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Could a quick cholesterol shot after a heart attack save lives?

NCT ID NCT07208006

Recruiting now Disease control Sponsor: Shanghai Zhongshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a powerful cholesterol-lowering drug (PCSK9 inhibitor) very early in the hospital, right after a heart attack, can reduce the chance of another heart attack, stroke, or death over the next year. About 1,500 adults with multiple blocked arteries will be split into two groups: one gets standard care, and the other gets the PCSK9 shot plus standard care. The goal is to see if the early, strong treatment helps stabilize dangerous plaques and prevents future heart problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PCSK9 monoclonal antibody (a type of drug that lowers cholesterol quickly and strongly)
What this could lead to
If it works, this could point toward a new standard treatment to prevent repeat heart attacks and strokes in people with multiple blocked arteries.
What could go wrong
This is a large but still early-stage trial, and the drug may not reduce heart events more than standard care. It also requires injections and may have side effects like injection-site reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYOCARDIAL INFARCTION (AMI)

Contacts and locations

Locations

  • Zhongshan Hospital, Fudan University

    RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

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Other studies related to the condition(s) this trial covers.