Could early Blood-Pressure drugs be a Game-Changer for sepsis?
NCT ID NCT05179499
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
Sepsis is a life-threatening reaction to infection where the immune system damages the body's own tissues. This phase 3 trial compares two early treatment approaches in the emergency department: giving fluids first then a blood-pressure-raising drug (norepinephrine) if needed, versus starting the drug immediately and adding fluids as needed. The study will enroll about 1,000 adults with septic shock to see which method leads to more days alive and out of the hospital within 90 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- norepinephrine
- What this could lead to
- If this approach works, it could lead to faster recovery and fewer complications for sepsis patients by starting blood-pressure support earlier.
- What could go wrong
- This is a large trial, but the benefit of early vasopressors is still unproven. There is a risk that early use may cause side effects or not improve outcomes compared to standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SEPSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Addenbrookes Hospital, Cambridge
RECRUITINGCambridge, United Kingdom
-
Aintree University Hospital
RECRUITINGAintree, United Kingdom
-
Fairfield General Hospital
RECRUITINGBury, United Kingdom
-
Glasgow Royal Infirmary
RECRUITINGGlasgow, United Kingdom
-
Hull Royal Infirmary
RECRUITINGHull, United Kingdom
-
John Radcliffe Hospital
RECRUITINGOxford, United Kingdom
-
Kettering General
RECRUITINGKettering, United Kingdom
-
Leicester Royal Infirmary
TERMINATEDLeicester, United Kingdom
-
Newham University Hospital
RECRUITINGLondon, United Kingdom
-
Peterborough City Hospital
RECRUITINGPeterborough, United Kingdom
-
Queen Elizabeth University Hospital
RECRUITINGGlasgow, United Kingdom
-
Queens Hospital Barking
RECRUITINGRomford, United Kingdom
-
Royal Alexandra Hospital
RECRUITINGPaisley, United Kingdom
-
Royal Berkshire Hospital
RECRUITINGReading, United Kingdom
-
Royal Blackburn Hospital
TERMINATEDBlackburn, United Kingdom
-
Royal Derby Hospital
RECRUITINGDerby, United Kingdom
-
Royal Infirmary of Edinburgh
RECRUITINGEdinburgh, United Kingdom
-
Royal Liverpool University Hospital
RECRUITINGLiverpool, United Kingdom
-
Royal London Hospital
RECRUITINGLondon, United Kingdom
-
Salford Royal
RECRUITINGSalford, United Kingdom
-
St George's
TERMINATEDLondon, United Kingdom
-
University Hospital Crosshouse
TERMINATEDKilmarnock, United Kingdom
-
University Hospital Lewisham
RECRUITINGLondon, United Kingdom
-
University Hospital Monklands
RECRUITINGLanark, United Kingdom
-
Victoria Hospital
RECRUITINGFife Keith, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can we optimize antibiotic dosing for children with sepsis?
- Could starting feeds sooner shield preterm babies from infection?
- Can brain waves predict thinking problems after sepsis?
- Can tailored nutrition boost recovery in the ICU?
- Blood markers may foretell brain fog after sepsis
- A hidden clue in the fingertips: could a pulse oximeter reading forecast sepsis outcomes?