Could a cheap heart drug prevent 'No-Reflow' during heart attack treatment?

NCT ID NCT07536802

Recruiting now Disease control Sponsor: National Institute of Cardiovascular Diseases, Pakistan Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving the drug adenosine just before emergency angioplasty (PCI) can improve blood flow in heart attack patients. About 1,148 adults having a severe type of heart attack (STEMI) will either receive adenosine or standard care. The goal is to see if adenosine reduces the 'no-reflow' problem, where blood still doesn't flow well even after opening the blocked artery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: adenosine
What this could lead to: If it works, this could point toward a simple pre-treatment to reduce heart muscle damage during emergency angioplasty for heart attacks.
What could go wrong: This is a single-center trial, so results may not apply everywhere. Adenosine can cause temporary heart block or low blood pressure, and the benefit over standard care is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction No-Reflow Phenomenon ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYOCARDIAL INFARCTION CORONARY SLOW FLOW NO-REFLOW PHENOMENON ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (STEMI)

Contacts and locations

Locations

National Institute of Cardiovascular Diseases
RECRUITING

Karachi, Sindh, 75510, Pakistan
National Institute of Cardiovascular Diseases
RECRUITING

Karachi, Sindh, 75510, Pakistan

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