Scientists probe gut and lung bacteria to unlock bronchiectasis mysteries

NCT ID NCT05731427

Recruiting now Knowledge-focused Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 150 adults with bronchiectasis for two years to understand how bacteria in the airways and gut influence disease progression. Researchers will also examine how macrolide antibiotics (like azithromycin) work to improve symptoms. Participants provide sputum, stool, and blood samples for advanced analysis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Macrolides (azithromycin or clarithromycin)
What this could lead to: If successful, this could clarify how macrolides work in bronchiectasis and why some patients get worse, potentially guiding better treatments.
What could go wrong: This is an observational study with some drug treatment, not a controlled trial. It may not prove cause and effect, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bronchiectasis Pseudomonas infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHIECTASIS

Contacts and locations

Locations

Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital
RECRUITING

Yichang, Hubei, 443000, China
Guizhou Provincial people's Hospital
RECRUITING

Guiyang, Guizhou, 550002, China
Wuhan Union Hospital
RECRUITING

Wuhan, Hubei, 430022, China

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