like palpitations or dizziness but have not been diagnosed before. About 1,230 participants will be randomly assigned to…

This study compares two treatments to prevent another stroke in people who have both atrial fibrillation (an irregular heartbeat) and hardened brain arteries. About 586 participants will receive either the blood thinner apixaban alone or apixaban plus clopidogrel for 30 days. The…

This study compares two sedatives, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium is a common and serious problem after heart surgery, leading to longer hospital stays and worse outcomes…

This study tests if a surgeon can numb the knee during surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see which approach provides better pain relief and recovery.

This study tests if listening to binaural beats (special sounds played through headphones) can help pregnant women feel calmer during a C-section, reducing the need for anxiety medication. About 100 women having a planned C-section under spinal anesthesia will either listen to th…

This study looks at two methods of pain relief after total knee replacement: a single injection of numbing medicine versus a continuous drip through a small tube. Researchers will check if the continuous method provides better pain control over 48 hours and improves recovery afte…

This study tests a smartphone app called One.Dr to see if it can reduce the drop in blood pressure that happens when people with orthostatic hypotension stand up. About 86 adults who get dizzy when standing will be randomly assigned to use the real app or a sham version for 6 wee…

This study compares how much radiation doctors are exposed to during heart procedures (PCI) when using two different arm access points: the left wrist versus the right wrist. About 748 adults scheduled for PCI will be randomly assigned to one of the two approaches. The goal is to…

This study is a large registry that will collect information from 10,000 adults who undergo exercise echocardiography (a heart ultrasound during exercise) as part of their regular care. The goal is to learn how the heart changes during exercise in people with different types of h…

This study will test a simulation-based training program for new surgical residents, anesthesia nurses, and operating room nurses at one hospital. Participants will complete two team training sessions with realistic scenarios and guided discussions. The goal is to see if the prog…

This study will test if listening to binaural beats (special sounds that can calm the brain) can lower the amount of anxiety medication needed during a C-section done with spinal anesthesia. About 200 pregnant women having planned C-sections will be randomly assigned to listen to…

This study is creating a registry of 200 adults who have had immediate allergic reactions to medications, like hives or anaphylaxis. Researchers will analyze blood samples and medical records to understand the causes of these reactions and improve diagnostic tests. The goal is to…