Transient ischemic attack

This study tests whether a structured rehabilitation program called HABIT-ILE, which combines intensive arm, hand, and leg exercises, can improve balance and coordination in people recovering from a stroke. The trial will include 44 stroke survivors aged 40 to 60, who will be ran…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This study tests an implanted electrical stimulation device designed to improve movement, standing, and walking in people with paralysis from spinal cord injury, stroke, multiple sclerosis, or traumatic brain injury. The device sends electrical signals to muscles in the trunk and…

This trial tests whether flushing a stent-graft with carbon dioxide before implanting it in the aorta can reduce the number of tiny air bubbles that travel to the brain during the procedure. These bubbles are a major cause of stroke and silent brain damage in patients undergoing …

This large trial compares robot-assisted rehabilitation to traditional one-on-one physiotherapy for people who have had a stroke. Researchers are measuring how well each approach helps patients regain independence in daily activities, as well as costs and patient satisfaction. Th…

This study compares two common procedures—radiofrequency and cryoablation—for treating persistent atrial fibrillation, a heart rhythm disorder that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, transient ischemic…

This trial is testing several different treatments for stroke, including different doses of a clot-busting drug called tenecteplase and blood pressure management strategies. It aims to find which treatments or combinations work best to improve recovery and reduce disability. The …

This phase 3 trial tests whether tegoprazan, a stomach acid blocker, can prevent gastrointestinal complications like bleeding and ulcers in people who have had an ischemic stroke and are taking antiplatelet drugs (blood thinners). About 1,500 adults in South Korea will receive ei…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study tests a tool called Savvy, which includes phone exercises, a weekly pill organizer, and text reminders, to help stroke survivors take their blood pressure medication as prescribed. Researchers will compare medication adherence and blood pressure control between those u…

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study is testing whether using a blood test to guide antiplatelet therapy can better prevent recurrent strokes in people who have had a mild stroke or transient ischemic attack (TIA). About 5,100 participants will be assigned to either standard clopidogrel or ticagrelor base…

This study compares a new ambulatory (same-day) stroke care model to standard hospital care for patients aged 60 and older who have had a mild stroke or transient ischemic attack (TIA). Participants receive a full neurological assessment and treatment plan on the same day and the…

This study tests whether a home hospitalization program (NORA-HOME) is safe and effective for people who have had a minor stroke or transient ischemic attack (TIA). Researchers will compare home monitoring with standard hospital care in 250 participants. The goal is to see if hom…

This study tests whether performing carotid artery surgery within 72 hours of a mini-stroke or minor stroke is safer and more effective than waiting 4 to 15 days. About 456 participants with a blocked neck artery will be randomly assigned to one of two timing groups. The goal is …

This study tests a smart management system that uses a WeChat app and home devices like blood pressure monitors to help people who have had a stroke or mini-stroke avoid another one. About 4,490 participants will either get usual care or use the system after leaving the hospital.…

This study tests whether a computer-based decision-support tool can help more people who have had a stroke or mini-stroke reach their LDL cholesterol goal of less than 1.8 mmol/L after one year of treatment with evolocumab. About 4,000 adults in China who recently had a non-cardi…

This study tests whether combining a statin with ezetimibe (another cholesterol-lowering drug) works better than a statin alone in people who recently had a stroke. Researchers will enroll 300 adults aged 20 or older who had a stroke or TIA within the past 30 days and have high L…

This study tests whether dulaglutide, a once-weekly diabetes injection, can improve blood flow in the brains of people with severely narrowed arteries. About 130 participants who recently had a mini-stroke or mild stroke will receive either standard care or dulaglutide plus stand…

This study compares two antiplatelet drug combinations—ticagrelor plus aspirin versus cilostazol plus aspirin—given within 24 hours of a minor stroke or TIA. The goal is to see which combination better prevents new strokes over 90 days while keeping bleeding complications low. Ab…

This phase 3 trial is testing whether two drugs—colchicine (used for gout) and ticagrelor (a blood thinner)—can prevent future strokes, heart attacks, and other vascular events in people who have already had a stroke. About 2,800 high-risk participants will be enrolled. The goal …

This phase 3 trial compares two anti-clotting drug combinations—aspirin plus ticagrelor versus aspirin plus clopidogrel—in 900 adults who recently had a minor stroke or transient ischemic attack (TIA) caused by a large artery blockage. Participants receive the drugs within 24 hou…

This study looks at 200 adults who have had an ischemic stroke or transient ischemic attack (TIA). Each participant will receive two types of imaging: a non-contrast magnetic resonance angiography (NC-MRA) and a carotid Doppler ultrasound. The goal is to see how well these two me…

This trial tests a new portable brain scanner designed to quickly detect bleeding in the brain (hemorrhagic stroke) using harmless radio waves. The helmet-like device could offer a faster, more accessible alternative to CT or MRI scans in emergency settings. Researchers will enro…

This study is developing and testing an artificial intelligence (AI) model to help diagnose a specific type of stroke called branch atheromatous disease (BAD)-related stroke. BAD strokes are hard to identify because symptoms are not specific, and diagnosis requires combining clin…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study tests a portable EEG device called StrokePointer that ambulance crews can use to detect severe strokes caused by large vessel blockages. Currently, over half of these patients are taken to hospitals that cannot perform the needed clot-removal procedure, causing an aver…

This pilot study tests a 12-week workshop called STEP-Home-SP for veterans who recently left military service. The workshop teaches emotional regulation and problem-solving skills to help with reintegration and reduce suicide risk. Researchers will enroll 120 veterans to see if t…

This study tests two rehabilitation methods—mirror therapy (sensory augmentation) and mild brain stimulation (tDCS)—to improve arm and hand movement in stroke survivors. 36 adults aged 45-65 with chronic stroke will be split into three groups, each receiving different combination…

This study tests two remote brain-training programs for Veterans who have had a traumatic brain injury (TBI) and struggle with focus, memory, or staying on track. About 120 Veterans will use either BrainStrong-GSR or BrainStrong-OPT via tele-rehabilitation and digital apps. The g…

This study tests whether taking krill oil supplements for 12 weeks can improve muscle strength and function in adults with long-term conditions like diabetes, heart disease, or arthritis. Thirty participants will be randomly assigned to receive either krill oil or a placebo. Rese…

This study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…

This study is looking for biological markers (biomarkers) in blood, urine, spinal fluid, and other samples that could help predict who will have a stroke and how they will recover. Researchers will follow 7,000 people with and without ischemic cerebrovascular disease for up to 4 …

This study tracks 400 people who had a procedure to close a patent foramen ovale (PFO), a small hole between the heart's upper chambers that can raise stroke risk. Researchers want to see how often strokes or mini-strokes return, whether a residual shunt persists, and what factor…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study is translating and testing a French version of the Trunk Impairment Scale (TIS), a tool that measures trunk control and balance while sitting. Researchers will enroll 67 stroke patients to check if the scale is accurate and reliable. The goal is to give French-speaking…

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This study looks at how a stroke can disrupt the body's automatic functions, like heart rate and blood pressure control. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart function tests. The goal is to understand why t…

This study tests a fast genetic test done in the hospital to see if it helps doctors pick the best blood thinner for stroke patients. Some people have a gene variation that makes the common drug clopidogrel less effective. The test checks for 11 known gene variants and alerts the…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study looks at whether a fast genetic test can help doctors pick the best blood-thinning medication for people who have had a minor stroke or a high-risk mini-stroke (TIA). The test checks a gene called CYP2C19, which affects how the body processes certain antiplatelet drugs…

This study is creating a biological bank of blood samples from 1,000 people with atrial fibrillation (AF) and stroke. Researchers will collect DNA and plasma to study the genetic roots of these conditions. The goal is to better understand why AF leads to stroke and find new drug …

This study compares a new, data-driven method for emergency responders to decide which hospital to take a stroke patient to, versus the current standard method. The goal is to see if the new approach helps rural patients get to a hospital that can perform specialized clot-removal…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This study follows 1,300 people who had a stroke or mini-stroke and completed a 1-year exercise program. Researchers will track them for 3 more years to see if the exercise helped prevent future strokes or improve daily function. No new treatments are given—this is purely observa…

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This study looks at blood markers related to inflammation and clotting in people with brain oxygen deprivation from stroke or bleeding. Researchers will compare these markers between patients with brain hypoxia and those without. The goal is to see if these markers are linked to …

This study looks at how emergency departments handle patients who have had a transient ischemic attack (TIA), also known as a mini-stroke. Researchers will review records of 300 adults diagnosed with TIA in 2024 to see if the care they received—like tests and treatments—matched t…

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study is testing whether a non-invasive ultrasound scan, combined with artificial intelligence (AI), can quickly identify bleeding in the brain (intracerebral hemorrhage) in people having a stroke. Researchers will enroll 500 adults with acute stroke and perform a standard C…

This study looks at whether a nurse-led transitional care program helps stroke survivors and their caregivers after leaving the hospital. About 130 stroke survivors, their caregivers, and healthcare workers in Tanzania will take part. The program includes face-to-face sessions an…

This study looks at how often antiphospholipid syndrome (APS) occurs in people aged 65 and older who have had a stroke or mini-stroke. Researchers will test blood for specific antibodies linked to APS, including some newer ones not yet standard. The goal is to better understand A…

This observational study will use combined PET/MR scans to measure blood flow and glucose metabolism in the brains of 200 people with severe carotid artery narrowing. Participants have already had a mini-stroke or stroke in the past year. The goal is to develop better imaging mar…

This study looks at how hospitals in Villavicencio, Colombia, manage stroke cases by reviewing patient records. Researchers want to find delays in treatment and see if doctors follow best-practice guidelines. About 100 adults diagnosed with stroke will be included. No new treatme…

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers studying new ways to improve recovery. No treatments or tests are given—just observation and data collection.

This observational study tests a new physical exam method to reliably find joint motion problems in healthy adults and people hospitalized with stroke or TIA. Researchers will compare motion patterns between groups and see if motion issues relate to quality of life after stroke. …