MYOCARDIAL INFARCTION

This study looks at whether a quick genetic test can help doctors pick a milder blood thinner for heart attack patients who are at high risk of bleeding. About 2,468 adults who had a heart attack and are on strong blood thinners will be randomly assigned to either continue a stro…

This study tests whether using only ticagrelor (a blood thinner) after a heart attack can reduce bleeding risks compared to the standard combination of aspirin and ticagrelor. About 2,570 adults who had a heart attack but did not receive stents or bypass surgery will be followed …

This study is testing whether two drugs, colchicine (an anti-inflammatory) and ticagrelor (a blood thinner), can reduce the risk of another stroke, heart attack, or related death in people who have already had an ischemic stroke. About 2,800 high-risk participants will take these…

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests a medicine called Xolatryp in adults who have had a severe type of heart attack (STEMI) and are getting a procedure to open the blocked artery. Participants receive either Xolatryp or a placebo as a one-time IV infusion over 6 hours. The study checks if the drug …

This study compares a new stomach acid reducer (tegoprazan) with a standard one (rabeprazole) in about 3,320 heart patients who take blood thinners and are at high risk for stomach bleeding or ulcers. The goal is to see if the new drug works just as well at preventing serious sto…

This study tests whether dapagliflozin, a drug used for diabetes, can reduce heart muscle damage in people having a severe heart attack (STEMI). About 256 participants will receive either the drug or a placebo right before a procedure to open blocked arteries. The main goal is to…

This study tests whether a new medicine called ziltivekimab can reduce plaque buildup in heart arteries after a heart attack. About 332 adults who recently had a heart attack will receive either the study drug or a placebo for around 15 months. The goal is to see if the drug help…

This study looks at whether people who had a heart attack but do not have heart failure can safely stop taking beta-blockers after at least one year. About 2,540 adults will be randomly assigned to either stop or continue the medication. The goal is to see if stopping is just as …

This study tests a noninvasive radiation treatment for people with dangerous heart rhythms (ventricular tachycardia) caused by scarred heart tissue. The treatment aims to destroy the faulty electrical pathways in the scar using precise radiation beams, similar to cancer therapy. …

This study is testing a new approach to reduce heart damage during a heart attack. When a heart artery is blocked, restoring blood flow can sometimes cause additional injury. Researchers are cooling the heart's arteries with a cold saline solution right after opening the blockage…

This study tests whether giving a cholesterol-lowering drug called inclisiran soon after a heart attack can reduce the chance of another heart problem within a year. About 300 adults in Russia who have had a heart attack and high cholesterol will receive the drug early. Researche…

This study tests whether a special nursing education program helps people recover better after a heart attack. Researchers will compare patients who receive extra nurse coaching on diet, exercise, and smoking to those who get standard care alone. The goal is to see if this suppor…

This study aims to find out if using a detailed imaging technique called OCT leads to better long-term results than standard angiography when placing stents in people who have just had a major heart attack. It will involve 1500 participants who are having emergency stent placemen…

This study aims to see if a new, noninvasive test called magnetocardiography (MCG) can accurately identify heart attacks. Researchers will enroll about 3,841 healthy volunteers and people with chest pain to compare MCG results with standard tests like EKG and blood tests. The goa…

This study tests a new smartphone-based 12-lead ECG device to see if it can accurately detect heart attacks (STEMI and NSTEMI) compared to standard hospital ECGs. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to validate the device as a…

This study tests a new imaging test (PET-CT scan) that can see blood clots in the heart arteries from outside the body. The goal is to better identify what caused a heart attack, so patients get the right treatment. Researchers will recruit 80 adults who recently had a heart atta…

This study tests whether people who have had a heart attack and have a weak heart can safely avoid getting a defibrillator implant if they take the latest heart medications. About 3,600 participants will be randomly assigned to receive either a defibrillator plus drugs or drugs a…

This study looks at whether using a handheld stress management device called CalmiGo, along with standard cardiac rehab, can improve blood vessel health and lower stress in people who recently had a heart attack. About 100 adults will use the device for 12 weeks and have their bl…

This study tests whether a therapy called EMDR can reduce PTSD symptoms in 60 adults who developed PTSD after a heart attack. Participants will receive EMDR sessions, and researchers will measure PTSD levels and stress responses at 3 and 6 months. If effective, EMDR could become …

This study tests a new heart rehab program that combines telehealth sessions at home with some in-clinic visits, compared to the usual all-clinic program. The goal is to see if the hybrid approach helps more people stick with rehab and improve their walking ability. About 250 adu…

This study tests if a device called Bioboosti, which uses pulsed electromagnetic waves, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow and exercise ability in 120 adults who cannot have standard heart procedures. Th…

This study is testing whether a home-based exercise plan, guided by a digital health app, can help people who are sedentary after a heart attack. The goal is to reduce their fear of physical activity (kinesiophobia) and improve their ability to walk and function. Researchers want…

This study looks at whether cholesterol tests taken during a heart attack hospital stay give reliable results. About 100 adults admitted for a heart attack will have their cholesterol checked at the start, two days later, and again 4-6 weeks after leaving the hospital. The goal i…

This study looks at blood platelets from 350 people who have had a heart attack and compares them to people with stable heart disease and healthy controls. Researchers want to understand how platelets differ in men and women and what role they play in causing heart attacks. Blood…

This study looks at why women often have worse outcomes after a heart attack than men. Researchers will track changes in heart size and shape in 1,650 adults who had their first heart attack. The goal is to understand these differences, not to test a new treatment.

This study uses a special MRI technique to look at the tiny structure of the heart muscle in people at risk for heart failure. Researchers want to see how the heart's fibers change over time in patients who have had a heart attack or have a thickened heart muscle. The goal is to …

This study looks at 1,000 adults aged 40-80 with high cholesterol but no heart symptoms. It compares two ways to find very high heart risk: a simple online calculator (SCORE2) versus detailed scans of neck and heart arteries. The goal is to see if scans catch more people who need…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study follows 15,000 adults aged 45 and older who are having same-day (noncardiac) surgery. The goal is to learn how often heart problems and other complications happen after these procedures, and to build a tool that helps doctors predict which patients are at higher risk. …

This study is a large registry that will collect health information from up to 60,000 patients with both heart and kidney disease. The goal is to better understand how these conditions interact and what factors affect patient outcomes. No new treatments are being tested; instead,…

This study is for adults with psoriasis who want to help researchers understand the link between psoriasis and heart disease. The goal is to see if certain heart tests and blood markers can predict future heart problems. Participants will be followed over time to track heart heal…

This study tracks 100 adults who had a heart attack to see how many develop anxiety or posttraumatic stress disorder (PTSD) later on. Researchers want to understand if early feelings of fear, stress, and pain during the heart attack raise the risk of long-term mental health probl…

This study looks at how moderate alcohol consumption affects heart function in people who recently had a heart attack. 220 participants will either drink a small amount daily or abstain for 3 months. Researchers will measure changes in heart pumping ability using ultrasound.

This study looks at people who had a heart attack but whose main heart arteries are not blocked. Researchers want to see if problems in the tiny blood vessels of the heart (called microvascular dysfunction) affect future health. 150 adults will be followed to compare outcomes lik…

This study is a registry for people who have had a heart attack but no blocked arteries (MINOCA). It aims to collect data from 3000 patients to better understand the causes, improve diagnosis, and guide future treatments. Participants will be followed over time to track outcomes …

This study compares two ways of delivering cardiac rehabilitation: in-person sessions at a clinic and telehealth sessions done from home. Researchers want to see if both methods produce similar improvements in walking ability and quality of life for people with heart conditions. …

This study is testing a new, specially built coil for a type of MRI scanner to see if it can take better pictures of the heart. Researchers will compare the new method with standard heart MRI in 150 people, including healthy volunteers and those who have had a heart attack. The g…

This study follows 20,000 heart attack patients who are discharged early from the hospital to see how well their medications are adjusted, track major heart events, and measure quality of life over one year. It aims to improve care for future patients by learning from real-world …

This study tests a new imaging method to find the exact location of electrical 'short circuits' in the heart that cause dangerous rapid heartbeats. Researchers will use special body-surface electrodes and CT or MRI scans to create 3D maps before and after a standard ablation proc…

This study follows 300 adults who had a severe type of heart attack (STEMI) to discover new biological and imaging markers that can predict how well they recover. Researchers will collect blood samples and perform MRI scans over one year, and track patients' health for up to five…