Sinusitis

This study will compare three FDA-approved biologic drugs (dupilumab, omalizumab, and mepolizumab) in 504 adults with chronic sinusitis and nasal polyps. The goal is to see which drug works best for different patients and whether simple tests can predict who will improve the most…

This study tests whether a balloon coated with the drug paclitaxel, used during standard sinus surgery, can reduce the need for additional procedures or medications in adults with chronic sinusitis. About 300 participants will receive either the drug-coated balloon or a plain bal…

This study follows 200 adults with severe chronic sinusitis and nasal polyps who are starting tezepelumab as part of their routine care. Researchers will track changes in symptoms and quality of life over up to two years using patient questionnaires. The goal is to see how well t…

This trial tests a new nanoparticle spray containing the steroid triamcinolone acetonide for people recovering from endoscopic sinus surgery. The spray is designed to deliver the drug directly to the nasal cavity to reduce inflammation and improve healing. Researchers compare it …

This study tests a single surgery that combines sinus endoscopy with oral surgery to treat sinusitis caused by dental issues. 36 adults who haven't improved with standard dental or medical care will receive this procedure. The goal is to see if this combined approach works better…

This study follows 900 adults with severe chronic sinusitis and nasal polyps who are taking biologic drugs. Researchers will track how these treatments affect quality of life, symptoms, and side effects over 5 years. The goal is to see which patients benefit most based on their h…

This study looks at whether people with severe nasal polyps who have been symptom-free for at least a year on biologic drugs like Dupixent or Nucala can safely stop taking them. 66 participants will either stop their medication or continue as usual, and researchers will track if …

This study tests whether transplanting nasal bacteria from a healthy donor can relieve chronic sinusitis. Fifty adults with sinusitis will receive either the bacteria rinse or a placebo for five days. The goal is to see if symptoms improve and if the nasal microbiome becomes heal…

This study tests whether adding lymphatic pump osteopathic manipulative therapy (OMT) to standard care helps older adults recover faster from respiratory illnesses like bronchitis, sinusitis, or pneumonia. Participants aged 65 to 100 with a new respiratory diagnosis will receive …

This study is testing four medical devices (PIR, NS, NHE, NHG) in 150 adults with acute viral rhinitis, rhinosinusitis, or rhinopharyngitis (common cold). The goal is to see if they are safe and help reduce symptoms like sneezing, runny nose, and sore throat. Participants use the…

This study tests whether a 3D-printed replica of a person's own nose can help them position their head better when using steroid nasal rinses. 200 adults with chronic sinusitis will use a daily steroid rinse for 8 weeks, with some getting the 3D model to guide their head position…

This study tests whether rinsing the sinuses with a probiotic (good bacteria) solution can reduce symptoms of chronic sinusitis better than a plain saltwater rinse. About 60 adults who have had sinus surgery in the past will use the rinse daily for a period and report changes in …

This early study tests whether ivacaftor, a drug used for cystic fibrosis, can help people with chronic sinusitis caused by hard-to-treat bacteria. Twenty adults will receive either ivacaftor plus standard care or standard care alone for 14 days. Researchers will check safety, sy…

This study tests whether a nasal spray called OPN-375 can reduce symptoms of chronic sinusitis (like stuffy nose, discharge, and facial pain) in adolescents aged 12 to 17. About 84 teens will receive either the spray or a placebo twice daily for 12 weeks. The main goal is to see …

This Phase 3 trial tests whether the drug Raphamin can quickly improve symptoms of acute rhinosinusitis (sinus infection) in adults. About 552 participants will receive either Raphamin or a placebo for a few days. The main goal is to see if more people feel much better by day 4 o…

This study tests whether using a navigation system during balloon sinus dilation improves success rates for people with chronic maxillary sinusitis. Fifty adults who have not had prior sinus surgery will be randomly assigned to receive either standard balloon dilation or navigati…

This study looks at whether antibiotics, nasal steroids, or nasal irrigation work best for treating sinus infections. About 3,720 adults with acute sinusitis will be randomly assigned to one of these treatments or a placebo. The goal is to see which approach provides the most sym…

This study looks at whether a Chinese herbal medicine nasal rinse can help people feel better and heal faster after sinus surgery for chronic sinusitis. About 80 adults who have already had surgery will use the rinse for two months. The goal is to see if it reduces symptoms and i…

This study compares two ways to treat chronic sinusitis with nasal polyps: a new in-clinic procedure done under local anesthesia versus standard sinus surgery in an operating room. Researchers will enroll 140 adults to see if the in-clinic approach controls symptoms just as well,…

This study tests whether smelling lavender essential oil during awake ear, nose, and throat procedures can lower anxiety and pain. About 184 adults will be randomly assigned to receive either lavender aromatherapy or a placebo (odorless liquid). Participants will rate their anxie…

This study looks at how well seawater nasal sprays work in everyday life for people with nasal and sinus issues like colds, allergies, or after surgery. About 1065 people of all ages, including pregnant women, will use the sprays and report their symptoms. The goal is to see if t…

This early-stage study tests a new nasal spray called VVN432 in 60 people. First, healthy volunteers will check for safety. Then, patients with chronic sinusitis will test if it helps symptoms. The goal is to see if the spray is safe and how the body processes it.

This study is testing a seawater spray mixed with essential oils to see how well it relieves nasal congestion from colds, sinus infections, or allergies. About 114 people aged 12 and older will use the spray for 7 days. The main goal is to see if nasal blockage improves after 3 d…

This study is testing a new seawater spray with essential oils to see if it safely relieves nasal congestion from colds, sinus infections, or allergies. About 101 people aged 12 and older will use the spray for 8 days. The main goal is to check if nasal stuffiness improves by at …

This study tests a new tablet called HTMC0658 in 30 adults with chronic sinusitis (no nasal polyps). The goal is to see if it safely reduces symptoms like congestion, facial pain, and discharge over 12 weeks. Participants will have CT scans and symptom checkups to measure improve…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study will collect and analyze nasal tissue from 230 Greek patients with chronic sinusitis (with or without nasal polyps) to identify different inflammation patterns, called endotypes. By understanding these patterns, researchers hope to better match patients with the most e…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This study follows 30 people with chronic sinusitis and nasal polyps who are starting dupilumab, a medication that can help restore smell. Researchers want to see if the degree of nasal blockage or specific electrical signals from the brain can predict who will regain their sense…

This study looks at people with smell loss caused by chronic rhinosinusitis. Participants will undergo a 3-month smell training program. Researchers will measure changes in smell function, mental health, and immune markers in blood and tissue samples. The goal is to understand th…

About 30 million US adults suffer from nasal sinus disease, often causing nasal obstruction and loss of smell. This study from Ohio State University will test a nasal plug (similar to a swimmer's nose clip) as a tool to better evaluate these symptoms. Researchers hope to develop …

This study follows 80 children aged 2-8 with cystic fibrosis to see how highly effective CF drugs (Kalydeco or Trikafta) impact sinus disease and sense of smell. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand whe…

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study is observing 120 patients with sinonasal or skull-base tumours at a specialist ear, nose, and throat centre. Researchers are tracking how these conditions are managed, what the outcomes are, and how patients' quality of life changes. The goal is to better understand cu…

This study is checking how safe and effective the Propel sinus implant family is when used as part of standard care for chronic rhinosinusitis in Japan. About 100 people who have had sinus surgery will be followed for 3 months. The main goal is to see how their symptoms change us…

This study follows 170 adults with cystic fibrosis and chronic sinusitis to see if sinus surgery improves lung function and quality of life compared to medical treatment alone. Participants either have surgery or continue with standard care. Researchers will track changes in brea…

This study looks at whether a partial problem with a salt channel (CFTR) in the nose contributes to chronic sinusitis. Researchers will measure how well the nose clears mucus in 20 people with sinusitis and healthy volunteers. The goal is to understand the disease better, not to …

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study looks at whether people with cystic fibrosis who are on highly effective modulator therapy can safely stop using nasal saline rinses and steroid sprays. Researchers will monitor sinus health, lung function, and quality of life in 64 adults. The goal is to see if these …