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New stomach drug could shield heart patients from bleeding

NCT ID NCT04416581

Recruiting now Disease control Sponsor: Duk-Woo Park, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems like bleeding or ulcers over 12 months. Participants will be randomly assigned to take one of the two drugs daily.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Tegoprazan
What this could lead to
If successful, this could offer a new option to protect the stomach and gut from bleeding in people with heart disease who must take blood thinners.
What could go wrong
This is a non-inferiority trial, meaning it only aims to show tegoprazan is not worse than the standard drug. It may not prove it is better, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome atrial fibrillation cerebrovascular disorder coronary artery disorder Gastrointestinal Hemorrhage heart valve disorder myocardial infarction peptic ulcer disease peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CORONARY SYNDROME CORONARY ARTERY DISEASE MYOCARDIAL INFARCTION PERCUTANEOUS CORONARY INTERVENTION

Contacts and locations

Locations

  • Ajou University Hospital

    RECRUITING

    Suwon, South Korea

  • Asan Medical Center

    RECRUITING

    Seoul, South Korea

  • Bucheon Sejong Hospital

    RECRUITING

    Bucheon-si, South Korea

  • Bundang CHA Hospital

    RECRUITING

    Seongnam, South Korea

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, South Korea

  • Chung-Ang University Hospital

    RECRUITING

    Seoul, South Korea

  • Chungbuk National University Hospital

    RECRUITING

    Cheonju, South Korea

  • Chungnam National University Hospital

    RECRUITING

    Daejeon, South Korea

  • Chungnam National University Sejong Hospital

    RECRUITING

    Sejong, South Korea

  • Dankook University Hospital

    WITHDRAWN

    Cheonan, South Korea

  • Dong-A Medical Center

    RECRUITING

    Pusan, South Korea

  • Ewha Womans University Medical Center

    WITHDRAWN

    Seoul, South Korea

  • Gangneung Asan Hospital

    RECRUITING

    Gangneung, South Korea

  • Gangwon National Univ. Hospital

    NOT_YET_RECRUITING

    Chuncheon, South Korea

  • Gyeongsang National University Changwon Hospital

    WITHDRAWN

    Changwon, South Korea

  • Hallym University Chuncheon Sacred Heart Hospital

    NOT_YET_RECRUITING

    Chuncheon, South Korea

  • Hallym University Dongtan Sacred Heart Hospital

    RECRUITING

    Hwaseong-si, South Korea

  • Hallym University Kangnam Sacred Heart Hospital

    RECRUITING

    Seoul, South Korea

  • Hallym University Sacred Heart Hospital

    RECRUITING

    Anyang, South Korea

  • Hanyang University Guri Hospital

    RECRUITING

    Guri-si, South Korea

  • Hanyang University Seoul Hospital

    RECRUITING

    Seoul, South Korea

  • Inje University Ilsan Paik Hospital

    RECRUITING

    Ilsan, South Korea

  • Inje University Pusan Paik Hospital

    RECRUITING

    Pusan, South Korea

  • Jeonbuk National University Hospital

    WITHDRAWN

    Jeonju, South Korea

  • Kangbuk Samsung Hospital

    RECRUITING

    Seoul, South Korea

  • Keimyung University Dongsan Medical Center

    RECRUITING

    Daegu, South Korea

  • Korea University Anam Hospital

    RECRUITING

    Seoul, South Korea

  • Korea University Guro Hospital

    RECRUITING

    Seoul, South Korea

  • Kosin University Gospel Hospital

    RECRUITING

    Busan, South Korea

  • Kwangju Christian Hospital

    WITHDRAWN

    Kwangju, South Korea

  • Kyung Hee University Hospital at Gangdong

    RECRUITING

    Seoul, South Korea

  • Kyung Hee University Medical Center

    RECRUITING

    Seoul, South Korea

  • Pusan National University Hospital

    RECRUITING

    Pusan, South Korea

  • Pusan National University Yangsan Hospital

    RECRUITING

    Yangsan, South Korea

  • SNU Boramae Medical Center

    RECRUITING

    Seoul, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, South Korea

  • Seoul university Bundang hospital

    RECRUITING

    Seongnam-si, South Korea

  • Severance Hospital

    RECRUITING

    Seoul, South Korea

  • Sungkyunkwan University Samsung Changwon Hospital

    WITHDRAWN

    Changwon, South Korea

  • The Catholic Univ. of Korea Eunpyeong St. Mary's hospital

    RECRUITING

    Seoul, South Korea

  • The Catholic Univ. of Korea Seoul St. Mary's hospital

    RECRUITING

    Seoul, South Korea

  • The Catholic University of Korea, ST. Vincent's Hospital

    RECRUITING

    Suwon, South Korea

  • Ulsan University Hospital

    RECRUITING

    Ulsan, South Korea

  • Yeungnam University Medical Center

    WITHDRAWN

    Daegu, South Korea

  • Yonsei University Yongin Severance Hospital

    RECRUITING

    Yongin-si, South Korea

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