Glaxosmithkline

This study is testing whether giving children a lower dose of an existing malaria vaccine, or giving it on a different schedule, is safe and still helps their bodies build protection. It involves 238 healthy children, aged 5 months to 5 years, who live in an area where malaria is…

This study is testing a new vaccine designed to prevent shingles (herpes zoster) in children and teenagers who have had a kidney transplant. These young patients have weakened immune systems from their transplant medications, making them more likely to get shingles. Researchers a…

This study is testing a new vaccine designed to protect against Respiratory Syncytial Virus (RSV) in Chinese adults aged 18 to 59 who have certain health conditions that put them at higher risk for severe RSV illness. Researchers will give a single dose of the vaccine to 750 part…

This study aims to see if a new chickenpox vaccine being developed works as well and is as safe as the vaccine already in use. It will involve 600 healthy toddlers who will receive two doses of either the new or the approved vaccine. Researchers will measure the children's immune…

This study is testing new flu vaccines made with mRNA technology, similar to some COVID-19 vaccines. It aims to see how well they trigger an immune response and how safe they are in 960 healthy adults aged 18 and older. Researchers will compare different vaccine versions to under…

This study is testing a new combination vaccine for chickenpox and measles, mumps, and rubella (MMR) in healthy toddlers. It compares giving the new vaccine as a standard shot in the muscle to giving the current chickenpox vaccine as a shot just under the skin. The main goals are…

This study is testing whether an injectable drug called depemokimab can reduce disease flares in adults with hypereosinophilic syndrome (HES), a rare condition where too many white blood cells cause inflammation and organ damage. Participants will receive either depemokimab or a …

This study continues testing an experimental Alzheimer's drug called GSK4527226 (AL101) to see how safe and effective it is over two years. It includes 220 people with early Alzheimer's disease who already participated in a previous trial. All participants receive the same drug w…

This study is a long-term follow-up for adults with lung scarring (interstitial lung disease) caused by autoimmune conditions like systemic sclerosis. It aims to see if the drug belimumab, given as a self-injection, continues to be safe and effective at slowing the decline in lun…

This study is testing whether an injectable medication called depemokimab can improve the physical structure of the lungs in adults with a specific, severe type of asthma. Researchers will use detailed CT scans and optional lung sampling to see if the drug reduces mucus plugs and…

This study is testing a new drug called belantamab for people with multiple myeloma, a type of blood cancer. It aims to find safe and effective doses, both when given alone and when combined with other standard treatments. The trial is for adults whose cancer has come back or sto…

This study aims to understand how well the drug belimumab works in everyday medical practice to protect kidney function in adults with lupus nephritis. It will follow 300 participants for up to 5 years to see if the treatment helps them avoid severe kidney decline and the need fo…

This study is testing a new drug called GSK5733584, given in combination with other cancer medicines, for people with advanced solid tumors that have spread and stopped responding to standard treatments. The main goals are to find a safe dose, see how the body processes the drug,…

This study is testing the drug belimumab in adults who were recently diagnosed with lupus. The goal is to see if the drug, given as a shot at home, can help control lupus disease activity over three years and allow patients to reduce their steroid use. Researchers will track how …

This Phase 3 trial compares two different three-drug combinations for adults newly diagnosed with multiple myeloma who cannot receive a stem cell transplant. Researchers want to see if the combination containing belantamab mafodotin (BRd) keeps the cancer from getting worse longe…

This study is testing if adding an immunotherapy drug called dostarlimab to standard chemotherapy works better than chemotherapy alone when given before colon cancer surgery. The goal is to see if the combination shrinks tumors more effectively in patients with a specific type of…

This is the first study in people testing a new drug called GSK5458514 for advanced prostate cancer that has spread and is no longer responding to standard hormone therapy. The main goals are to find a safe dose and see how the body processes the drug. The study will also check i…

This study allows patients with ovarian or breast cancer who are already benefiting from the drug niraparib in previous trials to continue receiving it. The main goal is to monitor the long-term safety of continued treatment. Researchers will track side effects and health changes…

This study is testing whether a new targeted drug called GSK5764227 works better than the standard treatment (topotecan) for people whose small cell lung cancer has returned after initial therapy. About 420 adults with relapsed lung cancer will be randomly assigned to receive eit…

This large study is testing if adding a new injectable medicine called depemokimab to standard inhaler therapy can help control Chronic Obstructive Pulmonary Disease (COPD). It aims to see if the medicine reduces the number of serious breathing flare-ups that require steroids, an…

This study is testing a new drug called GSK5764227 for people with advanced stomach, colon, rectal, or pancreatic cancers that have spread and cannot be removed by surgery. The trial aims to see if the drug is safe, how well it works to shrink tumors, and how the body processes i…

This study is testing if adding a third medicine (umeclidinium) to a standard two-medicine inhaler helps teens with asthma breathe better. About 290 teens aged 12-17 whose asthma is not well-controlled on their current inhaler will use either the triple or dual inhaler for 24 wee…

This is the first study in humans to test the safety of a new oral drug called GSK4024484, which is being developed to treat falciparum malaria. The trial will enroll 156 healthy adult volunteers to see how their bodies handle single and multiple doses of the drug, and whether ta…

This large, late-stage trial is testing whether a new immunotherapy drug called dostarlimab, given around the time of surgery, works better than standard chemotherapy for people with a specific type of colon cancer that has a high chance of returning. The study will enroll nearly…

This is the first study to give a new drug called GSK4528287 to people. It aims to treat inflammatory bowel diseases like ulcerative colitis. Researchers will give single, increasing doses to 48 healthy volunteers to check for side effects, see how long the drug stays in the bloo…

This large, late-stage study is testing whether a new drug called efimosfermin alfa is safe and can help control a type of fatty liver disease called MASH. It will involve about 1,250 adults with moderate liver scarring to see if the drug can reduce fat and stiffness in the liver…

This study is testing whether an experimental medication called GSK4532990 can help people with alcohol-related liver disease. Researchers will give different doses of the drug or a placebo to 393 adults over 28 weeks to see if it reduces liver stiffness and improves liver functi…

This study is testing whether a new injectable medicine called depemokimab can help adults with a specific type of COPD (chronic obstructive pulmonary disease) who continue to have flare-ups despite using standard inhalers. The main goal is to see if the medicine reduces the numb…

This early-stage study is testing a new oral drug called GSK5460025, given alone or with other cancer treatments, in adults with advanced solid tumors that have specific genetic characteristics (dMMR or MSI-H). The main goals are to find a safe dose, see how the body processes th…

This early-stage study is testing a new experimental drug called GSK5764227 in adults with advanced solid tumors that have spread or cannot be surgically removed. Researchers want to find the safest dose and see how the drug behaves in the body when given alone or combined with o…

This large, late-stage study is testing whether a new drug called efimosfermin alfa can help people with a serious form of fatty liver disease called MASH. The main goal is to see if the drug can reduce liver scarring and fat buildup over one year, compared to a placebo. The stud…

This study is testing whether combining two drugs, momelotinib and luspatercept, can help people with a rare bone marrow cancer called myelofibrosis who need frequent blood transfusions. The main goal is to see if the treatment can reduce or eliminate the need for transfusions ov…

This is the first time researchers are testing a new drug called GSK5471713 in people. The study aims to find a safe dose and see if it helps men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments and chemotherapy. Researchers will…

This study is testing whether a new drug called IDRX-42 works better than the current standard drug, sunitinib, for people with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The trial will involve 450 adults whose cancer has pro…

This study is for adults with a specific type of advanced head and neck cancer who have just finished standard chemoradiation treatment. The goal is to see if adding a drug called dostarlimab (an immunotherapy) after that standard treatment is better than a placebo at keeping the…

This study is testing whether adding the drug belimumab to standard treatment can help control lung scarring (interstitial lung disease) in adults whose scarring is caused by an underlying autoimmune condition like lupus or rheumatoid arthritis. Researchers will measure if the dr…

This study is testing whether adding the drug belimumab to standard treatment helps adults with scleroderma who have developed scarring in their lungs. It will measure if the drug can slow the decline in lung function and also improve skin thickening and symptoms like fatigue ove…

This study is testing whether adding the immunotherapy drug dostarlimab to standard chemotherapy works better for Chinese women with advanced or returning endometrial (uterine) cancer that has specific genetic markers. Researchers want to see if this combination helps shrink tumo…

This early-stage trial is testing a new cancer medicine called GSK5764227, which works like a targeted delivery system to bring a toxin directly to cancer cells while trying to avoid healthy ones. The study will combine this experimental drug with standard cancer treatments in 84…

This study is testing whether giving an extra dose of an RSV vaccine helps maintain protection in adults who have received a lung or kidney transplant. These patients are at high risk for severe RSV infection because their immune systems are weakened by anti-rejection medications…

This early-stage study aims to understand how a single dose of an experimental drug called efimosfermin alfa is processed by the body and how safe it is for adults with varying degrees of liver damage caused by fatty liver disease. It will enroll 32 participants with moderate to …

This early-stage study aims to check the safety and how the body processes a single dose of efimosfermin alfa, a potential future treatment for non-alcoholic fatty liver disease. Researchers will enroll 30 healthy participants of Chinese, Japanese, and White/European ancestry to …

This is the first study in humans of an experimental drug called GSK4527363. It aims to check the drug's basic safety and how the body processes it in healthy volunteers and in people with autoimmune conditions like lupus. The study will enroll 142 participants across four groups…

This study is testing whether a new, more environmentally friendly propellant (HFA-152a) works as well as the current standard (HFA-134a) in asthma rescue inhalers. It will involve 84 adults with mild asthma, who will use inhalers with each propellant. Researchers will measure ho…

This study aims to understand how a Hepatitis B drug called bepirovirsen behaves in the bodies of people with moderate or severe kidney disease. It will compare the drug's levels in their blood to those in healthy people after a single dose. The goal is to gather safety informati…

This study aims to see if new lab tests and a special type of PET scan can predict how well standard immunotherapy drugs work for people with recurrent non-small cell lung cancer. It will involve about 40 participants whose cancer has returned after initial treatment. The goal is…

This project aims to collect up to 10 years of past and future medical records from people who participated in a previous asthma study. By gathering this long-term health data, researchers hope to better understand how asthma develops, what factors influence it, and how treatment…