New stomach drug could shield heart patients from bleeding
NCT ID NCT04416581
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems like bleeding or ulcers over 12 months. Participants will be randomly assigned to take one of the two drugs daily.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tegoprazan
What this could lead to
If successful, this could offer a new option to protect the stomach and gut from bleeding in people with heart disease who must take blood thinners.
What could go wrong
This is a non-inferiority trial, meaning it only aims to show tegoprazan is not worse than the standard drug. It may not prove it is better, and results may not apply to all patients.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ajou University Hospital
RECRUITINGSuwon, South Korea
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Asan Medical Center
RECRUITINGSeoul, South Korea
Contact Email: •••••@•••••
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Bucheon Sejong Hospital
RECRUITINGBucheon-si, South Korea
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Bundang CHA Hospital
RECRUITINGSeongnam, South Korea
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Chonnam National University Hospital
RECRUITINGGwangju, South Korea
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Chung-Ang University Hospital
RECRUITINGSeoul, South Korea
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Chungbuk National University Hospital
RECRUITINGCheonju, South Korea
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Chungnam National University Hospital
RECRUITINGDaejeon, South Korea
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Chungnam National University Sejong Hospital
RECRUITINGSejong, South Korea
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Dankook University Hospital
WITHDRAWNCheonan, South Korea
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Dong-A Medical Center
RECRUITINGPusan, South Korea
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Ewha Womans University Medical Center
WITHDRAWNSeoul, South Korea
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Gangneung Asan Hospital
RECRUITINGGangneung, South Korea
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Gangwon National Univ. Hospital
NOT_YET_RECRUITINGChuncheon, South Korea
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Gyeongsang National University Changwon Hospital
WITHDRAWNChangwon, South Korea
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Hallym University Chuncheon Sacred Heart Hospital
NOT_YET_RECRUITINGChuncheon, South Korea
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Hallym University Dongtan Sacred Heart Hospital
RECRUITINGHwaseong-si, South Korea
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Hallym University Kangnam Sacred Heart Hospital
RECRUITINGSeoul, South Korea
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Hallym University Sacred Heart Hospital
RECRUITINGAnyang, South Korea
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Hanyang University Guri Hospital
RECRUITINGGuri-si, South Korea
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Hanyang University Seoul Hospital
RECRUITINGSeoul, South Korea
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Inje University Ilsan Paik Hospital
RECRUITINGIlsan, South Korea
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Inje University Pusan Paik Hospital
RECRUITINGPusan, South Korea
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Jeonbuk National University Hospital
WITHDRAWNJeonju, South Korea
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Kangbuk Samsung Hospital
RECRUITINGSeoul, South Korea
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Keimyung University Dongsan Medical Center
RECRUITINGDaegu, South Korea
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Korea University Anam Hospital
RECRUITINGSeoul, South Korea
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Korea University Guro Hospital
RECRUITINGSeoul, South Korea
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Kosin University Gospel Hospital
RECRUITINGBusan, South Korea
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Kwangju Christian Hospital
WITHDRAWNKwangju, South Korea
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Kyung Hee University Hospital at Gangdong
RECRUITINGSeoul, South Korea
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Kyung Hee University Medical Center
RECRUITINGSeoul, South Korea
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Pusan National University Hospital
RECRUITINGPusan, South Korea
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Pusan National University Yangsan Hospital
RECRUITINGYangsan, South Korea
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SNU Boramae Medical Center
RECRUITINGSeoul, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, South Korea
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Seoul university Bundang hospital
RECRUITINGSeongnam-si, South Korea
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Severance Hospital
RECRUITINGSeoul, South Korea
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Sungkyunkwan University Samsung Changwon Hospital
WITHDRAWNChangwon, South Korea
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The Catholic Univ. of Korea Eunpyeong St. Mary's hospital
RECRUITINGSeoul, South Korea
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The Catholic Univ. of Korea Seoul St. Mary's hospital
RECRUITINGSeoul, South Korea
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The Catholic University of Korea, ST. Vincent's Hospital
RECRUITINGSuwon, South Korea
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Ulsan University Hospital
RECRUITINGUlsan, South Korea
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Yeungnam University Medical Center
WITHDRAWNDaegu, South Korea
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Yonsei University Yongin Severance Hospital
RECRUITINGYongin-si, South Korea
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