Shanghai Zhongshan Hospital

This study tests a combination of four drugs—isatuximab, bortezomib, lenalidomide, and dexamethasone (Isa-VRd)—in people newly diagnosed with multiple myeloma who are not eligible for a stem cell transplant. The goal is to see how well the regimen controls the disease and what si…

This early-phase trial tests a single inhaled dose of a lab-made protein (Rh-KGF-2) in 24 adults with moderate to severe ARDS who are on ventilators. The goal is to see if the drug is safe and tolerable, and to find the right dose. Participants are split into three dose groups, w…

This study tests whether combining two drugs, teclistamab and daratumumab, can help people newly diagnosed with both multiple myeloma and light chain amyloidosis. About 30 adults will receive the treatment for up to 24 cycles. The goal is to see if the combo improves survival wit…

This early-phase study tests a new cell therapy for people with advanced biliary tract cancer (bile duct or gallbladder cancer) that has not responded to standard treatments. The therapy uses the patient's own immune T cells, enhanced with a protein called CD160 to better target …

This study tests a new weekly injection called HEC88473 in 30 women with polycystic ovary syndrome (PCOS). The drug targets two pathways to improve hormone levels and menstrual cycles. Researchers will track changes in free androgen index and menstrual regularity over 24 weeks.

This study tests a powerful combination of treatments for people with advanced liver cancer that cannot be surgically removed. The approach uses heat-based ablation to destroy the main tumor, followed by targeted therapy (lenvatinib), immunotherapy (tislelizumab), and a procedure…

This study tests a new combination of drugs for people with advanced intrahepatic cholangiocarcinoma, a type of liver cancer that cannot be removed by surgery. About 35 participants will receive an oral drug called chidamide along with standard chemotherapy and immunotherapy. The…

This study tests whether giving a continuous 24-hour intravenous infusion of lidocaine (a common local anesthetic) can lower the risk of serious lung complications like pneumonia or the need for a breathing machine after emergency abdominal surgery for infection. About 428 adults…

This early-phase trial tests a single infusion of genetically modified immune cells (CAR-T cells) designed to target and calm the immune attack that causes type 1 diabetes. Nine adults with early-stage type 1 diabetes will receive the cells and be monitored for safety, insulin ne…

This study tests whether a low dose of the weight-loss drug mazdutide, an intensive lifestyle program, or both can help people with obesity maintain weight loss for a year after initially losing weight with a higher drug dose. About 420 adults with a BMI between 28 and 45 will ta…

This study tests whether a balanced gelatin solution is safer and more effective than standard fluids for sepsis patients undergoing emergency abdominal surgery. Sepsis causes fluid loss, leading to low blood pressure and organ damage. The trial will enroll 318 adults and compare…

This early-phase trial tests HN2301, a new type of CAR-T therapy given directly into the blood, for people with refractory Graves' disease—a thyroid condition that doesn't respond well to standard treatments. The therapy reprograms the body's own immune cells to target and calm t…

This study compares two blood thinner combinations in adults over 65 who have had a heart attack or unstable angina and received a stent. One group gets indobufen plus ticagrelor, the other gets aspirin plus ticagrelor. The goal is to see which combo better prevents heart-related…

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with severe calcium deposits in their heart arteries. After using special tools to break up the calcium, 656 participants will be randomly assigned to one of the two treatments. Resear…

This study tests whether giving a powerful cholesterol-lowering drug (PCSK9 inhibitor) very early in the hospital, right after a heart attack, can reduce the chance of another heart attack, stroke, or death over the next year. About 1,500 adults with multiple blocked arteries wil…

This study is for people with stomach cancer that has spread to a few other places in the body. It tests whether adding surgery and other local treatments to a combination of immunotherapy and chemotherapy helps people live longer without the cancer getting worse. About 84 adults…

This phase 3 trial tests whether montelukast, a common asthma drug, can reduce heart damage in people having a heart attack. 512 patients with a specific type of heart attack will receive either montelukast or a placebo daily for 3 months. The goal is to see if the drug prevents …

This study tests whether giving chemotherapy plus immunotherapy before treatment can shrink esophageal tumors enough to remove them with an endoscope (a thin tube down the throat) instead of major surgery. About 60 adults with early-stage esophageal cancer will receive two or mor…

This early-phase trial tests a single infusion of genetically modified immune cells (CAR-T cells) in 4 people with refractory Graves' disease, a thyroid condition that doesn't respond well to standard medication. The cells target two proteins (CD19 and BCMA) to reset the immune s…

This Phase 3 trial tests whether a new combination of chemotherapy drugs (NALIRIFOX) plus targeted therapy works better than the standard FOLFOX regimen for people with metastatic colorectal cancer that has not been treated before. About 144 participants will receive one of the t…

This study tests whether asiaticoside, a compound from the herb Centella asiatica, can help overweight or obese adults lose weight. Thirty participants will take asiaticoside tablets for 12 weeks, and researchers will measure changes in metabolic rate and body weight. The goal is…

This study is testing an oral drug called surufatinib in 350 adults with advanced neuroendocrine tumors (NETs). The drug works by cutting off blood supply to tumors and boosting the immune system. Researchers want to see if it helps control the disease and improves survival in re…

This study is for people with advanced bile duct cancer that cannot be removed by surgery. It tests whether adding immunotherapy drugs (anti-PD-1/PD-L1 antibodies) to standard chemotherapy (gemcitabine and cisplatin) is safe and works better at shrinking tumors and delaying cance…

This study tests a combination of two types of drugs (anti-PD-1/PD-L1 and anti-VEGF) in 50 adults with advanced liver cancer that cannot be removed by surgery. The goal is to see if the combination is safe and helps shrink tumors or slow cancer growth. Participants will receive t…

This study tests a new drug called envafolimab combined with standard chemotherapy given before surgery for people with a type of esophageal cancer that can be removed. The goal is to see if this combination can shrink the tumor more effectively, potentially leading to better lon…

This study compares two types of surgery for advanced stomach cancer: keyhole (laparoscopic) and open total gastrectomy. About 1,018 patients will be randomly assigned to one of the two procedures. The main goal is to see if keyhole surgery offers similar long-term survival with …

This study tests whether an artificial intelligence (AI) system can help experienced radiologists write chest CT scan reports more quickly without lowering quality. One hundred board-certified radiologists will interpret complex chest CT cases, sometimes using an AI-generated dra…

This study tests whether a new software-based method called Angio-IMR can diagnose coronary microvascular disease (blockages in tiny heart arteries) as accurately as the current standard test that uses a pressure wire inside the artery. About 192 adults with stable chest pain or …

This study tests a new imaging method called µQFR to see how well it can detect blocked blood flow in small side branches after a heart stent is placed. About 290 adults with coronary artery disease will be enrolled. The goal is to see if this non-invasive approach can replace mo…

This study tests whether transplanting gut bacteria from healthy donors can relieve symptoms of irritable bowel syndrome (IBS). 102 adults who haven't responded to at least three standard treatments will receive donor bacteria either in capsules or through a tube into the nose an…

This study tests whether a high-flow nasal cannula (a device that delivers warm, humidified oxygen at high flow) can prevent low oxygen levels better than a standard face mask in people with visceral obesity undergoing sedated gastroscopy. The trial will enroll 200 participants a…

This study looks at how ongoing stress, anxiety, and poor sleep might affect the course of pancreatic cancer. Researchers will ask 320 participants to fill out simple questionnaires about their mental well-being and will also measure stress markers in leftover blood samples. The …

This study looks at people with high blood pressure in the liver that causes swollen veins in the esophagus and stomach. Researchers will compare those who get an endoscopic procedure (using a camera down the throat) with those who receive other treatments like medicine or surger…

This observational study looks at whether combining CT scans, blood tests, and pathology reports can more accurately predict how pancreatic cancer will progress. Researchers will collect existing medical records from about 1,030 participants who had surgery for pancreatic cancer.…

This study is a registry that will follow 6,000 people who had a heart attack and were treated with emergency angioplasty at Zhongshan Hospital. Researchers will collect information on their health, procedures, and medications, and track their recovery for up to two years. The go…

This study is testing whether a non-invasive blood pressure monitor can accurately detect blockages in the heart's main pumping chamber in people with hypertrophic cardiomyopathy (HCM). Researchers will compare blood pressure readings with standard invasive measurements in 800 ad…

This study will test a new, high-speed CT scanner to see if it can measure heart artery plaque stiffness and blood flow without invasive procedures. Researchers will enroll 500 adults with known or suspected coronary artery disease. The goal is to see if this new imaging method c…

This study looks at factors that help blood clots in the main liver vein dissolve in people with liver scarring (cirrhosis) and enlarged stomach veins. Researchers will follow 1,500 patients over time to see what influences clot recovery. The goal is to help doctors and patients …

This study looks at how an 8-week exercise program changes the bodies and cells of 40 overweight or obese adults with prediabetes. Researchers will measure weight, body fat, blood sugar, and other health markers. They will also use advanced techniques to study immune cells and fi…

This study is creating a large collection of medical data and biological samples from 1000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better unde…

This study will use a special camera (NIRS-OCT) to look inside the heart arteries of 1,516 people with diabetes. The goal is to find fatty plaques that might rupture and cause heart attacks. Researchers hope to create a new way to identify these dangerous plaques early, so doctor…

This study looks at why some people with coronary heart disease continue to have plaque buildup in their arteries even when they are on strong cholesterol-lowering medication. Researchers will follow 900 adults who have already had a heart procedure to see if leftover cholesterol…

This study follows 189 adults who experienced delirium in the ICU to understand their main recovery challenges after moving to a regular hospital ward. Researchers will assess physical abilities, thinking skills, and mental health using simple questionnaires. The goal is to ident…