Can closing a hole in the heart prevent future strokes? a long-term study seeks answers.

NCT ID NCT07724171

Recruiting now Knowledge-focused Sponsor: Yonsei University Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study tracks 400 people who had a procedure to close a patent foramen ovale (PFO), a small hole between the heart's upper chambers that can raise stroke risk. Researchers want to see how often strokes or mini-strokes return, whether a residual shunt persists, and what factors influence outcomes. Participants are followed for up to 10 years with regular heart imaging.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: percutaneous patent foramen ovale closure
What this could lead to: If successful, this could help identify which patients benefit most from PFO closure and how to reduce residual shunt and stroke recurrence.
What could go wrong: This is an observational registry, not a randomized trial, so it cannot prove cause and effect. Results may be limited by the single-center design and retrospective data.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation Ischemic Stroke patent foramen ovale stroke disorder transient ischemic attack

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION CRYPTOGENIC STROKE PATENT FORAMEN OVALE TRANSIENT ISCHEMIC ATTACK DUE TO EMBOLISM

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Yonsei University College of Medicine
RECRUITING

Seoul, South Korea

Contact Phone: •••-•••-•••• Email: •••••@•••••

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