SEPSIS

This study tests whether a device called MyokinE100, which sends electrical signals to the thigh muscles, is safe and practical for use in the ICU. It includes 50 critically ill patients with sepsis who are at risk of muscle weakness. Half will receive standard care plus daily 60…

This study tests an experimental drug called AZD4144 in 124 adults with sepsis who have also developed acute kidney injury. Participants receive either the drug or a placebo daily by IV while in the hospital. The main goal is to see if the drug helps maintain kidney function bett…

This early study tests a new drug called BAY 3389934 in 36 hospital ICU patients with sepsis-induced coagulopathy, a condition where the body forms dangerous blood clots. The main goal is to check safety and find the right dose. Researchers will monitor side effects and blood clo…

This study tests whether giving a personalized dose of Pentaglobin (an antibody treatment) after surgery helps people with severe abdominal infection (peritonitis) and sepsis recover better. Researchers will enroll 200 patients and track organ failure and survival. The goal is to…

This early-stage study tests whether adding an iron-binding drug (MEX-CD1) to dialysis fluid can safely remove extra iron from the blood of adults in the ICU with sepsis and acute kidney injury. Each participant will receive two 24-hour dialysis sessions—one with standard fluid a…

This pilot study tests whether adding fludrocortisone (a steroid pill) to standard hydrocortisone treatment helps people with septic shock. Only 32 critically ill adults will take part. The main goal is not to see if the combo works, but to check if a larger, more definitive tria…

This study tests whether the steroid methylprednisolone can help critically ill patients with severe inflammation from sepsis or acute respiratory distress syndrome (ARDS). About 150 adults will receive a high dose, low dose, or placebo for up to 7 days. Researchers will measure …

This study tests whether giving the oral drug midodrine early to sepsis patients with low blood pressure can help them stop needing IV blood-pressure medications sooner. Researchers will compare standard care plus midodrine to standard care alone in 308 adults. The goal is to see…

This early-phase trial tests whether using personalized dosing models for the antibiotic vancomycin can improve treatment in children with sepsis. The standard dosing approach may lead to blood levels that are too high (risking kidney injury) or too low (risking ineffective treat…

This study tests a special blood-filtering device (DPCAS+LPE) in 192 adults with acute-on-chronic liver failure and sepsis. The device removes harmful inflammatory substances from the blood. Researchers will compare survival rates and organ function between patients receiving thi…

This study tests whether a combination of gentamicin and a narrow-spectrum antibiotic works as well as broad-spectrum antibiotics for early sepsis, with less impact on antibiotic resistance. About 1,900 adults with suspected community-acquired sepsis will be randomly assigned to …

This study tests whether ivabradine, a drug that slows heart rate without weakening the heart's pumping strength, can help people with sepsis. Sepsis is a life-threatening infection that often causes a dangerously fast heart rate. The trial will enroll 172 adults in intensive car…

This study tests whether giving the drug norepinephrine early and adjusting the dose quickly can improve survival in adults with septic shock. Researchers will compare this approach to standard care with a placebo. Six hundred participants will be monitored for 28 days to see if …

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study looks at whether a special blood filter called oXiris helps people with septic shock and kidney failure survive. Researchers will review medical records of 360 adults in the ICU who needed continuous blood filtering. They will compare those who got the oXiris filter wi…

This study tests whether a balanced gelatin solution is safer and more effective than standard fluids for sepsis patients undergoing emergency abdominal surgery. Sepsis causes fluid loss, leading to low blood pressure and organ damage. The trial will enroll 318 adults and compare…

This study looks at whether continuous blood purification (a slow, steady filtering of the blood) works better than standard non-continuous methods for children with severe sepsis. Researchers will track survival rates and kidney function in 90 children aged 29 days to 18 years. …

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This early-stage trial tests whether an intravenous enzyme called DNase I is safe and feasible for ICU patients with sepsis. Sepsis is a life-threatening response to infection that can damage organs. The study will enroll 36 adults and monitor how many complete the treatment and …

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This study looks at 600 ICU patients with hospital-acquired sepsis to see if giving antibiotics continuously or adding a second antibiotic improves survival. Patients will be randomly assigned to receive a beta-lactam antibiotic either continuously or intermittently, and some wil…

This early study tests whether draining lymph fluid from the chest can lower harmful inflammation in people with septic shock. Ten adults in the surgical ICU will have a tube placed in their thoracic duct to drain lymph for up to 7 days. The goal is to see if this procedure is sa…

This study compares two types of blood purification membranes (AN69ST and polysulphone) in 80 children with sepsis, ages 29 days to 18 years. The goal is to see which membrane better reduces inflammatory cytokines and organ damage. Children receive continuous blood purification f…

This study tests an experimental drug called YD0743 in adults with sepsis who develop severe lung failure (ARDS) and need a breathing machine. The main goal is to see if the drug helps patients spend fewer days on the ventilator compared to a placebo. About 309 ICU patients will …

Sepsis is a life-threatening reaction to infection where the immune system damages the body's own tissues. This phase 3 trial compares two early treatment approaches in the emergency department: giving fluids first then a blood-pressure-raising drug (norepinephrine) if needed, ve…

This registry study is following 200 adults with sepsis or septic shock who receive ARTICE® therapy in the ICU. Researchers are tracking organ function, survival, and complications to see how well the treatment works in everyday practice. The goal is to identify which patients be…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study looks at whether giving steroids very early to patients with severe infections and low blood pressure works better than waiting until standard treatments fail. About 230 adults will be randomly assigned to get either early steroids or a placebo, and neither they nor th…

This study tests whether giving fluids and blood pressure medicines based on each patient's heart response can improve sepsis care. 188 adults with sepsis in the emergency department will be randomly assigned to either personalized treatment or standard care. The goal is to see i…

This study compares two common IV fluids—Ringer's Lactate and Sterofundin/Plasmalyte—in adults with sepsis after abdominal surgery. Researchers will measure how well each fluid helps clear lactate from the blood and supports kidney function. The goal is to find which fluid leads …

This study tests whether the drug fisetin can reduce organ failure in adults aged 65 and older who have sepsis (a severe response to infection). Researchers will give participants either one or two doses of fisetin or a placebo, and measure changes in heart, lung, and kidney func…

This study is testing whether a combination of two steroids (hydrocortisone and fludrocortisone) can reduce death or long-term organ failure in adults with sepsis in the ICU. About 1,800 participants will receive either the steroid combo or a placebo, and researchers will track t…

This study tests whether a combination of clinical guidelines, feedback, and education can reduce the overuse of vancomycin in children with suspected sepsis in intensive care units. Over 52,000 patients and many clinicians across five hospitals will take part. The goal is to low…

This study tests whether a nerve block (erector spinae plane block) can improve organ function in septic patients who also have acute gut injury. The block uses a numbing medicine (ropivacaine) delivered near the spine. Researchers will measure organ failure scores in 116 ICU adu…

This study tests a new method called IDBIORIV that can identify the germ causing a bloodstream infection and determine which antibiotics will work in just 90 minutes, compared to the usual 24-48 hours. Sepsis is a life-threatening condition that affects millions worldwide, and fa…

This study looks at whether a computer program called pediatric eCART can help doctors quickly identify children in the hospital who are at high risk of serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put into use, …

This study looks at using a computer algorithm to quickly diagnose sepsis and septic shock from routine hospital data. Researchers will analyze information from 10,000 ICU patients to see if the algorithm can speed up diagnosis and improve patient outcomes. The goal is to help do…

This study is looking for a better way to diagnose three serious conditions that can look alike: Still's disease, sepsis, and macrophage activation syndrome. Researchers will measure a specific form of a blood protein called glycosylated ferritin in 60 people suspected of having …

This study tests whether using a device that measures blood flow to the skin (called the peripheral perfusion index) can help doctors give fluids more precisely to elderly ICU patients with sepsis or shock. The goal is to prevent acute skin failure, a serious condition where the …

This phase 2 trial tests whether real acupuncture can improve outcomes for hospitalized sepsis patients compared to a sham (fake) version. Researchers will enroll 78 adults at Memorial Sloan Kettering Cancer Center to see if such a study is feasible. The goal is to gather initial…

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

This study tests whether virtual reality (VR) can help patients in the intensive care unit (ICU) relax, improve their mood, and keep their minds active. Participants will use a VR headset for about 15 to 45 minutes each day for up to 5 days, doing breathing exercises, brain games…

This study looks back at medical records of 60 critically ill adults in an intensive care unit who received a blood-cleaning treatment called hemoadsorption. The goal is to see if the therapy helps lower the need for drugs that raise blood pressure, improves lab results, and affe…

This study looks at whether a simple neck ultrasound can tell if a septic patient on a ventilator needs more fluids. Doctors will compare this quick method to a standard heart ultrasound. If it works, it could help avoid giving too much or too little fluid, which can be dangerous…

This study aims to create a tool that can predict which children aged 5 to 16 with sepsis are at risk of dying or getting sick again after leaving the hospital in East Africa. Researchers will follow 4,000 children for six months after discharge to collect data and build these pr…

This study looks at why some people who survive a serious illness in the ICU develop long-lasting muscle weakness. Researchers will test 50 former ICU patients with exercise on a bike to measure heart and muscle function. The goal is to better understand this condition, not to te…

This study is collecting blood and urine samples from 1,400 ICU patients in China to find new biological markers for sepsis. Researchers will analyze genes, proteins, and metabolites to build faster and more accurate diagnostic tests. The goal is to help doctors identify sepsis e…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study follows 150 older adults who survived a stay in the intensive care unit (ICU) for sepsis or lung injury. Researchers will measure muscle strength and physical function at hospital discharge and again at 3, 6, 12, and 24 months later. A small group will also have muscle…

This study looks at whether a simple ultrasound measurement of how well the right side of the heart works with the lungs can predict which sepsis patients are at higher risk of dying in the hospital. Researchers will follow 215 adults with sepsis in the ICU, measuring this heart-…

This study is observing 200 hospitalized adults with carbapenem-resistant Acinetobacter baumannii (CRAB) infections—a type of superbug—who are treated with the antibiotic sulbactam-durlobactam. Researchers will compare their outcomes to patients receiving other treatments to see …

This study is measuring cortisol levels in 183 adults with sepsis or septic shock in the ICU to see if those levels can predict who is at higher risk of dying. Researchers will track deaths in the ICU and at 28 and 90 days. The goal is to help doctors identify high-risk patients …

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This study will check if a new scoring system called SOFA-2 can better predict which ICU patients are likely to die within 30 days, compared to the current standard. Researchers will also measure how common sepsis and septic shock are in Turkish intensive care units. About 2,500 …

This study is testing two new risk scores that predict a patient's chance of developing sepsis or experiencing a sudden decline (like cardiac arrest or death) within the next 4 hours. The scores give a simple 1-to-4 color-coded risk level to alert hospital staff. The goal is to s…

This study tests whether patients with serious infections who are at risk for sepsis can be safely monitored at home using wearable devices and a smartphone app. About 120 adults will take part, and the goal is to see if this approach can reduce hospital visits while still catchi…

This study aims to create a new scoring system (SOFA-OBS) that better predicts death risk for pregnant and postpartum women in intensive care. Researchers will collect routine data from 130 patients and test if a simple pulse oximeter can replace painful blood draws. The goal is …

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study is testing whether a device that measures brain activity (called BIS) can help doctors classify how severe sepsis is in critically ill patients. Researchers will compare BIS readings with a standard blood test (procalcitonin) to see if the brain monitor can track worse…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at whether measuring how much a vein near the armpit collapses with breathing can predict if a sepsis patient needs more fluids. It involves 40 spontaneously breathing adults with sepsis and signs of poor circulation. The goal is to find a simple, non-invasive wa…

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants under 2 months old with a fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to find ou…

This study is tracking enterovirus infections in newborns across Italy, with a special focus on a dangerous strain called Echovirus 11. Researchers will analyze samples from 1,600 babies in intensive care to understand how common these infections are, what makes some cases severe…

This study at Mayo Clinic is testing whether a simple blood test can measure organ damage and immune system changes in people with sepsis. Researchers will take one extra blood sample from 1,000 patients in the emergency department and use advanced DNA analysis to look for signal…

This study looks at how sepsis causes lasting damage to the immune system, making people more likely to get serious infections later. Researchers will track 150 ICU patients with sepsis over 28 days, analyzing their blood cells and immune markers. The goal is to uncover the biolo…

This study looks at how a standard dose of IV fluid (Ringer's Lactate) moves between blood and tissues in people with early sepsis. Researchers will measure changes in blood volume and urine output to understand individual differences. The goal is to make fluid treatment more per…

This study is observing about 1,950 emergency patients with suspected sepsis to see if new blood tests (like calprotectin and bacterial DNA tests) can detect infections faster and more accurately than current methods. The goal is to find better ways to diagnose sepsis and tailor …

This study looks at neutrophils, a type of white blood cell, in children with sepsis (a severe infection). Researchers want to understand how these cells change and may cause lung injury. By comparing sepsis patients to healthy controls, they hope to find clues for future treatme…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study will gather health information from 5,000 children in China who have severe infections like pneumonia or sepsis. The goal is to learn how common these infections are, how well different treatments work, and to create tools that can predict which children are at highest…

Researchers in Slovenia are testing a new continuous glucose monitor called Syai Tag in 100 intensive care patients. The device uses small sensors on the upper arm to track blood sugar levels without needles. The study will compare its accuracy to standard blood tests to see if i…

This study looks at how sepsis (a severe infection) changes the body's inflammation, blood clotting, heart function, and certain genetic markers in 40 adults after major abdominal surgery. Researchers compare patients who develop sepsis with those who do not, using blood tests an…

This study is an anonymous online survey that tests healthcare workers' knowledge of sepsis across seven sub-Saharan African countries. Around 300 doctors, nurses, and trainees will answer questions to measure their understanding. The survey will be repeated every 12-24 months to…

This study is developing and testing artificial intelligence (AI) tools to help doctors make personalized decisions for patients with heart disease, breast cancer, or sepsis. The AI will be designed to explain its recommendations clearly and ensure safety. Researchers will use da…

This study is enrolling 4,000 adults in intensive care with ARDS, sepsis, or pneumonia. Researchers will collect blood, urine, and swab samples, plus track recovery for up to a year. The goal is to identify different patient subtypes and find clues that could lead to better treat…

This study looks at how well the Oxiris blood filter removes harmful toxins in adults with septic shock in the ICU. Researchers will take blood samples before and after the filter over 24 hours to see when it stops working. No new treatment is given—just observation. The goal is …

This study follows 40 adults who survived sepsis in the ICU to understand how their physical function changes after leaving the hospital. Researchers will test strength and mobility at several points, especially looking at how hospital readmissions affect recovery. The goal is to…

This study aims to find epigenetic markers in the blood that could predict whether a patient with sepsis will develop the more dangerous septic shock. Researchers will take blood samples from 25 male patients after major digestive cancer surgery who develop sepsis. By comparing m…

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system in people with sepsis. Researchers will analyze blood samples from 116 ICU patients with sepsis to see if these elements are linked to higher de…

This study looks back at medical records of 1,500 ICU patients with sepsis and low platelet counts to see if those who received platelet transfusions had better survival at 28 days. The researchers also track bleeding and blood clot risks. Because it is observational, it can only…

This study looks at a rare but often deadly infection caused by Bacillus cereus bacteria in premature newborns. Researchers will analyze the DNA of 40 bacterial samples from infected babies in French hospitals to see which genetic features make some strains more dangerous. The go…

This study is looking at whether small differences in certain genes make very low birth-weight babies more likely to develop chronic lung disease and other complications of prematurity. Researchers will compare the genes of 1,100 infants who develop these conditions with those wh…

This study looks at whether a blood test marker called Monocyte Distribution Width (MDW) can help predict complications and survival in elderly patients with hip fracture. Researchers will follow 100 patients aged 65 and older, measuring MDW and other inflammatory markers at admi…

This study follows 300 critically ill children with sepsis for five years after they leave the hospital. Researchers want to see how sepsis affects their growth, brain development, survival, and quality of life. The goal is to better understand the long-term challenges these chil…

This study looks at whether measuring the water outside cells (extracellular water) can help doctors understand fluid status in sepsis patients with unstable blood pressure. About 20 adults with sepsis in the ICU will have standard care plus extra water measurements. The goal is …

This study looks at how a special filter (OXIRIS membrane) used for kidney dialysis affects blood clotting and immune cells in intensive care patients with septic shock. Researchers will measure markers of clotting and immune activation before and after using the filter. The goal…

This study will test a needle-free device called PIVO that draws blood through an existing IV line in the emergency department. Researchers want to see if using this device reduces contamination of blood cultures and lowers the number of needle sticks for patients. Up to 10,000 p…

This study is looking at 100 intensive care patients to see if certain inflammatory markers in urine, blood, and sputum can help predict acute kidney injury. The researchers are comparing patients with sepsis, those recovering from major surgery, and non-inflamed individuals. The…

This study tests whether using changes in procalcitonin levels over time (kinetics) is better than a single measurement for deciding when to start antibiotics in critically ill patients with suspected infection. About 250 adults in the ICU will be randomly assigned to one of two …

This study looks at neutrophils—a type of white blood cell—in children with sepsis, a severe infection that can harm organs. Researchers want to learn how these cells change and cause damage. The goal is to find clues that could lead to better treatments. The study will compare 7…

This study looks at how severe infections (sepsis) and major injuries change the way the body produces certain immune cells called myeloid cells. Researchers want to understand why these changes can lead to ongoing inflammation and a weakened immune system. The study will follow …

This study looks at what happens to blood and bone marrow after a severe injury. Researchers want to understand why some trauma patients develop a weakened immune system and get serious infections like sepsis. About 255 adults with severe fractures will give blood and a small bon…

This study looks at how the immune system reacts during and after sepsis in 400 intensive care patients. Researchers will analyze blood samples to identify different immune response types, called immunotypes. The goal is to understand which immune patterns lead to better or worse…

This study tests whether measuring tiny blood flow (microcirculation) in sepsis patients in the emergency room can help doctors start fluid treatment earlier. Researchers will compare standard care plus these measurements to standard care alone in 556 adults with suspected sepsis…

This study is testing whether mathematical models can help doctors choose the best dose of anti-infective drugs for hospitalized patients, especially those with sepsis. Researchers will analyze drug levels and patient data from 60 adults to understand how factors like organ funct…

This study looks at whether measuring tiny molecules called microRNA in the blood can help doctors detect sepsis in children more quickly and accurately than current methods. Researchers will follow 50 children admitted to the pediatric ICU with suspected sepsis, tracking their m…

This study is observing 1,000 critically ill ICU patients to learn how their bodies respond to life-threatening infections and injuries. Researchers will collect blood and lung fluid samples to identify biological factors that could lead to earlier diagnosis and new treatments fo…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This study looks at 290 intensive care patients with sepsis to see which blood test best predicts their chance of recovery. Researchers will compare three different markers in the blood to see which one most accurately forecasts survival at 28 days. The goal is to help doctors id…

This study follows 200 adults with severe pancreatitis and sepsis who undergo open necrosectomy, a surgery to remove dead tissue. Researchers will measure how well the heart, lungs, and kidneys work over time using a standard scoring system. The goal is to understand how organ fu…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …