Yonsei University

This study tests a combination of a DNA vaccine (GX-188E), an immune booster (GX-I7), and an immunotherapy drug (nivolumab) in adults with advanced head and neck cancer caused by HPV types 16 or 18. Participants must have already tried platinum chemotherapy. The goal is to see if…

This study tests adding the immunotherapy drug durvalumab to standard chemotherapy and radiation before surgery for people with stage III non-small cell lung cancer that can be removed. The goal is to see if this combination is safe and can improve outcomes like tumor shrinkage a…

This study looks at whether slightly raising blood pressure after a stroke clot removal procedure helps patients recover better than the usual approach. About 176 adults who had a stroke and whose blood pressure stays low after the procedure will be randomly assigned to either a …

This study is for adults with liver cancer that still has active tumors or has come back after a previous treatment called TARE. Researchers want to see if a precise type of radiation called carbon ion radiotherapy can safely shrink or control these remaining tumors. About 48 par…

This study tests a precise form of radiation called carbon ion radiotherapy in 33 frail adults with pancreatic cancer who cannot have surgery or standard chemotherapy. The goal is to see if this treatment can help them live longer and control the tumor with fewer side effects. Pa…

This study tests whether the immunotherapy drug nivolumab can help people with advanced nasopharyngeal cancer who still have signs of cancer after standard chemotherapy and radiation. About 57 adults aged 19 and older will receive nivolumab infusions. The main goal is to see if t…

This study compares aspirin versus clopidogrel to prevent small blood clots on the new heart valve in people who have had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. About 254 participants will take both medicines for 4 weeks, then continue with ju…

This study tests whether a drug called Enavogliflozin, currently used for diabetes, can prevent atrial fibrillation (an irregular heartbeat) from returning after a catheter ablation procedure in people who also have heart failure. About 390 adults will be randomly assigned to rec…

This study tests whether adding a precise type of radiation (carbon ion radiotherapy) to standard immunotherapy drugs (atezolizumab and bevacizumab) can better control advanced liver cancer. About 52 adults with liver cancer that cannot be surgically removed will receive this com…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in people with ovarian cancer that has come back after treatment with PARP inhibitors. The drug targets a protein called HER2 found on some cancer cells. About 116 adults with HER2-positive ovarian cancer will be rando…

This study tests whether a medicine called pegfilgrastim can help prevent a serious infection (febrile neutropenia) in people with triple-negative breast cancer who are getting a specific type of chemotherapy. About 40 adults will receive the medicine after each chemo cycle. The …

This study compares robot-assisted nipple-sparing mastectomy to the traditional open surgery for women with early-stage breast cancer (stage 0 to IIIa) who want immediate breast reconstruction. About 790 participants will be randomly assigned to one of the two surgical methods. T…

This study looks at how long people with advanced chronic kidney disease should take two blood thinners (aspirin plus clopidogrel or prasugrel) after getting a heart stent. About 900 adults with severe kidney disease will be randomly assigned to either a short or long course of t…

This study tests whether a drug that boosts the immune system (dostarlimab), alone or with a drug that blocks blood vessel growth (bevacizumab), works better than standard chemotherapy for women whose gynecological clear cell cancer has come back. About 198 women will be randomly…

This study compares two methods to guide balloon treatment for blocked leg arteries in people with chronic limb-threatening ischemia (severe pain or wounds). One method uses standard X-ray images; the other adds a thin pressure wire to measure blood flow. The goal is to see which…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has worsened after first treatment. About 78 adults will be randomly assigned to one of the two gro…

This study tests a combination of two chemotherapy drugs, pemetrexed and cisplatin, in people with advanced or recurrent soft tissue sarcoma that has not responded to prior treatments. The goal is to see if this combination can slow tumor growth and improve outcomes. About 164 ad…

This study tests a drug called lazertinib, given alone or with chemotherapy, before surgery for people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer). The goal is to see if the treatment can shrink tumors and improve surgical outcomes. About 160 adul…

This study tests whether a smartphone chatbot that uses motivational interviewing can help high-risk drinkers reduce their alcohol intake. About 220 adults who want to drink less will use the app for four weeks, and their drinking will be compared to a control group. The goal is …

This study looks at whether using a smartphone app to guide care can help people with atrial fibrillation (an irregular heartbeat) do better after a procedure called FARAPULSE ablation. About 500 adults who are getting this treatment for the first time will be randomly assigned t…

This study compares two treatments for people who have had a heart stent placed: a high-intensity statin alone versus the same statin plus ezetimibe. The goal is to see if the combination therapy better prevents death, heart attacks, strokes, or the need for additional procedures…

This study looks at whether a new acid reflux drug, ZaStaprazan, changes how well the blood thinner clopidogrel works in people with chronic heart disease who have had a stent placed. About 100 adults will be randomly assigned to receive either ZaStaprazan or a standard acid refl…

This study tests if a newer pacing method, left bundle branch area pacing (LBBAP), is better than standard right ventricular pacing (RVP) for people who need a pacemaker for a slow heartbeat. The goal is to see if LBBAP reduces the risk of death, heart failure, or heart damage. A…

This study tests a new ultrasound technique called Fluctuational Imaging (FLI) to see if it can accurately diagnose hepatic hemangioma, a common benign liver tumor. Researchers will compare FLI results in 400 adults with liver lesions to standard diagnosis methods. If successful,…

This study looks at whether a low or moderate dose of statin works better and causes fewer muscle side effects in healthy adults aged 70 and older who have high cholesterol or heart disease risk. About 724 participants will take either a low or moderate statin dose and be followe…

This study tests whether a 6-week exercise program can improve fitness and quality of life in people with nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic lung infection. Researchers will enroll 50 adults aged 40-80 who have respiratory symptoms and a positive N…

This study is testing whether a kit of wearable devices and a smartphone app can help people improve their walking and daily activity after a stroke. The kit includes smart insoles for the shoes and a wrist-worn activity tracker, which send data to an app that provides feedback. …

This study tests whether a special map (dynamic coronary roadmap) helps doctors place a pressure wire in heart arteries faster. About 226 adults with narrowed heart arteries (50-90% blockage) will be randomly assigned to use the map or not during standard pressure tests. The main…

This study looks at how a robotic hip brace (exoskeleton) changes the way healthy adults walk. Researchers will measure step length, speed, muscle activity, and foot pressure while people walk with different levels of assistance from the device. The goal is to understand how the …

This study is creating a list of rare cancer patients at one hospital in Korea to see how many join clinical trials. About 500 adults with confirmed rare cancer and a life expectancy of at least 3 months will take part. No new treatments or drugs are being tested—just information…

This study looks at whether special insoles that measure how you walk, along with other health information, can predict how much your knee will improve after replacement surgery. About 200 adults with knee osteoarthritis scheduled for surgery will participate. The goal is to help…

This study compares two types of educational videos for people about to start radiation therapy: one made with an AI avatar and another using standard slides with voiceover. About 136 patients will watch one of the videos and answer questions about their anxiety and understanding…

This study looks at 25 people with Fabry disease to see if a 12-month treatment with agalsidase alfa reduces inflammation in the heart. Participants will get special PET and MRI scans at the start and after one year. The goal is to understand how well the therapy works on heart i…