BRONCHIECTASIS

This study tests a once-daily tablet called BI 1291583 in adults and teens (ages 12 and up) with bronchiectasis who produce sputum and have had flare-ups. About 1755 participants will be randomly assigned to receive the drug or a placebo for up to 76 weeks. The main goal is to se…

This study tests a device called BiWaze Clear, which helps people with bronchiectasis loosen mucus and expand their lungs. About 85 participants will use the device at home for 6 months. Researchers will track how often lung infections occur compared to the year before, to see if…

This study tests if a smartphone app can listen to your breathing and detect lung problems like asthma, COPD, or cystic fibrosis. Researchers will compare the app's results to standard breathing tests. If successful, this could make lung health checks easier and more accessible, …

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases like COPD, pneumonia, and pneumothorax. Researchers will enroll 700 adults with various lung conditions and healthy volunteers t…

This study is testing whether the antifungal drug itraconazole is a practical and safe treatment for adults with bronchiectasis who also have mold growing in their airways. Researchers will enroll 30 participants to see if people are willing to join, can stick with the 6-week tre…

This study tests the safety of an inhaled drug called CHF6333 in healthy volunteers and people with bronchiectasis, a chronic lung condition. In the first part, participants receive a single dose; in the second part, people with bronchiectasis receive repeated doses. The goal is …

This study tests a special breathing exercise program for adults with bronchiectasis, a chronic lung condition causing cough and mucus. The program combines breathing muscle training with core stability exercises. Researchers will measure lung function, muscle thickness, balance,…

This study looks at how using a handheld breathing device (oscillating PEP) affects quality of life in people with bronchiectasis. Researchers will ask 60 children (ages 8+) and adults to fill out questionnaires before and after using the device. The goal is to see if the device …

This study compares two breathing support methods for people with bronchiectasis who are having a sudden worsening of symptoms. It will test if a high flow nasal cannula works as well as non-invasive ventilation and is easier for patients to tolerate. The study involves 20 adults…

This study is testing a new interactive digital breathing game that children with bronchiectasis can use at home to help clear their airways. The goal is to see if the game can replace the need for a physiotherapist or healthcare professional for daily airway cleaning. The study …

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will collect blood samples, lung function tests, and health questionnaires from 200 participants, including healthy …

This study follows 1,850 people with bronchiectasis, a chronic lung condition, for three years. Researchers collect sputum samples monthly to analyze how bacteria in the lower airways evolve and adapt. The goal is to understand which bacterial changes lead to sudden worsening of …

This study looks at how having heart problems affects the severity of sudden worsening of symptoms (flare-ups) in people with bronchiectasis, a chronic lung condition. Researchers will measure a heart-related protein (BNP) and quality of life in 30 participants with both conditio…

This study aims to understand why bronchiectasis, a chronic lung disease, worsens over time. Researchers will collect sputum, stool, and blood samples from 150 adults and follow them for two years. By analyzing the microbes and chemicals in these samples, they hope to discover wh…

This study is collecting detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. The goal is to identify different disease subtypes and shared features, which could lead to more personaliz…

This study looks at how nutritional health, measured by things like arm circumference and grip strength, relates to the progression of bronchiectasis, a chronic lung condition. Researchers will follow 300 adults over time to track lung function and flare-ups. The goal is to bette…

This study looks at 80 adults to compare the health needs of people with a chronic lung infection called NTM and those with bronchiectasis alone. Participants will fill out questionnaires and do simple physical tests in one visit. The goal is to find out what symptoms matter most…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis who may also have an infection from NTM bacteria. Researchers will collect sputum and airway samples from 1000 participants to see if certain bacterial patterns are …

This study follows 900 people with bronchiectasis (damaged and infected airways) to learn why they get repeated lung infections. Researchers will collect blood, spit, and genetic samples from patients and their family members. The goal is to find inherited or immune system proble…

This study looks at how fungi found in homes and the environment affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect sputum, dust, and air samples from 125 adults aged 18-80 to measure fungal exposure and lung fu…