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Could a single biologic replace steroid sprays for nasal polyps?

NCT ID NCT07701967

Not yet recruiting Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study tests whether the biologic drug depemokimab, given as a shot, can shrink nasal polyps in Japanese adults with chronic sinusitis and nasal polyps who have not been helped by standard treatments. Participants receive depemokimab without using steroid nasal sprays. The main goal is to see if the drug reduces polyp size by at least one point on an 8-point scale without needing surgery or other medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
an experimental biologic drug called depemokimab
What this could lead to
If successful, this could offer a steroid-free treatment option for nasal polyps, reducing the need for surgery or oral steroids.
What could go wrong
This is a small, early-phase study in Japanese patients only, so results may not apply broadly. The drug may not shrink polyps enough or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nasal cavity polyp

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NASAL POLYPS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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