Hypotensive disorder

This trial compares two blood pressure medications—midodrine and droxidopa—against compression stockings and a placebo to see which best stabilizes blood pressure in people with spinal cord injury. Participants have a traumatic injury between C1 and T6, are at least a year post-i…

This trial tests whether a 5-microgram or 10-microgram bolus of norepinephrine is better at quickly raising dangerously low blood pressure during emergency abdominal surgery. Low blood pressure after anesthesia is common in these surgeries and can harm organs if not treated fast.…

This pilot study tests two medicines, dopamine and norepinephrine, in 30 full-term or near-term newborns with low blood pressure and lung problems caused by pulmonary hypertension. The goal is to see which drug better improves blood flow and oxygen levels. Results could help doct…

This study tests a special software called the Hypotension Prediction Index (HPI) that helps doctors predict and prevent low blood pressure during major aortic surgery. The trial involves 200 adults undergoing elective open or endovascular abdominal aortic surgery expected to las…

This early study tests a spinal cord stimulation therapy called ARC-IM in 5 people with Parkinson's disease or related conditions who experience severe drops in blood pressure when standing (orthostatic hypotension). The main goal is to check safety, and researchers will also mea…

This study compares giving norepinephrine continuously versus as needed to prevent low blood pressure during anesthesia in high-risk non-cardiac surgery patients. About 446 adults aged 45 and older with certain risk factors will participate. The goal is to see which method better…

This study tests whether giving the oral drug midodrine early to sepsis patients with low blood pressure can help them stop needing IV blood-pressure medications sooner. Researchers will compare standard care plus midodrine to standard care alone in 308 adults. The goal is to see…

This study tests whether giving the drug norepinephrine early and adjusting the dose quickly can improve survival in adults with septic shock. Researchers will compare this approach to standard care with a placebo. Six hundred participants will be monitored for 28 days to see if …

This study tests whether giving a medicine called noradrenaline through a vein during surgery can prevent dangerous drops in blood pressure better than usual care. About 750 adults aged 45 and older having non-cardiac surgery will take part. The goal is to see if this approach re…

This study tests whether angiotensin II, a drug that narrows blood vessels, can safely and effectively treat dangerously low blood pressure after heart surgery. About 100 adults undergoing heart surgery with a heart-lung machine will receive the drug as a first-line treatment. Re…

This phase 3 trial is testing three approaches to rapid sequence induction (RSI) in the operating room: propofol alone, ketamine alone, or a combination of both. The goal is to find which option gives the best balance—successful intubation on the first try without causing a dange…

This study tests a minimally invasive procedure to open narrowed veins above the heart in people with orthostatic hypotension or intolerance—conditions that cause dizziness, fainting, or fatigue when standing. 100 adults who haven't improved with standard treatments will receive …

This study compares two drugs, norepinephrine and phenylephrine, given as continuous infusions to maintain blood pressure during planned C-sections under spinal anesthesia. 140 healthy pregnant women will receive one of the two drugs, and researchers will measure effects on the b…

This study tests whether diaphragmatic breathing exercises can reduce heart rate, blood pressure, and dizziness in pregnant women with Postural Orthostatic Tachycardia Syndrome (POTS). 44 pregnant women will be split into two groups: one doing breathing exercises, the other recei…

This study compares two types of dialysis fluid—citrate-based versus acetate-based—to see which one causes fewer blood pressure drops during dialysis in intensive care unit (ICU) patients. About 48 adults with acute kidney failure who are at risk for low blood pressure will take …

This study looks at whether breathing air with a little extra carbon dioxide can help people with neurogenic orthostatic hypotension (NOH) — a condition where blood pressure drops sharply upon standing, causing dizziness and fainting. Researchers will test this in 80 adults (pati…

This study looks at giving hydrocortisone, a steroid, to newborns with brain injury from lack of oxygen who are being cooled and have low blood pressure. Researchers want to find the best dose for each baby by measuring steroid levels in the blood. The goal is to safely raise blo…

This study looks at whether carbonated water can help people stay steady on their feet and avoid fainting. Drinking water is known to raise blood pressure, but researchers want to see if the bubbles in carbonated water add an extra benefit by stretching the stomach. 25 healthy ad…

This study tests whether a 5-minute mindfulness-based breathing exercise, done just before spinal anesthesia, can reduce the common drop in blood pressure and ease anxiety in women having a planned C-section. Half of the 150 participants will do slow, guided breathing (about 6 br…

This study tests whether giving less or more IV fluids during a planned C-section helps reduce nausea and vomiting after surgery and helps the bowels recover faster. About 160 women having planned C-sections under spinal anesthesia will take part. The goal is to find the best flu…

This study compares two types of ultrasound-guided nerve blocks (supra-inguinal and infra-inguinal fascia iliaca blocks) in 60 adults aged 30-60 undergoing thigh or knee surgery. The goal is to see which block makes it easier for patients to get into position for spinal anesthesi…

This study looks at whether changing the ratio of carbidopa to levodopa in standard Parkinson's medication can reduce orthostatic hypotension—a sudden drop in blood pressure when standing that causes dizziness and fainting. Researchers will give 36 patients with Parkinson's disea…

This study compares two drugs, dexmedetomidine and dexamethasone, when added to a standard local anesthetic (ropivacaine) for a nerve block in the shoulder area. The goal is to see which combination provides faster pain relief for patients undergoing arm surgery. 66 adults aged 1…

This study tests whether a non-invasive spinal cord stimulation device can improve autonomic functions like blood pressure, bladder, bowel, and sexual control in people with chronic spinal cord injury. Thirty participants will receive targeted stimulation over several weeks. The …

This study compares two ultrasound-guided nerve blocks—supra-inguinal fascia iliaca block and pericapsular nerve group block—to see which one better reduces pain when positioning patients for spinal anesthesia during femur fracture surgery. Seventy adults with a broken femur will…

This study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …

This study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…

This study tests whether a wearable Holter monitor can detect early signs of fainting in people with orthostatic hypotension or reflex syncope. Forty adults who have already had a tilt-table test will wear the monitor for up to 21 days. The goal is to see if the device can pick u…

This study looks at whether a simple, non-invasive measure called the perfusion index (PI) can predict a sudden drop in blood pressure (hypotension) that often happens during spinal anesthesia for knee surgery. The PI, measured with a standard pulse oximeter on the finger, reflec…

This study looks at how blood pressure changes when standing affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants, with and without orthostatic hypotension (low blood pressure on standing), will take thinking tests while lying down and st…

This study tests whether measuring the optic nerve sheath diameter with ultrasound can predict post-dural puncture headache (PDPH) in women undergoing elective cesarean delivery under spinal anesthesia. Researchers will also monitor brain oxygen levels to see if drops in oxygen r…

This study explores whether a small accelerometer worn on the thigh can objectively measure how well treatments work for neurogenic orthostatic hypotension—a condition causing dizziness and fainting upon standing. Participants wear the device for one week on placebo and one week …

This study looks at how blood pressure changes in the first year after a spinal cord injury and whether a device that stimulates the spine through the skin can help. Five people with recent injuries will be followed for a year, testing the stimulation during sessions to see if it…

This study looks at whether keeping a patient's blood pressure within their personal safe range during heart surgery can reduce brain problems like confusion, stroke, or memory issues. Researchers will monitor 500 patients having heart surgery and track their blood pressure and b…

This study, called CEPEC, is a large platform trial enrolling 5,500 ICU patients across multiple countries. It tests different approaches to three common ICU treatments: how low to let blood pressure go with vasopressors, when to give platelet transfusions, and how to provide nut…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study looks at whether doctors can rely on feeling a patient's pulse (in the neck, groin, or wrist) to know if their blood pressure is dangerously low during shock. Researchers will compare pulse checks with standard blood pressure readings in 5,000 critically ill adults in …

This study is testing whether a continuous glucose monitor (CGM) designed for diabetes can work in intensive care patients with septic shock. Currently, nurses must prick patients' fingers every 2 hours to check blood sugar, which is painful and disruptive. The CGM uses a small s…

This study aims to create a new scoring system (SOFA-OBS) that better predicts death risk for pregnant and postpartum women in intensive care. Researchers will collect routine data from 130 patients and test if a simple pulse oximeter can replace painful blood draws. The goal is …

This study takes tissue samples from women having planned C-sections and tests four drugs (ephedrine, phenylephrine, norepinephrine, vasopressin) in a dish to see how they affect womb muscle and umbilical blood vessels. The goal is to understand which drugs might be safer for mot…

This study looks at whether two simple calculations using heart rate and blood pressure can predict which women will experience low blood pressure after receiving spinal anesthesia for planned C-sections. Researchers will monitor 300 women and track how often low blood pressure o…

This study compares general anesthesia alone versus general anesthesia plus an epidural during pancreatic surgery. The goal is to see which method causes fewer drops in blood pressure and leads to better recovery. About 206 adults scheduled for surgery will take part.

This study looks at whether waist size, body mass index (BMI), and a heart-related index can predict low blood pressure after spinal anesthesia during cesarean sections. Researchers will measure 321 pregnant women before their scheduled C-section and track blood pressure changes.…

This study is testing whether measuring skin conductance—a sign of nervous system activity—can predict dangerous drops in blood pressure after spinal anesthesia in elderly cancer patients. Researchers will monitor 102 patients aged 65 and older undergoing urologic cancer surgery.…

This study looks at whether giving paracetamol through a vein during emergency belly surgery causes a drop in blood pressure. Researchers will monitor 90 adults having this surgery to see how their blood pressure changes. The goal is to help doctors choose safer pain relief optio…

This study tests two common blood-pressure-raising drugs, noradrenaline and phenylephrine, in 32 people undergoing brain tumor surgery. The goal is to see which drug better maintains blood flow and oxygen delivery to the brain and other organs. Researchers will use PET scans to m…

This study looks at how the body controls blood pressure and heart rate in healthy young adults and older adults with high blood pressure. Participants will do tests like standing up and cycling while their heart and blood vessels are monitored. The goal is to better understand t…

This study compares continuous vital sign monitoring to standard nurse spot-checks for patients recovering from non-cardiac surgery on regular hospital wards. Researchers want to see if constant monitoring reduces the time patients spend with abnormal vital signs in the first 48 …

This study looks at whether a quick, painless neck ultrasound can help predict which older adults (65+) will have a dangerous drop in blood pressure after receiving spinal anesthesia for surgery. Researchers will measure the size and shape of a neck vein before surgery and track …

This study looks at different methods to predict whether giving IV fluids will help raise blood pressure in patients with impaired consciousness. Researchers will compare tests like ultrasound of the vena cava, leg raising, and fluid challenges in 222 ICU patients. The goal is to…

This study looks at how spinal anesthesia, commonly used in planned C-sections, affects the baby's nervous system. Researchers will monitor the baby's heart rate and the mother's vital signs in 50 pregnant women. The goal is to better understand and prevent complications like low…

This study looks at whether monitoring blood pressure through the femoral artery (in the groin) is better than the usual radial artery (in the wrist) during and after heart surgery. The goal is to see if femoral monitoring reduces the need for strong blood pressure medications an…

This study looks at how midodrine and droxidopa, two drugs used for low blood pressure upon standing, affect the veins in the abdomen of people with autonomic failure. About 34 adults aged 40-80 with conditions like multiple system atrophy or Parkinson's disease will participate.…

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …