Shanghai Zhongshan Hospital

This study is for adults with a type of esophageal cancer (squamous cell carcinoma) that can potentially be removed with surgery. The goal is to see if giving a combination of immunotherapy (tislelizumab) and chemotherapy (carboplatin and nab-paclitaxel) before any procedure can …

This study looks at how to help people with obesity keep weight off after losing it with a high-dose weight-loss drug called Mazdutide. About 420 adults will try either a year of intensive lifestyle changes, a lower weekly dose of Mazdutide, or both. The goal is to find a safe an…

This study tests a new combination of drugs for people with advanced intrahepatic cholangiocarcinoma, a type of liver cancer that cannot be removed by surgery. About 35 participants will receive an oral drug called chidamide along with standard chemotherapy and immunotherapy. The…

This study is testing a drug called surufatinib in 350 adults with advanced neuroendocrine tumors, a rare type of cancer. The goal is to see how well the drug controls the disease and what side effects occur when used in regular medical practice. Participants take the drug daily …

This study looks at whether a fluid called balanced gelatin is better than the usual fluid for people with sepsis who need emergency abdominal surgery. Sepsis causes dangerous fluid loss, and this gelatin fluid might help keep blood pressure stable and protect organs. About 318 a…

This study tests whether a drug called indobufen works better than aspirin in older adults (over 65) who have had a heart attack or unstable angina and received a stent. About 2,800 participants will take either indobufen plus ticagrelor or aspirin plus ticagrelor for one year. T…

This study is testing whether adding immunotherapy drugs (anti-PD-1/PD-L1 antibodies) to standard chemotherapy (gemcitabine and cisplatin) can help people with advanced bile duct cancer that cannot be removed by surgery. The trial will include about 50 adults and will check for s…

This early-phase study tests a new treatment called HN2301 for people with refractory Graves' disease, a thyroid condition that doesn't improve with standard medication. HN2301 works by turning the body's own immune cells into cancer-fighting-like cells inside the body to target …

This study tests a combination of two types of drugs (anti-PD-1/PD-L1 and anti-VEGF) in 50 adults with advanced liver cancer that cannot be surgically removed. The goal is to see if the combination is safe and can shrink or control tumors. Participants must have a life expectancy…

This study tests whether giving a powerful cholesterol-lowering drug (PCSK9 inhibitor) very early during a hospital stay for a heart attack can reduce the risk of another heart attack, stroke, or death over the next year. About 1,500 adults who had a recent heart attack and have …

This early-phase study tests a new treatment for type 1 diabetes using specially engineered immune cells (CAR-T cells) that target and calm the immune attack on the pancreas. Nine adults with early-stage type 1 diabetes will receive the therapy and be monitored for safety, blood …

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with severe calcium buildup in their heart arteries. After doctors first soften the calcium with special tools, participants are randomly assigned to receive either the balloon or the …

This early-stage study tests a new treatment called RD06-05, made from donor immune cells, for people with Graves' disease that hasn't improved with standard care. The goal is to see if it can safely stop the immune system from attacking the thyroid, allowing patients to stop thy…

This study tests whether asiaticoside, a compound from the Centella asiatica plant, can help adults with overweight or obesity lose weight. About 30 participants will take asiaticoside tablets for 12 weeks. Researchers will measure changes in metabolic rate and body weight to see…

This study tests whether montelukast, a common asthma medication, can reduce heart muscle damage and improve recovery in 512 adults who had a severe type of heart attack (anterior STEMI) and underwent emergency angioplasty. Participants receive montelukast or a placebo alongside …

This study tests whether giving a combination of three drugs (envafolimab, albumin-bound paclitaxel, and carboplatin) before surgery can help people with advanced esophageal cancer. The goal is to shrink or eliminate the tumor before the operation, improving the chances of comple…

This phase 3 trial tests whether a new chemotherapy combination (NALIRIFOX plus targeted therapy) works better than the standard FOLFOX plus targeted therapy for people with metastatic colorectal cancer that cannot be removed by surgery. The study includes 144 adults who have not…

This study looks at whether giving a continuous 24-hour intravenous infusion of lidocaine (a common local anesthetic) can lower the chance of serious lung complications after emergency abdominal surgery for an infection inside the belly. About 428 adults having emergency surgery …

This study tests whether adding surgery to a drug combination (immunotherapy plus chemotherapy, with or without targeted therapy) helps people with stomach cancer that has spread to a few other places. About 84 adults aged 18-79 will be randomly assigned to get either the drugs a…

This study tests a new imaging tool called µQFR to see how well it can detect leftover blockages in side branches of heart arteries after a single stent is placed. About 290 adults with complex coronary artery disease will be enrolled. The goal is to see if µQFR can accurately me…

This study tests whether fecal microbiota transplantation (FMT) can reduce symptoms of irritable bowel syndrome (IBS). About 102 adults with hard-to-treat IBS will receive FMT via oral capsules or a tube once a month for three months. Researchers will track symptom changes, quali…

This study compares two ways of giving oxygen during a sedated stomach scope in people with visceral obesity (belly fat). The goal is to see if a high-flow nasal cannula works better than a standard face mask at preventing low oxygen levels. About 200 adults will take part, and r…

This study looks at whether a non-invasive blood pressure monitor can accurately detect blockages in the heart's main pumping chamber in people with hypertrophic cardiomyopathy. Researchers will compare blood pressure readings with standard heart ultrasound measurements in 800 ad…

This observational study follows 189 adults who experienced delirium in the ICU to understand how it impacts their physical, mental, and cognitive recovery after moving to a regular hospital ward. Researchers will use questionnaires to track problems like memory loss, depression,…

This study looks at people with coronary heart disease who are already on intensive cholesterol-lowering therapy. Even with strong treatment, some patients still have worsening artery plaque. The researchers want to understand if leftover cholesterol or inflammation is the cause.…

This study collects blood, tissue, and imaging data from 1,000 people with portal hypertension (high blood pressure in the liver) who have or had variceal bleeding. The goal is to create a large database of genetic, imaging, and other health information to help doctors predict an…

This study is looking at 1,516 people with diabetes to see if a new imaging method can spot dangerous fatty plaques in heart arteries. Participants will get a special camera inside their arteries to measure plaque features. The goal is to find which plaques might cause future hea…

This study compares two types of surgery for people with advanced stomach cancer: laparoscopic (small incisions with a camera) and open (larger incision). About 1,018 participants will be randomly assigned to one of the two surgeries. The main goal is to see which approach leads …

This study is a registry that will follow 6,000 people who had a heart attack and received emergency angioplasty (a procedure to open blocked heart arteries) at Zhongshan Hospital in Shanghai. Researchers will collect information on patients' health, treatments, and outcomes duri…

This study looks at people with cirrhosis (scarred liver) who also have blood clots in the main vein to the liver and enlarged veins in the stomach or esophagus. Researchers will track 1500 participants over time to see what factors help the clot dissolve. The goal is to better u…

This study will test a new, faster CT scanner to see if it can better detect risky plaques and measure blood flow in the heart arteries of 500 adults with known or suspected coronary artery disease. Researchers will compare the CT results with standard tests like angiography and …

This study looks at how an 8-week exercise program affects metabolism in 40 overweight or obese adults with prediabetes. Researchers will measure changes in body fat, blood sugar, and other health markers, and use advanced cell analysis to understand the molecular changes. The go…