New fluid strategy could save lives in emergency sepsis surgery

NCT ID NCT07172451

Recruiting now Disease control Sponsor: Shanghai Zhongshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a balanced gelatin solution is safer and more effective than standard fluids for sepsis patients undergoing emergency abdominal surgery. Sepsis causes fluid loss, leading to low blood pressure and organ damage. The trial will enroll 318 adults and compare fluid balance, blood pressure stability, and kidney function between the two fluids. Results could guide better fluid management in this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Balanced gelatin solution (a type of fluid given intravenously to help maintain blood volume)
What this could lead to: If successful, this could show that balanced gelatin is a better fluid for stabilizing blood pressure and reducing fluid overload in septic patients during and after emergency abdominal surgery.
What could go wrong: This is a relatively small, early-phase trial (phase 4) and results may not apply to all sepsis patients. There are also known risks with gelatin solutions, including potential allergic reactions and kidney injury.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Intraabdominal Infections Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRA ABDOMINAL INFECTIONS SEPSIS

Contacts and locations

Locations

Affiliated Hospital of Xuzhou Medical University
NOT_YET_RECRUITING

Xuzhou, Jiangsu, 221000, China
The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, Jiangsu, 215006, China
The First Affiliated Hospital, Sun Yat-sen University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510080, China
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University (WMU)
NOT_YET_RECRUITING

Wenzhou, Zhejiang, 325000, China
The Second Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310058, China
Tianjin Medical University General Hospital
NOT_YET_RECRUITING

Tianjing, Tianjing, 300052, China
West China Hospital of Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, 610041, China
Zhongda Hospital, Southeast University
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210009, China
Zhongshan Hospital, Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200032, China

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