Could a simple pill help sepsis patients leave the ICU sooner?

NCT ID NCT06319248

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving the oral drug midodrine early to sepsis patients with low blood pressure can help them stop needing IV blood-pressure medications sooner. Researchers will compare standard care plus midodrine to standard care alone in 308 adults. The goal is to see if this approach shortens time on IV drugs, reduces hospital stays, and makes recovery smoother.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Midodrine (a blood-pressure-raising drug taken by mouth or feeding tube)
What this could lead to: If it works, this could offer a simpler way to wean sepsis patients off IV blood-pressure medications, leading to shorter hospital stays and fewer complications from tubes.
What could go wrong: This is a mid-stage trial with 308 participants, so results are not yet proven. Midodrine may not reduce IV vasopressor use or could cause side effects like high blood pressure or skin reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW BLOOD PRESSURE SEPSIS

Contacts and locations

Locations

Mayo Clinic Arizona
RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Health System - Eau Claire
RECRUITING

Eau Claire, Wisconsin, 54703, United States
Mayo Clinic Health System - Mankato
RECRUITING

Mankato, Minnesota, 56001, United States
Mayo Clinic Minnesota
RECRUITING

Rochester, Minnesota, 55905, United States

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