COPD, severe early onset

This Phase 3 trial is testing whether a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) can reduce serious heart and lung events in people with COPD who are at elevated risk. About 5,250 participants aged 40–80 will receive either the triple therapy or a d…

This study compares two ways of placing Zephyr valves in the lungs of people with severe emphysema (a type of COPD). The standard method treats the entire lobe in one session, but about 27% of patients develop a collapsed lung (pneumothorax). The experimental method spreads the v…

This phase 2 trial is testing a new medicine called WIN378 for people with moderate to severe COPD. WIN378 is a long-acting antibody that blocks a protein involved in lung inflammation. The study will test different doses in 105 adults who are former smokers and already on standa…

This study tests a new inhaled powder called HSK39004 in 376 adults with COPD, a long-term lung disease that makes breathing hard. Participants will use the powder daily for 12 weeks to see if it improves lung function compared to a placebo. The goal is to control symptoms and he…

This study is testing the long-term safety of a drug called tozorakimab in people with chronic obstructive pulmonary disease (COPD) who have had flare-ups in the past. About 82 participants who completed earlier studies will receive tozorakimab and be monitored for side effects. …

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study tests a new device called the IAB 50 Flex, an implantable artificial bronchus for adults with severe COPD or emphysema. The trial will enroll 20 participants across two hospitals to check if the implant is safe and if it helps improve breathing and daily activity. The …

This study tests a new device called an implantable artificial bronchus (IAB) for people with severe emphysema or COPD. The IAB is designed to help air move in and out of the lungs more easily. About 60 adults will receive the implant and be followed for 90 days to see if it impr…

This study tests whether a home-based breathing exercise program can reduce hospital readmissions and deaths in people recovering from a severe COPD flare-up. About 358 participants will either receive usual care or add daily inspiratory muscle training using a smartphone-connect…

This study tests whether a detailed, personalized care plan—including diet, exercise, and counseling—can reduce hospitalizations and improve quality of life for people with COPD who have recently been hospitalized. About 110 adults aged 40 and older who smoke or used to smoke wil…

This study tests whether a nebulized drug called ensifentrine can reduce inflammation in the lungs of people with COPD. About 56 adults aged 40-80 who smoke or have smoked will receive both the drug and a placebo at different times over 24 weeks. The main goal is to see changes i…

This study tests a one-time procedure called lung denervation for people with COPD who are already on standard care. The goal is to see if it safely improves lung function and breathing over 6 months. About 200 adults aged 40-80 who have smoked heavily in the past will take part.

This study tests a permanent implant called the Apreo BREATHE Airway Scaffold in up to 250 adults with COPD and emphysema who still feel short of breath despite standard treatments. The implant is designed to prop open airways and release trapped air to improve breathing. Researc…

This study looks at whether giving early, tailored COPD treatment to people being evaluated for lung cancer can improve their breathing and overall health. About 280 participants will receive either standard care or extra COPD consultations focusing on medication, smoking cessati…

This study is tracking about 400 adults with severe or very severe COPD in Brazil who are taking the triple-combination inhaler Trimbow. Researchers will measure changes in symptoms and lung function over 6 months during routine doctor visits. The goal is to see how well the medi…

This study tests an experimental drug called depemokimab in adults aged 40 to 80 with moderate to severe COPD and type 2 inflammation. The goal is to see if adding this medicine to standard care can reduce the number of serious flare-ups that require steroids, antibiotics, or hos…

This study tests whether clinical pharmacists can provide COPD care that is as good as care from lung specialists. About 4000 veterans with COPD will have their care reviewed by either a pharmacist or a specialist, who will send recommendations to their primary doctor. The goal i…

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This Phase 2 trial tests solrikitug, a biologic drug given as a shot, in 171 adults with moderate-to-severe COPD and high eosinophil levels. The study compares two doses of solrikitug against a placebo to see if it safely reduces inflammation and improves lung function over time.…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests whether eating more omega-3s (found in fish and certain oils) can improve breathing and daily life for people with COPD. Researchers will provide food to 200 adults with moderate-to-severe COPD and track their symptoms and flare-ups over time. The goal is to see …

This study is testing whether adding probiotics to standard pulmonary rehabilitation can help control inflammation and improve breathing, physical function, and nutrition in people with COPD. Researchers will measure markers like interleukin-6 and track exercise capacity. The goa…

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This study tests a smart eccentric cycling exercise for 170 people with COPD. The goal is to see if this type of training improves heart and lung fitness, immune function, and quality of life better than standard care. Participants must have been in pulmonary rehab for at least 3…

This study tests whether a 3-month program of twice-weekly exercise and monthly education sessions can help people with COPD maintain the benefits they gained from an initial 8-week pulmonary rehab program. 86 adults aged 40-75 with moderate to severe COPD will be randomly assign…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study tests whether a daily pill called JKN2403 can reduce serious flare-ups and improve quality of life in people with moderate-to-severe COPD. About 120 adults will take either the drug or a placebo for 24 weeks, with regular clinic visits and symptom diaries. The goal is …

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study is testing an inhaler called BGF 160 (also known as Breztri Aerosphere) in 35 adults with stable COPD. The goal is to see how the medicine changes the complexity and variability of breathing patterns over 30 days. Participants will use the inhaler twice daily, and rese…

This study tests whether adding depemokimab early to standard COPD treatment can reduce moderate to severe flare-ups in people with moderate to severe COPD who have type 2 inflammation. About 1,200 participants will receive either depemokimab or a placebo as an add-on therapy. Th…

This Phase 3 trial tests whether the experimental drug 611 can reduce moderate to severe COPD flare-ups in Chinese adults aged 40-85 with moderate to severe COPD. About 594 participants will receive either 611 or a placebo injection every two weeks. The study measures how often f…

This phase 2 trial is testing whether an inhaled drug called treprostinil (Tyvaso) can improve oxygen delivery in the lungs of people with COPD who have low blood oxygen. Ten adults will use the nebulizer four times daily for four weeks, starting at a low dose and increasing as t…

This study tests a specialized clinic designed to diagnose and treat muscle loss (sarcopenia) in people with COPD. The clinic brings together a team of experts to provide targeted care. Researchers will see if this approach improves muscle mass and function, and reduces hospitali…

This study tests an experimental drug called depemokimab for people with moderate to severe COPD who also have type 2 inflammation. The goal is to see if adding this medicine to standard treatment can reduce the number of serious flare-ups that require steroids, antibiotics, or h…

This study is testing whether eating freeze-dried aronia (black chokeberry) powder every day for 8 weeks can lower inflammation and improve breathing in people with COPD. Fifty participants aged 50-80 will be randomly assigned to take either the aronia powder or a placebo. Resear…

This study is testing whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will exercise 40-60 minutes, five times a week, for eight weeks, doing activities like brisk walking, jogging,…

This study is testing whether two simple breathing tests—oscillometry and FeNO—can help primary care doctors accurately diagnose asthma and COPD, compared to the usual specialist methods. Researchers will enroll 600 adults with suspected asthma or COPD across six countries. If th…

This study is enrolling 200 adults with asthma or COPD to see if combining chest CT scans with blood, sputum, and microbiome tests can more accurately tell the two diseases apart. Researchers will also look for clues that predict how well a patient will respond to treatment. No e…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will take an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their doctor or usual care. The goal is t…

This study is testing a computer algorithm that uses health records to predict whether a person has COPD. Many people with COPD are not diagnosed until the disease is advanced, while others are wrongly told they have it. The goal is to see if the algorithm can correctly identify …

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing sound waves from the phone's speaker and microphone. Researchers will enroll 800 people aged 8-70, including healthy volunteers an…

This study tests whether combining arm and leg endurance training is better than leg training alone for improving daily activities in people with COPD. 36 participants with moderate-to-severe COPD will undergo 14 supervised sessions. The main goal is to see if the combined traini…

This study tests whether a device called Airvo 3, which automatically adjusts oxygen levels, can keep COPD patients' blood oxygen in a healthy range better than manual adjustments by nurses. About 70 hospitalized adults with COPD and low oxygen will take part. The goal is to see …

This study looks at whether using a nasal high-flow device (which delivers warm, moist air at a high rate) can help people with COPD walk farther during a 6-minute walk test. Thirty adults with COPD will try both the high-flow device and a standard low-flow device on different da…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This study pools data from multiple countries to see how a triple-combination inhaler (BGF) affects the daily lives of 2,000 people with moderate to severe COPD. Researchers will compare health status scores at 1, 3, and 12 months after starting treatment. The goal is to understa…

This study tests whether three 15-minute hypnosis sessions can help people with persistent breathlessness from cancer, COPD, interstitial lung disease, or chronic heart failure feel more in control of their breathing. Researchers will measure changes using a standard questionnair…

This study compares two easy relaxation methods—Laura Mitchell's technique and Benson's relaxation response—in 38 adults aged 40–60 with moderate to severe COPD. Participants will practice one of the techniques for 15–20 minutes daily over 6 weeks. The goal is to see which method…

This study tests whether an 8-week isoinertial training program (a type of resistance exercise) can improve muscle strength and daily function in 30 adults aged 50-80 with moderate to severe COPD. Participants will do exercises that challenge muscles in a controlled way, and rese…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…

This study looks at whether interval exercise (short bursts of activity with rest) can improve daily steps, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part for 12 weeks. Th…

This study tests a small, hands-free device called PEP-buddy that creates gentle pressure when you breathe out. It is designed to quickly relieve sudden shortness of breath in people with COPD. Researchers will have 25 participants use the device for 4 weeks to measure if it redu…

This study tests whether dronabinol, a synthetic form of THC (the psychoactive compound in cannabis), can reduce severe breathlessness in people with advanced COPD. Thirty participants will receive both dronabinol and a placebo in random order to compare effects. The goal is to s…

This study tests whether adding a simple breathing technique called 'box breathing' to a short, 3-week pulmonary rehab program can reduce shortness of breath and improve physical function in people with mild COPD. Forty adults aged 40-65 will participate. The goal is to see if th…

This study looks at whether Street Racket, a simple racket sport, can be added to standard pulmonary rehabilitation for people with chronic lung disease. Twelve participants will play Street Racket every two weeks during their rehab program. Researchers will measure how acceptabl…

This study tests whether a 20-minute video call with a nurse, who teaches about oral hygiene, can improve mouth health in people with COPD. Researchers will compare oral health scores and quality of life between a group that gets the video call and a group that does not. The tria…

This early-stage study tests a new inhaled drug called HRS-9821 in 160 people. First, healthy volunteers get a single dose to check safety. Then, people with COPD receive multiple doses. The main goal is to see what side effects occur and how the drug moves through the body. This…

This study tests whether adding music to standard exercise training helps people with COPD and chronic respiratory failure improve their walking distance and feel less breathless. 156 participants will either do usual rehab or rehab while listening to music they choose (rock, mod…

This study tests whether a respiratory rehabilitation program (exercise and education sessions over 8 weeks) can improve sleep quality in people with stable COPD. 90 adults aged 50 and older will be randomly assigned to either the rehab program or usual care. Sleep will be measur…

This study tests whether a 12-week Coping Skills Training program can reduce depression and anxiety in 750 people with COPD, especially those facing health disparities like low income or rural living. Participants attend weekly sessions and complete surveys. The program is compar…

This study tests a remote program that combines walking with Tai Chi for veterans who have both COPD and long-term muscle or joint pain. The goal is to see if it helps them move better and feel less limited by their conditions. Researchers will track daily steps, pain levels, and…

This study tests whether combining posture correction exercises with breathing muscle training can reduce shortness of breath and improve lung function in people with COPD who also have forward head posture. 72 participants will be split into three groups, each doing different br…

This study tests a graduated support program for people with advanced COPD. The program includes regular needs assessments, advance care planning, and virtual meetings between healthcare teams. Researchers will compare quality of life and healthcare use of 100 participants who ge…

This study tests a 10-week community-based program called COPD Wellness, which combines exercise, education, and social support to help people with COPD feel better and move more easily. Some participants also get help from a Health Advocate to address social needs like transport…

This study tests a new program called PEACE, where specially trained paramedics visit people with COPD at home when their symptoms suddenly worsen. The goal is to treat flare-ups early and avoid trips to the emergency room. The study will enroll 50 adults with moderate to severe …

This study tests whether doing pulmonary rehabilitation in underground salt chambers improves breathing, exercise ability, and quality of life in people with COPD. 80 adults with stable COPD will be split into four groups: rehab in salt chambers, rehab in a gym, just sitting in s…

This study compares two breathing techniques—Pilates breathing and pursed lip breathing—to see which one better improves chest expansion and peak airflow in people with mild chronic obstructive pulmonary disease (COPD). Researchers will enroll 46 adults aged 40 to 64 with mild CO…

This study compares two COPD self-management education programs: a self-guided booklet and a counselor-led phone program. Researchers want to see which approach better reduces hospitalizations and improves quality of life. 448 adults with COPD who have been hospitalized in the pa…

This study compares a new asymmetric nasal cannula (DUET) to a standard one in 50 people with mild-to-moderate COPD flare-ups and high carbon dioxide levels. Each participant will try both devices for 3 hours to see which lowers CO2 better, reduces breathing effort, and feels mor…

This study tests a device that delivers gentle electric pulses to the airways to reduce chronic bronchitis symptoms in adults with COPD. About 210 participants will either receive the real treatment or a sham procedure. The goal is to see if the treatment improves breathing and q…

This study looks at how mucus plugs in the lungs affect breathing in people with severe asthma. Researchers will use special MRI scans to see air flow in blocked areas. Only 5 adults with severe asthma will take part, and the goal is to better understand lung function, not to tes…

This study looks at how well people with COPD understand health information and how that relates to their physical abilities, thinking skills, daily activities, and quality of life. Researchers will compare 144 adults with COPD to healthy volunteers using tests of walking, thinki…

This study will follow 693 people in Brazil with severe or very severe COPD to track how often they are hospitalized, have flare-ups, or die. Researchers want to understand the real-world impact of the disease in this group. No new treatments are being tested—only data is collect…

This study will follow 500 adults with stable COPD for at least 3 years to identify and describe different patient profiles. Researchers will use routine care data to group patients by their characteristics, treatments, and outcomes. The goal is to better understand the various f…

This study aims to better understand asthma and COPD by comparing immune markers in blood and airways of patients versus healthy volunteers. Researchers will analyze samples from 230 adults to identify distinct immune patterns linked to disease severity. The goal is to improve di…

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This study follows 1000 younger adults (ages 30-55) who smoke or are at risk for COPD. Researchers will use CT scans, blood and sputum tests, and lung function tests to find early warning signs of the disease. The goal is to better understand how COPD starts and how to catch it s…

This observational study will follow 850 Chinese adults with COPD or pre-COPD for one year. Researchers will collect medical history, lung function tests, blood samples, and CT scans to identify different disease types and markers. The goal is to better understand how COPD develo…

This study looks at whether a smart computer program (AI) can help doctors make sure people with COPD see a lung specialist within 30 days after leaving the hospital. About 485 adults who had a serious COPD flare-up will take part. The goal is to see if the AI tool improves follo…

This study looks at whether a short questionnaire called the COPD Assessment Test (CAT) can help predict breathing complications during and after surgery in people with COPD. Researchers will follow 120 patients aged 40-70 having elective surgery. They will compare those with low…

This study is analyzing the exhaled breath of 5,000 people with lung or airway diseases to find unique molecular patterns. The goal is to better identify and distinguish different respiratory conditions and improve disease management. Participants simply provide breath samples, a…

This study looks at 60 adult male smokers under 65 who have both heart disease (acute coronary syndrome) and pneumonia along with COPD. Researchers want to see if certain blood markers (GDF-15, MR proADM, and Presepsin) change after getting a flu shot. The goal is to understand h…

This study looks at how the relationship between doctors and patients affects the way medical decisions are made. Researchers will interview 300 patients and healthcare workers in Singapore to understand what makes a good partnership. The goal is to learn how these partnerships c…

This study tests whether induced pluripotent stem cells (iPS cells) can repair damaged lung tissue from people with COPD. Researchers will take small lung samples from 50 participants (COPD patients, smokers without COPD, and non-smokers) during a routine bronchoscopy. In the lab…

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart strain to help develop better treatments in the future. About 60 adults aged 40 and older with COPD will…

This study is testing a digital tool that includes a spirometer and an app to help people with COPD monitor their lung function daily at home. The goal is to see if the tool is easy to use, safe, and helps patients know when to seek medical care. Fifty adults with COPD who have h…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers will use heart imaging and other tests to identify different patterns of heart dysfunction. The goal is to better understand these patterns so that future …

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This study looks at the physical properties of lung mucus in people with obstructive pulmonary disease. Researchers will collect sputum samples before and after chest physiotherapy or exercise to see how these treatments change the mucus. The goal is to better understand the dise…

This study follows 20 people with severe emphysema who are scheduled to receive endobronchial valves. Researchers will measure how much oxygen patients use during everyday activities before and six months after the procedure. The goal is to see if the treatment reduces the physic…

This study tests a detailed half-day health assessment for people with COPD who have frequent flare-ups requiring steroid tablets. The assessment checks lung health, other conditions like heart disease, and lifestyle factors, then creates a personalized treatment plan. Researcher…

This study will check how many workers in an industrial zone in Thailand have asthma or COPD. About 310 adults will answer a questionnaire and take a breathing test. The goal is to find out how common these lung problems are in this group, not to test a treatment.

This study looks at whether a non-invasive breath measurement (EtCO2) can help doctors quickly tell how serious a COPD attack is. Researchers will monitor 240 adults in the emergency room to see if EtCO2 levels can predict the need for breathing support. If successful, this could…

This study is creating a Turkish version of a questionnaire that helps find breathing pattern problems in people with COPD. Researchers will test the questionnaire on 90 stable COPD patients to make sure it works well. The goal is to give doctors a better tool to understand and t…

This study looks at why people with COPD get very sick from a common cold virus (rhinovirus). Researchers will infect 50 volunteers—some with COPD, some healthy—in a controlled setting. They will compare lung and body responses to find new ways to prevent or treat COPD flare-ups.…

This study looks at how walking, strength training, and breathing exercises change oxygen levels in the brain and leg muscles of people with moderate-to-severe COPD. Researchers will compare 60 participants (30 with COPD and 30 healthy adults) using special light-based sensors. T…

This study will follow 1000 adults for up to 10 years, using a special type of CT scan (photon-counting) to look for lung nodules, tumors, and other lung conditions. Researchers will also use artificial intelligence to create a virtual copy of each person's lungs, called a 'digit…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study looks at whether CT scans done for lung cancer screening can also help find COPD, a common lung disease in smokers. Researchers will review scans from 200 current or former smokers aged 50–80 who already had a CT scan as part of routine care. The goal is to see how man…

This study is re-examining 1,400 adults in Stockholm to find early signs and risk factors for heart, lung, and liver diseases. Participants will get advanced scans, blood tests, and questionnaires. The goal is to better understand how these diseases develop and how to predict the…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study is testing different doses of aspirin to see which one best reduces inflammation in people with COPD. The goal is to find the right dose that could improve breathing and reduce flare-ups. The study involves 48 former smokers with COPD and will measure blood and urine m…

This study explores whether machine learning can analyze breathing test results to predict chronic respiratory diseases like asthma and COPD. Researchers will compare a newer technique called oscillometry with standard spirometry in 50 adults. The goal is to see if this approach …

This study is creating a registry of 420 people who are already getting lung cancer screening and may have COPD. Researchers will collect information like breathing tests, CT scans, and symptoms to better understand COPD in this group. The goal is to improve how COPD is found and…

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI results with lung tissue from 30 patients awaiting lung transplant. The goal is …

This study follows 25 people with COPD and high carbon dioxide levels who use a breathing machine at night. Researchers want to see if nighttime breathing problems can predict how well the machine works over 6 to 12 months. They will also check lung function, diaphragm health, an…

This study looks at how often heart failure with preserved ejection fraction (HFpEF) occurs in people with COPD and how it affects their health over time. Researchers will follow 200 adults aged 50–70 in Russia who are hospitalized with COPD. They will use heart and lung tests to…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study looks at why people with COPD may have overactive nerve signals that increase heart rate and narrow blood vessels. Researchers will measure nerve activity, breathing, and inflammation in 135 adults with COPD. The goal is to better understand the causes, not to test a n…

This study is testing a new type of CT scanner (photon-counting CT) to see if it can measure lung damage in people with COPD more accurately than current scanners. Researchers will compare scans from 40 participants to see if the new method gives more consistent results. The goal…

This study looks at how the diaphragm, the main muscle used for breathing, works in people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. About 800 adults will take breat…

This study looks at whether simple measurements—like thigh circumference and muscle stiffness—can reliably track muscle health in people with COPD. Researchers will measure 30 patients before and after a pulmonary rehabilitation program. The goal is to find an easy way to monitor…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study looks at people with COPD who use a home breathing machine called non-invasive ventilation (NIV). Researchers will use artificial intelligence (AI) to analyze breathing data from the machine, such as airflow and pressure, to find early signs of a flare-up. The study do…

This study looks at whether an ultrasound measurement of the diaphragm can help predict which patients hospitalized with a COPD flare-up will get worse and need breathing support or die. About 186 adults with severe COPD will have an extra ultrasound during their hospital stay. T…

This study is looking for better ways to predict if a lung transplant will be rejected. Researchers will collect blood samples from 244 lung transplant recipients over time and analyze them using advanced techniques. The goal is to create a model that can identify early signs of …

This study compares muscle strength, exercise ability, and oxygen use in 60 people with COPD, a condition called PRISm (which is like early-stage COPD), and healthy volunteers. Researchers will measure breathing muscle strength, arm and leg strength, and how well muscles use oxyg…

This study aims to understand why some people with alpha-1 antitrypsin deficiency (AATD) get more respiratory infections. Researchers will compare immune responses to a pneumonia vaccine (PCV20) in 30 adults who carry one abnormal copy of the SERPINA1 gene. Half have had frequent…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…

This study tests a French version of a questionnaire that measures the burden on caregivers of people with COPD. Researchers will ask 224 caregivers to fill out the questionnaire along with other surveys to see if it works well. The goal is to give doctors a reliable way to spot …

This study is building a registry of genetic and health information from 3,000 people with conditions like diabetes, high cholesterol, cancer, and heart disease. The goal is to help doctors choose the safest and most effective medications based on a person's genetic makeup. Parti…

This study follows 100 adults with COPD for one year to see how airway inflammation changes over time. Researchers use a simple breath test (FeNO) and a blood sample to measure inflammation markers. Participants visit the clinic three times—at the start, 6 months, and 12 months—t…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study follows 730 adults with COPD who still have severe shortness of breath even after using standard inhalers. Researchers will track their health over time to see what factors lead to more flare-ups, faster lung decline, or death. The goal is to better understand this dif…