Shanghai Zhongshan Hospital

This study is testing how well an oral medication called surufatinib works for people with advanced neuroendocrine tumors in real-world medical settings. About 350 patients will take the medication daily and be monitored for tumor response, side effects, and quality of life. The …

This study is testing whether adding immunotherapy drugs to standard chemotherapy is safe and effective for people with advanced bile duct cancer. It will involve about 50 adult patients who cannot have surgery to remove their cancer. The goal is to see if this combination can be…

This early study is testing a new type of treatment called HN2301 for people with Graves' disease that hasn't responded well to standard medications. The treatment aims to use the patient's own immune cells, modified inside the body, to target and control the disease. A small gro…

This study is comparing two types of IV fluids given during and after emergency abdominal surgery in adults with sepsis, a life-threatening infection. The goal is to see if a fluid called 'balanced gelatin' helps patients maintain better blood pressure and fluid balance than the …

This study is testing if a two-part strategy works better for advanced stomach cancer that has spread a little. One group gets strong drug therapy (immunotherapy plus chemo) followed by surgery to remove all visible tumors. The other group gets the drug therapy alone. The goal is…

This is an early-stage study to test the safety of a new type of immune cell therapy (CAR-T) for people with advanced liver cancer that has come back or hasn't responded to standard treatments. Researchers will give a small number of participants modified immune cells designed to…

This study aims to find out if a less invasive 'keyhole' surgery (laparoscopic) is as effective as traditional open surgery for treating advanced stomach cancer. It will follow over 1,000 patients to compare their long-term survival, cancer recurrence, and recovery after surgery.…

This study is testing whether asiaticoside, a compound from the traditional herb Centella asiatica, can help adults with overweight or obesity. Researchers will give participants asiaticoside tablets for 12 weeks to see if it helps with weight loss, body fat, and metabolic health…

This study compares two different chemotherapy combinations for people newly diagnosed with advanced colorectal cancer that has spread. Researchers want to see if a newer combination called NALIRIFOX works better and is safer than the standard FOLFOX treatment, when both are give…

This study aims to see if a drug-coated balloon works as well as a drug-coated stent for treating severely hardened heart arteries. Researchers will compare the two treatments in about 656 people after the hard plaque is first broken up. They will track heart-related problems and…

This early-stage study is testing a new type of treatment called CAR-T cell therapy for people with Graves' disease that hasn't responded well to standard medications. The therapy, which is borrowed from cancer treatments, aims to reset the patient's immune system to stop it from…

This study aims to find the safest and most effective blood-thinning drug combination for people over 65 who receive a heart stent after a heart attack or severe chest pain. It will compare a newer drug (indobufen) with the standard drug (aspirin), both taken with a second medica…

This study is testing if giving a powerful cholesterol-lowering drug (a PCSK9 inhibitor) very early in the hospital, right after a heart attack, can help prevent future heart problems. It will involve about 1,500 people who have had a heart attack and have multiple blocked arteri…

This study is testing whether a special high-flow nasal oxygen device works better than a standard oxygen mask at keeping oxygen levels safe during sedated stomach exams in patients with significant belly fat. People with high visceral fat are at greater risk for breathing proble…

This study aims to understand why some people with coronary heart disease continue to develop plaque buildup in their arteries despite taking strong cholesterol-lowering medications. Researchers will follow 900 patients who have had heart procedures, using special ultrasound imag…

This study is testing whether a treatment called fecal microbiota transplantation (FMT) can help people with irritable bowel syndrome (IBS) that hasn't improved with standard treatments. About 102 participants will receive healthy donor gut bacteria, given as capsules or through …

This study is testing a new three-drug combination given before surgery for locally advanced esophageal cancer. The goal is to see if this treatment can shrink or eliminate the tumor to make surgery more successful and reduce the chance of the cancer coming back. It is for adults…

This study is testing whether giving cancer-fighting drugs before a procedure can shrink tumors enough to allow doctors to remove esophageal cancer using a scope through the mouth, avoiding major surgery to remove the esophagus. It will involve about 60 adults with a specific typ…

This study is testing if montelukast, a common asthma and allergy medication, can help protect the heart in people who have just had a severe type of heart attack (anterior STEMI). Researchers want to see if giving this drug alongside standard stent treatment can reduce heart dam…

This study is testing a combination of two types of drugs for adults with advanced liver cancer that cannot be removed by surgery. The goal is to see if using these drugs together is safe and can help control the cancer. One drug aims to starve the tumor by blocking its blood sup…

This study is testing a new, high-resolution CT scanner to see if it can better identify dangerous, unstable plaque in heart arteries and assess blood flow problems without invasive procedures. It will enroll 500 adults with suspected or known heart disease or type 2 diabetes. Th…

This study is testing if a simple, wearable arm cuff that measures blood pressure can accurately detect a dangerous blockage in the heart's main pumping chamber. The test is for people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researcher…

This study is testing a computer-based tool called µQFR that analyzes standard heart scan images. The goal is to see if it can accurately tell when a smaller side-branch artery is still blocked enough to need treatment after a main artery has received a stent. Researchers will en…

This study aims to collect detailed medical information and samples from 1000 patients with portal hypertension, a condition of high blood pressure in the liver. The goal is to build a large database to help researchers understand why some patients experience dangerous bleeding f…

This study is creating a detailed registry of 6,000 heart attack patients who received emergency artery-opening surgery at Zhongshan Hospital. Researchers will track patients for up to two years after their procedure to understand what complications occur and how well patients re…

This study is testing a new, detailed type of heart scan to see if it can better identify dangerous, fatty buildups (plaques) in the arteries of people with diabetes and heart disease. Researchers will follow about 1,500 participants for two years to see if the scan results can p…

This study aims to understand what factors help or hinder the natural resolution of dangerous blood clots in the main vein of the liver (portal vein) in patients with advanced cirrhosis and swollen veins in their esophagus. Researchers will look back at and follow 1,500 patients …

This study aims to understand the biological reasons why exercise helps people with prediabetes. Researchers will enroll 40 overweight or obese participants with prediabetes in an 8-week exercise program. They will measure changes in weight, body fat, and blood markers, and analy…

This study aims to understand the recovery challenges patients face after experiencing delirium in the Intensive Care Unit (ICU). Researchers will follow 189 patients as they move from the ICU to a regular hospital ward, tracking their physical abilities, thinking skills, and men…