Can a single drug shrink nasal polyps and restore breathing?
NCT ID NCT04607005
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether mepolizumab, an injectable drug, can reduce nasal polyp size and improve symptoms like nasal blockage in adults with chronic rhinosinusitis and nasal polyps. Participants receive either mepolizumab or a placebo every four weeks for a year. The study aims to see if the drug offers a better way to control this condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an injectable drug called mepolizumab
- What this could lead to
- If it works, this could offer a new treatment option for people with nasal polyps that are hard to manage with standard care.
- What could go wrong
- This is an early-phase trial, so the drug may not prove effective or could cause side effects. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
GSK Investigational Site
Chiba, 262-0015, Japan
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- In-Clinic polyp removal could replace costly sinus surgery