New trial tests quick valve fix after heart attack to save lives

NCT ID NCT06282042

Recruiting now Disease control Sponsor: Fundación para la Investigación Biosanitaria del Principado de Asturias Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether repairing a leaky mitral valve soon after a heart attack can lower the chances of death or repeat hospital stays for heart failure. About 250 adults with moderate-to-severe valve leakage will either get the MitraClip procedure within 60 days or standard medical care. Researchers will track outcomes for up to two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MitraClip device
What this could lead to: If it works, this could reduce the risk of death and heart failure hospitalizations after a heart attack complicated by mitral regurgitation.
What could go wrong: This is a mid-sized trial without a placebo control, and the procedure carries risks like bleeding or device complications. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mitral valve insufficiency myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MITRAL REGURGITATION

Contacts and locations

Locations

Amphia Hospital
NOT_YET_RECRUITING

Breda, Breda, 4818 CK, Netherlands
Amsterdam University Medical Center
NOT_YET_RECRUITING

Amsterdam, Amsterdam, 1081 HV, Netherlands
Catharina Ziekenhuis Hospital
NOT_YET_RECRUITING

Eindhoven, Eindhoven, 5623 EJ, Netherlands
Centro Cardiológico Monzino
NOT_YET_RECRUITING

Milan, Milan, 20138, Italy
Civil Hospital of Brescia
NOT_YET_RECRUITING

Brescia, Brescia, 25123, Italy
Emek Medical Center
NOT_YET_RECRUITING

Afula, Afula, 1834111, Israel
Erasmus University Medical Center
NOT_YET_RECRUITING

Rotterdam, Rotterdam, 3015 GD, Netherlands
Hospital Clínic Barcelona
NOT_YET_RECRUITING

Barcelona, Barcelona, 08036, Spain
Hospital Clínico Universitario San Carlos
NOT_YET_RECRUITING

Madrid, Madrid, 28040, Spain
Hospital Clínico Universitario de Valladolid
NOT_YET_RECRUITING

Valladolid, Valladolid, 47003, Spain
Hospital General Universitario Dr. Balmis
NOT_YET_RECRUITING

Alicante, Alicante, 03010, Spain
Hospital Universitario Central de Asturias (HUCA)
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Doctor Negrin
NOT_YET_RECRUITING

Las Palmas de Gran Canaria, Las Palmas, 35010, Spain
Hospital Universitario Marqués de Valdecilla
NOT_YET_RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Puerta de Hierro
NOT_YET_RECRUITING

Madrid, Madrid, 28222, Spain
Hospital Universitario Ramón y Cajal
NOT_YET_RECRUITING

Madrid, Madrid, 28034, Spain
Hospital Universitario Reina Sofía
NOT_YET_RECRUITING

Córdoba, Córdoba, 14004, Spain
Hospital Universitario Vall d'Hebrón
NOT_YET_RECRUITING

Barcelona, Barcelona, 08035, Spain
Hospital Universitario Virgen de la Victoria
NOT_YET_RECRUITING

Málaga, Málaga, 29010, Spain
Hospital Universitario de Bellvitge
NOT_YET_RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital de la Santa Creu i Sant Pau
NOT_YET_RECRUITING

Barcelona, Barcelona, 08025, Spain
Hospital Álvaro Cunqueiro
NOT_YET_RECRUITING

Vigo, Pontevedra, 36312, Spain
Isala Hospital
NOT_YET_RECRUITING

Zwolle, Zwolle, 8025 AB, Netherlands
Leiden University Medical Center
NOT_YET_RECRUITING

Leiden, Leiden, 2333 ZA, Netherlands
Maastricht University Medical Center
NOT_YET_RECRUITING

Maastricht, Maastricht, 6229 HX, Netherlands
Ospedale Policlinico San Martino
NOT_YET_RECRUITING

Genova, Genova, 16132, Italy
Policlínico San Donato
NOT_YET_RECRUITING

San Donato Milanese, San Donato Milanese, 20097, Italy
Rabin Medical Center
NOT_YET_RECRUITING

Petah Tikva, Petah Tikva, 4941492, Israel
San Raffaele Hospital
NOT_YET_RECRUITING

Milan, Milano, 20132, Italy
Shaare Zedek Medical Center
RECRUITING

Jerusalem, Jerusalen, 9103102, Israel
Sheba Medical Center
NOT_YET_RECRUITING

Ramat Gan, Ramat Gan, Israel
St. Antonius Hospital
NOT_YET_RECRUITING

Nieuwegein, Nieuwegein, 3435 CM, Netherlands

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