Hypotensive disorder

This study tests a device called the Hypotension Prediction Index (HPI) that warns doctors when a patient's blood pressure is about to drop dangerously low after surgery. 210 adults having elective surgery under general anesthesia will be randomly assigned to either standard moni…

This trial compares two medications, ephedrine and phenylephrine, used to treat sudden low blood pressure during carotid surgery. The main question is whether one drug better preserves oxygen levels in the brain during the procedure. The study involves adults undergoing planned c…

This trial tests an automated system that monitors blood pressure and delivers medications to keep it stable during spinal anesthesia for cesarean sections. The system aims to prevent low blood pressure, which can cause side effects for both mother and baby. The study includes wo…

This trial tests an automated system that monitors blood pressure continuously and automatically delivers two medications to prevent low blood pressure during cesarean sections under spinal anesthesia. The system is compared to the standard manual approach of giving bolus doses. …

This study tested an experimental drug called REGN7544 in 76 adults hospitalized with sepsis and low blood pressure. The drug is an antibody designed to help raise blood pressure and reduce the need for standard medications. Researchers measured safety, blood pressure changes, an…

This study tested two drugs, norepinephrine and ephedrine, to prevent and treat low blood pressure during planned C-sections under spinal anesthesia. 196 healthy pregnant women were randomly assigned to receive one of the two drugs. Researchers tracked how many doses were needed …

This study compared two medications, norepinephrine and phenylephrine, given continuously during C-sections to prevent dangerously low blood pressure. 98 women participated. Norepinephrine was more effective, causing low blood pressure in only 14.9% of cases compared to 42.6% wit…

This study tested two common drugs, ephedrine and norepinephrine, to treat low blood pressure during C-sections under spinal anesthesia. Low blood pressure can reduce blood flow to the baby, so doctors want the safest option. The trial included 102 pregnant women having planned C…

This study tested whether giving norepinephrine early during major abdominal surgery could prevent drops in blood pressure and reduce organ problems afterward. 500 adults aged 50 and older took part. One group received norepinephrine early, while the other received the standard d…

This study tested a new computer program (nomogram) for the Aurora Xi plasmapheresis system, which collects plasma from donors. The goal was to see if the new software could lower the risk of sudden drops in blood pressure (hypotension) during donation. Over 6,700 donors took par…

This study tested whether giving the drug noradrenaline before anesthesia can prevent dangerous low blood pressure in patients with sepsis undergoing surgery. Eighty adults took part, and researchers measured how many experienced a drop in blood pressure after being put to sleep.…

This trial tests an AI software called Vital-PICASO that analyzes vital signs like blood pressure, heart rate, and oxygen levels to predict whether a hospital patient will experience hypotension (dangerously low blood pressure) within the next 24 hours. Researchers will review me…

This study tests whether a medicated skin patch called SP-103 can reduce pain and disability in people with moderate to severe acute lower back pain. Participants wear the patch for 12 hours daily over 28 days. The trial compares the active patch to a placebo patch to see if it t…

This trial tests whether giving a continuous infusion of phenylephrine (a drug that raises blood pressure) can prevent shivering after spinal anesthesia in women having a C-section. About 108 non-laboring women will be randomly assigned to receive either the phenylephrine infusio…

This study tested a device called the Hypotension Prediction Index (HPI) to see if it can reduce low blood pressure during planned C-sections. Low blood pressure after spinal anesthesia can harm both mother and baby. The device alerts doctors before blood pressure drops, so they …

This study tested two drugs, dexmedetomidine and nitroglycerin, to see which one better reduces bleeding during functional endoscopic sinus surgery (FESS). 66 adults having elective FESS were randomly assigned to receive one of the drugs to lower blood pressure and improve the su…

This study compared two sedatives, dexmedetomidine and propofol, in 100 high-risk patients undergoing ERCP. The goal was to see which drug causes fewer breathing and heart problems. Researchers monitored vital signs closely to find the safer option for these vulnerable patients.

This study tested an automated abdominal binder that inflates when a person stands, applying pressure to help maintain blood pressure. It included 28 adults with autonomic failure and disabling orthostatic hypotension. Participants wore either the active binder or a sham version …

This study looked at whether ondansetron, a drug often used for nausea, can reduce dangerous drops in blood pressure and heart rate in older adults (65+) undergoing spinal anesthesia for urologic surgery. Researchers tracked 140 patients to see if those who received ondansetron h…

This study tested whether using the length of the lower spine to calculate spinal anesthesia dose during C-sections could lower the risk of a dangerous drop in blood pressure. 446 women were randomly assigned to receive a dose based on spine length or standard height-based dosing…

This study tested whether wearing compression stockings or raising the legs during a planned C-section under spinal anesthesia helps prevent dangerously low blood pressure. 90 pregnant women were split into three groups: one wore stockings, one had legs elevated, and one received…

This study tested whether tilting elderly patients head-down at a 10-degree angle during the start of anesthesia could prevent dangerously low blood pressure. Researchers compared this position to lying flat in 168 patients aged 65-90 having abdominal surgery. The main goal was t…

This study tested whether raising a patient's legs before general anesthesia can prevent a sudden drop in blood pressure. Researchers studied 200 adults undergoing surgery. The goal was to see if this simple technique reduces the need for emergency medications and keeps the heart…

This study compared two medicines, ephedrine and norepinephrine, to treat low blood pressure that can happen during a C-section with spinal anesthesia. 70 healthy pregnant women took part. The goal was to see which drug controlled blood pressure better and to check for side effec…

This study tested two different drug combinations for pain relief after stoma reversal surgery. 86 adults received either ropivacaine plus dexamethasone or ropivacaine plus dexmedetomidine in a nerve block. The goal was to see which combination provides longer pain relief and red…

This study tested two methods of giving spinal anesthesia during C-sections: giving the drug all at once or in smaller doses over time. Researchers wanted to see which approach keeps the mother's blood pressure more stable and provides good pain relief. The trial involved 99 wome…

This study tested whether giving calcium before the drug diltiazem can prevent a sudden drop in blood pressure in people with a fast heart rate due to atrial fibrillation or flutter. 92 adults took part. The goal was to make the treatment safer and more comfortable.

This study compared two medications, norepinephrine and phenylephrine, for treating low blood pressure during spinal anesthesia in C-sections. 46 women were randomly given one of the two drugs when their blood pressure dropped. Both drugs worked well, but norepinephrine kept the …

This study is testing whether measuring residual blood volume and excess fluid during hemodialysis can predict the risk of intradialytic hypotension—a sudden drop in blood pressure that can cause dizziness, nausea, or fainting. Researchers will follow 60 adults with chronic kidne…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This study will collect routine data from 100 adult ICU patients to build a machine learning model that predicts low blood pressure (hypotension) up to 30 minutes before it happens. The model uses non-invasive vital signs, heart rate, medication records, and fluid balance. No tre…

This study looked at 110 adults having nose surgery (septoplasty) to see if different blood pressure targets during surgery affect kidney injury. Patients were split into two groups: one with a lower blood pressure target (50-57 mmHg) and one with a higher target (58-65 mmHg). Ki…

This study looked at whether intentionally lowering blood pressure during nose surgeries (like rhinoplasty) might cause hidden kidney injury. Researchers measured two sensitive kidney biomarkers (NGAL and cystatin C) in 35 adults before and after surgery. The goal was to detect e…

This study looked at how an abdominal compression binder (like a tight belt) helps people with autonomic failure who get dizzy or faint when standing due to low blood pressure. Researchers compared the binder to a standard medication (midodrine) and a placebo in 21 adults. The go…

This study tested whether wearing compression socks, tights, or an abdominal belt helps older adults with orthostatic hypotension (a sudden drop in blood pressure when standing up). 43 hospitalized patients aged 60+ had their blood pressure measured while standing, with and witho…

This study tests a motorized tilt table and lower-body pressure chamber designed to help military pilots train for and understand fainting and blood pooling. Forty-six pilots and cadets will be tilted and exposed to pressure changes while their heart rate, blood pressure, and bra…

This study looked at whether a simple, non-invasive ultrasound of the internal jugular vein in the neck can help predict a dangerous drop in blood pressure (hypotension) after spinal anesthesia in elderly patients. The study included 70 people aged 65 and older undergoing electiv…

This study looked at whether giving spinal anesthesia quickly (15 seconds) or slowly (90 seconds) changes blood pressure and heart function in elderly patients with hip fractures. Eighty-four patients were randomly assigned to one of the two speeds. The researchers measured blood…

This study aimed to create an artificial intelligence algorithm that can predict which patients are at risk of low blood pressure after receiving spinal anesthesia for a cesarean section. Researchers collected data from 370 patients, including their medical history, demographics,…

This study tested whether teaching dialysis staff and providing support to patients could reduce episodes of dangerously low blood pressure during treatment. Over 1,400 patients across multiple clinics took part. The goal was to make dialysis sessions safer and more stable.

This study looked at 101 adults having elective spine surgery to compare two medicines (norepinephrine and phenylephrine) used to keep blood pressure stable during the operation. The main goal was to see how much of each drug was needed. Researchers also checked if either drug le…

This study looked at over 3,600 adults having major surgery to find out which of two blood pressure drugs (norepinephrine or phenylephrine) works best to prevent complications like kidney injury or death. Patients received one of the two drugs during their operation. The goal was…

This study looked at 192 adults with septic shock to see if a simple finger-pressure test (capillary refill time) could predict outcomes as well as a standard blood test (lactate level). Researchers measured both at the same time and tracked which patients got worse or died withi…

This study looked at 110 people with high blood pressure who were having surgery with spinal anesthesia. Researchers used ultrasound to measure blood vessel features before the anesthesia to see if they could predict a dangerous drop in blood pressure. The goal is to help doctors…

This study tested whether using automatic pumps to switch syringes of noradrenalin (a drug that raises blood pressure) reduces the risk of hypotension compared to manual swaps. Fifty intensive care patients receiving noradrenalin were monitored. The goal was to see if automatic r…

This pilot study tested a new blood pressure monitor (ClearSight HPI) in 34 healthy pregnant women receiving epidural pain relief during labor. The goal was to see if the device helps nurses detect and treat low blood pressure faster than standard monitoring. The study focused on…

This completed study looked at 94 women who had a planned C-section under spinal anesthesia. Doctors compared two drugs used to prevent low blood pressure: a continuous drip of phenylephrine versus bolus injections of ephedrine. The main goal was to see which approach led to heal…

This study looked at how brain blood flow and oxygen levels change when doctors treat critically ill children for shock or very low blood pressure. Researchers used a special light-based device (NIRS) and ultrasound to monitor 27 children in the intensive care unit. The goal was …