Could early Blood-Pressure drugs be a Game-Changer for sepsis?

NCT ID NCT05179499

Recruiting now Disease control Sponsor: NHS Greater Glasgow and Clyde Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

Sepsis is a life-threatening reaction to infection where the immune system damages the body's own tissues. This phase 3 trial compares two early treatment approaches in the emergency department: giving fluids first then a blood-pressure-raising drug (norepinephrine) if needed, versus starting the drug immediately and adding fluids as needed. The study will enroll about 1,000 adults with septic shock to see which method leads to more days alive and out of the hospital within 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

norepinephrine

What this could lead to

If this approach works, it could lead to faster recovery and fewer complications for sepsis patients by starting blood-pressure support earlier.

What could go wrong

This is a large trial, but the benefit of early vasopressors is still unproven. There is a risk that early use may cause side effects or not improve outcomes compared to standard care.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS

Contacts and locations

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Locations

Addenbrookes Hospital, Cambridge
RECRUITING

Cambridge, United Kingdom

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Aintree University Hospital
RECRUITING

Aintree, United Kingdom

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Fairfield General Hospital
RECRUITING

Bury, United Kingdom

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Glasgow Royal Infirmary
RECRUITING

Glasgow, United Kingdom

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Hull Royal Infirmary
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Hull, United Kingdom

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John Radcliffe Hospital
RECRUITING

Oxford, United Kingdom

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Kettering General
RECRUITING

Kettering, United Kingdom

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Leicester Royal Infirmary
TERMINATED

Leicester, United Kingdom
Newham University Hospital
RECRUITING

London, United Kingdom

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Peterborough City Hospital
RECRUITING

Peterborough, United Kingdom

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Queen Elizabeth University Hospital
RECRUITING

Glasgow, United Kingdom

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Queens Hospital Barking
RECRUITING

Romford, United Kingdom

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Royal Alexandra Hospital
RECRUITING

Paisley, United Kingdom

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Royal Berkshire Hospital
RECRUITING

Reading, United Kingdom

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Royal Blackburn Hospital
TERMINATED

Blackburn, United Kingdom
Royal Derby Hospital
RECRUITING

Derby, United Kingdom

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Royal Infirmary of Edinburgh
RECRUITING

Edinburgh, United Kingdom

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Royal Liverpool University Hospital
RECRUITING

Liverpool, United Kingdom

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Royal London Hospital
RECRUITING

London, United Kingdom

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Salford Royal
RECRUITING

Salford, United Kingdom

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St George's
TERMINATED

London, United Kingdom
University Hospital Crosshouse
TERMINATED

Kilmarnock, United Kingdom
University Hospital Lewisham
RECRUITING

London, United Kingdom

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University Hospital Monklands
RECRUITING

Lanark, United Kingdom

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Victoria Hospital
RECRUITING

Fife Keith, United Kingdom

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