New drug aims to cut COPD Flare-Ups in patients with type 2 inflammation

NCT ID NCT06961214

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called depemokimab in adults aged 40 to 80 with moderate to severe COPD and type 2 inflammation. The goal is to see if adding this medicine to standard care can reduce the number of serious flare-ups that require steroids, antibiotics, or hospital stays. About 960 participants will receive either depemokimab or a placebo, and researchers will track how often flare-ups occur over time.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY DISEASE, CHRONIC OBSTRUCTIVE

Contacts and locations

Locations

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Sheffield, Alabama, 35660, United States
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Aurora, Colorado, 80012, United States
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Brooksville, Florida, 346135, United States
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Doral, Florida, 33172, United States
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Fort Lauderdale, Florida, 33316, United States
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Miami, Florida, 33122, United States
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Miami, Florida, 33125, United States
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Miami, Florida, 33155, United States
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Miami, Florida, 33165, United States
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Miami, Florida, 33175, United States
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Miami, Florida, 33176, United States
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Miami, Florida, 33176, United States
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Miami Lakes, Florida, 33016, United States
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Naples, Florida, 34102, United States
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New Port Richey, Florida, 34653, United States
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Ocala, Florida, 34471, United States
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Orlando, Florida, 32825, United States
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Ormond Beach, Florida, 32174, United States
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Palmetto Bay, Florida, 33157, United States
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St. Petersburg, Florida, 33704, United States
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Adairsville, Georgia, 30103, United States
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Cordele, Georgia, 31015, United States
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East Point, Georgia, 30344, United States
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Morrow, Georgia, 30260, United States
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Boise, Idaho, 83702, United States
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Chicago, Illinois, 60608, United States
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Baton Rouge, Louisiana, 70816, United States
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Lafayette, Louisiana, 70506, United States
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Shreveport, Louisiana, 71105, United States
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Bangor, Maine, 04401, United States
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Rockville, Maryland, 20854, United States
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Allen Park, Michigan, 48101, United States
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Detroit, Michigan, 48202, United States
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Garden City, Michigan, 48135, United States
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Troy, Michigan, 48085, United States
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Las Vegas, Nevada, 89144, United States
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Moorestown, New Jersey, 08057, United States
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Sewell, New Jersey, 08080, United States
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Mount Kisco, New York, 10549, United States
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New Windsor, New York, 12553, United States
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Shelby, North Carolina, 28152, United States
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DuBois, Pennsylvania, 15801, United States
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Philadelphia, Pennsylvania, 19140, United States
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Spartanburg, South Carolina, 29303, United States
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Union, South Carolina, 29379, United States
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Knoxville, Tennessee, 37919, United States
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Austin, Texas, 78744, United States
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Dallas, Texas, 75254, United States
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El Paso, Texas, 79902-1123, United States
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Houston, Texas, 77094, United States
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Lampasas, Texas, 76550, United States
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Richmond, Texas, 77407, United States
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San Antonio, Texas, 78229, United States
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Webster, Texas, 77598, United States
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Morgantown, West Virginia, 26505-0423, United States
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Buenos Aires, C1425BAD, Argentina
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Buenos Aires, C1426ABP, Argentina
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Córdoba, X5800AEV, Argentina
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Quilmes, 1878, Argentina
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Santa Fe, S3000ASF, Argentina
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Coffs Harbour, New South Wales, 2450, Australia
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Maroubra, New South Wales, 2035, Australia
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Westmead, New South Wales, 2145, Australia
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Midland, Western Australia, 6056, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Klagenfurt, 9020, Austria
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Linz, 4020, Austria
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Linz, 4020, Austria
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Linz, 4021, Austria
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Vienna, A-1090, Austria
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Dupnitsa, 2600, Bulgaria
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Haskovo, 6300, Bulgaria
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Lovech, 5500, Bulgaria
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Montana, 3400, Bulgaria
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Montana, 3400, Bulgaria
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Pleven, 5800, Bulgaria
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Rousse, 7002, Bulgaria
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Rousse, 7002, Bulgaria
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Sofia, 1510, Bulgaria
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Sofia, 1680, Bulgaria
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Jindřichův Hradec, 377 01, Czechia
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Kralupy nad Vltavou, 278 01, Czechia
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Nymburk, 288 02, Czechia
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Prague, 12000, Czechia
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Varnsdorf, 407 47, Czechia
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Munich, Bavaria, 80335, Germany
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Offenbach, Hesse, 63065, Germany
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Rheine, North Rhine-Westphalia, 48431, Germany
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Bendorf, 56170, Germany
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Berlin, 10119, Germany
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Berlin, 10625, Germany
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Berlin, 10717, Germany
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Berlin, 10961, Germany
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Berlin, 12203, Germany
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Berlin, 12627, Germany
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Berlin, 13187, Germany
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Darmstadt, 64283, Germany
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Essen, 45127, Germany
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Fürstenwalde, 15517, Germany
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Geesthacht, 21502, Germany
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Giessen, 35392, Germany
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Halle, 6108, Germany
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Immenhausen, 34376, Germany
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Leipzig, 04207, Germany
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Leipzig, 04299, Germany
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Leipzig, 04347, Germany
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Lübeck, 23552, Germany
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Schleswig, 24837, Germany
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Exochi, Thessaloniki, 57010, Greece
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Alexandroupoli, 68100, Greece
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Athens, 115 21, Greece
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Ioannina, 45500, Greece
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Marousi, 151 25, Greece
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Ashkelon, 7830604, Israel
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Beer-Yaakov, 703000, Israel
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Beersheba, 84101, Israel
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Haifa, 30000, Israel
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Haifa, 3109601, Israel
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Haifa, 3436212, Israel
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Jerusalem, 90000, Israel
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Jerusalem, 91031, Israel
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Kfar Saba, 44281, Israel
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Petah Tikva, 49100, Israel
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Ramat Gan, 52621, Israel
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Catania, 95123, Italy
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Ferrara, 44124, Italy
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Foggia, 71122, Italy
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Genova, 16132, Italy
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Roma, 00128, Italy
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Roma, 00133, Italy
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Roma, 00161, Italy
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Telese Terme, 82037, Italy
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Daugavpils, LV5410, Latvia
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Riga, LV 1079, Latvia
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Riga, LV-1002, Latvia
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Takapuna, Auckland, 0622, New Zealand
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Auckland, 1051, New Zealand
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Auckland, 1051, New Zealand
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Christchurch, 8023, New Zealand
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Ebdentown, 5018, New Zealand
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Hamilton, 3240, New Zealand
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Rotorua, 3010, New Zealand
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Oradea, Bihor County, 410155, Romania
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Oradea, Bihor County, 410176, Romania
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Timișoara, Timiș County, 300310, Romania
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Bucharest, 061692, Romania
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Cluj-Napoca, 400275, Romania
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Cluj-Napoca, 400371, Romania
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Constanța, 900002, Romania
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Seoul, 03181, South Korea
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Seoul, 5030, South Korea
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Corby, NN17 2UR, United Kingdom
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Dagenham, RM9 5NH, United Kingdom
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Glasgow, G20 7BE, United Kingdom
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Glasgow, G4 0SF, United Kingdom
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London, N8 0RA, United Kingdom
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London, NW10 2PB, United Kingdom
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Uxbridge, UB8 3NN, United Kingdom

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