Shanghai Zhongshan Hospital

This study is for people with advanced bile duct cancer that cannot be removed by surgery. It tests a combination of two chemotherapy drugs (gemcitabine and cisplatin) plus immunotherapy (anti-PD-1/PD-L1 antibodies) as a first treatment. The goal is to see if this combination is …

This study tests whether montelukast, a drug already used for asthma, can reduce heart muscle damage in people having a major heart attack. About 512 adults with a specific type of heart attack will receive montelukast or a placebo alongside standard treatment. The goal is to see…

This early-phase study tests a new treatment called HN2301 for people with refractory Graves' disease, a thyroid condition that doesn't get better with standard medication. HN2301 uses a special injection to turn the body's own immune cells into cancer-fighting-like cells that ta…

This study tests whether giving a powerful cholesterol-lowering drug (PCSK9 inhibitor) very early in the hospital, on top of standard care, can reduce the risk of another heart attack, stroke, or death in people who just had a heart attack and have blockages in multiple heart art…

This study tests a combination of two types of drugs (anti-PD-1/PD-L1 and anti-VEGF) in 50 adults with advanced liver cancer that cannot be removed by surgery or has spread. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. Participants mu…

This study compares two surgical methods for removing the entire stomach in people with locally advanced gastric cancer. About 1,018 adults aged 18-75 with tumors in the middle or upper stomach will be randomly assigned to either laparoscopic (keyhole) or open surgery. The main g…

This study tests whether giving a continuous 24-hour intravenous infusion of lidocaine (a common local anesthetic) can lower the risk of serious lung complications after emergency abdominal surgery for an infection inside the belly. About 428 adults undergoing such surgery will b…

This study tests if a fluid called balanced gelatin is better than standard fluids for people with sepsis (a severe infection) who need emergency abdominal surgery. Sepsis causes fluid loss, leading to low blood pressure and organ problems. The trial will compare the two fluids i…

This study is for people with stomach cancer that has spread to a few other places in the body. It tests whether adding surgery to remove the main tumor and some of the spread, along with other local treatments, to a combination of immunotherapy and chemotherapy helps people live…

This study looks at two ways to treat severe calcium buildup in heart arteries. About 656 adults with hardened arteries will first get a procedure to break up the calcium, then be randomly assigned to receive either a drug-coated balloon or a drug-eluting stent. Researchers will …

This early-phase study tests a new treatment called CD7-targeted CAR-T cells in 9 adults with early type 1 diabetes. The therapy uses specially engineered immune cells to target and calm the immune attack on the pancreas, aiming to preserve the body's ability to make insulin and …

This study tests whether a drug called indobufen works better and causes fewer bleeding problems than aspirin in people over 65 who have had a heart attack or unstable angina and received a stent. About 2,800 participants will take either indobufen or aspirin along with another b…

This study tests a combination of the immunotherapy drug envafolimab and two chemotherapy drugs given before surgery for people with a type of esophageal cancer that can be removed. The goal is to see if this treatment can shrink or eliminate the tumor before the operation. About…

This study looks at the best way to maintain weight loss after initial success with a high-dose weight-loss drug (mazdutide). Researchers will compare a year of intensive lifestyle changes, a lower weekly dose of mazdutide, or both, in 420 adults with obesity. The goal is to find…

This study tests a powerful mix of treatments for people with advanced liver cancer that cannot be surgically removed. The approach combines tumor destruction (ablation), targeted therapy (lenvatinib), immunotherapy (tislelizumab), and a procedure that blocks the tumor's blood su…

This study tests a new combination of drugs for people with advanced intrahepatic cholangiocarcinoma, a type of liver cancer that cannot be removed by surgery. About 35 participants will receive an oral drug called chidamide along with standard chemotherapy and immunotherapy. The…

This study is for adults with a type of esophageal cancer (squamous cell carcinoma) that can potentially be removed with surgery. The goal is to see if giving a combination of immunotherapy (tislelizumab) and chemotherapy (carboplatin and nab-paclitaxel) before any procedure can …

This study is testing a drug called surufatinib in 350 adults with advanced neuroendocrine tumors, a rare type of cancer. The goal is to see how well the drug controls the disease and what side effects occur when used in regular medical practice. Participants take the drug daily …

This study tests whether a new chemotherapy combination (NALIRIFOX) plus targeted therapy works better than the standard treatment (FOLFOX) plus targeted therapy for people with metastatic colorectal cancer that cannot be removed by surgery. About 144 adults who have not had prio…

This early-stage study tests a new treatment called RD06-05, made from donor immune cells, for people with Graves' disease that hasn't improved with standard care. The goal is to see if it can safely stop the immune system from attacking the thyroid, allowing patients to stop thy…

This study tests whether asiaticoside, a compound from the Centella asiatica plant, can help adults with overweight or obesity lose weight. About 30 participants will take asiaticoside tablets for 12 weeks. Researchers will measure changes in metabolic rate and body weight to see…

This study tests a new imaging method called µQFR to see if it can accurately detect leftover blockages in side branches of heart arteries after a single stent is placed. About 290 adults with coronary artery disease will have their results compared to the standard pressure-wire …

This study looks at whether a simple, non-invasive blood pressure monitor can detect blockages in the heart's main pumping chamber in people with hypertrophic cardiomyopathy. Researchers will compare the blood pressure readings with standard measurements in 800 adults with and wi…

This study compares two ways of giving oxygen during a sedated stomach scope (gastroscopy) in 200 people with belly obesity. The goal is to see if a high-flow nasal cannula works better than a standard face mask at preventing low oxygen levels. Participants must have a body mass …

This study tests whether fecal microbiota transplantation (FMT) can reduce symptoms of irritable bowel syndrome (IBS). About 102 adults with hard-to-treat IBS will receive FMT via oral capsules or a tube once a month for three months. Researchers will track symptom changes, quali…

This study will follow 6,000 people who had a heart attack and received a stent (a small tube to open blocked arteries) at Zhongshan Hospital. Researchers will collect information on their health during the hospital stay and for up to two years after. The goal is to better unders…

This study is creating a large collection of medical data and samples from 1,000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and artificial intelligence to bette…

This study looks at heart plaque in people with diabetes using a special camera that combines two imaging methods. Researchers want to see if a new measurement can help predict serious heart problems like heart attacks or chest pain. About 1,500 participants will be followed for …

This study looks at why some people with coronary heart disease continue to have plaque buildup in their arteries even when taking strong cholesterol-lowering medication. Researchers will follow 900 adults aged 18 to 75 who have had a stent placed and have mild blockages nearby. …

This study follows 1500 people with cirrhosis and varices who also have a blood clot in the portal vein (the main vein to the liver). Researchers will track who gets better and what factors help the clot dissolve over 1 to 5 years. The goal is to better understand the disease and…

This study will test a new, high-speed CT scanner to see if it can better detect dangerous plaques in heart arteries and measure blood flow, all without invasive procedures. Researchers will enroll 500 adults with known or suspected coronary artery disease. The goal is to see if …

This observational study follows 189 adults who experienced delirium in the ICU to understand how it impacts their physical, mental, and cognitive recovery after moving to a regular hospital ward. Researchers will use questionnaires to track problems like memory loss, depression,…

This study looks at how an 8-week exercise program affects metabolism in 40 overweight or obese adults with prediabetes. Researchers will measure changes in body fat, blood sugar, and other health markers, and use advanced cell analysis to understand the molecular changes. The go…