Myocardial infarction

This trial investigates whether a five-week vegetarian diet can dampen the inflammatory response of the immune system in people who recently had a heart attack, as well as in healthy volunteers. Participants will follow a vegetarian diet for five weeks, then return to their usual…

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This study tests whether a single dose of rituximab, a drug that calms the immune system, can help the heart pump better six months after a severe type of heart attack called an anterior STEMI. About 372 adults who have just had such an attack will receive either rituximab or a p…

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This trial tests whether fexofenadine, a common allergy medication, can help the heart heal better after a severe type of heart attack called STEMI. Participants will receive either fexofenadine or a placebo for six months, alongside standard care, after undergoing a procedure to…

This study tests whether starting inclisiran early after a heart attack can lower bad cholesterol and reduce the risk of another heart attack or stroke. About 300 adults in Russia who had a recent heart attack and have high cholesterol will receive inclisiran injections. Research…

This study is testing whether fexofenadine, a common allergy medication, can reduce the risk of serious heart and brain events in people who have recently had a heart attack. About 2,800 participants will receive either fexofenadine or a placebo for 24 months. The goal is to see …

This trial tests whether a smartphone app called HeartCheck can help people who have recently survived a heart attack better manage their blood pressure, cholesterol, blood sugar, and smoking habits. The app provides education, reminders, and easy-to-understand goals to support m…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study looks at the best timing for opening blocked arteries in people having a certain type of heart attack (NSTEMI) who have multiple blockages. About 1,014 participants will be randomly assigned to have all blockages fixed during the same procedure or to wait a few days be…

This early study is testing a new heart pump device (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The device is inserted through a blood vessel to help the heart pump. Researchers are checking if it is…

This study looks at whether heart attack patients with mild artery narrowing can be treated with medication alone instead of getting a stent. About 2,000 people will be randomly assigned to either standard medication or medication plus a stent. The goal is to see if medication al…

This study tests a new medicine called SGC001 in people who have had a serious type of heart attack (anterior STEMI) and are scheduled for a procedure to open blocked arteries. The goal is to see if SGC001 can reduce the size of the heart damage and lower the chance of future hea…

This trial tests whether a noninvasive procedure called RE-START, which uses a blood pressure cuff to temporarily stop blood flow in the arm, can improve blood flow in the heart's arteries before standard angioplasty in people having a severe heart attack (STEMI). The study invol…

This trial tests whether using a suction catheter to remove large blood clots before placing a stent improves outcomes in people having a severe heart attack (STEMI). Participants must have a large clot visible on angiography. Half receive standard stent placement alone, and half…

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This early-stage study tests STX-1150, a new medicine that temporarily turns off a gene (PCSK9) in the liver to lower bad cholesterol (LDL-C). It does not change your DNA. Up to 64 adults with high LDL-C will receive one or more doses and be followed for a year. The main goal is …

This study looks at people who have had a severe type of heart attack called STEMI. It compares a shorter course (about one month) of two blood thinners followed by just one drug (prasugrel) for a year, versus the standard one-year regimen of two blood thinners. The goal is to se…

This early-stage trial tests whether an experimental drug called UDP-003 is safe in healthy volunteers and people with heart disease. Researchers will give single or multiple doses of the drug or a placebo and monitor for side effects. The study includes 84 participants and is th…

This study tests whether a digital support program (called DEEPER) helps heart patients maintain their health after completing cardiac rehab. About 306 adults with heart disease or heart failure will be split into two groups: one gets standard follow-up care, the other gets stand…

This early-stage trial compares a new investigational drug, CG-0255, to the established blood thinner Plavix in 136 healthy adults aged 18-55. The goal is to see if CG-0255 is processed by the body similarly to Plavix and has the same effect on preventing blood clots. Participant…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study compares a new drug, Zastaprazan, against standard proton pump inhibitors (PPIs) for preventing stomach bleeding in 5,000 adults who had a heart attack and are on blood thinners. The goal is to see if routine use of Zastaprazan reduces serious complications like death,…

This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are eithe…

This study tests whether quickly upgrading from a standard heart pump (Impella CP) to a more powerful one (Impella 5.5) within 24 hours after a heart attack improves outcomes for people in cardiogenic shock. The trial will enroll 115 adults aged 18-77 who have had a heart attack …

This study looks at giving a blood thinner called heparin to heart attack patients as soon as they see a doctor, rather than waiting until they are in the procedure room. About 6,294 participants will be randomly assigned to early or standard timing. The goal is to see if early t…

This study tests whether a heart rehab program that combines telehealth sessions at home with some clinic visits helps more people stick with it and improve their fitness compared to the standard all-clinic program. About 250 adults who had a heart attack or related condition in …

This study tests whether adding the blood thinner rivaroxaban (Xarelto) to standard care helps dissolve dangerous blood clots in the heart after a major heart attack. Researchers will track 320 participants to see if the drug reduces strokes and other complications. The goal is t…

This study compares a new approach using fewer stents and a drug-coated balloon to the standard method of placing stents in heart attack patients. About 1,272 participants will be randomly assigned to one of the two treatments. The goal is to see if the reduced-stent strategy low…

This study compares two drugs given directly into the heart arteries during a heart attack: rhTNK-tPA, a clot dissolver, and tirofiban, a blood thinner. Researchers will enroll 300 patients with severe blockages to see which drug restores blood flow better and causes fewer bleedi…

This study tracks 1,000 heart attack patients to see if adding SuperSaturated Oxygen therapy to standard angioplasty reduces heart muscle damage and improves outcomes. Participants are adults aged 18-80 who had a specific type of heart attack. The goal is to learn if this extra t…

This study compares two ways to guide stent placement during a heart attack: standard angiography (X-ray) versus a more detailed imaging method called optical coherence tomography (OCT). The goal is to see if OCT leads to fewer future heart problems, like repeat blockages or hear…

This study tests whether montelukast, a common asthma drug, can reduce inflammation and limit heart muscle damage in people who have just had a heart attack. Eighty adults aged 30-75 will receive either montelukast or a placebo for 4 weeks. Researchers will measure changes in blo…

This study looks at whether using aspirin alone is as effective and safer than aspirin plus another blood thinner (fondaparinux) before a heart procedure in people with a type of heart attack called NSTEMI. About 5,000 participants will be randomly assigned to one of the two trea…

This study looks at two ways to treat blocked heart arteries in people aged 18 to 68. One uses a drug-coated balloon, and the other uses a temporary scaffold. The goal is to see which approach works better over time, with fewer heart problems or need for repeat procedures. About …

This study tests whether giving the drug adenosine just before emergency angioplasty (PCI) can improve blood flow in heart attack patients. About 1,148 adults having a severe type of heart attack (STEMI) will either receive adenosine or standard care. The goal is to see if adenos…

This study tests whether using a special catheter to remove blood clots during emergency heart attack treatment can reduce heart muscle damage. About 140 patients having a major heart attack will be randomly assigned to get either standard care or standard care plus clot removal.…

This phase 3 trial tests whether a single high dose of the steroid methylprednisolone, given in the ambulance before opening the blocked artery, can reduce deaths in people having a major heart attack (STEMI). About 5,200 adults will be randomly assigned to receive either the ste…

This study tests a new monthly injection called ziltivekimab in 10,000 people who recently had a heart attack. The goal is to see if it can lower the risk of having another heart attack, a stroke, or dying from heart disease. Participants will receive either the study drug or a p…

This study compares two blood-thinning approaches in 326 adults with acute coronary syndrome and coronary artery ectasia (enlarged heart arteries). One group gets standard dual antiplatelet therapy (aspirin plus clopidogrel), while the other gets clopidogrel plus the anticoagulan…

This study tests whether the drug deferiprone can safely reduce harmful iron buildup in the heart after a severe heart attack. About 89 adults with a specific type of heart attack will receive either deferiprone or a placebo for 6 months. The goal is to see if lowering iron level…

This study tests whether getting a flu vaccine soon after a heart attack can reduce inflammation in the heart's arteries. Researchers will compare the vaccine to a placebo in 90 adults who recently had a heart attack and a stent procedure. They will use special CT scans and blood…

This study tests a special balloon procedure called ischemic postconditioning in 1800 people having a heart attack. After opening the blocked artery, doctors briefly inflate and deflate a balloon four times to see if it reduces heart damage. The goal is to lower the chance of hea…

This study tests two methods used during emergency heart attack treatment: ischemic postconditioning (briefly pausing blood flow after opening the artery) and ultrasound-guided stent placement. The goal is to see if these techniques reduce death, heart failure, or the need for an…

This study tests if a drug-coated balloon works as well as the standard drug-coated stent for opening blocked arteries during a heart attack. About 600 adults having a severe type of heart attack (STEMI) will be randomly assigned to one of the two treatments. The goal is to see w…

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests whether a daily low dose of colchicine, an anti-inflammatory drug, can prevent heart attacks, strokes, and severe leg complications in people with peripheral artery disease (PAD). About 6,150 participants with symptomatic PAD will receive either colchicine or a p…

This study tests whether ziltivekimab, a monthly injection that reduces inflammation, can improve artery health in people who have recently had a heart attack. About 332 participants will receive either the drug or a placebo, alongside standard care. Researchers will use special …

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests a noninvasive radiation treatment (SBRT) for people with ventricular tachycardia, a dangerous heart rhythm that can cause sudden death. The 12 participants have structural heart disease and have not been helped by standard treatments like drugs or catheter ablati…

This trial tests whether doing a coronary angiogram (a special X-ray of the heart arteries) within 2 hours of diagnosis is better than waiting until the patient's heart failure symptoms improve. The study includes 780 adults with a type of heart attack called NSTEMI who also have…

This trial tests whether eplerenone, a drug used for high blood pressure and heart failure, can help people who have had a heart attack or heart injury but no blocked arteries. Many of these patients have damage to tiny blood vessels in the heart. The study will involve 400 adult…

This study tests whether a new medicine called ziltivekimab can reduce fatty plaque buildup in heart arteries after a heart attack. About 332 participants will receive either the drug or a placebo for 15 months. The goal is to see if the drug helps control artery disease and prev…

This study tests whether the drug ranolazine can protect the tiny blood vessels in the heart after a heart attack. One hundred adults who had a major heart attack and have at least one other blocked artery will receive either ranolazine plus standard care or standard care alone. …

This study looks at whether empagliflozin, a medicine used for diabetes, can help blood vessels and heart muscle recover after a heart attack. About 80 people who had a severe heart attack will either receive empagliflozin or standard care. Researchers will measure artery stiffne…

This study looks at the best blood-thinning medicine after a minimally invasive heart valve repair for mitral regurgitation, a common heart condition. About 1,032 participants will be randomly assigned to take either aspirin alone or aspirin plus clopidogrel. The goal is to see w…

This study tests whether taking only the blood thinner ticagrelor (instead of the usual combination of ticagrelor plus aspirin) can reduce bleeding after a heart attack. It involves 2,570 adults who had a heart attack but did not receive stents or bypass surgery. Participants wil…

This study looks at 880 people who had a minimally invasive heart valve repair and also need long-term blood thinners. It compares taking just one blood thinner (rivaroxaban) versus taking two (rivaroxaban plus clopidogrel) to see which causes fewer bleeding problems over one yea…

This study is testing a special balloon coated with the drug sirolimus to treat blocked heart arteries. The balloon is inflated inside the artery to push the blockage aside and release the drug, which helps prevent the artery from narrowing again. Researchers will follow over 1,1…

This trial studies whether removing blood clots from heart arteries during angioplasty improves outcomes for people who have had a major heart attack. 3500 participants will be randomly assigned to get either clot removal plus angioplasty or angioplasty alone. The main goal is to…

This study tests using a drug-coated balloon instead of a permanent stent to open blocked arteries during a heart attack. The balloon delivers medication to prevent re-blockage without leaving a metal implant. Researchers will track 300 participants to see if this approach is saf…

This study looks at how different types of aerobic exercise affect blood vessel health in people with ischemic heart disease (such as after a heart attack or angina). Researchers will compare high-intensity interval training with short bursts, long bursts, and moderate-intensity …

This study tests whether a personalized nutrition program, supported by digital tools like meal plans and remote guidance, can improve heart function in people who recently had a severe heart attack (STEMI). Two hundred participants will follow the program for three months, and d…

This study tests whether dapagliflozin, a diabetes drug, can limit heart muscle damage in people having a major heart attack (STEMI). Participants receive either the drug or a placebo for 7 days, and heart damage is measured with an MRI. The goal is to see if this drug can improv…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study follows 100 people who received Hearticellgram-AMI, a stem cell treatment for acute heart attacks, to see if any serious side effects appear years later. Researchers are watching for death, new cancers, or immune reactions. The goal is to confirm the treatment's long-t…

This study tests a new drug-coated stent and a blood thinner strategy without aspirin for people who have had a severe heart attack. The goal is to see if this approach lowers the risk of serious bleeding while still preventing future heart attacks, strokes, or the need for anoth…

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. Participants receive either orticumab or a placebo for 24 weeks. The main goal is to see if orticumab lowers inflammation measured by a special …

This study tests if a drug-coated balloon works as well as a drug-coated stent for people having a severe heart attack (STEMI). About 1,200 participants will receive either the balloon or the stent during emergency artery-opening procedures. The goal is to see if the balloon, whi…

This study tests a special balloon coated with two drugs to open blocked heart arteries in people with chest pain or minor heart attacks. The balloon is used instead of placing a new stent. About 30 participants will be followed for 12 months to see if the artery stays open and i…

This study tests whether giving a powerful cholesterol-lowering drug (PCSK9 inhibitor) very early in the hospital, right after a heart attack, can reduce the chance of another heart attack, stroke, or death over the next year. About 1,500 adults with multiple blocked arteries wil…

This study looks at whether giving a PCSK9 inhibitor (alirocumab) soon after a heart attack can help save more heart muscle. About 160 adults having a specific type of heart attack will either get the drug or standard care. The main goal is to see if the drug improves heart muscl…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests a weight-loss program delivered via telehealth for people who have had a stroke. The goal is to help participants lose weight and improve their health, especially those in underserved communities. The study will compare the program to a wait-list control group an…

This study looks at whether a genetic test can help choose a safer blood thinner for people who have had a heart attack. After one month on two blood thinners, some patients will switch to a single, lower-potency drug based on their genetic profile. The goal is to see if this app…

This phase 3 trial tests whether montelukast, a common asthma drug, can reduce heart damage in people having a heart attack. 512 patients with a specific type of heart attack will receive either montelukast or a placebo daily for 3 months. The goal is to see if the drug prevents …

This pilot study tests whether two diabetes drugs—dapagliflozin and semaglutide—can reduce inflammation after a heart attack. Researchers will enroll 44 people with type 2 diabetes, obesity, and high inflammation levels. Participants will take one of the drugs for 24 weeks, and t…

This study tests two diabetes medications (SGLT2 inhibitors and GLP-1 agonists) to see if they can reduce epicardial fat—the fat around the heart—in people who recently had a heart attack. About 136 participants with type 2 diabetes and obesity will have their heart fat measured …

This study tests a personalized smoking cessation program for smokers admitted to the hospital with heart or lung disease. Participants receive tailored medication, counseling, and text message support to help them quit and stay smoke-free. The goal is to see if this approach lea…

This study tests whether adding inclisiran (a twice-yearly injection) to standard care lowers LDL cholesterol more than standard care alone in 520 patients who recently had a heart attack, stroke, or urgent heart procedure. Participants are randomly assigned to receive inclisiran…

This study looks at whether people who have had a heart attack but do not have heart failure can safely stop taking beta-blockers after at least one year. About 2,540 adults will be randomly assigned to either continue or stop their beta-blocker medication. The goal is to see if …

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can help the heart heal better after a heart attack. About 450 adults who have had a heart attack and have weak heart pumping will receive either the drug or a placebo for 6 months. The go…

This study tests whether a device called Bioboosti, which delivers pulsed electromagnetic fields, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow during stress and track symptoms like chest pain and exercise capacity…

This study tests whether a single injection of morphine around certain neck nerves can reduce heart muscle damage after a heart attack. About 166 adults who have had a severe heart attack and undergone artery-opening treatment will receive either morphine or a saltwater placebo. …

This study tests a new way to reduce heart damage after a severe heart attack (STEMI). Doctors will cool the heart's arteries during the standard procedure to open blocked vessels. The goal is to see if this cooling prevents further injury and improves heart function. The trial i…

This study collects information from 150 adults with antiphospholipid syndrome who had an artery clot in the past year. Participants are already on one of four blood-thinning treatments. Researchers will track who has another clot or a major bleed over two years to see which trea…

This trial tests two ways to treat ventricular tachycardia (a fast, dangerous heart rhythm) in people who have had a heart attack and have an implanted defibrillator. One method uses standard ablation inside the heart; the other also ablates outside the heart. The study will trac…

This study compares a drug-coated balloon to a standard drug-eluting stent in 496 young adults (ages 18–50) having a heart attack. The balloon delivers medication to open the artery without leaving a permanent implant, which may reduce long-term risks like blood clots and the nee…

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study tests whether repairing a leaky mitral valve soon after a heart attack can lower the chances of death or repeat hospital stays for heart failure. About 250 adults with moderate-to-severe valve leakage will either get the MitraClip procedure within 60 days or standard m…

This study tests a new way to use blood thinners after a heart attack. The goal is to lower the risk of serious bleeding while still preventing another heart attack or stroke. About 2,300 adults who had a heart attack and received a stent will take part. Half will get a reduced d…

This study tests an experimental drug called RTP-026 in 96 adults who have had a severe type of heart attack (STEMI). Participants receive three short infusions of the drug or a placebo. The goal is to see if RTP-026 can reduce heart muscle damage, measured by blood markers. The …

This study tests whether an artificial intelligence (AI) mobile app can help doctors give clot-busting medicine earlier to people having a severe heart attack (STEMI) when a hospital procedure isn't possible within 2 hours. About 3,356 participants will be randomly assigned to ge…

This study is testing whether a simple, non-drug procedure called remote ischemic preconditioning (RIPC) can help people recover better after a heart attack. RIPC involves briefly inflating a blood pressure cuff on the arm or leg to restrict blood flow, then releasing it, repeate…

This study tests whether taking spirulina (a microalgae) or seaweed (Gelidium corneum) supplements for 20 weeks can improve markers of heart health and change gut bacteria in people at high risk for heart disease. The trial includes 150 adults aged 50 or older with conditions lik…

This study compares two ways of delivering cardiac rehabilitation: in-person sessions and telehealth sessions. Cardiac rehab includes exercise training, health education, and counseling for people with heart conditions like heart attack, heart failure, or after heart surgery. The…

This phase 3 trial is testing whether two drugs—colchicine (used for gout) and ticagrelor (a blood thinner)—can prevent future strokes, heart attacks, and other vascular events in people who have already had a stroke. About 2,800 high-risk participants will be enrolled. The goal …

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to s…

This study explores whether performing a cardiac MRI (CMR) before the standard invasive coronary angiography (ICA) can accurately diagnose the cause of a suspected non-ST-elevation heart attack (NSTEMI). Currently, patients with NSTEMI often undergo an invasive angiogram, and if …

This study tests whether an AI tool that reads ECGs can safely and effectively help emergency doctors decide if a patient with chest pain is having a heart attack. About 4,670 adults with chest pain suspicious for a heart attack will be randomly assigned to either AI-assisted or …

This study tests whether a lab technique called polyethylene glycol (PEG) precipitation can tell the difference between a true heart attack and a harmless condition called macrotroponin, where troponin molecules clump together and falsely signal heart damage. Researchers will com…

This study will test a new, more accurate blood test (Troponin T high-sensitivity Gen 6) to see if it helps doctors diagnose heart attacks faster. Researchers will compare emergency department visit data from 19,500 patients before and after the test is introduced. The goal is to…

This study is testing whether artificial intelligence (AI) can predict or rule out a heart attack using data from standard blood tests. Researchers will analyze white blood cell properties from over 3,000 adults who come to the hospital with chest pain. The goal is to see if AI c…

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study is testing a new way to analyze blood samples to see if it can better tell when someone is having a heart attack. Current tests can be misleading in patients with other conditions like kidney failure. Researchers will look at how troponin T, a protein released during h…

This study tests whether an artificial intelligence (AI) tool can help doctors identify heart attacks that standard ECG tests miss. About 500 adults with chest pain but no clear signs of a heart attack on their initial ECG will be randomly assigned to get either AI-assisted or st…

This study is testing a new smartphone-connected 12-lead ECG device to see if it can accurately diagnose heart attacks (STEMI and NSTEMI) in people with chest pain. Researchers will compare the smartphone ECG readings to standard hospital ECGs in 1000 adults. The goal is to valid…

This study tests a new, quick blood test done right in the emergency room to rule out heart attacks in people with chest pain. The goal is to see if this faster test can get patients discharged sooner compared to the usual lab test, which can take an hour or more. About 1,500 adu…

This study tests a new imaging test (PET-CT scan) that can detect blood clots in the heart arteries from outside the body. Researchers will recruit 80 adults who recently had a heart attack to see if the scan can identify which heart attacks are caused by clots. The goal is to he…

This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest, without needing extra medication or heart monitoring. About 30 adults who have been revived after a cardiac arrest will get this special CT scan, and the results w…

This study explores a new blood test that looks for DNA fragments from damaged heart cells to detect active heart inflammation in people with sarcoidosis. Researchers will compare results from 120 participants, including healthy volunteers and those with known heart conditions. I…

This study tests new, faster MRI techniques to get detailed images of the heart muscle in people with heart conditions like cardiomyopathy, myocarditis, and ischemic heart disease. The goal is to improve diagnosis and treatment planning. About 240 adults who already need a heart …

This study tests a new, noninvasive device that uses ultra-sensitive magnetocardiography to detect heart attacks. Researchers will enroll nearly 4,000 healthy volunteers and chest pain patients to see if this magnetic scan can identify heart damage more accurately than current me…

This study tests a new CT scan that works without an ECG to quickly check for heart disease in people with chest pain and high troponin levels. About 230 adults will get this scan plus the standard invasive test to see if the new method is accurate. If successful, it could reduce…

This phase 3 study tests whether the drug olpasiran can prevent first major heart events (like heart attacks) in 11,000 people aged 50+ who have high levels of lipoprotein(a), a genetic risk factor. Participants receive either olpasiran or a placebo as a shot under the skin. The …

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This large study in Denmark is testing whether the shingles vaccine (Shingrix) can do more than prevent shingles—it may also lower the risk of heart attacks, strokes, and dementia. About 162,000 adults aged 65 and older will either get the vaccine or no vaccine, and researchers w…

This study compares two approaches for heart attack survivors with weak hearts: taking modern medications alone versus getting a defibrillator implant plus medications. The goal is to see if medication alone is as good at preventing sudden cardiac death. About 3,600 participants …

This study tests whether watching nature videos through virtual reality glasses can lower anxiety and improve vital signs like heart rate and blood pressure in people recovering from a heart attack in the intensive care unit. Half of the 50 participants will use VR glasses for a …

This study tests whether EMDR, a therapy that uses guided eye movements, can help people with PTSD caused by a heart attack. Sixty adults who had a heart attack and developed PTSD will receive eight weekly EMDR sessions. The goal is to see if EMDR reduces PTSD symptoms and might …

This study at Mayo Clinic tests whether using a CalmiGo device—a small inhaler-like tool that guides slow breathing and grounding—can improve blood vessel function and reduce heart disease risk in people recovering from a heart attack. One hundred adults in cardiac rehab will eit…

This study is testing whether a single intravenous dose of iron can improve quality of life and reduce frailty in adults aged 65 and older who have iron deficiency after a heart attack. About 538 participants will be randomly assigned to receive either the iron infusion or standa…

This study tests whether a home-based walking plan delivered through a mobile health app can reduce fear of movement (kinesiophobia) and improve physical function in people who have had a heart attack and lead a sedentary lifestyle. Eighty-eight participants will walk 15-30 minut…

This study tests whether a virtual reality system that helps move a virtual hand using muscle signals, combined with mild brain stimulation, can improve arm function in stroke survivors. 45 people who had a mild to moderate stroke will try this approach. The goal is to see if thi…

This study looks at whether adding core muscle exercises (like Pilates) to standard cardiac rehab helps heart attack or heart failure patients recover better. Sixty adults will be split into three groups: core training only, aerobic exercise only, or both combined. The goal is to…

This pilot study tests whether a device called IVS3 is tolerable and easy to use for arm recovery in people who had a stroke at least 6 months ago. The device uses mirrored video to create the illusion that the affected arm is moving. Researchers will track how many sessions part…

This study looks at how certain white blood cells, called monocytes, react to injury from a heart attack or ischemic stroke. Researchers want to learn how these cells sense danger signals and produce substances that might help heart muscle and brain tissue heal. The study involve…

This study looks at whether two proteins released when heart muscle is damaged can be detected in the blood during a heart attack. Researchers want to see if higher levels of these proteins are linked to a greater chance of developing heart failure afterward. The study includes a…

This study investigates whether the types and behavior of certain immune cells (neutrophils and monocytes) in the blood are linked to how the heart repairs itself after a heart attack. Researchers will follow 50 adults who have had a severe type of heart attack and are scheduled …

This study looks at whether combining a new type of CT scan with a blood test for tiny molecules called microRNAs can better predict heart damage after a heart attack. Researchers will follow 95 patients who had a severe heart attack and measure changes in their heart size over s…

This study explores whether a special PET/MR scan can detect early signs of heart muscle damage after a heart attack. Researchers will scan 25 adults about 10 days after their heart attack and then track their heart function with MRI scans at 3 and 6 months. The goal is to see if…

This study observes up to 350 patients who had a heart attack complicated by cardiogenic shock and received an Impella CP heart pump during artery-opening procedures. Researchers will track safety issues like major bleeding, limb problems, and kidney injury, as well as survival a…

This study is a registry that collects information from all suspected heart attack cases in Tomsk, Russia. It aims to track how many people die within 28 days and one year after a heart attack. No new treatments or drugs are being tested—just observation and data gathering.

This study tests whether a new referral program helps more Veterans with heart conditions get into cardiac rehabilitation. Researchers will compare referral and attendance rates before and after the program starts at three VA hospitals, involving 816 participants over 12 months. …

This study looks at 300 people with rapid atrial fibrillation (a fast, irregular heartbeat) to understand why some have heart damage. Researchers will use blood tests and heart scans to see if blocked arteries are the cause. The goal is to improve how doctors diagnose and manage …

This registry will collect health information from 8,000 patients with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track what treatments patients receive and how they fare, including survival rates in the hosp…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This observational study follows 800 adults admitted to a cardiology department with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will review medical records from 2017 onward to see how treatments and survival rates…

After a heart attack, patients face a high risk of dangerous heart rhythms, but current monitoring methods may miss them. This trial tests whether a small implantable cardiac monitor (ICM) placed under the skin can catch these rhythms earlier and help doctors adjust treatment. Tw…

This study looks at people who had a heart attack and also developed a dangerous heart rhythm (ventricular arrhythmia) while still in the hospital. Researchers want to learn more about how these patients are treated and how many die after leaving the hospital. The study does not …

This study gives low-dose interleukin-2 to people who have had a heart attack and are scheduled for bypass surgery. Researchers want to see how the drug affects certain immune cells (regulatory T cells) inside heart tissue compared to blood. The goal is to understand whether thes…

This study is a large registry that will collect information from 10,000 adults who undergo exercise echocardiography (a heart ultrasound during exercise) as part of their regular care. The goal is to better understand how the heart works during exercise in people with various he…

This study is following 300 people who have had a severe type of heart attack (STEMI). Researchers will collect blood, urine, and stool samples, and perform MRI scans to look for new biological and imaging markers that could help predict long-term outcomes. The goal is to better …

This study examines how frailty and other health factors affect the short- and long-term outlook for people aged 75 and older who are hospitalized for a heart attack or unstable angina. Researchers will compare two treatment approaches—a procedure to open blocked arteries versus …

This study looks at 150 adults who had a heart attack but whose main heart arteries were not blocked. Researchers will use special imaging and pressure tests to check for problems in the tiny blood vessels of the heart. The goal is to see if these microvascular issues lead to wor…

This study is looking for clues in the blood that could predict if a person's heart will change shape or develop serious problems after a major heart attack. Researchers will collect blood samples and perform heart ultrasounds on 1,000 patients over six months. The goal is to fin…

This study looks at whether gum disease is more common in people who have had a heart attack. Researchers will compare the gum health of 320 adults—some who recently had a heart attack and some who haven't—to see if there's a link. The goal is to gather information that could lea…

This registry is following 2,000 people with chronic coronary artery disease who are taking long-term blood thinners (antiplatelet or anticoagulant drugs). The goal is to track how often serious bleeding or clotting events (like heart attacks or strokes) occur. By understanding t…

This study looks at whether long-term stress, measured by cortisol levels in hair, is linked to cardiac arrest. Researchers will take a small hair sample from 136 patients who had a cardiac arrest or heart attack. The goal is to see if higher stress levels over the past three mon…

This study is testing a new type of MRI scanner coil designed specifically for the heart. Researchers want to see if it can take clearer pictures of heart damage in people who have had a heart attack. The study will involve 150 participants, including healthy volunteers and heart…

This study looks at whether moderate alcohol consumption (about one drink per day) affects heart function in people who recently had a heart attack. 220 participants will either drink moderately or abstain for 3 months, and their heart pumping ability will be measured by ultrasou…

This study looks at blood cells called platelets in people who have had a heart attack. Researchers want to understand how these cells work and what genes are involved. They will compare heart attack patients with healthy people and those with stable chest pain. The goal is to le…

This study is testing whether a detailed CT scan of the heart and arteries can better predict future heart attacks, heart failure, or dangerous heart rhythms in people who have already had a heart attack and a stent placed. Researchers will follow 1,000 patients for up to five ye…

This study tests whether using artificial intelligence to read electrocardiograms (ECGs) helps doctors diagnose and treat a severe type of heart attack (occlusion myocardial infarction) more quickly. About 212,000 emergency room patients will be involved, and the study will also …

This study looks at how common mild depression is in people who have had their first heart attack. Researchers will follow 100 patients for 12 months to see if these mild symptoms affect recovery, heart health, and quality of life. The goal is to better understand the link betwee…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study tracks 774 adults who develop a new type of irregular heartbeat (atrial fibrillation) while hospitalized for a heart attack. Researchers will use continuous electronic monitoring to measure how much time patients spend in this abnormal rhythm. The goal is to see if the…

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study follows 15,000 adults aged 45+ (or 65+ without risk factors) who are having same-day noncardiac surgery. The goal is to learn how often heart problems and other complications happen after these surgeries, and to create tools that help doctors predict and reduce risks. …

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study tests whether combining detailed heart scans (MRI/CT) with electrical mapping can help doctors better target and treat scar-related ventricular tachycardia (VT), a dangerous heart rhythm. Twenty people with VT who already have an implanted defibrillator will undergo ex…

This study looks at whether people who have a heart attack can be discharged from the hospital after about 24 hours instead of the usual 36 hours or more. Researchers want to see if early discharge is just as safe and does not increase the risk of death, another heart attack, or …

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study follows 20,000 heart attack patients who are discharged early from the hospital after a minimally invasive procedure. Researchers want to see how well medications are adjusted, track major heart events, and measure quality of life over one year. No new treatment is giv…

This study tests whether a special nurse-led education program helps people who have had a heart attack feel more confident managing their health. Participants will either receive standard care or extra support including personalized advice on diet, exercise, and quitting smoking…

This study tracks 1,650 people who had a first heart attack to see if men and women's hearts change shape and size differently during recovery. Using repeated heart scans (echocardiograms and MRIs), researchers aim to understand why women tend to have worse outcomes like heart fa…

This study looks at 200 people having a heart attack to see if a special camera (OCT) inside the arteries correctly identifies the type of plaque that caused the attack. Researchers will compare the camera images with the actual plaque material removed during a standard procedure…

This study is creating a large registry of people who have had a spontaneous coronary artery dissection (SCAD), a type of heart attack. Researchers will collect medical history and follow participants over time to learn more about risk factors, treatments, and long-term outcomes.…

This study is following 1,000 people who have had a severe type of heart attack called STEMI. Researchers are collecting detailed medical data to understand how different organs talk to each other during recovery. The goal is to find key signals that could lead to better treatmen…

This study looks at whether a special heart MRI can help predict future heart attacks, strokes, or other serious heart problems in people with ischemic heart disease. Researchers will review medical records from 1,000 adults who have already had this MRI. The goal is to better un…

This study looks at a severe condition called mixed cardiogenic-vasoplegic shock, where the heart fails to pump and blood vessels widen too much. Researchers will review medical records from 2,500 patients in three French hospitals to understand who gets this condition and how th…

This study will use cardiac MRI scans to measure heart tissue in 2000 people with various heart conditions, such as heart attacks, cardiomyopathies, and myocarditis. The goal is to create a reference map of normal and abnormal tissue values, which may help doctors diagnose diseas…

This study follows 314 women under 50 who had a heart attack in France. Researchers will track their health, stress, anxiety, and quality of life over several years. The goal is to learn more about long-term risks and recovery, not to test a new treatment.

This observational study enrolls 5,000 adults hospitalized with acute coronary syndrome in Italy. Researchers will track how often doctors follow European quality indicators, like timely artery-opening procedures and proper discharge medications. Participants are followed for 12 …

This study is following 300 people in Norway who have had a spontaneous coronary artery dissection (SCAD), a rare cause of heart attacks, especially in women. Researchers will use scans, blood tests, and questionnaires to track their health for one year. The goal is to better und…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to better understand how these conditions interact and to find ways to predict and improve patient outcomes. No new treatments or procedure…

This study investigates why doctors often do not use advanced imaging tools like OCT or IVUS during complex heart stent procedures, even though guidelines recommend them. Researchers will survey doctors and review records from 1,000 patients across multiple centers. The goal is t…

This registry is following 5,000 people who had a heart attack and were treated with medications, stents, or bypass surgery at Asan Medical Center in Korea. Researchers are tracking deaths, repeat heart attacks, and other major events over the long term to understand which treatm…

This study uses a special type of MRI called diffusion tensor imaging to look at the structure of heart muscle in people with heart failure, recent heart attacks, or thickened heart walls. Researchers want to see how the heart's muscle fibers change over time, which may help expl…

This study looks at whether giving the beta-blocker landiolol early, during a heart attack, can reduce the amount of heart muscle that dies. It will follow 100 patients who get either landiolol or a standard oral beta-blocker, based on their doctor's choice. The main goal is to m…

This study looks at whether people having urgent heart catheterization need to fast beforehand. 400 patients with chest pain or mild heart attacks will be randomly assigned to either fast as usual or eat and drink normally. Researchers will measure comfort and safety to see if sk…

This study will check whether cholesterol test results are reliable throughout a hospital stay for a heart attack. Researchers will measure cholesterol levels in 100 patients at the start of their stay, two days later, and again 4-6 weeks after discharge. The goal is to see if a …

This study reviews medical records of 200 adults who came to the ER with a heart attack or unstable chest pain. It compares what happens when patients get two blood thinners (aspirin plus another) in the ER versus waiting to give the second one in the catheterization lab. The goa…

This study looks at 1000 adults (ages 40-80) with high cholesterol but no heart symptoms. Researchers want to see if using special scans of the neck and heart arteries can find hidden plaque better than the standard risk calculator. The goal is to improve early detection and prev…

This study is collecting information from 3,000 people who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how effective and safe the balloon is in real-world use, including for different types of blockages and patient conditions. Research…

This study is a registry that will follow 3000 people who had a heart attack but no blocked arteries (MINOCA). The goal is to learn more about this condition, improve diagnosis, and understand long-term outcomes. Participants will be tracked over time to see how they are doing an…

This study tracks 180 adults having elective lower back surgery to see how often heart injury occurs within 30 days after the operation. Researchers will also identify factors that make this injury more likely. The goal is to better understand and potentially prevent heart compli…

This study looks at 1,600 people who recently had a heart attack to see if a common blood test (the neutrophil-to-lymphocyte ratio, or NLR) can help predict who is at higher risk of dying or having another heart problem within 6 months. Researchers will measure NLR from blood sam…

This study tracks 100 heart attack survivors to see how many develop anxiety or posttraumatic stress disorder (PTSD) in the long run. Researchers will measure early pain, stress, and anxiety levels to understand their impact on mental health. The goal is to identify those at risk…

This study looks at 320 people who had a severe heart attack (STEMI) and have blockages in other arteries besides the one that caused the attack. Researchers will use CT scans and blood tests to see which blockages are likely to cause future problems. The goal is to find out if o…

This study is tracking 1,000 adults with psoriasis to see how their skin condition relates to heart disease. Researchers will use blood tests and heart imaging to find early signs of heart problems. The goal is to better understand why people with psoriasis have higher rates of h…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…

This study follows 15,000 people who survived a heart attack and were part of an earlier project. Researchers will call participants at 3 and 5 years after leaving the hospital to check their health, medications, and whether they had any major heart problems like another heart at…