Which drug keeps sinus surgery cleaner? dexmedetomidine vs. nitroglycerin

NCT ID NCT07585201

Completed Symptom relief Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two drugs, dexmedetomidine and nitroglycerin, to see which one better reduces bleeding during functional endoscopic sinus surgery (FESS). 66 adults having elective FESS were randomly assigned to receive one of the drugs to lower blood pressure and improve the surgeon's view. The main goal was to compare surgical field quality and drug costs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexmedetomidine and nitroglycerin
What this could lead to: If one drug works better, it could make sinus surgeries safer and cheaper by improving visibility and reducing bleeding.
What could go wrong: This is a small, completed study with only 66 participants, so results may not apply to everyone. Both drugs have side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Blood Loss, Surgical hypotensive disorder sinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FUNCTIONAL ENDOSCOPIC SINUS SURGERIES HYPOTENSION INTRAOPERATIVE BLEEDING

Contacts and locations

Locations

Zagazig university

Zagazig, Sharqia Province, 44111, Egypt

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