Hypotensive disorder

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study tested an experimental drug called REGN7544 in 76 adults hospitalized with sepsis and low blood pressure. The drug is an antibody designed to help raise blood pressure and reduce the need for standard medications. Researchers measured safety, blood pressure changes, an…

This study tested two drugs, norepinephrine and ephedrine, to prevent and treat low blood pressure during planned C-sections under spinal anesthesia. 196 healthy pregnant women were randomly assigned to receive one of the two drugs. Researchers tracked how many doses were needed …

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study compared two medications, norepinephrine and phenylephrine, given continuously during C-sections to prevent dangerously low blood pressure. 98 women participated. Norepinephrine was more effective, causing low blood pressure in only 14.9% of cases compared to 42.6% wit…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested two common drugs, ephedrine and norepinephrine, to treat low blood pressure during C-sections under spinal anesthesia. Low blood pressure can reduce blood flow to the baby, so doctors want the safest option. The trial included 102 pregnant women having planned C…

This study tested whether giving norepinephrine early during major abdominal surgery could prevent drops in blood pressure and reduce organ problems afterward. 500 adults aged 50 and older took part. One group received norepinephrine early, while the other received the standard d…

This study tested a new computer program (nomogram) for the Aurora Xi plasmapheresis system, which collects plasma from donors. The goal was to see if the new software could lower the risk of sudden drops in blood pressure (hypotension) during donation. Over 6,700 donors took par…

This study tested whether giving the drug noradrenaline before anesthesia can prevent dangerous low blood pressure in patients with sepsis undergoing surgery. Eighty adults took part, and researchers measured how many experienced a drop in blood pressure after being put to sleep.…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This trial tests whether giving a continuous infusion of phenylephrine (a drug that raises blood pressure) can prevent shivering after spinal anesthesia in women having a C-section. About 108 non-laboring women will be randomly assigned to receive either the phenylephrine infusio…

This study tested a device called the Hypotension Prediction Index (HPI) to see if it can reduce low blood pressure during planned C-sections. Low blood pressure after spinal anesthesia can harm both mother and baby. The device alerts doctors before blood pressure drops, so they …

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This study tested two drugs, dexmedetomidine and nitroglycerin, to see which one better reduces bleeding during functional endoscopic sinus surgery (FESS). 66 adults having elective FESS were randomly assigned to receive one of the drugs to lower blood pressure and improve the su…

This study compared two sedatives, dexmedetomidine and propofol, in 100 high-risk patients undergoing ERCP. The goal was to see which drug causes fewer breathing and heart problems. Researchers monitored vital signs closely to find the safer option for these vulnerable patients.

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested an automated abdominal binder that inflates when a person stands, applying pressure to help maintain blood pressure. It included 28 adults with autonomic failure and disabling orthostatic hypotension. Participants wore either the active binder or a sham version …

This study looked at whether ondansetron, a drug often used for nausea, can reduce dangerous drops in blood pressure and heart rate in older adults (65+) undergoing spinal anesthesia for urologic surgery. Researchers tracked 140 patients to see if those who received ondansetron h…

This study tested whether using the length of the lower spine to calculate spinal anesthesia dose during C-sections could lower the risk of a dangerous drop in blood pressure. 446 women were randomly assigned to receive a dose based on spine length or standard height-based dosing…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested whether wearing compression stockings or raising the legs during a planned C-section under spinal anesthesia helps prevent dangerously low blood pressure. 90 pregnant women were split into three groups: one wore stockings, one had legs elevated, and one received…

This study tested whether tilting elderly patients head-down at a 10-degree angle during the start of anesthesia could prevent dangerously low blood pressure. Researchers compared this position to lying flat in 168 patients aged 65-90 having abdominal surgery. The main goal was t…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested whether raising a patient's legs before general anesthesia can prevent a sudden drop in blood pressure. Researchers studied 200 adults undergoing surgery. The goal was to see if this simple technique reduces the need for emergency medications and keeps the heart…

This study compared two medicines, ephedrine and norepinephrine, to treat low blood pressure that can happen during a C-section with spinal anesthesia. 70 healthy pregnant women took part. The goal was to see which drug controlled blood pressure better and to check for side effec…

This study tested two different drug combinations for pain relief after stoma reversal surgery. 86 adults received either ropivacaine plus dexamethasone or ropivacaine plus dexmedetomidine in a nerve block. The goal was to see which combination provides longer pain relief and red…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study tested two methods of giving spinal anesthesia during C-sections: giving the drug all at once or in smaller doses over time. Researchers wanted to see which approach keeps the mother's blood pressure more stable and provides good pain relief. The trial involved 99 wome…

This study tested whether giving calcium before the drug diltiazem can prevent a sudden drop in blood pressure in people with a fast heart rate due to atrial fibrillation or flutter. 92 adults took part. The goal was to make the treatment safer and more comfortable.

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study compared two medications, norepinephrine and phenylephrine, for treating low blood pressure during spinal anesthesia in C-sections. 46 women were randomly given one of the two drugs when their blood pressure dropped. Both drugs worked well, but norepinephrine kept the …

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study looked at 110 adults having nose surgery (septoplasty) to see if different blood pressure targets during surgery affect kidney injury. Patients were split into two groups: one with a lower blood pressure target (50-57 mmHg) and one with a higher target (58-65 mmHg). Ki…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study looked at whether intentionally lowering blood pressure during nose surgeries (like rhinoplasty) might cause hidden kidney injury. Researchers measured two sensitive kidney biomarkers (NGAL and cystatin C) in 35 adults before and after surgery. The goal was to detect e…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study looked at how an abdominal compression binder (like a tight belt) helps people with autonomic failure who get dizzy or faint when standing due to low blood pressure. Researchers compared the binder to a standard medication (midodrine) and a placebo in 21 adults. The go…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study tested whether wearing compression socks, tights, or an abdominal belt helps older adults with orthostatic hypotension (a sudden drop in blood pressure when standing up). 43 hospitalized patients aged 60+ had their blood pressure measured while standing, with and witho…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study tests a motorized tilt table and lower-body pressure chamber designed to help military pilots train for and understand fainting and blood pooling. Forty-six pilots and cadets will be tilted and exposed to pressure changes while their heart rate, blood pressure, and bra…

This study looked at whether a simple, non-invasive ultrasound of the internal jugular vein in the neck can help predict a dangerous drop in blood pressure (hypotension) after spinal anesthesia in elderly patients. The study included 70 people aged 65 and older undergoing electiv…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study looked at whether giving spinal anesthesia quickly (15 seconds) or slowly (90 seconds) changes blood pressure and heart function in elderly patients with hip fractures. Eighty-four patients were randomly assigned to one of the two speeds. The researchers measured blood…

This study aimed to create an artificial intelligence algorithm that can predict which patients are at risk of low blood pressure after receiving spinal anesthesia for a cesarean section. Researchers collected data from 370 patients, including their medical history, demographics,…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study tested whether teaching dialysis staff and providing support to patients could reduce episodes of dangerously low blood pressure during treatment. Over 1,400 patients across multiple clinics took part. The goal was to make dialysis sessions safer and more stable.

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study looked at 101 adults having elective spine surgery to compare two medicines (norepinephrine and phenylephrine) used to keep blood pressure stable during the operation. The main goal was to see how much of each drug was needed. Researchers also checked if either drug le…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study looked at over 3,600 adults having major surgery to find out which of two blood pressure drugs (norepinephrine or phenylephrine) works best to prevent complications like kidney injury or death. Patients received one of the two drugs during their operation. The goal was…

This study looked at 192 adults with septic shock to see if a simple finger-pressure test (capillary refill time) could predict outcomes as well as a standard blood test (lactate level). Researchers measured both at the same time and tracked which patients got worse or died withi…

This study looked at 110 people with high blood pressure who were having surgery with spinal anesthesia. Researchers used ultrasound to measure blood vessel features before the anesthesia to see if they could predict a dangerous drop in blood pressure. The goal is to help doctors…

This study tested whether using automatic pumps to switch syringes of noradrenalin (a drug that raises blood pressure) reduces the risk of hypotension compared to manual swaps. Fifty intensive care patients receiving noradrenalin were monitored. The goal was to see if automatic r…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This pilot study tested a new blood pressure monitor (ClearSight HPI) in 34 healthy pregnant women receiving epidural pain relief during labor. The goal was to see if the device helps nurses detect and treat low blood pressure faster than standard monitoring. The study focused on…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This completed study looked at 94 women who had a planned C-section under spinal anesthesia. Doctors compared two drugs used to prevent low blood pressure: a continuous drip of phenylephrine versus bolus injections of ephedrine. The main goal was to see which approach led to heal…

This study looked at how brain blood flow and oxygen levels change when doctors treat critically ill children for shock or very low blood pressure. Researchers used a special light-based device (NIRS) and ultrasound to monitor 27 children in the intensive care unit. The goal was …

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…