Obstructive lung disease

This study tests a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) against a placebo in 56 people with COPD and lung hyperinflation. The goal is to see if the inhaler improves both lung function and heart function, measured by MRI. Participants will receiv…

This study looks at the long-term safety of the drug astegolimab in people with chronic obstructive pulmonary disease (COPD). It includes about 2,000 participants who already completed a one-year study with the drug. The main goal is to track any side effects that may occur with …

This study tests an experimental drug called AZD0292 in 435 people aged 12 and older who have bronchiectasis and a long-term lung infection with Pseudomonas aeruginosa. The goal is to see if the drug can reduce the number of moderate-to-severe lung flare-ups compared to a placebo…

This study tests a new drug called GSK3862995B in 446 adults with bronchiectasis, a long-term lung condition. The goal is to see if the drug can reduce the number of serious lung infections (exacerbations) compared to a placebo. Participants will receive either one of two doses o…

This study tests a new drug, BBT002, in healthy volunteers and people with chronic obstructive pulmonary disease (COPD) or chronic rhinosinusitis with nasal polyps (CRSwNP). The trial is double-blind and placebo-controlled, meaning some participants get the drug and some get a du…

This study follows 1,400 adults with moderate to severe COPD who are starting Breztri/Trixeo, a triple-combination inhaler. Researchers will track changes in symptoms and quality of life over 12 months in real-world clinics across Latin America, Asia, and the Middle East & Africa…

This study tests whether adding a spacer device to standard triple inhaler therapy can reduce serious flare-ups in older adults (65+) with asthma or COPD who are at high risk. 380 participants will either use the spacer with their inhaler or stick with the inhaler alone. The goal…

This Phase 3 trial is testing whether a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) can reduce serious heart and lung events in people with COPD who are at elevated risk. About 5,250 participants aged 40–80 will receive either the triple therapy or a d…

This study tests a daily pill called BI 1291583 (Verducatib) in 1755 adults and teens with bronchiectasis, a lung condition causing frequent infections and coughing. Participants take either the drug or a placebo for up to 76 weeks. The main goal is to see if the drug reduces the…

This Phase 3 study tests whether tezepelumab, a biologic drug, can reduce moderate to severe COPD flare-ups in adults aged 40-80. About 990 participants will receive either tezepelumab or a placebo as a shot under the skin. The main goal is to see if the drug lowers the number of…

This study compares two ways of placing Zephyr valves in the lungs of people with severe emphysema (a type of COPD). The standard method treats the entire lobe in one session, but about 27% of patients develop a collapsed lung (pneumothorax). The experimental method spreads the v…

This Phase 3 trial tests whether tezepelumab, a biologic drug given as a shot, can reduce the number of moderate to severe COPD flare-ups in adults aged 40 to 80. About 990 participants with moderate to very severe COPD will receive either tezepelumab or a placebo for up to 76 we…

This study compares a nasal high-flow device to standard non-invasive ventilation (NIV) for treating people who come to the emergency room with a severe COPD flare-up and high carbon dioxide levels. Participants are randomly assigned to receive one of the two breathing supports f…

This phase 2 trial is testing a new medicine called WIN378 for people with moderate to severe COPD. WIN378 is a long-acting antibody that blocks a protein involved in lung inflammation. The study will test different doses in 105 adults who are former smokers and already on standa…

This study tests an experimental drug called PF-07275315 in adults with moderate-to-severe COPD who have had at least two flare-ups in the past year. Participants receive either the drug or a placebo as injections over several months. The goal is to see if the drug improves lung …

This study tests an experimental drug called SAR445399 in 70 adults aged 18-80 with non-cystic fibrosis bronchiectasis, a lung condition causing mucus buildup and infections. Participants receive either the drug or a placebo for 24 weeks to see if it reduces mucus plugs seen on C…

This study tests a special balloon coated with the drug paclitaxel to treat benign (non-cancerous) narrowing of the windpipe or main breathing tubes. The balloon is inflated to open the airway, and the drug may help keep it open longer. About 200 adults with this condition will b…

This study tests a new drug called lunsekimig in adults aged 40-80 with COPD that is not well controlled despite standard treatments. The goal is to see if the drug can reduce the number of moderate-to-severe flare-ups over 48 weeks compared to a placebo. Participants will receiv…

This study tests a new injectable drug called lunsekimig in about 942 adults aged 40-80 with COPD that is not well controlled, especially those with a type linked to high eosinophils (a kind of white blood cell). Participants will receive either the drug or a placebo for about 48…

This study tests a new inhaled powder called HSK39004 in 376 adults with COPD, a long-term lung disease that makes breathing hard. Participants will use the powder daily for 12 weeks to see if it improves lung function compared to a placebo. The goal is to control symptoms and he…

This Phase 2 trial tests whether rademikibart, an injected drug, can help adults with COPD who are having a sudden flare-up and have a specific type of inflammation (type 2). The study will compare the drug to a placebo in 160 participants, looking at whether it reduces treatment…

This study tests whether dupilumab, an injectable drug, can reduce mucus plugs (blockages) in the lungs of people with moderate-to-severe COPD. About 218 current or former smokers aged 40-85 will receive either dupilumab or a placebo for 24 weeks. The main goal is to see if the d…

This study is testing the long-term safety of a drug called tozorakimab in people with chronic obstructive pulmonary disease (COPD) who have had flare-ups in the past. About 82 participants who completed earlier studies will receive tozorakimab and be monitored for side effects. …

This study is testing whether using an indoor air purifier can improve lung health in people with Chronic Obstructive Pulmonary Disease (COPD). About 120 adults with COPD who live in Shanghai will use either a real air purifier or a placebo device in their homes for a period of t…

This study tests an experimental drug called HSK39004, given as an inhaler, in 50 adults with chronic obstructive pulmonary disease (COPD). Participants are randomly assigned to receive either the drug or a placebo for 4 weeks. The main goal is to see if the drug improves lung fu…

This study tests whether a non-invasive ventilator (NIV) or a CPAP machine is better at preventing severe COPD flare-ups and death in people who also have sleep apnea. About 386 adults who recently survived a life-threatening breathing crisis will use one of the two machines at h…

This study tests whether a device called SIMEOX, used at home with remote physiotherapy, can improve quality of life and reduce lung infections in people with bronchiectasis (a chronic lung disease with mucus buildup). About 622 adults will use the device daily or get standard ca…

This study tests whether a new tablet called RSS0343 can safely reduce the number of moderate or severe COPD flare-ups. About 300 adults with COPD will receive either the drug or a placebo for 48 weeks. The main goal is to see if the drug lowers the yearly rate of serious breathi…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study tests an experimental tablet called AZD6793 in adults with moderate to very severe COPD. About 987 participants will take one of two doses of the drug or a placebo for 24 weeks. The goal is to see if the drug can reduce the number of serious flare-ups (exacerbations) c…

This study tests a new device called the IAB 50 Flex, an implantable artificial bronchus for adults with severe COPD or emphysema. The trial will enroll 20 participants across two hospitals to check if the implant is safe and if it helps improve breathing and daily activity. The …

This study tests the safety of a drug called HSK31858 in 669 adults with non-cystic fibrosis bronchiectasis, a lung condition that causes repeated infections and breathing problems. Participants who completed a prior study of the same drug will receive the medication and be monit…

This study tests a new fixed-dose combination of two drugs (ensifentrine and glycopyrrolate) given via nebulizer twice daily for 28 days in 480 adults with COPD. The goal is to see if the combination improves lung function more than either drug alone or placebo. The trial is curr…

This study tests a new device called an implantable artificial bronchus (IAB) for people with severe emphysema or COPD. The IAB is designed to help air move in and out of the lungs more easily. About 60 adults will receive the implant and be followed for 90 days to see if it impr…

This study tests a new way to give Alpha1-Proteinase Inhibitor—a medicine that helps protect the lungs in people with Alpha-1 Antitrypsin Deficiency. Instead of getting it through a vein at a clinic, participants will receive it as a weekly injection under the skin. The trial wil…

This pilot study is testing whether the antifungal drug itraconazole is feasible and safe for people with bronchiectasis who have mold growing in their airways. Thirty participants will take itraconazole twice daily for six weeks. The study will measure how many people complete t…

This study tests whether a home-based breathing exercise program can reduce hospital readmissions and deaths in people recovering from a severe COPD flare-up. About 358 participants will either receive usual care or add daily inspiratory muscle training using a smartphone-connect…

This early-stage study tests a new drug called SAR448501 (DR-0201) in 62 adults with lupus or rheumatoid arthritis. The drug is a bispecific antibody designed to target the immune system. The main goal is to check safety and find the right dose, not yet to prove it works. Partici…

This study tests whether a detailed, personalized care plan—including diet, exercise, and counseling—can reduce hospitalizations and improve quality of life for people with COPD who have recently been hospitalized. About 110 adults aged 40 and older who smoke or used to smoke wil…

This study tests whether a nebulized drug called ensifentrine can reduce inflammation in the lungs of people with COPD. About 56 adults aged 40-80 who smoke or have smoked will receive both the drug and a placebo at different times over 24 weeks. The main goal is to see changes i…

This study tests an inhaled drug called ensifentrine in 284 adults with non-cystic fibrosis bronchiectasis, a lung condition that causes frequent infections and breathing problems. Participants will receive either the drug or a placebo twice daily for at least 24 weeks. The goal …

This study looks at whether treating a common stomach infection (H. pylori) can improve symptoms and lung function in people with COPD. Researchers will give standard antibiotic therapy to 54 H. pylori-positive COPD patients and then measure changes in their breathing tests and s…

This early-stage trial tests a new drug called AIR-001 in 54 adults with alpha-1 antitrypsin deficiency (AATD) who have a specific genetic type (PiZZ). The study aims to check safety and how the body processes the drug. Participants receive increasing doses of AIR-001 under the s…

This study tests a one-time procedure called lung denervation for people with COPD who are already on standard care. The goal is to see if it safely improves lung function and breathing over 6 months. About 200 adults aged 40-80 who have smoked heavily in the past will take part.

This study tests a permanent implant called the Apreo BREATHE Airway Scaffold in up to 250 adults with COPD and emphysema who still feel short of breath despite standard treatments. The implant is designed to prop open airways and release trapped air to improve breathing. Researc…

This study looks at whether giving early, tailored COPD treatment to people being evaluated for lung cancer can improve their breathing and overall health. About 280 participants will receive either standard care or extra COPD consultations focusing on medication, smoking cessati…

This study is monitoring the safety and tolerability of Breztri Aerosphere, a triple-combination inhaler, in 150 Indian patients with moderate to severe COPD. Participants will use the inhaler as maintenance treatment while researchers track side effects. The goal is to ensure th…

This study is tracking about 400 adults with severe or very severe COPD in Brazil who are taking the triple-combination inhaler Trimbow. Researchers will measure changes in symptoms and lung function over 6 months during routine doctor visits. The goal is to see how well the medi…

This Phase 2 trial tests an injection called RC1416 in 180 people with moderate to severe COPD. Participants will receive either the drug or a placebo to see if it reduces serious flare-ups and improves lung function over time. The study is double-blind, meaning neither patients …

This study tests a device called BiWaze Clear that helps people with bronchiectasis clear mucus from their lungs using gentle vibrations and lung expansion. About 85 participants will use the device at home for 6 months. Researchers will track how many lung infections they get co…

This study tests whether completing the gaps between lung lobes with surgery before placing standard lung valves can improve outcomes for people with severe emphysema or COPD. About 20 participants will either receive the combined procedure or standard medical care. The goal is t…

This pilot study tests a surgical procedure for people with severe emphysema or COPD who did not get enough benefit from a standard treatment using bronchoscopic lung volume reduction (valves). The surgery uses small chest incisions to complete the fissures between lung lobes and…

This study tests an experimental drug called depemokimab in adults aged 40 to 80 with moderate to severe COPD and type 2 inflammation. The goal is to see if adding this medicine to standard care can reduce the number of serious flare-ups that require steroids, antibiotics, or hos…

This study tests an experimental tablet called VENT-03 for people with active cutaneous lupus erythematosus (CLE), a condition causing painful skin rashes. Twenty-four adults will take either VENT-03 or a placebo for 4 weeks, then everyone gets VENT-03 for 8 more weeks. Researche…

This study looks at whether a dual bronchodilator (a combination inhaler) can improve breathing, heart function, and quality of life in people newly diagnosed with moderate-to-severe COPD. Researchers will measure changes in exercise capacity and lung function over 12 weeks. The …

This study tests whether clinical pharmacists can provide COPD care that is as good as care from lung specialists. About 4000 veterans with COPD will have their care reviewed by either a pharmacist or a specialist, who will send recommendations to their primary doctor. The goal i…

This early-stage trial is testing whether infusions of clonal fetal mesenchymal stem cells (cfMSCs) are safe and can help control severe symptoms in people with moderate to severe COPD. About 30 adults aged 40-80 who have not responded well to standard treatments will receive the…

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This Phase 2 trial tests solrikitug, a biologic drug given as a shot, in 171 adults with moderate-to-severe COPD and high eosinophil levels. The study compares two doses of solrikitug against a placebo to see if it safely reduces inflammation and improves lung function over time.…

This early-phase trial tests REGEND007, a stem cell therapy made from airway cells, in 12 people with COPD. The cells are given by IV infusion in increasing doses to see if they are safe and can help repair lung damage. The study is still recruiting and focuses on safety first.

This study compares two steroids, hydrocortisone and prednisolone, in 2000 adults over 40 with COPD flare-ups. The goal is to see which one reduces hospital readmissions and deaths within 30 days. Participants are randomly assigned to one of the two treatments.

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests whether eating more omega-3s (found in fish and certain oils) can improve breathing and daily life for people with COPD. Researchers will provide food to 200 adults with moderate-to-severe COPD and track their symptoms and flare-ups over time. The goal is to see …

This early-stage study tests a gene therapy for people with alpha-1 antitrypsin deficiency, a condition that can damage the lungs. The treatment is given once through a vein and aims to produce a special protein that protects the lungs. Researchers will check safety and measure p…

This study tests a foam called AeriSeal that is squirted into damaged parts of the lung to block tiny air leaks. After the foam, doctors check if the lung is now sealed enough to place a one-way valve that lets trapped air escape. The goal is to help people with severe emphysema …

This study is testing whether adding probiotics to standard pulmonary rehabilitation can help control inflammation and improve breathing, physical function, and nutrition in people with COPD. Researchers will measure markers like interleukin-6 and track exercise capacity. The goa…

This study tests if umbilical cord stem cells can improve lung function and quality of life in people with severe COPD. All 20 participants already receive standard triple-inhaler therapy. They will get stem cells or a placebo intravenously and be followed for 12 months. The goal…

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This study tests an experimental drug called CM326, given as a shot, in 318 people with moderate-to-severe COPD. The goal is to see if it can reduce the number of serious flare-ups over 24 to 52 weeks compared to a placebo. Participants must be at least 40 years old, have had COP…

This study tests if omalizumab (Xolair), an allergy drug, can reduce serious flare-ups in people with COPD who also have allergies. About 334 participants will receive injections of the drug or a placebo for 12 months. The goal is to see if the drug lowers the number of COPD exac…

This early-stage trial tests whether inhaling small mobile stem cells (SMS) is safe for people with mild to moderate COPD. 18 participants aged 39–69 will receive the cells via a nebulizer. The study focuses on safety and side effects, not yet on whether the treatment works.

This study tests a smart eccentric cycling exercise for 170 people with COPD. The goal is to see if this type of training improves heart and lung fitness, immune function, and quality of life better than standard care. Participants must have been in pulmonary rehab for at least 3…

This study tests whether using high-flow oxygen at home can reduce severe COPD attacks or death in 406 patients who have just been hospitalized for a flare-up. Participants receive either high-flow oxygen or standard oxygen therapy. The goal is to see if high-flow oxygen helps th…

This study tests whether a 3-month program of twice-weekly exercise and monthly education sessions can help people with COPD maintain the benefits they gained from an initial 8-week pulmonary rehab program. 86 adults aged 40-75 with moderate to severe COPD will be randomly assign…

This study tests a short, scripted conversation between doctors and Black adults with uncontrolled asthma. The goal is to help patients and doctors make decisions together about asthma medicines. Researchers will enroll 400 adults at community health centers to see if this approa…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study tests whether a daily pill called JKN2403 can reduce serious flare-ups and improve quality of life in people with moderate-to-severe COPD. About 120 adults will take either the drug or a placebo for 24 weeks, with regular clinic visits and symptom diaries. The goal is …

This study is testing a new approach for people with severe lung disease (like pulmonary fibrosis or COPD) who also have bone marrow failure. First, participants receive a lung transplant to restore breathing. Then, about 8 weeks later, they get a bone marrow transplant using the…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with severe pulmonary hypertension caused by chronic obstructive pulmonary disease (COPD). About 200 adults with both conditions will receive either tadalafil or a placebo daily for 16…

This study tests whether training the muscles used to breathe in can improve exercise capacity, quality of life, and short-term outcomes in people who have had a lung transplant. Thirty participants will use a device called POWERBreathe Plus® along with standard rehab. The goal i…

This study tests a personalized smoking cessation program for smokers admitted to the hospital with heart or lung disease. Participants receive tailored medication, counseling, and text message support to help them quit and stay smoke-free. The goal is to see if this approach lea…

This study follows 350 adults with uncontrolled COPD who are starting dupilumab, a medication that reduces lung inflammation. Researchers will track changes in quality of life and breathing symptoms over two years using simple questionnaires. The goal is to see how well the drug …

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study is testing an inhaler called BGF 160 (also known as Breztri Aerosphere) in 35 adults with stable COPD. The goal is to see how the medicine changes the complexity and variability of breathing patterns over 30 days. Participants will use the inhaler twice daily, and rese…

This phase II trial is testing an experimental drug called 9MW1911 in 360 adults with moderate-to-severe COPD who have had at least two flare-ups in the past year. Participants receive either the drug or a placebo every 28 days for a year. The main goal is to see if the drug redu…

This study tests whether the drug vimseltinib is safe and effective for adults with moderate to severe chronic graft-versus-host disease (cGVHD) who have not improved after at least two prior treatments. About 48 participants will take vimseltinib daily for up to two years. The g…

This study tests whether adding depemokimab early to standard COPD treatment can reduce moderate to severe flare-ups in people with moderate to severe COPD who have type 2 inflammation. About 1,200 participants will receive either depemokimab or a placebo as an add-on therapy. Th…

This Phase 3 trial tests whether the experimental drug 611 can reduce moderate to severe COPD flare-ups in Chinese adults aged 40-85 with moderate to severe COPD. About 594 participants will receive either 611 or a placebo injection every two weeks. The study measures how often f…

This study tests an inhaled medicine called CSL787 in adults with non-cystic fibrosis bronchiectasis, a lung condition that causes frequent infections and breathing problems. The goal is to see if CSL787 can delay the time until a person's next lung flare-up (exacerbation) compar…

This phase 2 trial is testing whether an inhaled drug called treprostinil (Tyvaso) can improve oxygen delivery in the lungs of people with COPD who have low blood oxygen. Ten adults will use the nebulizer four times daily for four weeks, starting at a low dose and increasing as t…

This study tests a specialized clinic designed to diagnose and treat muscle loss (sarcopenia) in people with COPD. The clinic brings together a team of experts to provide targeted care. Researchers will see if this approach improves muscle mass and function, and reduces hospitali…

This study tests whether placing two high-efficiency air cleaners in the homes of 770 people with COPD can reduce flare-ups and improve quality of life over a year. Participants receive either active cleaners that remove particles and gases, or sham cleaners that look and sound t…

This study tests whether personalized home-based coaching can help people with COPD better manage their symptoms and avoid hospital visits. Researchers will enroll 300 adults from diverse backgrounds in New York City. Participants will receive support from health coaches, includi…

This study tests an experimental drug called depemokimab for people with moderate to severe COPD who also have type 2 inflammation. The goal is to see if adding this medicine to standard treatment can reduce the number of serious flare-ups that require steroids, antibiotics, or h…

This study is testing whether eating freeze-dried aronia (black chokeberry) powder every day for 8 weeks can lower inflammation and improve breathing in people with COPD. Fifty participants aged 50-80 will be randomly assigned to take either the aronia powder or a placebo. Resear…

This study looks at two ways to manage sedation in COPD patients who need a breathing machine (ventilator). One group gets no sedation at all, while the other has their sedation paused every day. The goal is to see which approach helps patients spend more days off the ventilator …

This study tests a new way to treat severe emphysema using heated water vapor (InterVapor) to shrink damaged lung tissue. Researchers want to see if treating smaller, targeted areas (subsegments) works better than treating larger sections. 100 adults with severe emphysema will be…

This study is testing whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will exercise 40-60 minutes, five times a week, for eight weeks, doing activities like brisk walking, jogging,…

This study will test a handheld ultrasonic spirometer against a conventional hospital spirometer in 100 adults with chronic respiratory diseases like COPD or asthma. Each participant will use both devices to see if the portable one gives accurate and reliable results. If successf…

This study tests whether an AI program can help emergency doctors find undiagnosed heart failure, COPD, and cancer by analyzing chest X-rays. Researchers will compare diagnosis rates when doctors have access to the AI's findings versus when they don't. The trial involves 17,000 a…

This study is testing whether a simple blood test, combined with artificial intelligence (AI), can help find lung cancer early in people with COPD who are current or former smokers. About 1,000 participants will give a blood sample, and those flagged as high-risk by the AI will g…

This study is testing whether two simple breathing tests—oscillometry and FeNO—can help primary care doctors accurately diagnose asthma and COPD, compared to the usual specialist methods. Researchers will enroll 600 adults with suspected asthma or COPD across six countries. If th…

This study is enrolling 200 adults with asthma or COPD to see if combining chest CT scans with blood, sputum, and microbiome tests can more accurately tell the two diseases apart. Researchers will also look for clues that predict how well a patient will respond to treatment. No e…

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study tests a wearable device called the C-mo System that automatically detects and describes coughs. Researchers want to see if it can accurately count coughs, measure their intensity, and identify wheezing. 300 people aged 2 and older with cough-related conditions will wea…

This study looks for early signs of pulmonary hypertension (high blood pressure in the lungs) in people with chronic lung diseases like COPD or pulmonary fibrosis. Researchers will analyze collagen fragments in blood and lung tissue to create a 'fingerprint' that could lead to si…

This study explores whether a lung ultrasound can safely detect rejection or infection in lung transplant recipients who have no symptoms. Currently, patients need an invasive bronchoscopy with biopsy to check for rejection. If ultrasound works, it could offer a faster, safer, an…

This study tests a non-invasive imaging method called electrical impedance tomography (EIT) to monitor lung function in 400 adults with lung diseases like COPD, asthma, or pneumonia. Unlike standard spirometry, which requires active blowing, EIT works even in patients who cannot …

This study aims to find people who have asthma or COPD but don't know it yet. Participants will take an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their doctor or usual care. The goal is t…

This study is testing a computer algorithm that uses health records to predict whether a person has COPD. Many people with COPD are not diagnosed until the disease is advanced, while others are wrongly told they have it. The goal is to see if the algorithm can correctly identify …

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing sound waves from the phone's speaker and microphone. Researchers will enroll 800 people aged 8-70, including healthy volunteers an…

This study is testing whether a new risk score called PVD-B65 can accurately predict who will survive for one year after being diagnosed with pulmonary hypertension related to chronic lung disease. Researchers will follow 100 adults and track deaths and other health changes. The …

This study tests whether a single 20-minute session with a medical device called Simeox can reduce the amount of air trapped in the lungs of people with severe COPD. The device applies gentle suction during exhalation to help move air out. Researchers will measure lung function b…

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

This study tests whether combining arm and leg endurance training is better than leg training alone for improving daily activities in people with COPD. 36 participants with moderate-to-severe COPD will undergo 14 supervised sessions. The main goal is to see if the combined traini…

This study tests whether a device called Airvo 3, which automatically adjusts oxygen levels, can keep COPD patients' blood oxygen in a healthy range better than manual adjustments by nurses. About 70 hospitalized adults with COPD and low oxygen will take part. The goal is to see …

This study looks at whether using a nasal high-flow device (which delivers warm, moist air at a high rate) can help people with COPD walk farther during a 6-minute walk test. Thirty adults with COPD will try both the high-flow device and a standard low-flow device on different da…

This study tests a new program called Mindful-Breath for people with chronic obstructive pulmonary disease (COPD). The program combines mindfulness, breathing exercises, and lifestyle coaching through group sessions and chat support. Researchers want to see if it is feasible and …

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This study pools data from multiple countries to see how a triple-combination inhaler (BGF) affects the daily lives of 2,000 people with moderate to severe COPD. Researchers will compare health status scores at 1, 3, and 12 months after starting treatment. The goal is to understa…

This study tests whether inhaling a salty mist (3% hypertonic saline) can improve breathing symptoms in people with nontuberculous mycobacterial (NTM) lung disease who haven't yet started antibiotics. About 262 adults will either start the saltwater treatment right away for 6 mon…

This study tests whether using a portable oxygen concentrator (a lightweight, battery-powered device) during walking or exercise helps people with interstitial lung disease (ILD) or COPD feel less breathless and be more active in their daily lives. Twenty-four participants will t…

This study tests whether three 15-minute hypnosis sessions can help people with persistent breathlessness from cancer, COPD, interstitial lung disease, or chronic heart failure feel more in control of their breathing. Researchers will measure changes using a standard questionnair…

This study compares two easy relaxation methods—Laura Mitchell's technique and Benson's relaxation response—in 38 adults aged 40–60 with moderate to severe COPD. Participants will practice one of the techniques for 15–20 minutes daily over 6 weeks. The goal is to see which method…

This pilot study tests a technique called cryo-analgesia, where doctors freeze chest nerves during double lung transplant surgery. The goal is to see if this reduces pain, morphine use, and time in the hospital for people with end-stage COPD. Forty participants will either get th…

This early-stage study tests an inhaled drug called GDC-6988 in people with lung conditions that cause thick mucus, like non-CF bronchiectasis and COPD. The main goal is to check if the drug is safe and tolerable. About 128 adults with stable disease and good lung function will t…

This study tests whether sildenafil, a drug that widens blood vessels in the lungs, can improve exercise ability and reduce shortness of breath in people with mild COPD. Researchers think poor blood flow in the lungs may cause breathing trouble during activity. The trial will com…

This study tests two ways to encourage people with COPD to finish pulmonary rehabilitation (PR) after a flare-up. One group gets phone coaching from someone who has been through PR themselves, another watches videos of patients sharing their rehab journey, and a third gets standa…

This study tests whether a device that uses gentle pressure changes to clear mucus and trapped air from the lungs can reduce shortness of breath after walking in people with COPD. About 33 adults who have completed pulmonary rehab will use the active device or a placebo at home f…

This study tests whether an 8-week isoinertial training program (a type of resistance exercise) can improve muscle strength and daily function in 30 adults aged 50-80 with moderate to severe COPD. Participants will do exercises that challenge muscles in a controlled way, and rese…

This study is testing a hypertonic seawater aerosol spray (a saltwater mist) to see if it helps relieve nasal symptoms, improve sleep, and thin mucus in people with colds, sinus infections, or similar upper respiratory infections. About 110 adults and children aged 2 and older wi…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This study aims to bring pulmonary rehabilitation—a proven treatment for COPD—to people living in rural areas who currently have no access to it. Researchers will test whether a home-based program can improve breathing, fatigue, and emotional well-being. About 306 adults aged 40 …

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…

This study compares two ways to help people with bronchiectasis breathe easier during a sudden worsening of their condition. Twenty patients in the ICU will receive either a high flow nasal cannula or non-invasive ventilation. Researchers will measure how long patients stay in th…

This study looks at whether interval exercise (short bursts of activity with rest) can improve daily steps, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part for 12 weeks. Th…

This study tests a small, hands-free device called PEP-buddy that creates gentle pressure when you breathe out. It is designed to quickly relieve sudden shortness of breath in people with COPD. Researchers will have 25 participants use the device for 4 weeks to measure if it redu…

This registry study is tracking 150 adults with severe emphysema who receive the Spiration Valve System, a one-way valve placed in the lung via a bronchoscope. The goal is to see if the device safely reduces shortness of breath and lung overinflation over 12 to 36 months. Partici…

This pilot study tests whether semaglutide (Ozempic), a drug used for diabetes and obesity, is safe and tolerable for weight loss in people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take weekly injections for 12 weeks. Res…

This study tests whether dronabinol, a synthetic form of THC (the psychoactive compound in cannabis), can reduce severe breathlessness in people with advanced COPD. Thirty participants will receive both dronabinol and a placebo in random order to compare effects. The goal is to s…

This study tests whether adding alternate nostril breathing to standard pursed lip breathing helps people with mild COPD breathe better and feel better. About 40 adults aged 40-65 will be split into two groups: one does pursed lip breathing alone, the other does both techniques. …

This early-phase trial tests whether a single low dose of morphine can reduce the chance that COPD patients in respiratory distress will fail non-invasive ventilation (a breathing mask). The study will enroll 24 adults with a COPD flare-up who need a breathing mask. Researchers w…

This study follows 200 adults with bronchiectasis who use the LibAirty airway clearance system at home as part of their regular care. Researchers want to see how often lung flare-ups happen over a year. Participants fill out short questionnaires and have their medical records rev…

This study looks at whether walking on an incline is better than walking faster on flat ground for people with COPD. The goal is to find ways to improve exercise programs so patients feel less short of breath. About 54 veterans with COPD will take part, and researchers will measu…

This study tests whether adding a simple breathing technique called 'box breathing' to a short, 3-week pulmonary rehab program can reduce shortness of breath and improve physical function in people with mild COPD. Forty adults aged 40-65 will participate. The goal is to see if th…

This study looks at whether the Vivifrail exercise program can improve physical function and quality of life in older adults with COPD who are also frail. Researchers will enroll 80 participants aged 60 and older, giving half the exercise program and half standard care. The goal …

This study tests whether 10 weeks of online singing training can reduce symptoms and improve physical function and quality of life in people who had surgery for non-small cell lung cancer 6 to 18 months ago. One hundred participants will be randomly assigned to either the singing…

This study tests whether doing special breathing exercises (inspiratory muscle training) before a lung transplant can help people recover more quickly after surgery. Researchers will enroll 90 adults with lung disease who are waiting for a transplant. The goal is to see if these …

This study tests a short, pre-surgery rehab program for people who smoke and have a lung nodule that may be cancer. About 20 participants will do breathing exercises and get help to stop smoking. The goal is to see if this program is practical and can improve fitness, reduce symp…

This study tests whether a specific type of breathing exercise, called functional inspiratory muscle training, can improve breathing, daily function, and quality of life in people with COPD. About 51 participants will be assigned to different training programs. The goal is to see…

This study tests a device called the Lung Master, which is meant to increase lung capacity by practicing slow, deep breaths. Twenty adults with or without breathing conditions will use the device daily at home for one month. Researchers will measure lung function before and after…

This study looks at whether Street Racket, a simple racket sport, can be added to standard pulmonary rehabilitation for people with chronic lung disease. Twelve participants will play Street Racket every two weeks during their rehab program. Researchers will measure how acceptabl…

This study tests a special arm exercise program for people with moderate to severe COPD. Participants will do light arm exercises while wearing cuffs that slightly restrict blood flow. The goal is to see if this approach can improve arm strength, daily activities, and quality of …

This study tests whether a 20-minute video call with a nurse, who teaches about oral hygiene, can improve mouth health in people with COPD. Researchers will compare oral health scores and quality of life between a group that gets the video call and a group that does not. The tria…

This early-stage trial tests the safety of an inhaled study drug called CHF6333. It involves 45 participants: first, healthy volunteers and people with bronchiectasis receive a single dose; then, people with bronchiectasis receive repeated doses. The goal is to check for side eff…

This study tests whether a new device called Simeox, which uses gentle vibrations to loosen mucus without forced breathing, works better than standard chest physiotherapy for people with bronchiectasis. Forty adults with stable disease will try both methods in a crossover design.…

This early-stage study tests a new inhaled drug called HRS-9821 in 160 people. First, healthy volunteers get a single dose to check safety. Then, people with COPD receive multiple doses. The main goal is to see what side effects occur and how the drug moves through the body. This…

This study tests whether adding music to standard exercise training helps people with COPD and chronic respiratory failure improve their walking distance and feel less breathless. 156 participants will either do usual rehab or rehab while listening to music they choose (rock, mod…

This study looks at whether adding maximal strength training (heavy leg presses) to standard endurance exercise helps people with COPD walk more efficiently and feel less breathless. Twenty participants will do either strength-plus-endurance or endurance-only training for 8 weeks…

This study tests whether a respiratory rehabilitation program (exercise and education sessions over 8 weeks) can improve sleep quality in people with stable COPD. 90 adults aged 50 and older will be randomly assigned to either the rehab program or usual care. Sleep will be measur…

This study tests a special breathing exercise program for adults with bronchiectasis, a chronic lung disease that causes coughing and shortness of breath. The program combines breathing muscle training with core-strengthening exercises. Researchers will measure lung function, mus…

This study is testing whether inhaling nitric oxide gas can improve exercise tolerance in people with moderate-to-severe COPD. Sixteen participants will use a special device to breathe the gas for one week. Researchers will measure changes in oxygen use and breathing efficiency d…

This study tests whether a 12-week Coping Skills Training program can reduce depression and anxiety in 750 people with COPD, especially those facing health disparities like low income or rural living. Participants attend weekly sessions and complete surveys. The program is compar…

This study is testing whether using an oscillating PEP (OPEP) device—a handheld breathing tool that helps clear mucus—can improve quality of life for people with bronchiectasis. Researchers will give questionnaires to 60 children (ages 8+) and adults before and after they start u…

This study tests a remote program that combines walking with Tai Chi for veterans who have both COPD and long-term muscle or joint pain. The goal is to see if it helps them move better and feel less limited by their conditions. Researchers will track daily steps, pain levels, and…

This study is testing a new interactive digital breathing game designed to help children with bronchiectasis clear mucus from their lungs at home. The game aims to replace the need for a physiotherapist by using a device connected to a phone or computer. The trial will involve 40…

This study tests whether a home-based breathing and respiratory muscle training program, supported by a health coach, can help people with non-cystic fibrosis bronchiectasis improve their exercise ability and lung function. About 50 participants will use a digital program at home…

This early-stage study tests a new drug called BBT002 in healthy people and those with COPD to see if it is safe and tolerable. Researchers will also look for early signs that it might ease breathing problems. About 68 participants will receive either the drug or a placebo, with …

This study tests whether combining posture correction exercises with breathing muscle training can reduce shortness of breath and improve lung function in people with COPD who also have forward head posture. 72 participants will be split into three groups, each doing different br…

This study compares two types of exercise for people with COPD who recently left the hospital after a flare-up. One group does high-intensity strength training with heavy weights and few repetitions, while the other does traditional endurance exercise. The goal is to see which ap…

This study tests a graduated support program for people with advanced COPD. The program includes regular needs assessments, advance care planning, and virtual meetings between healthcare teams. Researchers will compare quality of life and healthcare use of 100 participants who ge…

This study tests a 10-week community-based program called COPD Wellness, which combines exercise, education, and social support to help people with COPD feel better and move more easily. Some participants also get help from a Health Advocate to address social needs like transport…

This study tests a new program called PEACE, where specially trained paramedics visit people with COPD at home when their symptoms suddenly worsen. The goal is to treat flare-ups early and avoid trips to the emergency room. The study will enroll 50 adults with moderate to severe …

This study tests whether doing pulmonary rehabilitation in underground salt chambers improves breathing, exercise ability, and quality of life in people with COPD. 80 adults with stable COPD will be split into four groups: rehab in salt chambers, rehab in a gym, just sitting in s…

This study tests if a dry powder form of ivy leaf extract (Syrup Prospan) works better than a common medicine called N-acetylcysteine (NAC) at reducing cough and mucus in people with COPD. About 100 adults with stable COPD will take one of the two treatments for a set time. The g…

This study looks at whether inhaling menthol can quickly relieve shortness of breath in healthy adults and people with COPD. Researchers will measure brain activity and breathing to understand how menthol works. The goal is to find a simple, drug-free way to ease breathing discom…

This study compares two breathing techniques—Pilates breathing and pursed lip breathing—to see which one better improves chest expansion and peak airflow in people with mild chronic obstructive pulmonary disease (COPD). Researchers will enroll 46 adults aged 40 to 64 with mild CO…

This study tests whether a 12-week program of walking and elastic band exercises can improve anxiety, depression, breathlessness, sleep, and quality of life in people with COPD. 68 participants will either do the exercise program plus standard care or just wear a smart bracelet t…

This study compares two COPD self-management education programs: a self-guided booklet and a counselor-led phone program. Researchers want to see which approach better reduces hospitalizations and improves quality of life. 448 adults with COPD who have been hospitalized in the pa…

This study tests whether gentle electrical stimulation of the chest and leg muscles can improve lung function and reduce restless leg symptoms in people with COPD. Sixty participants will receive either real or placebo stimulation alongside standard pulmonary rehab. The main goal…

This study tests a 12-month telehealth program that combines healthy eating, exercise coaching, and remote pulmonary rehab for 400 overweight veterans with both COPD and obstructive sleep apnea. Participants use a Fitbit and app to track progress, with the goal of improving physi…

This study compares a new asymmetric nasal cannula (DUET) to a standard one in 50 people with mild-to-moderate COPD flare-ups and high carbon dioxide levels. Each participant will try both devices for 3 hours to see which lowers CO2 better, reduces breathing effort, and feels mor…

This study tests a device called FreeO2 that automatically adjusts oxygen levels during noninvasive breathing support. It includes 10 patients with COPD flare-ups or after weight-loss surgery. The goal is to see if the device keeps oxygen in a safe range better than manual adjust…

This study tests a device that delivers gentle electric pulses to the airways to reduce chronic bronchitis symptoms in adults with COPD. About 210 participants will either receive the real treatment or a sham procedure. The goal is to see if the treatment improves breathing and q…

This study aims to develop a better way to remotely monitor people with chronic respiratory failure who use a breathing machine (noninvasive ventilation) at home. Researchers will collect data from standard monitoring tools and new non-invasive devices to assess breathing, lung f…

This study follows 900 people with bronchiectasis—a condition where airways are damaged and prone to infection—to learn why they get sick repeatedly. Researchers will collect medical history, lung function tests, and blood, urine, and sputum samples from patients and their family…

This study looks at how mucus plugs in the lungs affect breathing in people with severe asthma. Researchers will use special MRI scans to see air flow in blocked areas. Only 5 adults with severe asthma will take part, and the goal is to better understand lung function, not to tes…

This study looks at how well people with COPD understand health information and how that relates to their physical abilities, thinking skills, daily activities, and quality of life. Researchers will compare 144 adults with COPD to healthy volunteers using tests of walking, thinki…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or interstitial lung disease will do two walking tests—one with their usual oxygen and one w…

This observational study compares how people with bronchiectasis and healthy volunteers respond to different exercise tests, including a 6-minute stepper test, a 6-minute walk test, and a 1-minute sit-to-stand test. Researchers will measure breathing, heart rate, and muscle stren…

This study is testing whether a program that includes virtual pulmonary rehabilitation, integrated care, and remote monitoring using a smartwatch and home spirometer is feasible for people with COPD after a recent flare-up. Researchers will enroll 100 patients and track how many …

This study reviews medical records of 500 Polynesian patients with bronchiectasis (widened airways) to understand why the condition is so common in French Polynesia. Researchers will look at age of onset, family history, infections, and CT scan patterns to see if a genetic cause …

This study looks at why immune cells in people with COPD don't work properly to clear bacteria from the lungs. Researchers will collect cells from the lungs and blood of 189 participants, including COPD patients and healthy smokers and non-smokers. They will study how these cells…

This study collects exhaled breath from 240 adults—some with COPD and some without—to compare the types and amounts of bacteria present. Participants breathe through a straw into a device for 5 minutes, and a second sample is taken a year later. The goal is to understand how the …

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This study follows 320 Chinese adults with non-cystic fibrosis bronchiectasis (a chronic lung condition causing cough and infections) and some healthy volunteers for 12 months. Researchers will collect lung function tests, blood samples, and imaging to identify biomarkers and dis…

This study will check 1,000 smokers aged 40+ who visit heart doctors to see how many have undiagnosed COPD, a lung disease that often goes unnoticed. Participants will take a simple breathing test and answer a questionnaire. The goal is to find out how common hidden COPD is in th…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study will follow 693 people in Brazil with severe or very severe COPD to track how often they are hospitalized, have flare-ups, or die. Researchers want to understand the real-world impact of the disease in this group. No new treatments are being tested—only data is collect…

This study tracks quality of life in 200 adults with chronic respiratory failure who use breathing support like non-invasive ventilation. Researchers will use questionnaires to see how treatments impact daily living over time. The goal is to better understand patient experiences,…

This study will follow 500 adults with stable COPD for at least 3 years to identify and describe different patient profiles. Researchers will use routine care data to group patients by their characteristics, treatments, and outcomes. The goal is to better understand the various f…

This study aims to better understand asthma and COPD by comparing immune markers in blood and airways of patients versus healthy volunteers. Researchers will analyze samples from 230 adults to identify distinct immune patterns linked to disease severity. The goal is to improve di…

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This study follows 1000 younger adults (ages 30-55) who smoke or are at risk for COPD. Researchers will use CT scans, blood and sputum tests, and lung function tests to find early warning signs of the disease. The goal is to better understand how COPD starts and how to catch it s…

This observational study will follow 850 Chinese adults with COPD or pre-COPD for one year. Researchers will collect medical history, lung function tests, blood samples, and CT scans to identify different disease types and markers. The goal is to better understand how COPD develo…

This study looks at whether a smart computer program (AI) can help doctors make sure people with COPD see a lung specialist within 30 days after leaving the hospital. About 485 adults who had a serious COPD flare-up will take part. The goal is to see if the AI tool improves follo…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart. Researchers will compare people with one or both conditions and test two breathing treatments—a special mask that helps breathing at night and extra oxygen—to see which may impro…

This study looks at whether a short questionnaire called the COPD Assessment Test (CAT) can help predict breathing complications during and after surgery in people with COPD. Researchers will follow 120 patients aged 40-70 having elective surgery. They will compare those with low…

This study uses electrical impedance tomography (EIT), a non-invasive imaging method, to measure how air moves between the lungs in patients with acute respiratory distress syndrome (ARDS) who are on ventilators. Researchers aim to detect delays in lung inflation that could help …

This study is analyzing the exhaled breath of 5,000 people with lung or airway diseases to find unique molecular patterns. The goal is to better identify and distinguish different respiratory conditions and improve disease management. Participants simply provide breath samples, a…

This study will collect information from about 500 adults in Moscow who have moderate to very severe COPD and have had frequent flare-ups. Researchers will look at their medical history, current treatments, and overall health to better understand the disease and how it is managed…

This study looks at older veterans who have both sleep apnea and COPD, a combination called 'overlap syndrome.' Researchers want to see if having both conditions worsens thinking and memory more than having just one. They will also test whether using a breathing machine (CPAP) pl…

This study follows 1000 adults hospitalized for a sudden worsening of COPD (a lung disease). Researchers will collect medical data and biological samples over time to better understand these flare-ups. The goal is to improve future prevention and treatment, not to test a new drug…

This study looks at whether lung ultrasound can detect emphysema (a type of lung damage) as well as CT scans do. About 1,600 people with or without emphysema will get both an ultrasound and a CT scan. The goal is to find patterns on ultrasound that match the damage seen on CT, wh…

This study looks at 60 adult male smokers under 65 who have both heart disease (acute coronary syndrome) and pneumonia along with COPD. Researchers want to see if certain blood markers (GDF-15, MR proADM, and Presepsin) change after getting a flu shot. The goal is to understand h…

This observational study is developing a computer model to identify different types of bronchiectasis in adults. Researchers will collect health data from 750 participants over time to see if they can predict disease patterns. No treatments or interventions are given; participant…

This study will enroll 25 adults with interstitial lung disease or COPD to investigate the physical origins of ultrasound artifacts seen in lung scans. Researchers will compare ultrasound findings with CT scans and wearable sensor data to understand what these artifacts really me…

This study follows 1,000 people aged 12 and older in China who have severe eosinophilic asthma and are prescribed benralizumab. Researchers will track how well the drug controls asthma symptoms over time using questionnaires, and note reasons for stopping or switching treatment. …

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people with COPD, heart problems, fractures, or minor stroke. Participants use the platform for six months, receiving personalized recommendations and…

This study is creating a new scoring system called BASE to measure how severe bronchiectasis is and predict the chance of a flare-up over the next year. Researchers will follow 750 adults with non-cystic fibrosis bronchiectasis for 12 months, collecting routine medical data. No n…

This study looks at how the relationship between doctors and patients affects the way medical decisions are made. Researchers will interview 300 patients and healthcare workers in Singapore to understand what makes a good partnership. The goal is to learn how these partnerships c…

This study looks at 80 adults—40 with NTM lung disease (not on antibiotics) and 40 with bronchiectasis alone—to see if their health needs differ. Using questionnaires and simple physical tests, researchers will assess quality of life, nutrition, mood, and muscle strength. The goa…

This study looks at how having heart problems affects the severity of lung flare-ups and quality of life in people with bronchiectasis (a chronic lung condition). Researchers will compare 30 adults with bronchiectasis who also have heart conditions to those without heart issues. …

This study looks at 100 COPD patients on breathing machines to see if a new ultrasound-based method (D-RSBI) is better than the standard method (RSBI) at predicting when they can safely breathe on their own. Researchers will measure both methods during a breathing trial and check…

This study is developing and testing a new tool called the CLEAR model to help doctors predict when people with severe COPD can safely stop using a ventilator or non-invasive breathing support. Researchers will enroll 400 adults in the ICU and track how well the model predicts su…

This study tests whether induced pluripotent stem cells (iPS cells) can repair damaged lung tissue from people with COPD. Researchers will take small lung samples from 50 participants (COPD patients, smokers without COPD, and non-smokers) during a routine bronchoscopy. In the lab…

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart strain to help develop better treatments in the future. About 60 adults aged 40 and older with COPD will…

This study is testing a digital tool that includes a spirometer and an app to help people with COPD monitor their lung function daily at home. The goal is to see if the tool is easy to use, safe, and helps patients know when to seek medical care. Fifty adults with COPD who have h…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers will use heart imaging and other tests to identify different patterns of heart dysfunction. The goal is to better understand these patterns so that future …

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This study examines how a minimally invasive lung valve treatment changes leg muscle function in people with severe emphysema. Researchers will use MRI scans and small muscle samples to measure energy use and muscle structure before and after treatment. The goal is to understand …

This study looks at the physical properties of lung mucus in people with obstructive pulmonary disease. Researchers will collect sputum samples before and after chest physiotherapy or exercise to see how these treatments change the mucus. The goal is to better understand the dise…

This study follows 20 people with severe emphysema who are scheduled to receive endobronchial valves. Researchers will measure how much oxygen patients use during everyday activities before and six months after the procedure. The goal is to see if the treatment reduces the physic…

This study tests a detailed half-day health assessment for people with COPD who have frequent flare-ups requiring steroid tablets. The assessment checks lung health, other conditions like heart disease, and lifestyle factors, then creates a personalized treatment plan. Researcher…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study will check how many workers in an industrial zone in Thailand have asthma or COPD. About 310 adults will answer a questionnaire and take a breathing test. The goal is to find out how common these lung problems are in this group, not to test a treatment.

This study looks at why some people hospitalized for a severe COPD flare-up have low levels of a certain white blood cell (eosinophils) and how long it takes for those levels to return to normal. Researchers will follow 200 patients to identify factors linked to this condition an…

This study looks at whether a non-invasive breath measurement (EtCO2) can help doctors quickly tell how serious a COPD attack is. Researchers will monitor 240 adults in the emergency room to see if EtCO2 levels can predict the need for breathing support. If successful, this could…

This study is creating a Turkish version of a questionnaire that helps find breathing pattern problems in people with COPD. Researchers will test the questionnaire on 90 stable COPD patients to make sure it works well. The goal is to give doctors a better tool to understand and t…

This study looks at why people with COPD get very sick from a common cold virus (rhinovirus). Researchers will infect 50 volunteers—some with COPD, some healthy—in a controlled setting. They will compare lung and body responses to find new ways to prevent or treat COPD flare-ups.…

This study looks at how walking, strength training, and breathing exercises change oxygen levels in the brain and leg muscles of people with moderate-to-severe COPD. Researchers will compare 60 participants (30 with COPD and 30 healthy adults) using special light-based sensors. T…

This study follows about 500 adults with COPD who are already taking dupilumab as part of their regular care. Researchers will collect health information over 3 years to see how patients are doing and check for any side effects. The goal is to learn more about the real-world effe…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study will follow 1000 adults for up to 10 years, using a special type of CT scan (photon-counting) to look for lung nodules, tumors, and other lung conditions. Researchers will also use artificial intelligence to create a virtual copy of each person's lungs, called a 'digit…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study looks at how different frequencies of whole body vibration affect lung function, breathing muscles, arm strength, flexibility, and quality of life in healthy adults and people with moderate to severe COPD. About 102 participants will try three vibration frequencies in …

This study compares exercise ability, muscle strength, blood vessel stiffness, and quality of life among three groups: people with COPD, those with a less-known condition called PRISm (Preserved Ratio Impaired Spirometry), and healthy individuals. Researchers will measure these f…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study is enrolling 100 adults with stable bronchiectasis (a chronic lung condition) to see if certain blood markers and CT scan findings can predict who will have frequent flare-ups. Researchers will measure inflammation markers like CRP and cell ratios, along with detailed …

This study looks at whether CT scans done for lung cancer screening can also help find COPD, a common lung disease in smokers. Researchers will review scans from 200 current or former smokers aged 50–80 who already had a CT scan as part of routine care. The goal is to see how man…

This study looks at physical fitness in children aged 7 to 18 who have bronchiectasis, a lung condition. Researchers will use fun, game-like tests to measure fitness, along with lung function and muscle strength. The goal is to better understand how the disease impacts children's…

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

This study is observing 10,000 adults aged 40-80 with COPD to learn how combining Western medicine with Traditional Chinese Medicine (like tongue and pulse checks) and wearable devices can help predict and manage other health problems that often come with COPD. The goal is to cre…

This study is re-examining 1,400 adults in Stockholm to find early signs and risk factors for heart, lung, and liver diseases. Participants will get advanced scans, blood tests, and questionnaires. The goal is to better understand how these diseases develop and how to predict the…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study will analyze data from 100,000 COPD patients in Hong Kong to build computer models that predict who is likely to be readmitted to the hospital or die within a year. The goal is to help doctors identify high-risk patients early. No new treatments are being tested; inste…

This observational study is investigating how patients with chronic airway diseases like COPD and asthma perceive breathing difficulty. Researchers will assess about 950 participants (800 patients and 150 healthy volunteers) using questionnaires, lung function tests, blood sample…

This study is testing different doses of aspirin to see which one best reduces inflammation in people with COPD. The goal is to find the right dose that could improve breathing and reduce flare-ups. The study involves 48 former smokers with COPD and will measure blood and urine m…

This study aims to find risk factors—including genetic ones—that make some COPD patients more likely to have severe flare-ups. Researchers will follow 200 adults with COPD to see which ones have acute exacerbations. The goal is to help doctors personalize treatment and prevent se…

This early-stage study tests whether a new inhaler spray called TQC3302 is safe and how it moves through the body. It involves 57 healthy adults in China, not people with lung disease. The goal is to check for side effects and measure drug levels, not to treat any condition.

This study aims to understand why some COPD patients benefit from inhaled corticosteroids (ICS) while others do not, by looking at molecular changes in the body. Researchers will enroll 135 former smokers with stable COPD who are already on dual bronchodilators. Participants will…

This study looks at whether exercise, like walking and telehealth coaching, along with smoking cessation advice, can improve the lung function of smokers who already have early signs of lung trouble. Researchers will track 90 adults for a year to see if these steps help prevent c…

This study will give 50 COPD patients a wearable device to track their heart rate, breathing, oxygen levels, and activity for three months after a severe flare-up. The goal is to understand how symptoms change at home and build a computer model that could one day warn patients an…

This study explores whether machine learning can analyze breathing test results to predict chronic respiratory diseases like asthma and COPD. Researchers will compare a newer technique called oscillometry with standard spirometry in 50 adults. The goal is to see if this approach …

This study is creating a registry of 420 people who are already getting lung cancer screening and may have COPD. Researchers will collect information like breathing tests, CT scans, and symptoms to better understand COPD in this group. The goal is to improve how COPD is found and…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis who may also have an NTM infection. Researchers will collect sputum and airway samples from 1000 participants to compare the lung microbiome of those with and withou…

This study looks at how chronic obstructive pulmonary disease (COPD) changes the way people walk and move in daily life. Researchers will measure foot pressure, walking ability, and heart-lung function in 60 adults aged 45 to 65. The goal is to find better ways to evaluate and im…

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI results with lung tissue from 30 patients awaiting lung transplant. The goal is …

This study is gathering detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze clinical, biological, and lifestyle factors to identify distinct disease subtypes. …

This study follows 25 people with COPD and high carbon dioxide levels who use a breathing machine at night. Researchers want to see if nighttime breathing problems can predict how well the machine works over 6 to 12 months. They will also check lung function, diaphragm health, an…

This study looks at how often heart failure with preserved ejection fraction (HFpEF) occurs in people with COPD and how it affects their health over time. Researchers will follow 200 adults aged 50–70 in Russia who are hospitalized with COPD. They will use heart and lung tests to…

This study looks at how breathing in dust from the World Trade Center attacks may harm the heart and lungs of FDNY first responders. Researchers will measure certain substances in the blood and breathing tests to find early signs of disease. The goal is to better understand these…

This study looks at how immune cells behave in people with lung cancer, sarcoidosis, and COPD. Researchers will collect blood and tissue samples from 425 participants to analyze immune function. No experimental treatments are given. The goal is to understand why some patients don…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study looks at why people with COPD may have overactive nerve signals that increase heart rate and narrow blood vessels. Researchers will measure nerve activity, breathing, and inflammation in 135 adults with COPD. The goal is to better understand the causes, not to test a n…

This study is testing a new type of CT scanner (photon-counting CT) to see if it can measure lung damage in people with COPD more accurately than current scanners. Researchers will compare scans from 40 participants to see if the new method gives more consistent results. The goal…

This study looks at how the diaphragm, the main muscle used for breathing, works in people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. About 800 adults will take breat…

This study tests whether monitoring changes in airway resistance can help doctors decide the best time to suction mucus from the lungs of patients on ventilators. Researchers will use machine learning to analyze data from 258 patients with conditions like ARDS or severe pneumonia…

This study looks at whether people newly diagnosed with idiopathic pulmonary fibrosis (IPF) have problems in their small airways, which are tiny air passages in the lungs. Researchers will use a simple breath test called nitrogen washout to check for these issues before starting …

This study looks at the bacteria living in the lungs of smokers with and without early-stage COPD. Researchers will use a bronchoscopy to collect samples and analyze how these bacteria and the body's immune response differ between the two groups. The goal is to better understand …

This study is looking at whether small differences in certain genes make very low birth-weight babies more likely to develop chronic lung disease and other complications of prematurity. Researchers will compare the genes of 1,100 infants who develop these conditions with those wh…

This study explores how emotional, practical, and social support affects the ability of people with COPD to manage their own health. Researchers will survey 111 adults aged 40 and older with COPD, and interview 20 of them in depth. The goal is to understand what helps or hinders …

This study looks at whether simple measurements—like thigh circumference and muscle stiffness—can reliably track muscle health in people with COPD. Researchers will measure 30 patients before and after a pulmonary rehabilitation program. The goal is to find an easy way to monitor…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study follows 80 adults with PiMZ alpha-1 antitrypsin deficiency and mild-to-moderate COPD over three years. Researchers will use CT scans and blood tests to measure lung density changes and look for biomarkers that could be used in future treatment trials. No new treatment …

This study looks back at medical records of 1,000 people with COPD who also had a special heart test called right heart catheterization. Researchers want to understand a specific lung-heart problem called pulmonary hypertension. By analyzing this data, they hope to better identif…

This early-stage study tests a new drug called RSS0343 in 48 healthy adults to see if it is safe and how the body handles it. Participants take the drug or a placebo by mouth for a short time. The goal is to check for side effects and measure drug levels in the blood. This study …

This study looks at whether doing exercise training in the morning or afternoon makes a difference for people with COPD. Researchers will measure walking distance, endurance, and balance in 90 patients. The goal is to see if matching exercise time to the body's natural clock can …

This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples …

This study uses brain scans (fMRI) to see if people with cancer, COPD, or heart failure have different brain activity patterns when they feel breathless. It also tests whether immersive virtual reality can help ease that breathlessness. Only 16 participants are being recruited to…

This observational study will use CT scans to measure mucus plugging in the airways of people with asthma, COPD, or chronic cough, and compare them to healthy volunteers. Researchers hope to understand how mucus changes over time and find biomarkers that could guide treatment. Th…

This study observes oxygen levels in the airway during rigid bronchoscopy, a procedure to treat blocked airways. Researchers will measure how long it takes for oxygen to drop to a safe level when using a special ventilator mode. The goal is to reduce the risk of airway fires duri…

This study follows 150 adults with bronchiectasis for two years to understand how bacteria in the airways and gut influence disease progression. Researchers will also examine how macrolide antibiotics (like azithromycin) work to improve symptoms. Participants provide sputum, stoo…

This study tests whether a wrist-worn device that counts coughs can predict serious COPD flare-ups early. Fifty adults with COPD will wear the Hyfe monitor, which tracks cough frequency without recording audio. Participants also answer weekly symptom questions. The goal is to see…

This study looks at how fungi in the environment (like mold in homes) affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect dust and sputum samples from 125 adults aged 18–80 and follow them for 6 months. The goal …

This study follows 600 adults who have received a stem cell transplant to learn more about a lung condition called bronchiolitis obliterans syndrome. Researchers will track how common this lung problem is and how it develops over time. No new treatments are being tested; the goal…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study is testing whether wearable sensors that track things like heart rate and breathing can detect changes during a chest infection in adults with cystic fibrosis or bronchiectasis. Researchers will monitor 50 patients who are starting intravenous antibiotics for a lung in…

This study looks at people with COPD who use a home breathing machine called non-invasive ventilation (NIV). Researchers will use artificial intelligence (AI) to analyze breathing data from the machine, such as airflow and pressure, to find early signs of a flare-up. The study do…

This study looks at whether an ultrasound measurement of the diaphragm can help predict which patients hospitalized with a COPD flare-up will get worse and need breathing support or die. About 186 adults with severe COPD will have an extra ultrasound during their hospital stay. T…

This study aims to better understand bronchiectasis, a chronic lung disease, in Chinese patients. Researchers will collect data from 1500 adults to identify different disease types and their underlying causes. The goal is to improve diagnosis and tailor treatments for each patien…

This study is looking for better ways to predict if a lung transplant will be rejected. Researchers will collect blood samples from 244 lung transplant recipients over time and analyze them using advanced techniques. The goal is to create a model that can identify early signs of …

This study is recruiting 90 people aged 8-25 who are survivors of childhood leukemia, chronic lung disease of prematurity, or heart transplant, plus healthy controls. Researchers will use non-invasive exercise tests to measure heart and lung function during physical activity. The…

This study compares muscle strength, exercise ability, and oxygen use in 60 people with COPD, a condition called PRISm (which is like early-stage COPD), and healthy volunteers. Researchers will measure breathing muscle strength, arm and leg strength, and how well muscles use oxyg…

This study looks at how plant-based and whey (dairy) proteins affect muscle building in older adults, including those with muscle loss (sarcopenia). Researchers will measure how the body processes amino acids from each protein type. The goal is to learn which protein composition …

This study follows 1,850 bronchiectasis patients over three years, collecting sputum samples monthly to analyze how lung bacteria change over time. Researchers will sequence the DNA of bacteria like Pseudomonas aeruginosa to see how they evolve and become resistant to antibiotics…

This study looks at whether mucus plugs in the airways of COPD patients lead to lung fibrosis (scarring). Researchers will collect lung tissue and mucus from 20 people during lung cancer surgery and compare those with and without COPD. The goal is to understand the link and find …

This study collects blood, airway, and urine samples from 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare samples to establish normal ranges and learn how genes change in lung disease. The goal is to better underst…

This study aims to understand why some people with alpha-1 antitrypsin deficiency (AATD) get more respiratory infections. Researchers will compare immune responses to a pneumonia vaccine (PCV20) in 30 adults who carry one abnormal copy of the SERPINA1 gene. Half have had frequent…

This study aims to find the genes that make some people develop severe COPD at a young age, even if they smoke. Researchers will collect DNA and health information from 2,000 participants with early-onset COPD. The goal is to understand why some people are more prone to this lung…

This study looks at whether a special CT scan analysis called parametric response mapping (PRM) can detect early signs of chronic lung disease in people who have had a stem cell transplant. Researchers will follow 375 patients for one year to see if PRM patterns predict lung func…

This study aims to understand and improve how patients with COPD and asthma use their inhalers. Researchers will assess patients' inhaler technique and provide education, while also evaluating healthcare professionals' knowledge. The goal is to boost adherence to treatment and re…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study looks at how nutrition impacts the progression of bronchiectasis, a chronic lung disease. Researchers will measure things like arm circumference, grip strength, and body mass index in 300 adults. They will track how often participants have flare-ups and how their lung …

This study is creating a registry of people with emphysema to collect DNA, lung function tests, and medical information. Researchers hope to use this data to better understand the disease and develop new therapies. The registry will also help identify volunteers for future resear…

This study looks at how blood vessels control blood flow in healthy people and those with conditions like COPD, heart failure, and high blood pressure. Researchers will measure changes in blood flow and blood pressure after exercise and other tests. The goal is to understand why …

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…

This study tests a French version of a questionnaire that measures the burden on caregivers of people with COPD. Researchers will ask 224 caregivers to fill out the questionnaire along with other surveys to see if it works well. The goal is to give doctors a reliable way to spot …

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study is building a registry of genetic and health information from 3,000 people with conditions like diabetes, high cholesterol, cancer, and heart disease. The goal is to help doctors choose the safest and most effective medications based on a person's genetic makeup. Parti…

This study follows 100 adults with COPD for one year to see how airway inflammation changes over time. Researchers use a simple breath test (FeNO) and a blood sample to measure inflammation markers. Participants visit the clinic three times—at the start, 6 months, and 12 months—t…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study is testing a wearable system called WearME to see if it can accurately measure lung function and breathing in people with COPD. Researchers will compare the device's readings to standard hospital tests like spirometry. The goal is to find a simpler way for patients to …

This study follows 730 adults with COPD who still have severe shortness of breath even after using standard inhalers. Researchers will track their health over time to see what factors lead to more flare-ups, faster lung decline, or death. The goal is to better understand this dif…

This study surveys 384 adults in Türkiye who have completed a pulmonary rehabilitation program for lung conditions like COPD or asthma. Researchers want to learn how satisfied patients are and how the rehab team's structure affects their experience. No new treatment is being test…

This study looks at lung tissue from 186 people having surgery for suspected lung cancer. Researchers will compare smokers with and without COPD to non-smokers, focusing on cells that help repair the lungs. The goal is to understand why some smokers develop COPD while others do n…