Can a daily pill cut dangerous lung Flare-Ups in bronchiectasis?

NCT ID NCT05238675

Completed Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests an experimental drug, BI 1291583, in adults with bronchiectasis who produce sputum and have a history of flare-ups. Participants are randomly assigned to one of three doses of the drug or a placebo, taken once daily for at least 24 weeks. The study measures how long it takes for the first flare-up to occur and tracks overall health and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental drug called BI 1291583 (verducatib)
What this could lead to: If it works, this could point toward a new treatment to reduce dangerous lung flare-ups in people with bronchiectasis.
What could go wrong: This is an early phase 2 trial, so the drug may not prove effective or could have side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

bronchiectasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHIECTASIS

Contacts and locations

Locations

A.O. Univ. Policlinico "Paolo Giaccone"

Palermo, 90127, Italy
Aalborg Sygehus Syd

Aalborg, 9000, Denmark
Accelerium S de RL de CV

Monterrey, 64000, Mexico
Alergopneuma Medical Center

Świdnik, 21040, Poland
Altamed Specjalistyczna Praktyka Lekarska Pawel Siwinski

Warsaw, 01-456, Poland
Amsterdam UMC, location VUMC

Amsterdam, 1081 HV, Netherlands
Asan Medical Center

Seoul, 05505, South Korea
Central Florida Pulmonary Group

Altamonte Springs, Florida, 32701, United States
Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec, H2X 0A9, Canada
Charité - Universitätsmedizin Berlin

Berlin, 10117, Germany
Chungbuk National University Hospital

Cheongju-si, 28644, South Korea
Clinical Research Institute S.C.

Tlalnepantla, 54055, Mexico
Copenhagen University Hospital, Rigshospitalet

København Ø, 2100, Denmark
Da Vinci Private Clinic

Pécs, 7635, Hungary
Daugavpils Regional Hospital LTD Centre Outpatient Clinic

Daugavpils, 5401, Latvia
Diagnostics Research Group

San Antonio, Texas, 78229, United States
Dr. Piotr Napora, Center of Clinical Research

Wroclaw, 51162, Poland
Fondazione IRCCS Policlinico S. Matteo

Pavia, 27100, Italy
Fukujuji Hospital

Tokyo, Kiyose, 204-8522, Japan
Fukuoka University Hospital

Fukuoka, Fukuoka, 814-0180, Japan
Gelre Ziekenhuis Zutphen

Zutphen, 7207 AE, Netherlands
HOP Amiens-Picardie Sud

Amiens, 80054, France
HOP Arnaud de Villeneuve

Montpellier, 34295, France
HOP Cochin

Paris, 75679, France
HOP Pontchaillou

Rennes, 35033, France
Hadassah Medical Center, Ein-Karem

Jerusalem, 9112001, Israel
Hirosaki University Hospital

Aomori, Hirosaki, 036-8563, Japan
Hospital Clínic de Barcelona

Barcelona, 08036, Spain
Hospital General Universitario Gregorio Marañón

Madrid, 28007, Spain
Hospital Quirónsalud Madrid

Pozuelo de Alarcón, 28223, Spain
Hospital Universitario Dr Jose Eleuterio Gonzalez

Nuevo León, 64460, Mexico
Hospital Universitario Nuevo de Nuevo León - CEPREP

Monterrey, Nuevo León, C.P. 64460, Mexico
Hospital de Bellvitge

L'Hospitalet de Llobregat, 08907, Spain
Hospital de Mérida

Mérida, 06800, Spain
Hvidovre Hospital

Hvidovre, 2650, Denmark
IKF Pneumologie GmbH & Co. KG

Frankfurt, 60596, Germany
IUCPQ (Laval University)

Québec, Quebec, G1V 4G5, Canada
Ibarakihigashi National Hospial

Ibaraki, Naka-gun, 319-1113, Japan
Institute for Respiratory Health

Nedlands, Western Australia, 6009, Australia
Institute for Translational Oncology Research

Greenville, South Carolina, 29605, United States
Istituto Clinico Humanitas

Rozzano (MI), 20089, Italy
Jewish General Hospital

Montreal, Migration Data, H3T 1E2, Canada
Kagoshima University Hospital

Kagoshima, Kagoshima, 890-8520, Japan
Kameda Clinic

Chiba, Kamogawa, 296-0041, Japan
Kitasato Institute Hospital

Tokyo, Minato-ku, 108-8642, Japan
Klinikum Konstanz

Konstanz, 78464, Germany
Klinikum der Universität München - Campus Innenstadt

München, 80336, Germany
Korea University Guro Hospital

Seoul, 08308, South Korea
Kyushu University Hospital

Fukuoka, Fukuoka, 812-8582, Japan
LUMPII Doctors practice

Riga, 1011, Latvia
Lady Davis Carmel Medical Center

Haifa, 3436212, Israel
Liverpool Heart & Chest Hospital

Liverpool, L14 3PE, United Kingdom
Lung Research Queensland

Chermside, Queensland, 4032, Australia
Lungenfachklinik Immenhausen

Immenhausen, 34376, Germany
Macquarie University

North Ryde, New South Wales, 2109, Australia
Malcom Randall VA Medical Center

Gainesville, Florida, 32608, United States
Marmara University Pendik Training and Research Hospital

Istanbul, 34890, Turkey (Türkiye)
Mater Research Institute

South Brisbane, Queensland, 4101, Australia
Matsusaka City Hospital

Mie, Matsusaka, 515-8544, Japan
Med.Center OLVI Health Center Assotiation,Private Practice

Daugavpils, 5410, Latvia
Mediadvance Clinical S.A.P.I de C.V.

Chihuahua City, 31203, Mexico
Medica Center Hera - Montana Branch

Montana, 3400, Bulgaria
Medical Center "Zdrave-1"

Kozloduy, 3320, Bulgaria
Medical Center Hera EOOD

Sofia, 1510, Bulgaria
Medical Center ReSpiro Ltd

Razgrad, 7200, Bulgaria
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Metroplex Pulmonary & Sleep Center

McKinney, Texas, 75069, United States
Nagoya University Hospital

Aichi, Nagoya, 466-8560, Japan
New York University Langone Medical Center

New York, New York, 10016, United States
NewYork-Presbyterian/Weill Cornell Medical Center

New York, New York, 10065, United States
Newport Native MD, Inc

Newport Beach, California, 92663, United States
Niigata University Medical and Dental Hospital

Niigata, Niigata, 951-8520, Japan
Ninewells Hospital & Medical School

Dundee, Scotland, DD1 9SY, United Kingdom
Oaxaca Site Management Organization, S.C.

Oaxaca City, 68000, Mexico
Odense University Hospital

Odense, 5000 C, Denmark
Osaka Toneyama Medical Center

Osaka, Toyonaka, 560-8552, Japan
Pauls Stradins Clinical University Hospital

Riga, 1002, Latvia
Phoenix Medical Group

Peoria, Arizona, 85381, United States
Pulmonary Private Practice Kralupy

Kralupy nad Vltavou, 27801, Czechia
Respiratory Medicine Centre, private prac., Bialystok

Bialystok, 15044, Poland
Riga 1st Hospital

Riga, 1001, Latvia
Royal Papworth Hospital

Cambridge, CB2 0AY, United Kingdom
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH

Essen, 45239, Germany
SHATPFD "Dr. Dimitar Gramatikov"

Rousse, 7002, Bulgaria
SMG-SNU Boramae Medical Center

Seoul, 156-707, South Korea
Saga University Hospital

Saga, Saga, 849-8501, Japan
Screenmed Sp. z o.o.

Piaseczno, 05500, Poland
Semmelweis University

Budapest, 1083, Hungary
Sjællands Universitetshospital

Roskilde, 4000, Denmark
Soroka Univ. Medical Center

Beersheba, 8410101, Israel
Sourasky Medical Center

Tel Aviv, 6093246, Israel
Southeastern Research Center

Winston-Salem, North Carolina, 27103, United States
Sureyyapasa Egitim ve Arastirma Hastanesi

Istanbul, 34890, Turkey (Türkiye)
The Catholic University of Korea, Eunpyeong St. Mary's Hospital

Seoul, 22711, South Korea
The First Pulmonary Private Practice

Prague, 19000, Czechia
Trialswest

Spearwood, Western Australia, 6153, Australia
ULS de Santa Maria, E.P.E

Lisbon, 1064-035, Portugal
UNIV UZ Gent

Ghent, 9000, Belgium
UZ Leuven

Leuven, 3000, Belgium
Uludag Universitesi Tip Fakultesi

Bursa, 16120, Turkey (Türkiye)
Univ. Gen. Hosp. of Ioannina

Ioannina, 45 500, Greece
University of California Davis

Sacramento, California, 95817, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Florida College of Medicine

Jacksonville, Florida, 32209, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Texas Health Science Center at Tyler

Tyler, Texas, 75708, United States
VCA Dubultu Medical center

Jūrmala, 2015, Latvia
Vejle University Hospital

Vejle, 7100, Denmark
Velocity Clinical Research Germany GmbH

Großhansdorf, 22927, Germany
Velocity Clinical Research Germany GmbH

Lübeck, 23552, Germany
Velocity Clinical Research Germany GmbH

Wiesbaden, 65189, Germany
Westmead Hospital

Westmead, New South Wales, 2145, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.