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Nanoparticle steroid spray could transform recovery after sinus surgery

NCT ID NCT07714525

Recruiting now Disease control Sponsor: Deraya University Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This trial tests a new nanoparticle spray containing the steroid triamcinolone acetonide for people recovering from endoscopic sinus surgery. The spray is designed to deliver the drug directly to the nasal cavity to reduce inflammation and improve healing. Researchers compare it to standard saline irrigation in adults with chronic rhinosinusitis or nasal polyps. The goal is to see if the nanoparticle formulation leads to better recovery and fewer complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
triamcinolone acetonide-loaded polymeric nanocapsules
What this could lead to
If it works, this could offer a more effective and safer way to deliver steroids after sinus surgery, reducing inflammation and improving healing with fewer side effects.
What could go wrong
This is a small, early-phase trial, so results may not be conclusive. The nanoparticle formulation may not work better than standard care, and there is a risk of corticosteroid-related side effects.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis nasal cavity polyp

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS (CRS) NASAL POLYPS POSTOPERATIVE HEALING AFTER ENDOSCOPIC NASAL SURGERY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Deraya university, faculty of pharmacy

    RECRUITING

    Minya, Menia Governorate, Egypt

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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